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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 2-61488185-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=61488185&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "2",
"pos": 61488185,
"ref": "G",
"alt": "T",
"effect": "synonymous_variant",
"transcript": "ENST00000401558.7",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPO1",
"gene_hgnc_id": 12825,
"hgvs_c": "c.2293C>A",
"hgvs_p": "p.Arg765Arg",
"transcript": "NM_003400.4",
"protein_id": "NP_003391.1",
"transcript_support_level": null,
"aa_start": 765,
"aa_end": null,
"aa_length": 1071,
"cds_start": 2293,
"cds_end": null,
"cds_length": 3216,
"cdna_start": 3094,
"cdna_end": null,
"cdna_length": 4988,
"mane_select": "ENST00000401558.7",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPO1",
"gene_hgnc_id": 12825,
"hgvs_c": "c.2293C>A",
"hgvs_p": "p.Arg765Arg",
"transcript": "ENST00000401558.7",
"protein_id": "ENSP00000384863.2",
"transcript_support_level": 1,
"aa_start": 765,
"aa_end": null,
"aa_length": 1071,
"cds_start": 2293,
"cds_end": null,
"cds_length": 3216,
"cdna_start": 3094,
"cdna_end": null,
"cdna_length": 4988,
"mane_select": "NM_003400.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPO1",
"gene_hgnc_id": 12825,
"hgvs_c": "c.2293C>A",
"hgvs_p": "p.Arg765Arg",
"transcript": "ENST00000406957.5",
"protein_id": "ENSP00000385559.1",
"transcript_support_level": 1,
"aa_start": 765,
"aa_end": null,
"aa_length": 1071,
"cds_start": 2293,
"cds_end": null,
"cds_length": 3216,
"cdna_start": 2436,
"cdna_end": null,
"cdna_length": 3479,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPO1",
"gene_hgnc_id": 12825,
"hgvs_c": "c.2293C>A",
"hgvs_p": "p.Arg765Arg",
"transcript": "ENST00000404992.6",
"protein_id": "ENSP00000385942.2",
"transcript_support_level": 2,
"aa_start": 765,
"aa_end": null,
"aa_length": 1071,
"cds_start": 2293,
"cds_end": null,
"cds_length": 3216,
"cdna_start": 2700,
"cdna_end": null,
"cdna_length": 4105,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPO1",
"gene_hgnc_id": 12825,
"hgvs_c": "c.2293C>A",
"hgvs_p": "p.Arg765Arg",
"transcript": "ENST00000676553.1",
"protein_id": "ENSP00000504247.1",
"transcript_support_level": null,
"aa_start": 765,
"aa_end": null,
"aa_length": 1071,
"cds_start": 2293,
"cds_end": null,
"cds_length": 3216,
"cdna_start": 2549,
"cdna_end": null,
"cdna_length": 4603,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPO1",
"gene_hgnc_id": 12825,
"hgvs_c": "c.2293C>A",
"hgvs_p": "p.Arg765Arg",
"transcript": "ENST00000676667.1",
"protein_id": "ENSP00000503809.1",
"transcript_support_level": null,
"aa_start": 765,
"aa_end": null,
"aa_length": 1071,
"cds_start": 2293,
"cds_end": null,
"cds_length": 3216,
"cdna_start": 3747,
"cdna_end": null,
"cdna_length": 5801,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPO1",
"gene_hgnc_id": 12825,
"hgvs_c": "c.2293C>A",
"hgvs_p": "p.Arg765Arg",
"transcript": "ENST00000677150.1",
"protein_id": "ENSP00000503167.1",
"transcript_support_level": null,
"aa_start": 765,
"aa_end": null,
"aa_length": 1071,
"cds_start": 2293,
"cds_end": null,
"cds_length": 3216,
"cdna_start": 2587,
"cdna_end": null,
"cdna_length": 4641,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPO1",
"gene_hgnc_id": 12825,
"hgvs_c": "c.2293C>A",
"hgvs_p": "p.Arg765Arg",
"transcript": "ENST00000677239.1",
"protein_id": "ENSP00000504087.1",
"transcript_support_level": null,
"aa_start": 765,
"aa_end": null,
"aa_length": 1071,
"cds_start": 2293,
"cds_end": null,
"cds_length": 3216,
"cdna_start": 2722,
"cdna_end": null,
"cdna_length": 4776,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPO1",
"gene_hgnc_id": 12825,
"hgvs_c": "c.2293C>A",
"hgvs_p": "p.Arg765Arg",
"transcript": "ENST00000677417.1",
"protein_id": "ENSP00000503572.1",
"transcript_support_level": null,
"aa_start": 765,
"aa_end": null,
"aa_length": 1071,
"cds_start": 2293,
"cds_end": null,
"cds_length": 3216,
"cdna_start": 2398,
"cdna_end": null,
"cdna_length": 4452,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPO1",
"gene_hgnc_id": 12825,
"hgvs_c": "c.2293C>A",
"hgvs_p": "p.Arg765Arg",
"transcript": "ENST00000677813.1",
"protein_id": "ENSP00000504543.1",
"transcript_support_level": null,
"aa_start": 765,
"aa_end": null,
"aa_length": 1071,
"cds_start": 2293,
"cds_end": null,
"cds_length": 3216,
"cdna_start": 2495,
"cdna_end": null,
"cdna_length": 4549,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPO1",
"gene_hgnc_id": 12825,
"hgvs_c": "c.2293C>A",
"hgvs_p": "p.Arg765Arg",
"transcript": "ENST00000677814.1",
"protein_id": "ENSP00000504848.1",
"transcript_support_level": null,
"aa_start": 765,
"aa_end": null,
"aa_length": 1071,
"cds_start": 2293,
"cds_end": null,
"cds_length": 3216,
