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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 2-37109243-A-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=37109243&ref=A&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "2",
"pos": 37109243,
"ref": "A",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_002759.4",
"consequences": [
{
"aa_ref": "I",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF2AK2",
"gene_hgnc_id": 9437,
"hgvs_c": "c.1430T>A",
"hgvs_p": "p.Ile477Asn",
"transcript": "NM_001135651.3",
"protein_id": "NP_001129123.1",
"transcript_support_level": null,
"aa_start": 477,
"aa_end": null,
"aa_length": 551,
"cds_start": 1430,
"cds_end": null,
"cds_length": 1656,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000233057.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001135651.3"
},
{
"aa_ref": "I",
"aa_alt": "N",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF2AK2",
"gene_hgnc_id": 9437,
"hgvs_c": "c.1430T>A",
"hgvs_p": "p.Ile477Asn",
"transcript": "ENST00000233057.9",
"protein_id": "ENSP00000233057.4",
"transcript_support_level": 2,
"aa_start": 477,
"aa_end": null,
"aa_length": 551,
"cds_start": 1430,
"cds_end": null,
"cds_length": 1656,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001135651.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000233057.9"
},
{
"aa_ref": "I",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF2AK2",
"gene_hgnc_id": 9437,
"hgvs_c": "c.1307T>A",
"hgvs_p": "p.Ile436Asn",
"transcript": "ENST00000405334.5",
"protein_id": "ENSP00000385014.1",
"transcript_support_level": 1,
"aa_start": 436,
"aa_end": null,
"aa_length": 510,
"cds_start": 1307,
"cds_end": null,
"cds_length": 1533,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000405334.5"
},
{
"aa_ref": "I",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF2AK2",
"gene_hgnc_id": 9437,
"hgvs_c": "c.1430T>A",
"hgvs_p": "p.Ile477Asn",
"transcript": "NM_002759.4",
"protein_id": "NP_002750.1",
"transcript_support_level": null,
"aa_start": 477,
"aa_end": null,
"aa_length": 551,
"cds_start": 1430,
"cds_end": null,
"cds_length": 1656,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_002759.4"
},
{
"aa_ref": "I",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF2AK2",
"gene_hgnc_id": 9437,
"hgvs_c": "c.1430T>A",
"hgvs_p": "p.Ile477Asn",
"transcript": "ENST00000395127.6",
"protein_id": "ENSP00000378559.2",
"transcript_support_level": 5,
"aa_start": 477,
"aa_end": null,
"aa_length": 551,
"cds_start": 1430,
"cds_end": null,
"cds_length": 1656,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000395127.6"
},
{
"aa_ref": "I",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF2AK2",
"gene_hgnc_id": 9437,
"hgvs_c": "c.1430T>A",
"hgvs_p": "p.Ile477Asn",
"transcript": "ENST00000679507.1",
"protein_id": "ENSP00000506024.1",
"transcript_support_level": null,
"aa_start": 477,
"aa_end": null,
"aa_length": 551,
"cds_start": 1430,
"cds_end": null,
"cds_length": 1656,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000679507.1"
},
{
"aa_ref": "I",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF2AK2",
"gene_hgnc_id": 9437,
"hgvs_c": "c.1430T>A",
"hgvs_p": "p.Ile477Asn",
"transcript": "ENST00000681463.1",
"protein_id": "ENSP00000505138.1",
"transcript_support_level": null,
"aa_start": 477,
"aa_end": null,
"aa_length": 551,
"cds_start": 1430,
"cds_end": null,
"cds_length": 1656,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000681463.1"
},
{
"aa_ref": "I",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF2AK2",
"gene_hgnc_id": 9437,
"hgvs_c": "c.1430T>A",
"hgvs_p": "p.Ile477Asn",
"transcript": "ENST00000681507.1",
"protein_id": "ENSP00000505772.1",
"transcript_support_level": null,
"aa_start": 477,
"aa_end": null,
"aa_length": 551,
"cds_start": 1430,
"cds_end": null,
"cds_length": 1656,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000681507.1"
},
{
"aa_ref": "I",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF2AK2",
"gene_hgnc_id": 9437,
"hgvs_c": "c.1430T>A",
"hgvs_p": "p.Ile477Asn",
"transcript": "ENST00000874614.1",
"protein_id": "ENSP00000544673.1",
"transcript_support_level": null,
"aa_start": 477,
"aa_end": null,
"aa_length": 551,
