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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 2-32197743-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=32197743&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 3,
          "criteria": [
            "PM2",
            "BP4_Moderate",
            "BP7"
          ],
          "effects": [
            "synonymous_variant"
          ],
          "gene_symbol": "SLC30A6",
          "hgnc_id": 19305,
          "hgvs_c": "c.702C>T",
          "hgvs_p": "p.Phe234Phe",
          "inheritance_mode": "AR",
          "pathogenic_score": 2,
          "score": -1,
          "transcript": "NM_001193513.3",
          "verdict": "Likely_benign"
        }
      ],
      "acmg_classification": "Likely_benign",
      "acmg_criteria": "PM2,BP4_Moderate,BP7",
      "acmg_score": -1,
      "allele_count_reference_population": 57,
      "alphamissense_prediction": null,
      "alphamissense_score": null,
      "alt": "T",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Benign",
      "bayesdelnoaf_score": -0.28,
      "chr": "2",
      "clinvar_classification": "",
      "clinvar_disease": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "computational_prediction_selected": "Benign",
      "computational_score_selected": -0.2800000011920929,
      "computational_source_selected": "BayesDel_noAF",
      "consequences": [
        {
          "aa_alt": "F",
          "aa_end": null,
          "aa_length": 461,
          "aa_ref": "F",
          "aa_start": 194,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5089,
          "cdna_start": 619,
          "cds_end": null,
          "cds_length": 1386,
          "cds_start": 582,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 14,
          "exon_rank": 10,
          "exon_rank_end": null,
          "feature": "NM_017964.5",
          "gene_hgnc_id": 19305,
          "gene_symbol": "SLC30A6",
          "hgvs_c": "c.582C>T",
          "hgvs_p": "p.Phe194Phe",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000282587.9",
          "protein_coding": true,
          "protein_id": "NP_060434.2",
          "strand": true,
          "transcript": "NM_017964.5",
          "transcript_support_level": null
        },
        {
          "aa_alt": "F",
          "aa_end": null,
          "aa_length": 461,
          "aa_ref": "F",
          "aa_start": 194,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 5089,
          "cdna_start": 619,
          "cds_end": null,
          "cds_length": 1386,
          "cds_start": 582,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 14,
          "exon_rank": 10,
          "exon_rank_end": null,
          "feature": "ENST00000282587.9",
          "gene_hgnc_id": 19305,
          "gene_symbol": "SLC30A6",
          "hgvs_c": "c.582C>T",
          "hgvs_p": "p.Phe194Phe",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_017964.5",
          "protein_coding": true,
          "protein_id": "ENSP00000282587.5",
          "strand": true,
          "transcript": "ENST00000282587.9",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "F",
          "aa_end": null,
          "aa_length": 501,
          "aa_ref": "F",
          "aa_start": 234,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2354,
          "cdna_start": 739,
          "cds_end": null,
          "cds_length": 1506,
          "cds_start": 702,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 15,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "ENST00000379343.6",
          "gene_hgnc_id": 19305,
          "gene_symbol": "SLC30A6",
          "hgvs_c": "c.702C>T",
          "hgvs_p": "p.Phe234Phe",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000368648.2",
          "strand": true,
          "transcript": "ENST00000379343.6",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "F",
          "aa_end": null,
          "aa_length": 438,
          "aa_ref": "F",
          "aa_start": 194,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4776,
          "cdna_start": 642,
          "cds_end": null,
          "cds_length": 1317,
          "cds_start": 582,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 13,
          "exon_rank": 10,
          "exon_rank_end": null,
          "feature": "ENST00000435660.5",
          "gene_hgnc_id": 19305,
          "gene_symbol": "SLC30A6",
          "hgvs_c": "c.582C>T",
          "hgvs_p": "p.Phe194Phe",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000399005.1",
          "strand": true,
          "transcript": "ENST00000435660.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "F",
          "aa_end": null,
          "aa_length": 387,
          "aa_ref": "F",
          "aa_start": 120,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4589,
          "cdna_start": 399,
          "cds_end": null,
          "cds_length": 1164,
          "cds_start": 360,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 11,
          "exon_rank": 7,
          "exon_rank_end": null,
          "feature": "ENST00000406369.2",
          "gene_hgnc_id": 19305,
          "gene_symbol": "SLC30A6",
          "hgvs_c": "c.360C>T",
          "hgvs_p": "p.Phe120Phe",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000384041.1",
          "strand": true,
