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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 2-36981587-C-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=36981587&ref=C&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 0,
          "criteria": [
            "PM2",
            "PP3"
          ],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "HEATR5B",
          "hgnc_id": 29273,
          "hgvs_c": "c.6119G>T",
          "hgvs_p": "p.Arg2040Leu",
          "inheritance_mode": "AR",
          "pathogenic_score": 3,
          "score": 3,
          "transcript": "NM_019024.3",
          "verdict": "Uncertain_significance"
        }
      ],
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PM2,PP3",
      "acmg_score": 3,
      "allele_count_reference_population": 0,
      "alphamissense_prediction": "Pathogenic",
      "alphamissense_score": 0.7502,
      "alt": "A",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Pathogenic",
      "bayesdelnoaf_score": 0.19,
      "chr": "2",
      "clinvar_classification": "Uncertain significance",
      "clinvar_disease": "not specified",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "computational_prediction_selected": "Pathogenic",
      "computational_score_selected": 0.8343828916549683,
      "computational_source_selected": "MetaRNN",
      "consequences": [
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 2071,
          "aa_ref": "R",
          "aa_start": 2040,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6937,
          "cdna_start": 6245,
          "cds_end": null,
          "cds_length": 6216,
          "cds_start": 6119,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 36,
          "exon_rank": 36,
          "exon_rank_end": null,
          "feature": "NM_019024.3",
          "gene_hgnc_id": 29273,
          "gene_symbol": "HEATR5B",
          "hgvs_c": "c.6119G>T",
          "hgvs_p": "p.Arg2040Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000233099.6",
          "protein_coding": true,
          "protein_id": "NP_061897.1",
          "strand": false,
          "transcript": "NM_019024.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 2071,
          "aa_ref": "R",
          "aa_start": 2040,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 6937,
          "cdna_start": 6245,
          "cds_end": null,
          "cds_length": 6216,
          "cds_start": 6119,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 36,
          "exon_rank": 36,
          "exon_rank_end": null,
          "feature": "ENST00000233099.6",
          "gene_hgnc_id": 29273,
          "gene_symbol": "HEATR5B",
          "hgvs_c": "c.6119G>T",
          "hgvs_p": "p.Arg2040Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_019024.3",
          "protein_coding": true,
          "protein_id": "ENSP00000233099.5",
          "strand": false,
          "transcript": "ENST00000233099.6",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 2071,
          "aa_ref": "R",
          "aa_start": 2040,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 7257,
          "cdna_start": 6685,
          "cds_end": null,
          "cds_length": 6216,
          "cds_start": 6119,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 36,
          "exon_rank": 36,
          "exon_rank_end": null,
          "feature": "ENST00000903982.1",
          "gene_hgnc_id": 29273,
          "gene_symbol": "HEATR5B",
          "hgvs_c": "c.6119G>T",
          "hgvs_p": "p.Arg2040Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000574041.1",
          "strand": false,
          "transcript": "ENST00000903982.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 2071,
          "aa_ref": "R",
          "aa_start": 2040,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6810,
          "cdna_start": 6222,
          "cds_end": null,
          "cds_length": 6216,
          "cds_start": 6119,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 36,
          "exon_rank": 36,
          "exon_rank_end": null,
          "feature": "ENST00000920714.1",
          "gene_hgnc_id": 29273,
          "gene_symbol": "HEATR5B",
          "hgvs_c": "c.6119G>T",
          "hgvs_p": "p.Arg2040Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000590773.1",
          "strand": false,
          "transcript": "ENST00000920714.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 2071,
          "aa_ref": "R",
          "aa_start": 2040,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6856,
          "cdna_start": 6281,
          "cds_end": null,
          "cds_length": 6216,
          "cds_start": 6119,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 37,
          "exon_rank": 37,
          "exon_rank_end": null,
          "feature": "ENST00000920715.1",
          "gene_hgnc_id": 29273,
          "gene_symbol": "HEATR5B",
          "hgvs_c": "c.6119G>T",