"cdna_start": 2446,
"cdna_end": null,
"cdna_length": 4500,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPO1",
"gene_hgnc_id": 12825,
"hgvs_c": "c.2293C>A",
"hgvs_p": "p.Arg765Arg",
"transcript": "ENST00000677928.1",
"protein_id": "ENSP00000504198.1",
"transcript_support_level": null,
"aa_start": 765,
"aa_end": null,
"aa_length": 1071,
"cds_start": 2293,
"cds_end": null,
"cds_length": 3216,
"cdna_start": 2540,
"cdna_end": null,
"cdna_length": 4594,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPO1",
"gene_hgnc_id": 12825,
"hgvs_c": "c.2293C>A",
"hgvs_p": "p.Arg765Arg",
"transcript": "ENST00000677933.1",
"protein_id": "ENSP00000503482.1",
"transcript_support_level": null,
"aa_start": 765,
"aa_end": null,
"aa_length": 1071,
"cds_start": 2293,
"cds_end": null,
"cds_length": 3216,
"cdna_start": 2642,
"cdna_end": null,
"cdna_length": 4696,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPO1",
"gene_hgnc_id": 12825,
"hgvs_c": "c.2293C>A",
"hgvs_p": "p.Arg765Arg",
"transcript": "ENST00000678182.1",
"protein_id": "ENSP00000504594.1",
"transcript_support_level": null,
"aa_start": 765,
"aa_end": null,
"aa_length": 1071,
"cds_start": 2293,
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"cds_length": 3216,
"cdna_start": 2639,
"cdna_end": null,
"cdna_length": 4693,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPO1",
"gene_hgnc_id": 12825,
"hgvs_c": "c.2293C>A",
"hgvs_p": "p.Arg765Arg",
"transcript": "ENST00000678790.1",
"protein_id": "ENSP00000503419.1",
"transcript_support_level": null,
"aa_start": 765,
"aa_end": null,
"aa_length": 1071,
"cds_start": 2293,
"cds_end": null,
"cds_length": 3216,
"cdna_start": 2556,
"cdna_end": null,
"cdna_length": 4610,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPO1",
"gene_hgnc_id": 12825,
"hgvs_c": "c.2248C>A",
"hgvs_p": "p.Arg750Arg",
"transcript": "ENST00000676771.1",
"protein_id": "ENSP00000503808.1",
"transcript_support_level": null,
"aa_start": 750,
"aa_end": null,
"aa_length": 1056,
"cds_start": 2248,
"cds_end": null,
"cds_length": 3171,
"cdna_start": 2386,
"cdna_end": null,
"cdna_length": 4440,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPO1",
"gene_hgnc_id": 12825,
"hgvs_c": "c.2158C>A",
"hgvs_p": "p.Arg720Arg",
"transcript": "NM_001410799.1",
"protein_id": "NP_001397728.1",
"transcript_support_level": null,
"aa_start": 720,
"aa_end": null,
"aa_length": 1026,
"cds_start": 2158,
"cds_end": null,
"cds_length": 3081,
"cdna_start": 2542,
"cdna_end": null,
"cdna_length": 4436,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPO1",
"gene_hgnc_id": 12825,
"hgvs_c": "c.2158C>A",
"hgvs_p": "p.Arg720Arg",
"transcript": "ENST00000676999.1",
"protein_id": "ENSP00000502940.1",
"transcript_support_level": null,
"aa_start": 720,
"aa_end": null,
"aa_length": 1026,
"cds_start": 2158,
"cds_end": null,
"cds_length": 3081,
"cdna_start": 2245,
"cdna_end": null,
"cdna_length": 4299,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPO1",
"gene_hgnc_id": 12825,
"hgvs_c": "c.2158C>A",
"hgvs_p": "p.Arg720Arg",
"transcript": "ENST00000678081.1",
"protein_id": "ENSP00000503194.1",
"transcript_support_level": null,
"aa_start": 720,
"aa_end": null,
"aa_length": 1026,
"cds_start": 2158,
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"cdna_start": 2383,
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"cdna_length": 4437,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPO1",
"gene_hgnc_id": 12825,
"hgvs_c": "c.2293C>A",
"hgvs_p": "p.Arg765Arg",
"transcript": "ENST00000676789.1",
"protein_id": "ENSP00000504617.1",
"transcript_support_level": null,
"aa_start": 765,
"aa_end": null,
"aa_length": 1007,
"cds_start": 2293,
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"cds_length": 3024,
"cdna_start": 2518,
"cdna_end": null,
"cdna_length": 4184,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPO1",
"gene_hgnc_id": 12825,
"hgvs_c": "c.2077C>A",
"hgvs_p": "p.Arg693Arg",
"transcript": "ENST00000677803.1",
"protein_id": "ENSP00000503702.1",
"transcript_support_level": null,
"aa_start": 693,
"aa_end": null,
"aa_length": 999,
"cds_start": 2077,
"cds_end": null,
"cds_length": 3000,
"cdna_start": 2316,
"cdna_end": null,
"cdna_length": 4370,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPO1",
"gene_hgnc_id": 12825,
"hgvs_c": "c.2017C>A",
"hgvs_p": "p.Arg673Arg",
"transcript": "ENST00000678877.1",
"protein_id": "ENSP00000502889.1",
"transcript_support_level": null,
"aa_start": 673,
"aa_end": null,
"aa_length": 979,
"cds_start": 2017,
"cds_end": null,
"cds_length": 2940,
"cdna_start": 2185,
"cdna_end": null,
"cdna_length": 4239,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XPO1",
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}
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}