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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 2-85552984-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=85552984&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "2",
"pos": 85552984,
"ref": "G",
"alt": "C",
"effect": "synonymous_variant",
"transcript": "NM_000821.7",
"consequences": [
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GGCX",
"gene_hgnc_id": 4247,
"hgvs_c": "c.1242C>G",
"hgvs_p": "p.Thr414Thr",
"transcript": "NM_000821.7",
"protein_id": "NP_000812.2",
"transcript_support_level": null,
"aa_start": 414,
"aa_end": null,
"aa_length": 758,
"cds_start": 1242,
"cds_end": null,
"cds_length": 2277,
"cdna_start": 1307,
"cdna_end": null,
"cdna_length": 7556,
"mane_select": "ENST00000233838.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_000821.7"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GGCX",
"gene_hgnc_id": 4247,
"hgvs_c": "c.1242C>G",
"hgvs_p": "p.Thr414Thr",
"transcript": "ENST00000233838.9",
"protein_id": "ENSP00000233838.3",
"transcript_support_level": 1,
"aa_start": 414,
"aa_end": null,
"aa_length": 758,
"cds_start": 1242,
"cds_end": null,
"cds_length": 2277,
"cdna_start": 1307,
"cdna_end": null,
"cdna_length": 7556,
"mane_select": "NM_000821.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000233838.9"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GGCX",
"gene_hgnc_id": 4247,
"hgvs_c": "c.1242C>G",
"hgvs_p": "p.Thr414Thr",
"transcript": "ENST00000911478.1",
"protein_id": "ENSP00000581537.1",
"transcript_support_level": null,
"aa_start": 414,
"aa_end": null,
"aa_length": 768,
"cds_start": 1242,
"cds_end": null,
"cds_length": 2307,
"cdna_start": 1283,
"cdna_end": null,
"cdna_length": 6364,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000911478.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GGCX",
"gene_hgnc_id": 4247,
"hgvs_c": "c.1242C>G",
"hgvs_p": "p.Thr414Thr",
"transcript": "ENST00000896458.1",
"protein_id": "ENSP00000566517.1",
"transcript_support_level": null,
"aa_start": 414,
"aa_end": null,
"aa_length": 756,
"cds_start": 1242,
"cds_end": null,
"cds_length": 2271,
"cdna_start": 1633,
"cdna_end": null,
"cdna_length": 3982,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000896458.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GGCX",
"gene_hgnc_id": 4247,
"hgvs_c": "c.1242C>G",
"hgvs_p": "p.Thr414Thr",
"transcript": "ENST00000942085.1",
"protein_id": "ENSP00000612144.1",
"transcript_support_level": null,
"aa_start": 414,
"aa_end": null,
"aa_length": 754,
"cds_start": 1242,
"cds_end": null,
"cds_length": 2265,
"cdna_start": 1279,
"cdna_end": null,
"cdna_length": 2868,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942085.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GGCX",
"gene_hgnc_id": 4247,
"hgvs_c": "c.1173C>G",
"hgvs_p": "p.Thr391Thr",
"transcript": "ENST00000689276.1",
"protein_id": "ENSP00000510012.1",
"transcript_support_level": null,
"aa_start": 391,
"aa_end": null,
"aa_length": 735,
"cds_start": 1173,
"cds_end": null,
"cds_length": 2208,
"cdna_start": 1181,
"cdna_end": null,
"cdna_length": 3068,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000689276.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GGCX",
"gene_hgnc_id": 4247,
"hgvs_c": "c.1242C>G",
"hgvs_p": "p.Thr414Thr",
"transcript": "ENST00000896463.1",
"protein_id": "ENSP00000566522.1",
"transcript_support_level": null,
"aa_start": 414,
"aa_end": null,
"aa_length": 735,
"cds_start": 1242,
"cds_end": null,
"cds_length": 2208,
"cdna_start": 1283,
"cdna_end": null,
"cdna_length": 2642,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000896463.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GGCX",
"gene_hgnc_id": 4247,
"hgvs_c": "c.1242C>G",
"hgvs_p": "p.Thr414Thr",
"transcript": "ENST00000942081.1",
"protein_id": "ENSP00000612140.1",
