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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 2-30454409-A-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=30454409&ref=A&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "2",
"pos": 30454409,
"ref": "A",
"alt": "C",
"effect": "intron_variant",
"transcript": "NM_182551.5",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "LCLAT1",
"gene_hgnc_id": 26756,
"hgvs_c": "c.-5+7026A>C",
"hgvs_p": null,
"transcript": "NM_001002257.3",
"protein_id": "NP_001002257.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 376,
"cds_start": null,
"cds_end": null,
"cds_length": 1131,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000379509.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001002257.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "LCLAT1",
"gene_hgnc_id": 26756,
"hgvs_c": "c.-5+7026A>C",
"hgvs_p": null,
"transcript": "ENST00000379509.8",
"protein_id": "ENSP00000368823.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 376,
"cds_start": null,
"cds_end": null,
"cds_length": 1131,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001002257.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000379509.8"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "LCLAT1",
"gene_hgnc_id": 26756,
"hgvs_c": "c.-61-5143A>C",
"hgvs_p": null,
"transcript": "ENST00000309052.8",
"protein_id": "ENSP00000310551.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 414,
"cds_start": null,
"cds_end": null,
"cds_length": 1245,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000309052.8"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "LCLAT1",
"gene_hgnc_id": 26756,
"hgvs_c": "c.-61-5143A>C",
"hgvs_p": null,
"transcript": "NM_182551.5",
"protein_id": "NP_872357.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 414,
"cds_start": null,
"cds_end": null,
"cds_length": 1245,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_182551.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "LCLAT1",
"gene_hgnc_id": 26756,
"hgvs_c": "c.-409-5143A>C",
"hgvs_p": null,
"transcript": "NM_001304445.2",
"protein_id": "NP_001291374.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 376,
"cds_start": null,
"cds_end": null,
"cds_length": 1131,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001304445.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "LCLAT1",
"gene_hgnc_id": 26756,
"hgvs_c": "c.-175-5143A>C",
"hgvs_p": null,
"transcript": "ENST00000897444.1",
"protein_id": "ENSP00000567503.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 376,
"cds_start": null,
"cds_end": null,
"cds_length": 1131,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897444.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "LCLAT1",
"gene_hgnc_id": 26756,
"hgvs_c": "c.-256-5143A>C",
"hgvs_p": null,
"transcript": "ENST00000897445.1",
"protein_id": "ENSP00000567504.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 376,
"cds_start": null,
"cds_end": null,
"cds_length": 1131,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897445.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "LCLAT1",
"gene_hgnc_id": 26756,
"hgvs_c": "c.-234-5143A>C",
"hgvs_p": null,
"transcript": "ENST00000897446.1",
"protein_id": "ENSP00000567505.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 376,
"cds_start": null,
"cds_end": null,
"cds_length": 1131,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897446.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "LCLAT1",
"gene_hgnc_id": 26756,
"hgvs_c": "c.-5+6460A>C",
"hgvs_p": null,
"transcript": "ENST00000897448.1",
"protein_id": "ENSP00000567507.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 376,
"cds_start": null,
"cds_end": null,
"cds_length": 1131,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897448.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "LCLAT1",
"gene_hgnc_id": 26756,
"hgvs_c": "c.-64+7026A>C",
"hgvs_p": null,
"transcript": "ENST00000897449.1",
"protein_id": "ENSP00000567508.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 376,
"cds_start": null,
"cds_end": null,
"cds_length": 1131,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897449.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "LCLAT1",
"gene_hgnc_id": 26756,
"hgvs_c": "c.-315-5143A>C",
"hgvs_p": null,
"transcript": "ENST00000897450.1",
"protein_id": "ENSP00000567509.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 376,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897450.1"
},
{
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"canonical": false,
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"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 6,
"intron_rank": 1,
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"gene_symbol": "LCLAT1",
"gene_hgnc_id": 26756,
"hgvs_c": "c.-5+7026A>C",
"hgvs_p": null,
"transcript": "ENST00000921893.1",
"protein_id": "ENSP00000591952.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 371,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000921893.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 5,
"intron_rank": 1,
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"gene_symbol": "LCLAT1",
"gene_hgnc_id": 26756,
"hgvs_c": "c.-5+7026A>C",
"hgvs_p": null,
"transcript": "ENST00000897447.1",
"protein_id": "ENSP00000567506.1",
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"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897447.1"
},
{
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"canonical": false,
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 6,
"intron_rank": 1,
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"gene_symbol": "LCLAT1",
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"hgvs_c": "c.-175-5143A>C",
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 6,
"intron_rank": 1,
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"gene_symbol": "LCLAT1",
"gene_hgnc_id": 26756,
"hgvs_c": "c.-175-5143A>C",
"hgvs_p": null,
"transcript": "ENST00000897451.1",
"protein_id": "ENSP00000567510.1",
"transcript_support_level": null,
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"cds_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000897451.1"
},
{
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"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 5,
"intron_rank": 1,
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"gene_symbol": "LCLAT1",
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"hgvs_c": "c.-5+7005A>C",
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"transcript": "ENST00000921891.1",
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000921891.1"
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "LCLAT1",
"gene_hgnc_id": 26756,
"hgvs_c": "c.-61-5143A>C",
"hgvs_p": null,
"transcript": "ENST00000319406.8",
"protein_id": "ENSP00000368826.1",
"transcript_support_level": 2,
"aa_start": null,
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"cds_start": null,
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"cds_length": 927,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000319406.8"
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "LCLAT1",
"gene_hgnc_id": 26756,
"hgvs_c": "c.-365+7005A>C",
"hgvs_p": null,
"transcript": "NM_001304446.2",
"protein_id": "NP_001291375.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
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"cds_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "NM_001304446.2"
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 4,
"intron_rank": 1,
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"gene_symbol": "LCLAT1",
"gene_hgnc_id": 26756,
"hgvs_c": "c.-5+7026A>C",
"hgvs_p": null,
"transcript": "ENST00000476038.5",
"protein_id": "ENSP00000419646.1",
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 4,
"intron_rank": 1,
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"gene_symbol": "LCLAT1",
"gene_hgnc_id": 26756,
"hgvs_c": "c.-61-5143A>C",
"hgvs_p": null,
"transcript": "ENST00000497423.1",
"protein_id": "ENSP00000417875.1",
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},
{
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"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"intron_rank": 1,
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"gene_symbol": "LCLAT1",
"gene_hgnc_id": 26756,
"hgvs_c": "c.-5+7026A>C",
"hgvs_p": null,
"transcript": "ENST00000466477.5",
"protein_id": "ENSP00000419966.1",
"transcript_support_level": 3,
"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000466477.5"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "LCLAT1",
"gene_hgnc_id": 26756,
"hgvs_c": "c.-5+6886A>C",
"hgvs_p": null,
"transcript": "ENST00000476535.1",
"protein_id": "ENSP00000419444.1",
"transcript_support_level": 4,
"aa_start": null,
"aa_end": null,
"aa_length": 136,
"cds_start": null,
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"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000476535.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
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}