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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 2-36981591-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=36981591&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "2",
      "pos": 36981591,
      "ref": "C",
      "alt": "T",
      "effect": "missense_variant",
      "transcript": "NM_019024.3",
      "consequences": [
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 36,
          "exon_rank_end": null,
          "exon_count": 36,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HEATR5B",
          "gene_hgnc_id": 29273,
          "hgvs_c": "c.6115G>A",
          "hgvs_p": "p.Val2039Ile",
          "transcript": "NM_019024.3",
          "protein_id": "NP_061897.1",
          "transcript_support_level": null,
          "aa_start": 2039,
          "aa_end": null,
          "aa_length": 2071,
          "cds_start": 6115,
          "cds_end": null,
          "cds_length": 6216,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000233099.6",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_019024.3"
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 36,
          "exon_rank_end": null,
          "exon_count": 36,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HEATR5B",
          "gene_hgnc_id": 29273,
          "hgvs_c": "c.6115G>A",
          "hgvs_p": "p.Val2039Ile",
          "transcript": "ENST00000233099.6",
          "protein_id": "ENSP00000233099.5",
          "transcript_support_level": 1,
          "aa_start": 2039,
          "aa_end": null,
          "aa_length": 2071,
          "cds_start": 6115,
          "cds_end": null,
          "cds_length": 6216,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_019024.3",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000233099.6"
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 36,
          "exon_rank_end": null,
          "exon_count": 36,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HEATR5B",
          "gene_hgnc_id": 29273,
          "hgvs_c": "c.6115G>A",
          "hgvs_p": "p.Val2039Ile",
          "transcript": "ENST00000903982.1",
          "protein_id": "ENSP00000574041.1",
          "transcript_support_level": null,
          "aa_start": 2039,
          "aa_end": null,
          "aa_length": 2071,
          "cds_start": 6115,
          "cds_end": null,
          "cds_length": 6216,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000903982.1"
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 36,
          "exon_rank_end": null,
          "exon_count": 36,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HEATR5B",
          "gene_hgnc_id": 29273,
          "hgvs_c": "c.6115G>A",
          "hgvs_p": "p.Val2039Ile",
          "transcript": "ENST00000920714.1",
          "protein_id": "ENSP00000590773.1",
          "transcript_support_level": null,
          "aa_start": 2039,
          "aa_end": null,
          "aa_length": 2071,
          "cds_start": 6115,
          "cds_end": null,
          "cds_length": 6216,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000920714.1"
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 37,
          "exon_rank_end": null,
          "exon_count": 37,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HEATR5B",
          "gene_hgnc_id": 29273,
          "hgvs_c": "c.6115G>A",
          "hgvs_p": "p.Val2039Ile",
          "transcript": "ENST00000920715.1",
          "protein_id": "ENSP00000590774.1",
          "transcript_support_level": null,
          "aa_start": 2039,
          "aa_end": null,
          "aa_length": 2071,
          "cds_start": 6115,
          "cds_end": null,
          "cds_length": 6216,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000920715.1"
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 36,
          "exon_rank_end": null,
          "exon_count": 36,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HEATR5B",
          "gene_hgnc_id": 29273,
          "hgvs_c": "c.6115G>A",
          "hgvs_p": "p.Val2039Ile",
          "transcript": "ENST00000920718.1",
          "protein_id": "ENSP00000590777.1",
          "transcript_support_level": null,
          "aa_start": 2039,
          "aa_end": null,
          "aa_length": 2071,
          "cds_start": 6115,
          "cds_end": null,
          "cds_length": 6216,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000920718.1"
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 36,
          "exon_rank_end": null,
          "exon_count": 36,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HEATR5B",
          "gene_hgnc_id": 29273,
          "hgvs_c": "c.6112G>A",
          "hgvs_p": "p.Val2038Ile",
          "transcript": "ENST00000903978.1",
          "protein_id": "ENSP00000574037.1",
          "transcript_support_level": null,
          "aa_start": 2038,
          "aa_end": null,
          "aa_length": 2070,
          "cds_start": 6112,
          "cds_end": null,
          "cds_length": 6213,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000903978.1"
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 36,
          "exon_rank_end": null,
          "exon_count": 36,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HEATR5B",
          "gene_hgnc_id": 29273,
          "hgvs_c": "c.6112G>A",
          "hgvs_p": "p.Val2038Ile",
          "transcript": "ENST00000903979.1",
          "protein_id": "ENSP00000574038.1",
          "transcript_support_level": null,
          "aa_start": 2038,
          "aa_end": null,
          "aa_length": 2070,
          "cds_start": 6112,
          "cds_end": null,
          "cds_length": 6213,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000903979.1"
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 36,
          "exon_rank_end": null,
          "exon_count": 36,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HEATR5B",
          "gene_hgnc_id": 29273,
          "hgvs_c": "c.6079G>A",
          "hgvs_p": "p.Val2027Ile",
          "transcript": "ENST00000903977.1",
          "protein_id": "ENSP00000574036.1",
          "transcript_support_level": null,
