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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 2-55334505-TA-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=55334505&ref=TA&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "2",
      "pos": 55334505,
      "ref": "TA",
      "alt": "T",
      "effect": "frameshift_variant",
      "transcript": "NM_001365480.1",
      "consequences": [
        {
          "aa_ref": "L",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 33,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CCDC88A",
          "gene_hgnc_id": 25523,
          "hgvs_c": "c.2315delT",
          "hgvs_p": "p.Leu772fs",
          "transcript": "NM_001365480.1",
          "protein_id": "NP_001352409.1",
          "transcript_support_level": null,
          "aa_start": 772,
          "aa_end": null,
          "aa_length": 1871,
          "cds_start": 2315,
          "cds_end": null,
          "cds_length": 5616,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000436346.7",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001365480.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 33,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CCDC88A",
          "gene_hgnc_id": 25523,
          "hgvs_c": "c.2315delT",
          "hgvs_p": "p.Leu772fs",
          "transcript": "ENST00000436346.7",
          "protein_id": "ENSP00000410608.1",
          "transcript_support_level": 5,
          "aa_start": 772,
          "aa_end": null,
          "aa_length": 1871,
          "cds_start": 2315,
          "cds_end": null,
          "cds_length": 5616,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_001365480.1",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000436346.7"
        },
        {
          "aa_ref": "L",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 33,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CCDC88A",
          "gene_hgnc_id": 25523,
          "hgvs_c": "c.2315delT",
          "hgvs_p": "p.Leu772fs",
          "transcript": "ENST00000336838.10",
          "protein_id": "ENSP00000338728.6",
          "transcript_support_level": 1,
          "aa_start": 772,
          "aa_end": null,
          "aa_length": 1870,
          "cds_start": 2315,
          "cds_end": null,
          "cds_length": 5613,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000336838.10"
        },
        {
          "aa_ref": "L",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CCDC88A",
          "gene_hgnc_id": 25523,
          "hgvs_c": "c.2315delT",
          "hgvs_p": "p.Leu772fs",
          "transcript": "ENST00000263630.13",
          "protein_id": "ENSP00000263630.8",
          "transcript_support_level": 1,
          "aa_start": 772,
          "aa_end": null,
          "aa_length": 1843,
          "cds_start": 2315,
          "cds_end": null,
          "cds_length": 5532,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000263630.13"
        },
        {
          "aa_ref": "L",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 34,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CCDC88A",
          "gene_hgnc_id": 25523,
          "hgvs_c": "c.2315delT",
          "hgvs_p": "p.Leu772fs",
          "transcript": "ENST00000413716.7",
          "protein_id": "ENSP00000404431.3",
          "transcript_support_level": 1,
          "aa_start": 772,
          "aa_end": null,
          "aa_length": 1797,
          "cds_start": 2315,
          "cds_end": null,
          "cds_length": 5394,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000413716.7"
        },
        {
          "aa_ref": "L",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 33,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CCDC88A",
          "gene_hgnc_id": 25523,
          "hgvs_c": "c.2315delT",
          "hgvs_p": "p.Leu772fs",
          "transcript": "ENST00000642200.1",
          "protein_id": "ENSP00000495919.1",
          "transcript_support_level": null,
          "aa_start": 772,
          "aa_end": null,
          "aa_length": 1871,
          "cds_start": 2315,
          "cds_end": null,
          "cds_length": 5616,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000642200.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 33,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CCDC88A",
          "gene_hgnc_id": 25523,
          "hgvs_c": "c.2315delT",
          "hgvs_p": "p.Leu772fs",
          "transcript": "NM_001135597.2",
          "protein_id": "NP_001129069.1",
          "transcript_support_level": null,
          "aa_start": 772,
          "aa_end": null,
          "aa_length": 1870,
          "cds_start": 2315,
          "cds_end": null,
          "cds_length": 5613,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001135597.2"
        },
        {
          "aa_ref": "L",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CCDC88A",
          "gene_hgnc_id": 25523,
          "hgvs_c": "c.2315delT",
          "hgvs_p": "p.Leu772fs",
          "transcript": "ENST00000935827.1",
          "protein_id": "ENSP00000605886.1",
          "transcript_support_level": null,
          "aa_start": 772,
          "aa_end": null,
          "aa_length": 1870,
          "cds_start": 2315,
          "cds_end": null,
          "cds_length": 5613,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000935827.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CCDC88A",
          "gene_hgnc_id": 25523,
          "hgvs_c": "c.2315delT",
          "hgvs_p": "p.Leu772fs",
          "transcript": "ENST00000935824.1",
          "protein_id": "ENSP00000605883.1",
          "transcript_support_level": null,
          "aa_start": 772,
          "aa_end": null,
          "aa_length": 1844,
          "cds_start": 2315,
          "cds_end": null,
          "cds_length": 5535,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000935824.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CCDC88A",
          "gene_hgnc_id": 25523,
          "hgvs_c": "c.2315delT",
          "hgvs_p": "p.Leu772fs",
          "transcript": "NM_018084.5",
          "protein_id": "NP_060554.3",
          "transcript_support_level": null,
          "aa_start": 772,
          "aa_end": null,
          "aa_length": 1843,
          "cds_start": 2315,
          "cds_end": null,
          "cds_length": 5532,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_018084.5"
        },
        {
          "aa_ref": "L",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CCDC88A",
          "gene_hgnc_id": 25523,