          "hgvs_p": "p.Arg2040Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000590774.1",
          "strand": false,
          "transcript": "ENST00000920715.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 2071,
          "aa_ref": "R",
          "aa_start": 2040,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 7139,
          "cdna_start": 6568,
          "cds_end": null,
          "cds_length": 6216,
          "cds_start": 6119,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 36,
          "exon_rank": 36,
          "exon_rank_end": null,
          "feature": "ENST00000920718.1",
          "gene_hgnc_id": 29273,
          "gene_symbol": "HEATR5B",
          "hgvs_c": "c.6119G>T",
          "hgvs_p": "p.Arg2040Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000590777.1",
          "strand": false,
          "transcript": "ENST00000920718.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 2070,
          "aa_ref": "R",
          "aa_start": 2039,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 7006,
          "cdna_start": 6268,
          "cds_end": null,
          "cds_length": 6213,
          "cds_start": 6116,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 36,
          "exon_rank": 36,
          "exon_rank_end": null,
          "feature": "ENST00000903978.1",
          "gene_hgnc_id": 29273,
          "gene_symbol": "HEATR5B",
          "hgvs_c": "c.6116G>T",
          "hgvs_p": "p.Arg2039Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000574037.1",
          "strand": false,
          "transcript": "ENST00000903978.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 2070,
          "aa_ref": "R",
          "aa_start": 2039,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6902,
          "cdna_start": 6212,
          "cds_end": null,
          "cds_length": 6213,
          "cds_start": 6116,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 36,
          "exon_rank": 36,
          "exon_rank_end": null,
          "feature": "ENST00000903979.1",
          "gene_hgnc_id": 29273,
          "gene_symbol": "HEATR5B",
          "hgvs_c": "c.6116G>T",
          "hgvs_p": "p.Arg2039Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000574038.1",
          "strand": false,
          "transcript": "ENST00000903979.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 2059,
          "aa_ref": "R",
          "aa_start": 2028,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 7301,
          "cdna_start": 6187,
          "cds_end": null,
          "cds_length": 6180,
          "cds_start": 6083,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 36,
          "exon_rank": 36,
          "exon_rank_end": null,
          "feature": "ENST00000903977.1",
          "gene_hgnc_id": 29273,
          "gene_symbol": "HEATR5B",
          "hgvs_c": "c.6083G>T",
          "hgvs_p": "p.Arg2028Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000574036.1",
          "strand": false,
          "transcript": "ENST00000903977.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 2040,
          "aa_ref": "R",
          "aa_start": 2009,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6702,
          "cdna_start": 6126,
          "cds_end": null,
          "cds_length": 6123,
          "cds_start": 6026,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 36,
          "exon_rank": 36,
          "exon_rank_end": null,
          "feature": "ENST00000903981.1",
          "gene_hgnc_id": 29273,
          "gene_symbol": "HEATR5B",
          "hgvs_c": "c.6026G>T",
          "hgvs_p": "p.Arg2009Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000574040.1",
          "strand": false,
          "transcript": "ENST00000903981.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 1986,
          "aa_ref": "R",
          "aa_start": 1955,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6538,
          "cdna_start": 5961,
          "cds_end": null,
          "cds_length": 5961,
          "cds_start": 5864,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 35,
          "exon_rank": 35,
          "exon_rank_end": null,
          "feature": "ENST00000920717.1",
          "gene_hgnc_id": 29273,
          "gene_symbol": "HEATR5B",
          "hgvs_c": "c.5864G>T",
          "hgvs_p": "p.Arg1955Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000590776.1",
          "strand": false,
          "transcript": "ENST00000920717.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 1982,
          "aa_ref": "R",
          "aa_start": 1951,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6534,
          "cdna_start": 5954,
          "cds_end": null,
          "cds_length": 5949,
          "cds_start": 5852,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 35,
          "exon_rank": 35,
          "exon_rank_end": null,
          "feature": "ENST00000903980.1",
          "gene_hgnc_id": 29273,
          "gene_symbol": "HEATR5B",