          "aa_start": 2027,
          "aa_end": null,
          "aa_length": 2059,
          "cds_start": 6079,
          "cds_end": null,
          "cds_length": 6180,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000903977.1"
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 36,
          "exon_rank_end": null,
          "exon_count": 36,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HEATR5B",
          "gene_hgnc_id": 29273,
          "hgvs_c": "c.6022G>A",
          "hgvs_p": "p.Val2008Ile",
          "transcript": "ENST00000903981.1",
          "protein_id": "ENSP00000574040.1",
          "transcript_support_level": null,
          "aa_start": 2008,
          "aa_end": null,
          "aa_length": 2040,
          "cds_start": 6022,
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          "cds_length": 6123,
          "cdna_start": null,
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          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000903981.1"
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 35,
          "exon_rank_end": null,
          "exon_count": 35,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HEATR5B",
          "gene_hgnc_id": 29273,
          "hgvs_c": "c.5860G>A",
          "hgvs_p": "p.Val1954Ile",
          "transcript": "ENST00000920717.1",
          "protein_id": "ENSP00000590776.1",
          "transcript_support_level": null,
          "aa_start": 1954,
          "aa_end": null,
          "aa_length": 1986,
          "cds_start": 5860,
          "cds_end": null,
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          "cdna_start": null,
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          "mane_select": null,
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          "biotype": "protein_coding",
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        },
        {
          "aa_ref": "V",
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          "consequences": [
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          ],
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          "exon_count": 35,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HEATR5B",
          "gene_hgnc_id": 29273,
          "hgvs_c": "c.5848G>A",
          "hgvs_p": "p.Val1950Ile",
          "transcript": "ENST00000903980.1",
          "protein_id": "ENSP00000574039.1",
          "transcript_support_level": null,
          "aa_start": 1950,
          "aa_end": null,
          "aa_length": 1982,
          "cds_start": 5848,
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        {
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          "strand": false,
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          ],
          "exon_rank": 34,
          "exon_rank_end": null,
          "exon_count": 34,
          "intron_rank": null,
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          "gene_symbol": "HEATR5B",
          "gene_hgnc_id": 29273,
          "hgvs_c": "c.5785G>A",
          "hgvs_p": "p.Val1929Ile",
          "transcript": "ENST00000920713.1",
          "protein_id": "ENSP00000590772.1",
          "transcript_support_level": null,
          "aa_start": 1929,
          "aa_end": null,
          "aa_length": 1961,
          "cds_start": 5785,
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          "biotype": "protein_coding",
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        },
        {
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          "strand": false,
          "consequences": [
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          "exon_rank": 34,
          "exon_rank_end": null,
          "exon_count": 34,
          "intron_rank": null,
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          "gene_symbol": "HEATR5B",
          "gene_hgnc_id": 29273,
          "hgvs_c": "c.5785G>A",
          "hgvs_p": "p.Val1929Ile",
          "transcript": "ENST00000920716.1",
          "protein_id": "ENSP00000590775.1",
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        {
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          "intron_rank": null,
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          "gene_symbol": "HEATR5B",
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          "hgvs_c": "c.5755G>A",
          "hgvs_p": "p.Val1919Ile",
          "transcript": "ENST00000950344.1",
          "protein_id": "ENSP00000620403.1",
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          "aa_start": 1919,
          "aa_end": null,
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          "cds_start": 5755,
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          "cdna_start": null,
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          "biotype": "protein_coding",
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        {
          "aa_ref": "V",
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          "canonical": false,
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          "strand": false,
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          ],
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          "exon_count": 36,
          "intron_rank": null,
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          "gene_symbol": "HEATR5B",
          "gene_hgnc_id": 29273,
          "hgvs_c": "c.6112G>A",
          "hgvs_p": "p.Val2038Ile",
          "transcript": "XM_006712034.3",
          "protein_id": "XP_006712097.1",
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        {
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          ],
          "exon_rank": 36,
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          "exon_count": 36,
          "intron_rank": null,
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          "gene_symbol": "HEATR5B",
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          "hgvs_c": "c.6079G>A",
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        {
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          "gene_symbol": "HEATR5B",
