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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 2-55636268-G-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=55636268&ref=G&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "2",
      "pos": 55636268,
      "ref": "G",
      "alt": "A",
      "effect": "missense_variant",
      "transcript": "NM_033109.5",
      "consequences": [
        {
          "aa_ref": "P",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 28,
          "exon_rank_end": null,
          "exon_count": 28,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PNPT1",
          "gene_hgnc_id": 23166,
          "hgvs_c": "c.2321C>T",
          "hgvs_p": "p.Pro774Leu",
          "transcript": "NM_033109.5",
          "protein_id": "NP_149100.2",
          "transcript_support_level": null,
          "aa_start": 774,
          "aa_end": null,
          "aa_length": 783,
          "cds_start": 2321,
          "cds_end": null,
          "cds_length": 2352,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000447944.7",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_033109.5"
        },
        {
          "aa_ref": "P",
          "aa_alt": "L",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 28,
          "exon_rank_end": null,
          "exon_count": 28,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PNPT1",
          "gene_hgnc_id": 23166,
          "hgvs_c": "c.2321C>T",
          "hgvs_p": "p.Pro774Leu",
          "transcript": "ENST00000447944.7",
          "protein_id": "ENSP00000400646.2",
          "transcript_support_level": 1,
          "aa_start": 774,
          "aa_end": null,
          "aa_length": 783,
          "cds_start": 2321,
          "cds_end": null,
          "cds_length": 2352,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_033109.5",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000447944.7"
        },
        {
          "aa_ref": "P",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 28,
          "exon_rank_end": null,
          "exon_count": 28,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PNPT1",
          "gene_hgnc_id": 23166,
          "hgvs_c": "c.2339C>T",
          "hgvs_p": "p.Pro780Leu",
          "transcript": "ENST00000917025.1",
          "protein_id": "ENSP00000587084.1",
          "transcript_support_level": null,
          "aa_start": 780,
          "aa_end": null,
          "aa_length": 789,
          "cds_start": 2339,
          "cds_end": null,
          "cds_length": 2370,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000917025.1"
        },
        {
          "aa_ref": "P",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 28,
          "exon_rank_end": null,
          "exon_count": 28,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PNPT1",
          "gene_hgnc_id": 23166,
          "hgvs_c": "c.2318C>T",
          "hgvs_p": "p.Pro773Leu",
          "transcript": "ENST00000867135.1",
          "protein_id": "ENSP00000537194.1",
          "transcript_support_level": null,
          "aa_start": 773,
          "aa_end": null,
          "aa_length": 782,
          "cds_start": 2318,
          "cds_end": null,
          "cds_length": 2349,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000867135.1"
        },
        {
          "aa_ref": "P",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 28,
          "exon_rank_end": null,
          "exon_count": 28,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PNPT1",
          "gene_hgnc_id": 23166,
          "hgvs_c": "c.2318C>T",
          "hgvs_p": "p.Pro773Leu",
          "transcript": "ENST00000917023.1",
          "protein_id": "ENSP00000587082.1",
          "transcript_support_level": null,
          "aa_start": 773,
          "aa_end": null,
          "aa_length": 782,
          "cds_start": 2318,
          "cds_end": null,
          "cds_length": 2349,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000917023.1"
        },
        {
          "aa_ref": "P",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 28,
          "exon_rank_end": null,
          "exon_count": 28,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PNPT1",
          "gene_hgnc_id": 23166,
          "hgvs_c": "c.2315C>T",
          "hgvs_p": "p.Pro772Leu",
          "transcript": "ENST00000949803.1",
          "protein_id": "ENSP00000619862.1",
          "transcript_support_level": null,
          "aa_start": 772,
          "aa_end": null,
          "aa_length": 781,
          "cds_start": 2315,
          "cds_end": null,
          "cds_length": 2346,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000949803.1"
        },
        {
          "aa_ref": "P",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 28,
          "exon_rank_end": null,
          "exon_count": 28,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PNPT1",
          "gene_hgnc_id": 23166,
          "hgvs_c": "c.2312C>T",
          "hgvs_p": "p.Pro771Leu",
          "transcript": "ENST00000949801.1",
          "protein_id": "ENSP00000619860.1",
          "transcript_support_level": null,
          "aa_start": 771,
          "aa_end": null,
          "aa_length": 780,
          "cds_start": 2312,
          "cds_end": null,
          "cds_length": 2343,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000949801.1"
        },
        {
          "aa_ref": "P",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 27,
          "exon_rank_end": null,
          "exon_count": 27,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PNPT1",
          "gene_hgnc_id": 23166,
          "hgvs_c": "c.2273C>T",
          "hgvs_p": "p.Pro758Leu",
          "transcript": "ENST00000867137.1",
          "protein_id": "ENSP00000537196.1",
          "transcript_support_level": null,
          "aa_start": 758,
          "aa_end": null,
          "aa_length": 767,
          "cds_start": 2273,
          "cds_end": null,
          "cds_length": 2304,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000867137.1"
        },
        {
          "aa_ref": "P",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 27,
          "exon_rank_end": null,
          "exon_count": 27,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PNPT1",
