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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 2-73730577-TATTC-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=73730577&ref=TATTC&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "2",
      "pos": 73730577,
      "ref": "TATTC",
      "alt": "T",
      "effect": "frameshift_variant",
      "transcript": "NM_001330386.2",
      "consequences": [
        {
          "aa_ref": "MN",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TPRKB",
          "gene_hgnc_id": 24259,
          "hgvs_c": "c.420_423delGAAT",
          "hgvs_p": "p.Met140fs",
          "transcript": "NM_016058.5",
          "protein_id": "NP_057142.1",
          "transcript_support_level": null,
          "aa_start": 140,
          "aa_end": null,
          "aa_length": 175,
          "cds_start": 420,
          "cds_end": null,
          "cds_length": 528,
          "cdna_start": 489,
          "cdna_end": null,
          "cdna_length": 664,
          "mane_select": "ENST00000272424.11",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_016058.5"
        },
        {
          "aa_ref": "MN",
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TPRKB",
          "gene_hgnc_id": 24259,
          "hgvs_c": "c.420_423delGAAT",
          "hgvs_p": "p.Met140fs",
          "transcript": "ENST00000272424.11",
          "protein_id": "ENSP00000272424.5",
          "transcript_support_level": 1,
          "aa_start": 140,
          "aa_end": null,
          "aa_length": 175,
          "cds_start": 420,
          "cds_end": null,
          "cds_length": 528,
          "cdna_start": 489,
          "cdna_end": null,
          "cdna_length": 664,
          "mane_select": "NM_016058.5",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000272424.11"
        },
        {
          "aa_ref": "MN",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TPRKB",
          "gene_hgnc_id": 24259,
          "hgvs_c": "c.537_540delGAAT",
          "hgvs_p": "p.Met179fs",
          "transcript": "NM_001330386.2",
          "protein_id": "NP_001317315.1",
          "transcript_support_level": null,
          "aa_start": 179,
          "aa_end": null,
          "aa_length": 214,
          "cds_start": 537,
          "cds_end": null,
          "cds_length": 645,
          "cdna_start": 606,
          "cdna_end": null,
          "cdna_length": 781,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001330386.2"
        },
        {
          "aa_ref": "MN",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TPRKB",
          "gene_hgnc_id": 24259,
          "hgvs_c": "c.537_540delGAAT",
          "hgvs_p": "p.Met179fs",
          "transcript": "NM_001330387.2",
          "protein_id": "NP_001317316.1",
          "transcript_support_level": null,
          "aa_start": 179,
          "aa_end": null,
          "aa_length": 214,
          "cds_start": 537,
          "cds_end": null,
          "cds_length": 645,
          "cdna_start": 603,
          "cdna_end": null,
          "cdna_length": 778,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001330387.2"
        },
        {
          "aa_ref": "MN",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TPRKB",
          "gene_hgnc_id": 24259,
          "hgvs_c": "c.537_540delGAAT",
          "hgvs_p": "p.Met179fs",
          "transcript": "ENST00000318190.7",
          "protein_id": "ENSP00000325398.7",
          "transcript_support_level": 5,
          "aa_start": 179,
          "aa_end": null,
          "aa_length": 214,
          "cds_start": 537,
          "cds_end": null,
          "cds_length": 645,
          "cdna_start": 661,
          "cdna_end": null,
          "cdna_length": 819,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000318190.7"
        },
        {
          "aa_ref": "MN",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TPRKB",
          "gene_hgnc_id": 24259,
          "hgvs_c": "c.537_540delGAAT",
          "hgvs_p": "p.Met179fs",
          "transcript": "ENST00000409716.6",
          "protein_id": "ENSP00000386936.2",
          "transcript_support_level": 5,
          "aa_start": 179,
          "aa_end": null,
          "aa_length": 214,
          "cds_start": 537,
          "cds_end": null,
          "cds_length": 645,
          "cdna_start": 658,
          "cdna_end": null,
          "cdna_length": 816,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000409716.6"
        },
        {
          "aa_ref": "MN",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TPRKB",
          "gene_hgnc_id": 24259,
          "hgvs_c": "c.537_540delGAAT",
          "hgvs_p": "p.Met179fs",
          "transcript": "ENST00000904806.1",
          "protein_id": "ENSP00000574865.1",
          "transcript_support_level": null,
          "aa_start": 179,
          "aa_end": null,
          "aa_length": 214,
          "cds_start": 537,
          "cds_end": null,
          "cds_length": 645,
          "cdna_start": 1329,
          "cdna_end": null,
          "cdna_length": 1500,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000904806.1"
        },
        {
          "aa_ref": "MN",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TPRKB",
          "gene_hgnc_id": 24259,
          "hgvs_c": "c.537_540delGAAT",
          "hgvs_p": "p.Met179fs",
          "transcript": "ENST00000904807.1",
          "protein_id": "ENSP00000574866.1",
          "transcript_support_level": null,
          "aa_start": 179,
          "aa_end": null,
          "aa_length": 214,
          "cds_start": 537,
          "cds_end": null,
          "cds_length": 645,
          "cdna_start": 786,
          "cdna_end": null,
          "cdna_length": 947,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000904807.1"
        },
        {
          "aa_ref": "MN",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TPRKB",
          "gene_hgnc_id": 24259,
          "hgvs_c": "c.537_540delGAAT",
          "hgvs_p": "p.Met179fs",
          "transcript": "ENST00000904810.1",
          "protein_id": "ENSP00000574869.1",
          "transcript_support_level": null,
          "aa_start": 179,
          "aa_end": null,
          "aa_length": 214,
          "cds_start": 537,
          "cds_end": null,
          "cds_length": 645,
          "cdna_start": 954,
          "cdna_end": null,
          "cdna_length": 1112,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000904810.1"
        },
        {
          "aa_ref": "MN",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TPRKB",
          "gene_hgnc_id": 24259,
          "hgvs_c": "c.537_540delGAAT",
          "hgvs_p": "p.Met179fs",
          "transcript": "ENST00000939338.1",
          "protein_id": "ENSP00000609397.1",
          "transcript_support_level": null,
          "aa_start": 179,
          "aa_end": null,
          "aa_length": 214,
          "cds_start": 537,
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          "cds_length": 645,
          "cdna_start": 763,
          "cdna_end": null,
          "cdna_length": 998,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000939338.1"
        },
        {
          "aa_ref": "MN",
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TPRKB",
          "gene_hgnc_id": 24259,
          "hgvs_c": "c.537_540delGAAT",
          "hgvs_p": "p.Met179fs",
          "transcript": "ENST00000939345.1",
          "protein_id": "ENSP00000609404.1",
          "transcript_support_level": null,
          "aa_start": 179,
          "aa_end": null,
          "aa_length": 214,
