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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 2-43935027-A-G (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=43935027&ref=A&alt=G&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "2",
      "pos": 43935027,
      "ref": "A",
      "alt": "G",
      "effect": "intron_variant",
      "transcript": "NM_133259.4",
      "consequences": [
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 38,
          "intron_rank": 23,
          "intron_rank_end": null,
          "gene_symbol": "LRPPRC",
          "gene_hgnc_id": 15714,
          "hgvs_c": "c.2505-149T>C",
          "hgvs_p": null,
          "transcript": "NM_133259.4",
          "protein_id": "NP_573566.2",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1394,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 4185,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000260665.12",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_133259.4"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 38,
          "intron_rank": 23,
          "intron_rank_end": null,
          "gene_symbol": "LRPPRC",
          "gene_hgnc_id": 15714,
          "hgvs_c": "c.2505-149T>C",
          "hgvs_p": null,
          "transcript": "ENST00000260665.12",
          "protein_id": "ENSP00000260665.7",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1394,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 4185,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_133259.4",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000260665.12"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 39,
          "intron_rank": 23,
          "intron_rank_end": null,
          "gene_symbol": "LRPPRC",
          "gene_hgnc_id": 15714,
          "hgvs_c": "c.2505-149T>C",
          "hgvs_p": null,
          "transcript": "ENST00000683125.1",
          "protein_id": "ENSP00000507939.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1430,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 4293,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000683125.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 38,
          "intron_rank": 23,
          "intron_rank_end": null,
          "gene_symbol": "LRPPRC",
          "gene_hgnc_id": 15714,
          "hgvs_c": "c.2505-149T>C",
          "hgvs_p": null,
          "transcript": "ENST00000958038.1",
          "protein_id": "ENSP00000628097.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1407,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 4224,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000958038.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 38,
          "intron_rank": 23,
          "intron_rank_end": null,
          "gene_symbol": "LRPPRC",
          "gene_hgnc_id": 15714,
          "hgvs_c": "c.2535-149T>C",
          "hgvs_p": null,
          "transcript": "ENST00000683220.1",
          "protein_id": "ENSP00000507151.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1404,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 4215,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000683220.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 38,
          "intron_rank": 23,
          "intron_rank_end": null,
          "gene_symbol": "LRPPRC",
          "gene_hgnc_id": 15714,
          "hgvs_c": "c.2526-149T>C",
          "hgvs_p": null,
          "transcript": "ENST00000918909.1",
          "protein_id": "ENSP00000588968.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1401,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 4206,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000918909.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 38,
          "intron_rank": 23,
          "intron_rank_end": null,
          "gene_symbol": "LRPPRC",
          "gene_hgnc_id": 15714,
          "hgvs_c": "c.2505-149T>C",
          "hgvs_p": null,
          "transcript": "ENST00000682480.1",
          "protein_id": "ENSP00000508344.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1400,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 4203,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000682480.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 38,
          "intron_rank": 23,
          "intron_rank_end": null,
          "gene_symbol": "LRPPRC",
          "gene_hgnc_id": 15714,
          "hgvs_c": "c.2508-149T>C",
          "hgvs_p": null,
          "transcript": "ENST00000683213.1",
          "protein_id": "ENSP00000507751.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1395,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 4188,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000683213.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 38,
          "intron_rank": 23,
          "intron_rank_end": null,
          "gene_symbol": "LRPPRC",
          "gene_hgnc_id": 15714,
          "hgvs_c": "c.2502-149T>C",
          "hgvs_p": null,
          "transcript": "ENST00000682546.1",
          "protein_id": "ENSP00000508188.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1393,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 4182,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000682546.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 38,
          "intron_rank": 23,
          "intron_rank_end": null,
          "gene_symbol": "LRPPRC",
          "gene_hgnc_id": 15714,
          "hgvs_c": "c.2505-149T>C",
          "hgvs_p": null,
          "transcript": "ENST00000903379.1",
          "protein_id": "ENSP00000573438.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 1392,
          "cds_start": null,
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          "cds_length": 4179,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
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          "biotype": "protein_coding",
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        },
        {
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          "canonical": false,
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          "strand": false,
          "consequences": [
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          "intron_rank": 23,
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          "gene_symbol": "LRPPRC",
          "gene_hgnc_id": 15714,
          "hgvs_c": "c.2496-149T>C",
          "hgvs_p": null,
          "transcript": "ENST00000682779.1",
          "protein_id": "ENSP00000507947.1",
          "transcript_support_level": null,
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          "aa_length": 1391,
          "cds_start": null,
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          "cdna_start": null,
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          "mane_select": null,
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          "biotype": "protein_coding",
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        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": true,
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          "consequences": [
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          "intron_rank": 23,
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          "gene_symbol": "LRPPRC",
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        {
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          "protein_id": "ENSP00000628095.1",
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        {
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          "gene_symbol": "LRPPRC",
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          "hgvs_p": null,
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        {
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          "intron_rank": 23,
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          "gene_symbol": "LRPPRC",
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          "gene_symbol": "LRPPRC",
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          "transcript": "ENST00000918910.1",
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          "consequences": [
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          "intron_rank": 23,
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          "gene_symbol": "LRPPRC",
          "gene_hgnc_id": 15714,
          "hgvs_c": "c.2412-149T>C",
          "hgvs_p": null,
          "transcript": "ENST00000683623.1",
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        {
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      "clinvar_classification": "Benign",
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      "clinvar_submissions_summary": "B:1",
      "phenotype_combined": "not provided",
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      "custom_annotations": null
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  "message": null
}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.