          "transcript": "ENST00000406369.2",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "F",
          "aa_end": null,
          "aa_length": 501,
          "aa_ref": "F",
          "aa_start": 234,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5209,
          "cdna_start": 739,
          "cds_end": null,
          "cds_length": 1506,
          "cds_start": 702,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 15,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "NM_001193513.3",
          "gene_hgnc_id": 19305,
          "gene_symbol": "SLC30A6",
          "hgvs_c": "c.702C>T",
          "hgvs_p": "p.Phe234Phe",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001180442.1",
          "strand": true,
          "transcript": "NM_001193513.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": "F",
          "aa_end": null,
          "aa_length": 479,
          "aa_ref": "F",
          "aa_start": 212,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2551,
          "cdna_start": 674,
          "cds_end": null,
          "cds_length": 1440,
          "cds_start": 636,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 14,
          "exon_rank": 10,
          "exon_rank_end": null,
          "feature": "ENST00000866171.1",
          "gene_hgnc_id": 19305,
          "gene_symbol": "SLC30A6",
          "hgvs_c": "c.636C>T",
          "hgvs_p": "p.Phe212Phe",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000536230.1",
          "strand": true,
          "transcript": "ENST00000866171.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "F",
          "aa_end": null,
          "aa_length": 447,
          "aa_ref": "F",
          "aa_start": 219,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4754,
          "cdna_start": 695,
          "cds_end": null,
          "cds_length": 1344,
          "cds_start": 657,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 12,
          "exon_rank": 10,
          "exon_rank_end": null,
          "feature": "ENST00000954367.1",
          "gene_hgnc_id": 19305,
          "gene_symbol": "SLC30A6",
          "hgvs_c": "c.657C>T",
          "hgvs_p": "p.Phe219Phe",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000624426.1",
          "strand": true,
          "transcript": "ENST00000954367.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "F",
          "aa_end": null,
          "aa_length": 445,
          "aa_ref": "F",
          "aa_start": 194,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2518,
          "cdna_start": 604,
          "cds_end": null,
          "cds_length": 1338,
          "cds_start": 582,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 13,
          "exon_rank": 10,
          "exon_rank_end": null,
          "feature": "ENST00000866170.1",
          "gene_hgnc_id": 19305,
          "gene_symbol": "SLC30A6",
          "hgvs_c": "c.582C>T",
          "hgvs_p": "p.Phe194Phe",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000536229.1",
          "strand": true,
          "transcript": "ENST00000866170.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "F",
          "aa_end": null,
          "aa_length": 439,
          "aa_ref": "F",
          "aa_start": 172,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5020,
          "cdna_start": 553,
          "cds_end": null,
          "cds_length": 1320,
          "cds_start": 516,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 13,
          "exon_rank": 9,
          "exon_rank_end": null,
          "feature": "ENST00000911305.1",
          "gene_hgnc_id": 19305,
          "gene_symbol": "SLC30A6",
          "hgvs_c": "c.516C>T",
          "hgvs_p": "p.Phe172Phe",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000581364.1",
          "strand": true,
          "transcript": "ENST00000911305.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "F",
          "aa_end": null,
          "aa_length": 438,
          "aa_ref": "F",
          "aa_start": 194,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5020,
          "cdna_start": 619,
          "cds_end": null,
          "cds_length": 1317,
          "cds_start": 582,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 13,
          "exon_rank": 10,
          "exon_rank_end": null,
          "feature": "NM_001193514.3",
          "gene_hgnc_id": 19305,
          "gene_symbol": "SLC30A6",
          "hgvs_c": "c.582C>T",
          "hgvs_p": "p.Phe194Phe",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001180443.1",
          "strand": true,
          "transcript": "NM_001193514.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": "F",
          "aa_end": null,
          "aa_length": 432,
          "aa_ref": "F",
          "aa_start": 165,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5002,
          "cdna_start": 532,
          "cds_end": null,
          "cds_length": 1299,
          "cds_start": 495,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 13,
          "exon_rank": 9,
          "exon_rank_end": null,
          "feature": "NM_001193515.3",
          "gene_hgnc_id": 19305,
          "gene_symbol": "SLC30A6",
          "hgvs_c": "c.495C>T",
          "hgvs_p": "p.Phe165Phe",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001180444.1",
          "strand": true,