"cds_start": 1430,
"cds_end": null,
"cds_length": 1656,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000874614.1"
},
{
"aa_ref": "I",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF2AK2",
"gene_hgnc_id": 9437,
"hgvs_c": "c.1430T>A",
"hgvs_p": "p.Ile477Asn",
"transcript": "ENST00000937455.1",
"protein_id": "ENSP00000607514.1",
"transcript_support_level": null,
"aa_start": 477,
"aa_end": null,
"aa_length": 551,
"cds_start": 1430,
"cds_end": null,
"cds_length": 1656,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000937455.1"
},
{
"aa_ref": "I",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF2AK2",
"gene_hgnc_id": 9437,
"hgvs_c": "c.1430T>A",
"hgvs_p": "p.Ile477Asn",
"transcript": "ENST00000937456.1",
"protein_id": "ENSP00000607515.1",
"transcript_support_level": null,
"aa_start": 477,
"aa_end": null,
"aa_length": 551,
"cds_start": 1430,
"cds_end": null,
"cds_length": 1656,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000937456.1"
},
{
"aa_ref": "I",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF2AK2",
"gene_hgnc_id": 9437,
"hgvs_c": "c.1430T>A",
"hgvs_p": "p.Ile477Asn",
"transcript": "ENST00000874615.1",
"protein_id": "ENSP00000544674.1",
"transcript_support_level": null,
"aa_start": 477,
"aa_end": null,
"aa_length": 546,
"cds_start": 1430,
"cds_end": null,
"cds_length": 1641,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000874615.1"
},
{
"aa_ref": "I",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF2AK2",
"gene_hgnc_id": 9437,
"hgvs_c": "c.1430T>A",
"hgvs_p": "p.Ile477Asn",
"transcript": "ENST00000874619.1",
"protein_id": "ENSP00000544678.1",
"transcript_support_level": null,
"aa_start": 477,
"aa_end": null,
"aa_length": 546,
"cds_start": 1430,
"cds_end": null,
"cds_length": 1641,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000874619.1"
},
{
"aa_ref": "I",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF2AK2",
"gene_hgnc_id": 9437,
"hgvs_c": "c.1430T>A",
"hgvs_p": "p.Ile477Asn",
"transcript": "ENST00000681516.1",
"protein_id": "ENSP00000506573.1",
"transcript_support_level": null,
"aa_start": 477,
"aa_end": null,
"aa_length": 541,
"cds_start": 1430,
"cds_end": null,
"cds_length": 1626,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000681516.1"
},
{
"aa_ref": "I",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF2AK2",
"gene_hgnc_id": 9437,
"hgvs_c": "c.1430T>A",
"hgvs_p": "p.Ile477Asn",
"transcript": "ENST00000874617.1",
"protein_id": "ENSP00000544676.1",
"transcript_support_level": null,
"aa_start": 477,
"aa_end": null,
"aa_length": 541,
"cds_start": 1430,
"cds_end": null,
"cds_length": 1626,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000874617.1"
},
{
"aa_ref": "I",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF2AK2",
"gene_hgnc_id": 9437,
"hgvs_c": "c.1430T>A",
"hgvs_p": "p.Ile477Asn",
"transcript": "ENST00000874621.1",
"protein_id": "ENSP00000544680.1",
"transcript_support_level": null,
"aa_start": 477,
"aa_end": null,
"aa_length": 541,
"cds_start": 1430,
"cds_end": null,
"cds_length": 1626,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000874621.1"
},
{
"aa_ref": "I",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF2AK2",
"gene_hgnc_id": 9437,
"hgvs_c": "c.1430T>A",
"hgvs_p": "p.Ile477Asn",
"transcript": "ENST00000874616.1",
"protein_id": "ENSP00000544675.1",
"transcript_support_level": null,
"aa_start": 477,
"aa_end": null,
"aa_length": 533,
"cds_start": 1430,
"cds_end": null,
"cds_length": 1602,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000874616.1"
},
{
"aa_ref": "I",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF2AK2",
"gene_hgnc_id": 9437,
"hgvs_c": "c.1430T>A",
"hgvs_p": "p.Ile477Asn",
"transcript": "ENST00000874620.1",
"protein_id": "ENSP00000544679.1",
"transcript_support_level": null,
"aa_start": 477,
"aa_end": null,
"aa_length": 533,
"cds_start": 1430,
"cds_end": null,
"cds_length": 1602,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000874620.1"
},
{
"aa_ref": "I",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF2AK2",
"gene_hgnc_id": 9437,
"hgvs_c": "c.1430T>A",
"hgvs_p": "p.Ile477Asn",
"transcript": "ENST00000937454.1",
"protein_id": "ENSP00000607513.1",