          "cds_start": 537,
          "cds_end": null,
          "cds_length": 645,
          "cdna_start": 626,
          "cdna_end": null,
          "cdna_length": 787,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
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        },
        {
          "aa_ref": "MN",
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
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          "intron_rank": null,
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          "gene_symbol": "TPRKB",
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          "hgvs_c": "c.537_540delGAAT",
          "hgvs_p": "p.Met179fs",
          "transcript": "ENST00000939352.1",
          "protein_id": "ENSP00000609411.1",
          "transcript_support_level": null,
          "aa_start": 179,
          "aa_end": null,
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          "cds_start": 537,
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          "cdna_start": 791,
          "cdna_end": null,
          "cdna_length": 966,
          "mane_select": null,
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          "biotype": "protein_coding",
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        {
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
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          "gene_symbol": "TPRKB",
          "gene_hgnc_id": 24259,
          "hgvs_c": "c.537_540delGAAT",
          "hgvs_p": "p.Met179fs",
          "transcript": "ENST00000939354.1",
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          "cds_start": 537,
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          "cdna_start": 803,
          "cdna_end": null,
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          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000939354.1"
        },
        {
          "aa_ref": "MN",
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TPRKB",
          "gene_hgnc_id": 24259,
          "hgvs_c": "c.537_540delGAAT",
          "hgvs_p": "p.Met179fs",
          "transcript": "ENST00000939361.1",
          "protein_id": "ENSP00000609420.1",
          "transcript_support_level": null,
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          "cds_start": 537,
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          "mane_select": null,
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        },
        {
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          "intron_rank": null,
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          "gene_symbol": "TPRKB",
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          "hgvs_c": "c.438_441delGAAT",
          "hgvs_p": "p.Met146fs",
          "transcript": "ENST00000939344.1",
          "protein_id": "ENSP00000609403.1",
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          "aa_end": null,
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          "cds_start": 438,
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          "cdna_start": 514,
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          "cdna_length": 689,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000939344.1"
        },
        {
          "aa_ref": "MN",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 5,
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          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TPRKB",
          "gene_hgnc_id": 24259,
          "hgvs_c": "c.438_441delGAAT",
          "hgvs_p": "p.Met146fs",
          "transcript": "ENST00000939350.1",
          "protein_id": "ENSP00000609409.1",
          "transcript_support_level": null,
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          "aa_length": 181,
          "cds_start": 438,
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          "cdna_start": 504,
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          "cdna_length": 662,
          "mane_select": null,
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        },
        {
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          "aa_alt": null,
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          "consequences": [
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          ],
          "exon_rank": 5,
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          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TPRKB",
          "gene_hgnc_id": 24259,
          "hgvs_c": "c.420_423delGAAT",
          "hgvs_p": "p.Met140fs",
          "transcript": "NM_001330388.2",
          "protein_id": "NP_001317317.1",
          "transcript_support_level": null,
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          "biotype": "protein_coding",
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        {
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          "exon_count": 5,
          "intron_rank": null,
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          "gene_symbol": "TPRKB",
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          "hgvs_c": "c.420_423delGAAT",
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          "protein_id": "NP_001317318.1",
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          "cds_start": 420,
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          "cdna_length": 661,
          "mane_select": null,
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          "biotype": "protein_coding",
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        {
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          ],
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          "intron_rank": null,
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          "gene_symbol": "TPRKB",
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          "protein_id": "ENSP00000574864.1",
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          "cdna_start": 626,
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          "cdna_length": 785,
          "mane_select": null,
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          "biotype": "protein_coding",
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        },
        {
          "aa_ref": "MN",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TPRKB",
          "gene_hgnc_id": 24259,
          "hgvs_c": "c.420_423delGAAT",
          "hgvs_p": "p.Met140fs",
          "transcript": "ENST00000904808.1",
          "protein_id": "ENSP00000574867.1",
          "transcript_support_level": null,
          "aa_start": 140,
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          "aa_length": 175,
          "cds_start": 420,
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          "cdna_start": 1212,
          "cdna_end": null,
          "cdna_length": 1370,
          "mane_select": null,
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          "verdict": "Uncertain_significance",
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      "clinvar_disease": "not provided,not specified",
      "clinvar_classification": "Uncertain significance",
      "clinvar_review_status": "criteria provided, multiple submitters, no conflicts",
      "clinvar_submissions_summary": "US:2",
      "phenotype_combined": "not specified|not provided",
      "pathogenicity_classification_combined": "Uncertain significance",
      "custom_annotations": null
    }
  ],
  "message": null
}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.