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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 2-43410859-A-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=43410859&ref=A&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "2",
"pos": 43410859,
"ref": "A",
"alt": "C",
"effect": "intron_variant",
"transcript": "NM_022065.5",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 38,
"intron_rank": 28,
"intron_rank_end": null,
"gene_symbol": "THADA",
"gene_hgnc_id": 19217,
"hgvs_c": "c.4059-12720T>G",
"hgvs_p": null,
"transcript": "NM_022065.5",
"protein_id": "NP_071348.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1953,
"cds_start": null,
"cds_end": null,
"cds_length": 5862,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000405975.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_022065.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 38,
"intron_rank": 28,
"intron_rank_end": null,
"gene_symbol": "THADA",
"gene_hgnc_id": 19217,
"hgvs_c": "c.4059-12720T>G",
"hgvs_p": null,
"transcript": "ENST00000405975.7",
"protein_id": "ENSP00000386088.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1953,
"cds_start": null,
"cds_end": null,
"cds_length": 5862,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_022065.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000405975.7"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 38,
"intron_rank": 28,
"intron_rank_end": null,
"gene_symbol": "THADA",
"gene_hgnc_id": 19217,
"hgvs_c": "c.4059-12720T>G",
"hgvs_p": null,
"transcript": "ENST00000405006.8",
"protein_id": "ENSP00000385995.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1953,
"cds_start": null,
"cds_end": null,
"cds_length": 5862,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000405006.8"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": 28,
"intron_rank_end": null,
"gene_symbol": "THADA",
"gene_hgnc_id": 19217,
"hgvs_c": "n.*3154-12720T>G",
"hgvs_p": null,
"transcript": "ENST00000408045.7",
"protein_id": "ENSP00000384172.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000408045.7"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 38,
"intron_rank": 28,
"intron_rank_end": null,
"gene_symbol": "THADA",
"gene_hgnc_id": 19217,
"hgvs_c": "c.4059-12720T>G",
"hgvs_p": null,
"transcript": "NM_001083953.2",
"protein_id": "NP_001077422.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1953,
"cds_start": null,
"cds_end": null,
"cds_length": 5862,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001083953.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": 29,
"intron_rank_end": null,
"gene_symbol": "THADA",
"gene_hgnc_id": 19217,
"hgvs_c": "c.4059-12720T>G",
"hgvs_p": null,
"transcript": "NM_001345925.2",
"protein_id": "NP_001332854.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1953,
"cds_start": null,
"cds_end": null,
"cds_length": 5862,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001345925.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": 29,
"intron_rank_end": null,
"gene_symbol": "THADA",
"gene_hgnc_id": 19217,
"hgvs_c": "c.4059-12720T>G",
"hgvs_p": null,
"transcript": "ENST00000855634.1",
"protein_id": "ENSP00000525693.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1953,
"cds_start": null,
"cds_end": null,
"cds_length": 5862,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000855634.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 38,
"intron_rank": 28,
"intron_rank_end": null,
"gene_symbol": "THADA",
"gene_hgnc_id": 19217,
"hgvs_c": "c.4059-12720T>G",
"hgvs_p": null,
"transcript": "ENST00000915746.1",
"protein_id": "ENSP00000585805.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1953,
"cds_start": null,
"cds_end": null,
"cds_length": 5862,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000915746.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 38,
"intron_rank": 28,
"intron_rank_end": null,
"gene_symbol": "THADA",
"gene_hgnc_id": 19217,
"hgvs_c": "c.4059-12720T>G",
"hgvs_p": null,
"transcript": "ENST00000944893.1",
"protein_id": "ENSP00000614952.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1953,
"cds_start": null,
"cds_end": null,
"cds_length": 5862,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000944893.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 38,
"intron_rank": 28,
"intron_rank_end": null,
"gene_symbol": "THADA",
"gene_hgnc_id": 19217,
"hgvs_c": "c.4056-12720T>G",
"hgvs_p": null,
"transcript": "NM_001345923.2",
"protein_id": "NP_001332852.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1952,
"cds_start": null,
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"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001345923.2"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 38,
"intron_rank": 28,
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"gene_symbol": "THADA",
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"hgvs_c": "c.4056-12720T>G",
"hgvs_p": null,
"transcript": "ENST00000855632.1",
"protein_id": "ENSP00000525691.1",
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"aa_length": 1952,
"cds_start": null,
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"cdna_start": null,
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"biotype": "protein_coding",
"feature": "ENST00000855632.1"
},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 39,
"intron_rank": 29,
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"gene_symbol": "THADA",
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"hgvs_c": "c.4056-12720T>G",
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"transcript": "ENST00000855637.1",
"protein_id": "ENSP00000525696.1",
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"aa_start": null,
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"biotype": "protein_coding",
"feature": "ENST00000855637.1"
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 28,
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"gene_symbol": "THADA",
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"hgvs_c": "c.3939-12720T>G",
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"transcript": "ENST00000855630.1",
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},
{
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],
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"gene_symbol": "THADA",
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"hgvs_c": "c.3939-12720T>G",
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},
{
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"strand": false,
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],
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"intron_rank": 28,
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"gene_symbol": "THADA",
"gene_hgnc_id": 19217,
"hgvs_c": "c.3936-12720T>G",
"hgvs_p": null,
"transcript": "NM_001345924.2",
"protein_id": "NP_001332853.1",
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"feature": "NM_001345924.2"
},
{
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],
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"intron_rank": 28,
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"gene_symbol": "THADA",
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"feature": "ENST00000855633.1"
},
{
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"strand": false,
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],
"exon_rank": null,
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"intron_rank": 27,
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"gene_symbol": "THADA",
"gene_hgnc_id": 19217,
"hgvs_c": "c.3897-12720T>G",
"hgvs_p": null,
"transcript": "ENST00000944894.1",
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"feature": "ENST00000944894.1"
},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 38,
"intron_rank": 28,
"intron_rank_end": null,
"gene_symbol": "THADA",
"gene_hgnc_id": 19217,
"hgvs_c": "c.3852-12720T>G",
"hgvs_p": null,
"transcript": "ENST00000944896.1",
"protein_id": "ENSP00000614955.1",
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},
{
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"strand": false,
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],
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"intron_rank": 26,
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"gene_symbol": "THADA",
"gene_hgnc_id": 19217,
"hgvs_c": "c.3837-12720T>G",
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},
{
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"protein_coding": true,
"strand": false,
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],
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"gene_symbol": "THADA",
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"hgvs_c": "c.3837-12720T>G",
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"transcript": "ENST00000855639.1",
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},
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],
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"intron_rank_end": null,
"gene_symbol": "THADA",
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"hgvs_c": "c.3939-12720T>G",
"hgvs_p": null,
"transcript": "ENST00000944895.1",
"protein_id": "ENSP00000614954.1",
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"biotype": "protein_coding",
"feature": "ENST00000944895.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 36,
"intron_rank": 26,
"intron_rank_end": null,
"gene_symbol": "THADA",
"gene_hgnc_id": 19217,
"hgvs_c": "c.3696-12720T>G",
"hgvs_p": null,
"transcript": "ENST00000855631.1",
"protein_id": "ENSP00000525690.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 1832,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000855631.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 36,
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}