"transcript_support_level": null,
"aa_start": 477,
"aa_end": null,
"aa_length": 533,
"cds_start": 1430,
"cds_end": null,
"cds_length": 1602,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000937454.1"
},
{
"aa_ref": "I",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF2AK2",
"gene_hgnc_id": 9437,
"hgvs_c": "c.1307T>A",
"hgvs_p": "p.Ile436Asn",
"transcript": "NM_001135652.2",
"protein_id": "NP_001129124.1",
"transcript_support_level": null,
"aa_start": 436,
"aa_end": null,
"aa_length": 510,
"cds_start": 1307,
"cds_end": null,
"cds_length": 1533,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001135652.2"
},
{
"aa_ref": "I",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF2AK2",
"gene_hgnc_id": 9437,
"hgvs_c": "c.1301T>A",
"hgvs_p": "p.Ile434Asn",
"transcript": "ENST00000679979.1",
"protein_id": "ENSP00000506455.1",
"transcript_support_level": null,
"aa_start": 434,
"aa_end": null,
"aa_length": 508,
"cds_start": 1301,
"cds_end": null,
"cds_length": 1527,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000679979.1"
},
{
"aa_ref": "I",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF2AK2",
"gene_hgnc_id": 9437,
"hgvs_c": "c.1301T>A",
"hgvs_p": "p.Ile434Asn",
"transcript": "ENST00000874618.1",
"protein_id": "ENSP00000544677.1",
"transcript_support_level": null,
"aa_start": 434,
"aa_end": null,
"aa_length": 508,
"cds_start": 1301,
"cds_end": null,
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{
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{
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{
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{
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{
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{
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],
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{
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],
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{
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],
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"biotype": "pseudogene",
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],
"gene_symbol": "EIF2AK2",
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"dbsnp": null,
"frequency_reference_population": null,
"hom_count_reference_population": 0,
"allele_count_reference_population": 0,
"gnomad_exomes_af": null,
"gnomad_genomes_af": null,
"gnomad_exomes_ac": null,
"gnomad_genomes_ac": null,
"gnomad_exomes_homalt": null,
"gnomad_genomes_homalt": null,
"gnomad_mito_homoplasmic": null,
"gnomad_mito_heteroplasmic": null,
"computational_score_selected": 0.9047607779502869,
"computational_prediction_selected": "Pathogenic",
"computational_source_selected": "MetaRNN",
"splice_score_selected": 0,
"splice_prediction_selected": "Benign",
"splice_source_selected": "max_spliceai",
"revel_score": 0.524,
"revel_prediction": "Uncertain_significance",
"alphamissense_score": 0.7853,
"alphamissense_prediction": null,
"bayesdelnoaf_score": 0.03,
"bayesdelnoaf_prediction": "Uncertain_significance",
"phylop100way_score": 4.486,
"phylop100way_prediction": "Uncertain_significance",
"spliceai_max_score": 0,
"spliceai_max_prediction": "Benign",
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"dbscsnv_ada_prediction": null,
"apogee2_score": null,
"apogee2_prediction": null,
"mitotip_score": null,
"mitotip_prediction": null,
"acmg_score": 4,
"acmg_classification": "Uncertain_significance",
"acmg_criteria": "PM2,PP3_Moderate",
"acmg_by_gene": [
{
"score": 4,
"benign_score": 0,
"pathogenic_score": 4,
"criteria": [
"PM2",
"PP3_Moderate"
],
"verdict": "Uncertain_significance",
"transcript": "NM_002759.4",
"gene_symbol": "EIF2AK2",
"hgnc_id": 9437,
"effects": [
"missense_variant"
],
"inheritance_mode": "AD,Unknown",
"hgvs_c": "c.1430T>A",
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],
"clinvar_disease": "not provided",
"clinvar_classification": "Uncertain significance",
"clinvar_review_status": "criteria provided, single submitter",
"clinvar_submissions_summary": "US:1",
"phenotype_combined": "not provided",
"pathogenicity_classification_combined": "Uncertain significance",
"custom_annotations": null
}
],
"message": null
}