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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 2-36988807-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=36988807&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "2",
      "pos": 36988807,
      "ref": "C",
      "alt": "T",
      "effect": "missense_variant",
      "transcript": "NM_019024.3",
      "consequences": [
        {
          "aa_ref": "R",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 35,
          "exon_rank_end": null,
          "exon_count": 36,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HEATR5B",
          "gene_hgnc_id": 29273,
          "hgvs_c": "c.5750G>A",
          "hgvs_p": "p.Arg1917His",
          "transcript": "NM_019024.3",
          "protein_id": "NP_061897.1",
          "transcript_support_level": null,
          "aa_start": 1917,
          "aa_end": null,
          "aa_length": 2071,
          "cds_start": 5750,
          "cds_end": null,
          "cds_length": 6216,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000233099.6",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_019024.3"
        },
        {
          "aa_ref": "R",
          "aa_alt": "H",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 35,
          "exon_rank_end": null,
          "exon_count": 36,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HEATR5B",
          "gene_hgnc_id": 29273,
          "hgvs_c": "c.5750G>A",
          "hgvs_p": "p.Arg1917His",
          "transcript": "ENST00000233099.6",
          "protein_id": "ENSP00000233099.5",
          "transcript_support_level": 1,
          "aa_start": 1917,
          "aa_end": null,
          "aa_length": 2071,
          "cds_start": 5750,
          "cds_end": null,
          "cds_length": 6216,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_019024.3",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000233099.6"
        },
        {
          "aa_ref": "R",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 35,
          "exon_rank_end": null,
          "exon_count": 36,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HEATR5B",
          "gene_hgnc_id": 29273,
          "hgvs_c": "c.5750G>A",
          "hgvs_p": "p.Arg1917His",
          "transcript": "ENST00000903982.1",
          "protein_id": "ENSP00000574041.1",
          "transcript_support_level": null,
          "aa_start": 1917,
          "aa_end": null,
          "aa_length": 2071,
          "cds_start": 5750,
          "cds_end": null,
          "cds_length": 6216,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000903982.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 35,
          "exon_rank_end": null,
          "exon_count": 36,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HEATR5B",
          "gene_hgnc_id": 29273,
          "hgvs_c": "c.5750G>A",
          "hgvs_p": "p.Arg1917His",
          "transcript": "ENST00000920714.1",
          "protein_id": "ENSP00000590773.1",
          "transcript_support_level": null,
          "aa_start": 1917,
          "aa_end": null,
          "aa_length": 2071,
          "cds_start": 5750,
          "cds_end": null,
          "cds_length": 6216,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000920714.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 36,
          "exon_rank_end": null,
          "exon_count": 37,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HEATR5B",
          "gene_hgnc_id": 29273,
          "hgvs_c": "c.5750G>A",
          "hgvs_p": "p.Arg1917His",
          "transcript": "ENST00000920715.1",
          "protein_id": "ENSP00000590774.1",
          "transcript_support_level": null,
          "aa_start": 1917,
          "aa_end": null,
          "aa_length": 2071,
          "cds_start": 5750,
          "cds_end": null,
          "cds_length": 6216,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000920715.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 35,
          "exon_rank_end": null,
          "exon_count": 36,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HEATR5B",
          "gene_hgnc_id": 29273,
          "hgvs_c": "c.5750G>A",
          "hgvs_p": "p.Arg1917His",
          "transcript": "ENST00000920718.1",
          "protein_id": "ENSP00000590777.1",
          "transcript_support_level": null,
          "aa_start": 1917,
          "aa_end": null,
          "aa_length": 2071,
          "cds_start": 5750,
          "cds_end": null,
          "cds_length": 6216,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000920718.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 35,
          "exon_rank_end": null,
          "exon_count": 36,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HEATR5B",
          "gene_hgnc_id": 29273,
          "hgvs_c": "c.5747G>A",
          "hgvs_p": "p.Arg1916His",
          "transcript": "ENST00000903978.1",
          "protein_id": "ENSP00000574037.1",
          "transcript_support_level": null,
          "aa_start": 1916,
          "aa_end": null,
          "aa_length": 2070,
          "cds_start": 5747,
          "cds_end": null,
          "cds_length": 6213,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000903978.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 35,
          "exon_rank_end": null,
          "exon_count": 36,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HEATR5B",
          "gene_hgnc_id": 29273,
          "hgvs_c": "c.5747G>A",