          "gene_hgnc_id": 23166,
          "hgvs_c": "c.2273C>T",
          "hgvs_p": "p.Pro758Leu",
          "transcript": "ENST00000917022.1",
          "protein_id": "ENSP00000587081.1",
          "transcript_support_level": null,
          "aa_start": 758,
          "aa_end": null,
          "aa_length": 767,
          "cds_start": 2273,
          "cds_end": null,
          "cds_length": 2304,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000917022.1"
        },
        {
          "aa_ref": "P",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 27,
          "exon_rank_end": null,
          "exon_count": 27,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PNPT1",
          "gene_hgnc_id": 23166,
          "hgvs_c": "c.2267C>T",
          "hgvs_p": "p.Pro756Leu",
          "transcript": "ENST00000867134.1",
          "protein_id": "ENSP00000537193.1",
          "transcript_support_level": null,
          "aa_start": 756,
          "aa_end": null,
          "aa_length": 765,
          "cds_start": 2267,
          "cds_end": null,
          "cds_length": 2298,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000867134.1"
        },
        {
          "aa_ref": "P",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 28,
          "exon_rank_end": null,
          "exon_count": 28,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PNPT1",
          "gene_hgnc_id": 23166,
          "hgvs_c": "c.2252C>T",
          "hgvs_p": "p.Pro751Leu",
          "transcript": "ENST00000949804.1",
          "protein_id": "ENSP00000619863.1",
          "transcript_support_level": null,
          "aa_start": 751,
          "aa_end": null,
          "aa_length": 760,
          "cds_start": 2252,
          "cds_end": null,
          "cds_length": 2283,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000949804.1"
        },
        {
          "aa_ref": "P",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 27,
          "exon_rank_end": null,
          "exon_count": 27,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PNPT1",
          "gene_hgnc_id": 23166,
          "hgvs_c": "c.2249C>T",
          "hgvs_p": "p.Pro750Leu",
          "transcript": "ENST00000917024.1",
          "protein_id": "ENSP00000587083.1",
          "transcript_support_level": null,
          "aa_start": 750,
          "aa_end": null,
          "aa_length": 759,
          "cds_start": 2249,
          "cds_end": null,
          "cds_length": 2280,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000917024.1"
        },
        {
          "aa_ref": "P",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 27,
          "exon_rank_end": null,
          "exon_count": 27,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PNPT1",
          "gene_hgnc_id": 23166,
          "hgvs_c": "c.2246C>T",
          "hgvs_p": "p.Pro749Leu",
          "transcript": "ENST00000867136.1",
          "protein_id": "ENSP00000537195.1",
          "transcript_support_level": null,
          "aa_start": 749,
          "aa_end": null,
          "aa_length": 758,
          "cds_start": 2246,
          "cds_end": null,
          "cds_length": 2277,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000867136.1"
        },
        {
          "aa_ref": "P",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 27,
          "exon_rank_end": null,
          "exon_count": 27,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PNPT1",
          "gene_hgnc_id": 23166,
          "hgvs_c": "c.2237C>T",
          "hgvs_p": "p.Pro746Leu",
          "transcript": "ENST00000867132.1",
          "protein_id": "ENSP00000537192.1",
          "transcript_support_level": null,
          "aa_start": 746,
          "aa_end": null,
          "aa_length": 755,
          "cds_start": 2237,
          "cds_end": null,
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          "cdna_start": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000867132.1"
        },
        {
          "aa_ref": "P",
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
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          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PNPT1",
          "gene_hgnc_id": 23166,
          "hgvs_c": "c.2213C>T",
          "hgvs_p": "p.Pro738Leu",
          "transcript": "ENST00000949802.1",
          "protein_id": "ENSP00000619861.1",
          "transcript_support_level": null,
          "aa_start": 738,
          "aa_end": null,
          "aa_length": 747,
          "cds_start": 2213,
          "cds_end": null,
          "cds_length": 2244,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000949802.1"
        },
        {
          "aa_ref": "P",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 27,
          "exon_rank_end": null,
          "exon_count": 27,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PNPT1",
          "gene_hgnc_id": 23166,
          "hgvs_c": "c.2207C>T",
          "hgvs_p": "p.Pro736Leu",
          "transcript": "ENST00000949800.1",
          "protein_id": "ENSP00000619859.1",
          "transcript_support_level": null,
          "aa_start": 736,
          "aa_end": null,
          "aa_length": 745,
          "cds_start": 2207,
          "cds_end": null,
          "cds_length": 2238,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000949800.1"
        },
        {
          "aa_ref": "P",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 26,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PNPT1",
          "gene_hgnc_id": 23166,
          "hgvs_c": "c.2147C>T",
          "hgvs_p": "p.Pro716Leu",
          "transcript": "ENST00000917027.1",
          "protein_id": "ENSP00000587086.1",
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          "cds_start": 2147,
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          "cdna_start": null,
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          "cdna_length": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000917027.1"
        },
        {
          "aa_ref": "P",
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          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
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          "exon_rank_end": null,