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          "hgvs_c": "c.6076G>A",
          "hgvs_p": "p.Val2026Ile",
          "transcript": "XM_047444810.1",
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        {
          "aa_ref": "V",
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          "exon_count": 35,
          "intron_rank": null,
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          "gene_symbol": "HEATR5B",
          "gene_hgnc_id": 29273,
          "hgvs_c": "c.5848G>A",
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          "transcript": "XM_017004378.2",
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          "aa_end": null,
          "aa_length": 1982,
          "cds_start": 5848,
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          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_017004378.2"
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 35,
          "exon_rank_end": null,
          "exon_count": 35,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HEATR5B",
          "gene_hgnc_id": 29273,
          "hgvs_c": "c.5845G>A",
          "hgvs_p": "p.Val1949Ile",
          "transcript": "XM_047444811.1",
          "protein_id": "XP_047300767.1",
          "transcript_support_level": null,
          "aa_start": 1949,
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          "cds_start": 5845,
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          "aa_length": 1970,
          "cds_start": 5812,
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          "cdna_length": null,
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          "biotype": "protein_coding",
          "feature": "XM_047444812.1"
        },
        {
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          "protein_coding": true,
          "strand": false,
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          "exon_count": 36,
          "intron_rank": null,
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          "gene_symbol": "HEATR5B",
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          "hgvs_c": "c.5740G>A",
          "hgvs_p": "p.Val1914Ile",
          "transcript": "XM_047444814.1",
          "protein_id": "XP_047300770.1",
          "transcript_support_level": null,
          "aa_start": 1914,
          "aa_end": null,
          "aa_length": 1946,
          "cds_start": 5740,
          "cds_end": null,
          "cds_length": 5841,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "XM_047444814.1"
        },
        {
          "aa_ref": "V",
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          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 25,
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          "exon_count": 25,
          "intron_rank": null,
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          "gene_symbol": "HEATR5B",
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          "hgvs_c": "c.4264G>A",
          "hgvs_p": "p.Val1422Ile",
          "transcript": "XM_011532935.4",
          "protein_id": "XP_011531237.1",
          "transcript_support_level": null,
          "aa_start": 1422,
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          "cds_start": 4264,
          "cds_end": null,
          "cds_length": 4365,
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          "cdna_length": null,
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          "biotype": "protein_coding",
          "feature": "XM_011532935.4"
        },
        {
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          ],
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          "exon_count": 2,
          "intron_rank": 1,
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          "gene_symbol": "HEATR5B",
          "gene_hgnc_id": 29273,
          "hgvs_c": "c.214+7055G>A",
          "hgvs_p": null,
          "transcript": "ENST00000425467.5",
          "protein_id": "ENSP00000408222.1",
          "transcript_support_level": 3,
          "aa_start": null,
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          "aa_length": 115,
          "cds_start": null,
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          "cds_length": 348,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000425467.5"
        }
      ],
      "gene_symbol": "HEATR5B",
      "gene_hgnc_id": 29273,
      "dbsnp": "rs142274487",
      "frequency_reference_population": 0.00004151069,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 67,
      "gnomad_exomes_af": 0.0000424111,
      "gnomad_genomes_af": 0.0000328601,
      "gnomad_exomes_ac": 62,
      "gnomad_genomes_ac": 5,
      "gnomad_exomes_homalt": 0,
      "gnomad_genomes_homalt": 0,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.06315648555755615,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": 0.068,
      "revel_prediction": "Benign",
      "alphamissense_score": 0.0855,
      "alphamissense_prediction": "Benign",
      "bayesdelnoaf_score": -0.61,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": 2.999,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": -2,
      "acmg_classification": "Likely_benign",
      "acmg_criteria": "PM2,BP4_Strong",
      "acmg_by_gene": [
        {
          "score": -2,
          "benign_score": 4,
          "pathogenic_score": 2,
          "criteria": [
            "PM2",
            "BP4_Strong"
          ],
          "verdict": "Likely_benign",
          "transcript": "NM_019024.3",
          "gene_symbol": "HEATR5B",
          "hgnc_id": 29273,
          "effects": [
            "missense_variant"
          ],
          "inheritance_mode": "AR",
          "hgvs_c": "c.6115G>A",
          "hgvs_p": "p.Val2039Ile"
        }
      ],
      "clinvar_disease": "not specified",
      "clinvar_classification": "Uncertain significance",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "phenotype_combined": "not specified",
      "pathogenicity_classification_combined": "Uncertain significance",
      "custom_annotations": null
    }
  ],
  "message": null
}