          "hgvs_p": "p.Arg1916His",
          "transcript": "ENST00000903979.1",
          "protein_id": "ENSP00000574038.1",
          "transcript_support_level": null,
          "aa_start": 1916,
          "aa_end": null,
          "aa_length": 2070,
          "cds_start": 5747,
          "cds_end": null,
          "cds_length": 6213,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000903979.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 35,
          "exon_rank_end": null,
          "exon_count": 36,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HEATR5B",
          "gene_hgnc_id": 29273,
          "hgvs_c": "c.5714G>A",
          "hgvs_p": "p.Arg1905His",
          "transcript": "ENST00000903977.1",
          "protein_id": "ENSP00000574036.1",
          "transcript_support_level": null,
          "aa_start": 1905,
          "aa_end": null,
          "aa_length": 2059,
          "cds_start": 5714,
          "cds_end": null,
          "cds_length": 6180,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000903977.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 35,
          "exon_rank_end": null,
          "exon_count": 36,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HEATR5B",
          "gene_hgnc_id": 29273,
          "hgvs_c": "c.5657G>A",
          "hgvs_p": "p.Arg1886His",
          "transcript": "ENST00000903981.1",
          "protein_id": "ENSP00000574040.1",
          "transcript_support_level": null,
          "aa_start": 1886,
          "aa_end": null,
          "aa_length": 2040,
          "cds_start": 5657,
          "cds_end": null,
          "cds_length": 6123,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000903981.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 34,
          "exon_rank_end": null,
          "exon_count": 35,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HEATR5B",
          "gene_hgnc_id": 29273,
          "hgvs_c": "c.5495G>A",
          "hgvs_p": "p.Arg1832His",
          "transcript": "ENST00000920717.1",
          "protein_id": "ENSP00000590776.1",
          "transcript_support_level": null,
          "aa_start": 1832,
          "aa_end": null,
          "aa_length": 1986,
          "cds_start": 5495,
          "cds_end": null,
          "cds_length": 5961,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000920717.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 34,
          "exon_rank_end": null,
          "exon_count": 35,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HEATR5B",
          "gene_hgnc_id": 29273,
          "hgvs_c": "c.5483G>A",
          "hgvs_p": "p.Arg1828His",
          "transcript": "ENST00000903980.1",
          "protein_id": "ENSP00000574039.1",
          "transcript_support_level": null,
          "aa_start": 1828,
          "aa_end": null,
          "aa_length": 1982,
          "cds_start": 5483,
          "cds_end": null,
          "cds_length": 5949,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000903980.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 33,
          "exon_rank_end": null,
          "exon_count": 34,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HEATR5B",
          "gene_hgnc_id": 29273,
          "hgvs_c": "c.5420G>A",
          "hgvs_p": "p.Arg1807His",
          "transcript": "ENST00000920713.1",
          "protein_id": "ENSP00000590772.1",
          "transcript_support_level": null,
          "aa_start": 1807,
          "aa_end": null,
          "aa_length": 1961,
          "cds_start": 5420,
          "cds_end": null,
          "cds_length": 5886,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000920713.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 33,
          "exon_rank_end": null,
          "exon_count": 34,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HEATR5B",
          "gene_hgnc_id": 29273,
          "hgvs_c": "c.5420G>A",
          "hgvs_p": "p.Arg1807His",
          "transcript": "ENST00000920716.1",
          "protein_id": "ENSP00000590775.1",
          "transcript_support_level": null,
          "aa_start": 1807,
          "aa_end": null,
          "aa_length": 1961,
          "cds_start": 5420,
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          "cds_length": 5886,
          "cdna_start": null,
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          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000920716.1"
        },
        {
          "aa_ref": "R",
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 33,
          "exon_rank_end": null,
          "exon_count": 34,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HEATR5B",
          "gene_hgnc_id": 29273,
          "hgvs_c": "c.5390G>A",
          "hgvs_p": "p.Arg1797His",
          "transcript": "ENST00000950344.1",
          "protein_id": "ENSP00000620403.1",
          "transcript_support_level": null,
          "aa_start": 1797,
          "aa_end": null,
          "aa_length": 1951,
          "cds_start": 5390,
          "cds_end": null,
          "cds_length": 5856,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000950344.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HEATR5B",
          "gene_hgnc_id": 29273,
          "hgvs_c": "c.53G>A",
          "hgvs_p": "p.Arg18His",
          "transcript": "ENST00000425467.5",
          "protein_id": "ENSP00000408222.1",
          "transcript_support_level": 3,
          "aa_start": 18,