          "exon_count": 24,
          "intron_rank": null,
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          "gene_symbol": "PNPT1",
          "gene_hgnc_id": 23166,
          "hgvs_c": "c.2003C>T",
          "hgvs_p": "p.Pro668Leu",
          "transcript": "ENST00000917026.1",
          "protein_id": "ENSP00000587085.1",
          "transcript_support_level": null,
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          "aa_end": null,
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          "cds_start": 2003,
          "cds_end": null,
          "cds_length": 2034,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
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          "biotype": "protein_coding",
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        },
        {
          "aa_ref": "P",
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          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PNPT1",
          "gene_hgnc_id": 23166,
          "hgvs_c": "c.395C>T",
          "hgvs_p": "p.Pro132Leu",
          "transcript": "ENST00000867138.1",
          "protein_id": "ENSP00000537197.1",
          "transcript_support_level": null,
          "aa_start": 132,
          "aa_end": null,
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          "cds_start": 395,
          "cds_end": null,
          "cds_length": 426,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000867138.1"
        },
        {
          "aa_ref": "P",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 28,
          "exon_rank_end": null,
          "exon_count": 28,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PNPT1",
          "gene_hgnc_id": 23166,
          "hgvs_c": "c.2081C>T",
          "hgvs_p": "p.Pro694Leu",
          "transcript": "XM_005264629.3",
          "protein_id": "XP_005264686.1",
          "transcript_support_level": null,
          "aa_start": 694,
          "aa_end": null,
          "aa_length": 703,
          "cds_start": 2081,
          "cds_end": null,
          "cds_length": 2112,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_005264629.3"
        },
        {
          "aa_ref": "P",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 27,
          "exon_rank_end": null,
          "exon_count": 27,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PNPT1",
          "gene_hgnc_id": 23166,
          "hgvs_c": "c.2081C>T",
          "hgvs_p": "p.Pro694Leu",
          "transcript": "XM_017005172.2",
          "protein_id": "XP_016860661.1",
          "transcript_support_level": null,
          "aa_start": 694,
          "aa_end": null,
          "aa_length": 703,
          "cds_start": 2081,
          "cds_end": null,
          "cds_length": 2112,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_017005172.2"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 27,
          "exon_rank_end": null,
          "exon_count": 27,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PNPT1",
          "gene_hgnc_id": 23166,
          "hgvs_c": "n.*1863C>T",
          "hgvs_p": null,
          "transcript": "ENST00000260604.8",
          "protein_id": "ENSP00000260604.4",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000260604.8"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 28,
          "exon_rank_end": null,
          "exon_count": 29,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PNPT1",
          "gene_hgnc_id": 23166,
          "hgvs_c": "n.2321C>T",
          "hgvs_p": null,
          "transcript": "ENST00000415374.5",
          "protein_id": "ENSP00000393953.1",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000415374.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 27,
          "exon_rank_end": null,
          "exon_count": 27,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PNPT1",
          "gene_hgnc_id": 23166,
          "hgvs_c": "n.*1863C>T",
          "hgvs_p": null,
          "transcript": "ENST00000260604.8",
          "protein_id": "ENSP00000260604.4",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000260604.8"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "downstream_gene_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PNPT1",
          "gene_hgnc_id": 23166,
          "hgvs_c": "n.*102C>T",
          "hgvs_p": null,
          "transcript": "ENST00000481066.1",
          "protein_id": null,
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000481066.1"
        }
      ],
      "gene_symbol": "PNPT1",
      "gene_hgnc_id": 23166,
      "dbsnp": "rs774365432",
      "frequency_reference_population": 0.000009585181,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 14,
      "gnomad_exomes_af": 0.00000958518,
      "gnomad_genomes_af": null,
      "gnomad_exomes_ac": 14,
      "gnomad_genomes_ac": null,
      "gnomad_exomes_homalt": 0,
      "gnomad_genomes_homalt": null,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.042939990758895874,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": 0.068,
      "revel_prediction": "Benign",
      "alphamissense_score": 0.0876,
      "alphamissense_prediction": "Benign",
      "bayesdelnoaf_score": -0.46,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": 3.019,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": -4,
      "acmg_classification": "Likely_benign",
      "acmg_criteria": "BP4_Strong",
      "acmg_by_gene": [
        {
          "score": -4,
          "benign_score": 4,
          "pathogenic_score": 0,
          "criteria": [
            "BP4_Strong"
          ],
          "verdict": "Likely_benign",
          "transcript": "NM_033109.5",
          "gene_symbol": "PNPT1",
          "hgnc_id": 23166,
          "effects": [
            "missense_variant"
          ],
          "inheritance_mode": "Unknown,AR,AD",
          "hgvs_c": "c.2321C>T",
          "hgvs_p": "p.Pro774Leu"
        }
      ],
      "clinvar_disease": "not provided",
      "clinvar_classification": "Uncertain significance",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "phenotype_combined": "not provided",
      "pathogenicity_classification_combined": "Uncertain significance",
      "custom_annotations": null
    }
  ],
  "message": null
}