          "hgvs_c": "c.2315delT",
          "hgvs_p": "p.Leu772fs",
          "transcript": "ENST00000935825.1",
          "protein_id": "ENSP00000605884.1",
          "transcript_support_level": null,
          "aa_start": 772,
          "aa_end": null,
          "aa_length": 1843,
          "cds_start": 2315,
          "cds_end": null,
          "cds_length": 5532,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000935825.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
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          "gene_symbol": "CCDC88A",
          "gene_hgnc_id": 25523,
          "hgvs_c": "c.2315delT",
          "hgvs_p": "p.Leu772fs",
          "transcript": "ENST00000935826.1",
          "protein_id": "ENSP00000605885.1",
          "transcript_support_level": null,
          "aa_start": 772,
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          "aa_length": 1843,
          "cds_start": 2315,
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          "cds_length": 5532,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000935826.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CCDC88A",
          "gene_hgnc_id": 25523,
          "hgvs_c": "c.2315delT",
          "hgvs_p": "p.Leu772fs",
          "transcript": "ENST00000643413.1",
          "protein_id": "ENSP00000494811.1",
          "transcript_support_level": null,
          "aa_start": 772,
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          "aa_length": 1842,
          "cds_start": 2315,
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          "cds_length": 5529,
          "cdna_start": null,
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          "cdna_length": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000643413.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 34,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CCDC88A",
          "gene_hgnc_id": 25523,
          "hgvs_c": "c.2315delT",
          "hgvs_p": "p.Leu772fs",
          "transcript": "NM_001254943.2",
          "protein_id": "NP_001241872.1",
          "transcript_support_level": null,
          "aa_start": 772,
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          "aa_length": 1796,
          "cds_start": 2315,
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        },
        {
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          ],
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          "exon_count": 34,
          "intron_rank": null,
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          "gene_symbol": "CCDC88A",
          "gene_hgnc_id": 25523,
          "hgvs_c": "c.2315delT",
          "hgvs_p": "p.Leu772fs",
          "transcript": "ENST00000646796.1",
          "protein_id": "ENSP00000493703.1",
          "transcript_support_level": null,
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          "cds_start": 2315,
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          "cdna_start": null,
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          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000646796.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 25,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CCDC88A",
          "gene_hgnc_id": 25523,
          "hgvs_c": "c.1679delT",
          "hgvs_p": "p.Leu560fs",
          "transcript": "ENST00000647401.1",
          "protein_id": "ENSP00000496148.1",
          "transcript_support_level": null,
          "aa_start": 560,
          "aa_end": null,
          "aa_length": 1604,
          "cds_start": 1679,
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          "cds_length": 4815,
          "cdna_start": null,
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          "biotype": "protein_coding",
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        },
        {
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CCDC88A",
          "gene_hgnc_id": 25523,
          "hgvs_c": "c.2315delT",
          "hgvs_p": "p.Leu772fs",
          "transcript": "ENST00000645477.1",
          "protein_id": "ENSP00000495712.1",
          "transcript_support_level": null,
          "aa_start": 772,
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          "cds_start": 2315,
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        {
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          ],
          "exon_rank": 15,
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          "exon_count": 26,
          "intron_rank": null,
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          "gene_symbol": "CCDC88A",
          "gene_hgnc_id": 25523,
          "hgvs_c": "c.2315delT",
          "hgvs_p": "p.Leu772fs",
          "transcript": "ENST00000645072.1",
          "protein_id": "ENSP00000494030.1",
          "transcript_support_level": null,
          "aa_start": 772,
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          "cds_length": 4482,
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          "biotype": "protein_coding",
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        {
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          "strand": false,
          "consequences": [
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          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
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          "gene_symbol": "CCDC88A",
          "gene_hgnc_id": 25523,
          "hgvs_c": "c.185delT",
          "hgvs_p": "p.Leu62fs",
          "transcript": "ENST00000647396.1",
          "protein_id": "ENSP00000496591.1",
          "transcript_support_level": null,
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          "aa_length": 1134,
          "cds_start": 185,
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          "cds_length": 3405,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000647396.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CCDC88A",
          "gene_hgnc_id": 25523,
          "hgvs_c": "c.38delT",
          "hgvs_p": "p.Leu13fs",
          "transcript": "ENST00000645860.1",
          "protein_id": "ENSP00000496581.1",
          "transcript_support_level": null,
          "aa_start": 13,
          "aa_end": null,
          "aa_length": 1112,
          "cds_start": 38,
          "cds_end": null,
          "cds_length": 3339,
          "cdna_start": null,
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}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.