          "aa_end": null,
          "aa_length": 115,
          "cds_start": 53,
          "cds_end": null,
          "cds_length": 348,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000425467.5"
        },
        {
          "aa_ref": "R",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 35,
          "exon_rank_end": null,
          "exon_count": 36,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HEATR5B",
          "gene_hgnc_id": 29273,
          "hgvs_c": "c.5747G>A",
          "hgvs_p": "p.Arg1916His",
          "transcript": "XM_006712034.3",
          "protein_id": "XP_006712097.1",
          "transcript_support_level": null,
          "aa_start": 1916,
          "aa_end": null,
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          "cdna_start": null,
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          "biotype": "protein_coding",
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        {
          "aa_ref": "R",
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          "protein_coding": true,
          "strand": false,
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          ],
          "exon_rank": 35,
          "exon_rank_end": null,
          "exon_count": 36,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HEATR5B",
          "gene_hgnc_id": 29273,
          "hgvs_c": "c.5714G>A",
          "hgvs_p": "p.Arg1905His",
          "transcript": "XM_006712035.5",
          "protein_id": "XP_006712098.1",
          "transcript_support_level": null,
          "aa_start": 1905,
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          "cds_start": 5714,
          "cds_end": null,
          "cds_length": 6180,
          "cdna_start": null,
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          "biotype": "protein_coding",
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        },
        {
          "aa_ref": "R",
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          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 35,
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          "exon_count": 36,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HEATR5B",
          "gene_hgnc_id": 29273,
          "hgvs_c": "c.5711G>A",
          "hgvs_p": "p.Arg1904His",
          "transcript": "XM_047444810.1",
          "protein_id": "XP_047300766.1",
          "transcript_support_level": null,
          "aa_start": 1904,
          "aa_end": null,
          "aa_length": 2058,
          "cds_start": 5711,
          "cds_end": null,
          "cds_length": 6177,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047444810.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 34,
          "exon_rank_end": null,
          "exon_count": 35,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HEATR5B",
          "gene_hgnc_id": 29273,
          "hgvs_c": "c.5483G>A",
          "hgvs_p": "p.Arg1828His",
          "transcript": "XM_017004378.2",
          "protein_id": "XP_016859867.1",
          "transcript_support_level": null,
          "aa_start": 1828,
          "aa_end": null,
          "aa_length": 1982,
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        {
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          "biotype": "protein_coding",
          "feature": "XM_047444813.1"
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      ],
      "gene_symbol": "HEATR5B",
      "gene_hgnc_id": 29273,
      "dbsnp": "rs766983676",
      "frequency_reference_population": 0.000015491061,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 25,
      "gnomad_exomes_af": 0.0000164181,
      "gnomad_genomes_af": 0.00000657739,
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      "gnomad_genomes_ac": 1,
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      "gnomad_genomes_homalt": 0,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.2248106300830841,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0.14000000059604645,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": 0.264,
      "revel_prediction": "Benign",
      "alphamissense_score": 0.3719,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.03,
      "bayesdelnoaf_prediction": "Uncertain_significance",
      "phylop100way_score": 5.791,
      "phylop100way_prediction": "Uncertain_significance",
      "spliceai_max_score": 0.14,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": -2,
      "acmg_classification": "Likely_benign",
      "acmg_criteria": "BP4_Moderate",
      "acmg_by_gene": [
        {
          "score": -2,
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          "criteria": [
            "BP4_Moderate"
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          "verdict": "Likely_benign",
          "transcript": "NM_019024.3",
          "gene_symbol": "HEATR5B",
          "hgnc_id": 29273,
          "effects": [
            "missense_variant"
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          "hgvs_p": "p.Arg1917His"
        }
      ],
      "clinvar_disease": "not specified",
      "clinvar_classification": "Uncertain significance",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "phenotype_combined": "not specified",
      "pathogenicity_classification_combined": "Uncertain significance",
      "custom_annotations": null
    }
  ],
  "message": null
}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.