          "transcript": "NM_001193515.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": "F",
          "aa_end": null,
          "aa_length": 432,
          "aa_ref": "F",
          "aa_start": 165,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4758,
          "cdna_start": 555,
          "cds_end": null,
          "cds_length": 1299,
          "cds_start": 495,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 13,
          "exon_rank": 9,
          "exon_rank_end": null,
          "feature": "ENST00000357055.7",
          "gene_hgnc_id": 19305,
          "gene_symbol": "SLC30A6",
          "hgvs_c": "c.495C>T",
          "hgvs_p": "p.Phe165Phe",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000349563.4",
          "strand": true,
          "transcript": "ENST00000357055.7",
          "transcript_support_level": 2
        },
        {
          "aa_alt": "F",
          "aa_end": null,
          "aa_length": 422,
          "aa_ref": "F",
          "aa_start": 194,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4679,
          "cdna_start": 619,
          "cds_end": null,
          "cds_length": 1269,
          "cds_start": 582,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 12,
          "exon_rank": 10,
          "exon_rank_end": null,
          "feature": "ENST00000911306.1",
          "gene_hgnc_id": 19305,
          "gene_symbol": "SLC30A6",
          "hgvs_c": "c.582C>T",
          "hgvs_p": "p.Phe194Phe",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000581365.1",
          "strand": true,
          "transcript": "ENST00000911306.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "F",
          "aa_end": null,
          "aa_length": 416,
          "aa_ref": "F",
          "aa_start": 172,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2450,
          "cdna_start": 557,
          "cds_end": null,
          "cds_length": 1251,
          "cds_start": 516,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 12,
          "exon_rank": 9,
          "exon_rank_end": null,
          "feature": "ENST00000911307.1",
          "gene_hgnc_id": 19305,
          "gene_symbol": "SLC30A6",
          "hgvs_c": "c.516C>T",
          "hgvs_p": "p.Phe172Phe",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000581366.1",
          "strand": true,
          "transcript": "ENST00000911307.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "F",
          "aa_end": null,
          "aa_length": 412,
          "aa_ref": "F",
          "aa_start": 145,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5375,
          "cdna_start": 905,
          "cds_end": null,
          "cds_length": 1239,
          "cds_start": 435,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 14,
          "exon_rank": 10,
          "exon_rank_end": null,
          "feature": "NM_001330479.2",
          "gene_hgnc_id": 19305,
          "gene_symbol": "SLC30A6",
          "hgvs_c": "c.435C>T",
          "hgvs_p": "p.Phe145Phe",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001317408.1",
          "strand": true,
          "transcript": "NM_001330479.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "F",
          "aa_end": null,
          "aa_length": 387,
          "aa_ref": "F",
          "aa_start": 120,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4874,
          "cdna_start": 404,
          "cds_end": null,
          "cds_length": 1164,
          "cds_start": 360,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 11,
          "exon_rank": 7,
          "exon_rank_end": null,
          "feature": "NM_001330476.2",
          "gene_hgnc_id": 19305,
          "gene_symbol": "SLC30A6",
          "hgvs_c": "c.360C>T",
          "hgvs_p": "p.Phe120Phe",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001317405.1",
          "strand": true,
          "transcript": "NM_001330476.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "F",
          "aa_end": null,
          "aa_length": 177,
          "aa_ref": "F",
          "aa_start": 165,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 573,
          "cdna_start": 532,
          "cds_end": null,
          "cds_length": 536,
          "cds_start": 495,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 9,
          "exon_rank": 9,
          "exon_rank_end": null,
          "feature": "ENST00000440718.5",
          "gene_hgnc_id": 19305,
          "gene_symbol": "SLC30A6",
          "hgvs_c": "c.495C>T",
          "hgvs_p": "p.Phe165Phe",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000393946.1",
          "strand": true,
          "transcript": "ENST00000440718.5",
          "transcript_support_level": 4
        },
        {
          "aa_alt": "F",
          "aa_end": null,
          "aa_length": 478,
          "aa_ref": "F",
          "aa_start": 234,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5140,
          "cdna_start": 739,
          "cds_end": null,
          "cds_length": 1437,
          "cds_start": 702,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 14,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "XM_011532959.4",
          "gene_hgnc_id": 19305,
          "gene_symbol": "SLC30A6",
          "hgvs_c": "c.702C>T",
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For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.