          "hgvs_c": "c.5852G>T",
          "hgvs_p": "p.Arg1951Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000574039.1",
          "strand": false,
          "transcript": "ENST00000903980.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 1961,
          "aa_ref": "R",
          "aa_start": 1930,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6498,
          "cdna_start": 5910,
          "cds_end": null,
          "cds_length": 5886,
          "cds_start": 5789,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 34,
          "exon_rank": 34,
          "exon_rank_end": null,
          "feature": "ENST00000920713.1",
          "gene_hgnc_id": 29273,
          "gene_symbol": "HEATR5B",
          "hgvs_c": "c.5789G>T",
          "hgvs_p": "p.Arg1930Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000590772.1",
          "strand": false,
          "transcript": "ENST00000920713.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 1961,
          "aa_ref": "R",
          "aa_start": 1930,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6935,
          "cdna_start": 6355,
          "cds_end": null,
          "cds_length": 5886,
          "cds_start": 5789,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 34,
          "exon_rank": 34,
          "exon_rank_end": null,
          "feature": "ENST00000920716.1",
          "gene_hgnc_id": 29273,
          "gene_symbol": "HEATR5B",
          "hgvs_c": "c.5789G>T",
          "hgvs_p": "p.Arg1930Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000590775.1",
          "strand": false,
          "transcript": "ENST00000920716.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 1951,
          "aa_ref": "R",
          "aa_start": 1920,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6465,
          "cdna_start": 5888,
          "cds_end": null,
          "cds_length": 5856,
          "cds_start": 5759,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 34,
          "exon_rank": 34,
          "exon_rank_end": null,
          "feature": "ENST00000950344.1",
          "gene_hgnc_id": 29273,
          "gene_symbol": "HEATR5B",
          "hgvs_c": "c.5759G>T",
          "hgvs_p": "p.Arg1920Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000620403.1",
          "strand": false,
          "transcript": "ENST00000950344.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 2070,
          "aa_ref": "R",
          "aa_start": 2039,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6934,
          "cdna_start": 6242,
          "cds_end": null,
          "cds_length": 6213,
          "cds_start": 6116,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 36,
          "exon_rank": 36,
          "exon_rank_end": null,
          "feature": "XM_006712034.3",
          "gene_hgnc_id": 29273,
          "gene_symbol": "HEATR5B",
          "hgvs_c": "c.6116G>T",
          "hgvs_p": "p.Arg2039Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_006712097.1",
          "strand": false,
          "transcript": "XM_006712034.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 2059,
          "aa_ref": "R",
          "aa_start": 2028,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6901,
          "cdna_start": 6209,
          "cds_end": null,
          "cds_length": 6180,
          "cds_start": 6083,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 36,
          "exon_rank": 36,
          "exon_rank_end": null,
          "feature": "XM_006712035.5",
          "gene_hgnc_id": 29273,
          "gene_symbol": "HEATR5B",
          "hgvs_c": "c.6083G>T",
          "hgvs_p": "p.Arg2028Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_006712098.1",
          "strand": false,
          "transcript": "XM_006712035.5",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 2058,
          "aa_ref": "R",
          "aa_start": 2027,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6898,
          "cdna_start": 6206,
          "cds_end": null,
          "cds_length": 6177,
          "cds_start": 6080,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 36,
          "exon_rank": 36,
          "exon_rank_end": null,
          "feature": "XM_047444810.1",
          "gene_hgnc_id": 29273,
          "gene_symbol": "HEATR5B",
          "hgvs_c": "c.6080G>T",
          "hgvs_p": "p.Arg2027Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_047300766.1",
          "strand": false,
          "transcript": "XM_047444810.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 1982,
          "aa_ref": "R",
          "aa_start": 1951,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6670,
          "cdna_start": 5978,
          "cds_end": null,
          "cds_length": 5949,
          "cds_start": 5852,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 35,
          "exon_rank": 35,
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}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.