"transcript_support_level": null,
"aa_start": 414,
"aa_end": null,
"aa_length": 712,
"cds_start": 1242,
"cds_end": null,
"cds_length": 2139,
"cdna_start": 1336,
"cdna_end": null,
"cdna_length": 3097,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942081.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GGCX",
"gene_hgnc_id": 4247,
"hgvs_c": "c.1071C>G",
"hgvs_p": "p.Thr357Thr",
"transcript": "ENST00000896461.1",
"protein_id": "ENSP00000566520.1",
"transcript_support_level": null,
"aa_start": 357,
"aa_end": null,
"aa_length": 705,
"cds_start": 1071,
"cds_end": null,
"cds_length": 2118,
"cdna_start": 1108,
"cdna_end": null,
"cdna_length": 2734,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000896461.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GGCX",
"gene_hgnc_id": 4247,
"hgvs_c": "c.1071C>G",
"hgvs_p": "p.Thr357Thr",
"transcript": "NM_001142269.4",
"protein_id": "NP_001135741.1",
"transcript_support_level": null,
"aa_start": 357,
"aa_end": null,
"aa_length": 701,
"cds_start": 1071,
"cds_end": null,
"cds_length": 2106,
"cdna_start": 1136,
"cdna_end": null,
"cdna_length": 7385,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001142269.4"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GGCX",
"gene_hgnc_id": 4247,
"hgvs_c": "c.1071C>G",
"hgvs_p": "p.Thr357Thr",
"transcript": "ENST00000430215.7",
"protein_id": "ENSP00000408045.3",
"transcript_support_level": 2,
"aa_start": 357,
"aa_end": null,
"aa_length": 701,
"cds_start": 1071,
"cds_end": null,
"cds_length": 2106,
"cdna_start": 1175,
"cdna_end": null,
"cdna_length": 2314,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000430215.7"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GGCX",
"gene_hgnc_id": 4247,
"hgvs_c": "c.1071C>G",
"hgvs_p": "p.Thr357Thr",
"transcript": "ENST00000896459.1",
"protein_id": "ENSP00000566518.1",
"transcript_support_level": null,
"aa_start": 357,
"aa_end": null,
"aa_length": 699,
"cds_start": 1071,
"cds_end": null,
"cds_length": 2100,
"cdna_start": 1163,
"cdna_end": null,
"cdna_length": 3056,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000896459.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GGCX",
"gene_hgnc_id": 4247,
"hgvs_c": "c.1071C>G",
"hgvs_p": "p.Thr357Thr",
"transcript": "ENST00000942083.1",
"protein_id": "ENSP00000612142.1",
"transcript_support_level": null,
"aa_start": 357,
"aa_end": null,
"aa_length": 697,
"cds_start": 1071,
"cds_end": null,
"cds_length": 2094,
"cdna_start": 1144,
"cdna_end": null,
"cdna_length": 2733,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942083.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GGCX",
"gene_hgnc_id": 4247,
"hgvs_c": "c.1071C>G",
"hgvs_p": "p.Thr357Thr",
"transcript": "ENST00000896465.1",
"protein_id": "ENSP00000566524.1",
"transcript_support_level": null,
"aa_start": 357,
"aa_end": null,
"aa_length": 678,
"cds_start": 1071,
"cds_end": null,
"cds_length": 2037,
"cdna_start": 1108,
"cdna_end": null,
"cdna_length": 2160,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000896465.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GGCX",
"gene_hgnc_id": 4247,
"hgvs_c": "c.972C>G",
"hgvs_p": "p.Thr324Thr",
"transcript": "ENST00000896464.1",
"protein_id": "ENSP00000566523.1",
"transcript_support_level": null,
"aa_start": 324,
"aa_end": null,
"aa_length": 666,
"cds_start": 972,
"cds_end": null,
"cds_length": 2001,
"cdna_start": 1009,
"cdna_end": null,
"cdna_length": 2205,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000896464.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GGCX",
"gene_hgnc_id": 4247,
"hgvs_c": "c.1071C>G",
"hgvs_p": "p.Thr357Thr",
"transcript": "ENST00000942084.1",
"protein_id": "ENSP00000612143.1",
"transcript_support_level": null,
"aa_start": 357,
"aa_end": null,
"aa_length": 655,
"cds_start": 1071,
"cds_end": null,
"cds_length": 1968,
"cdna_start": 1139,
"cdna_end": null,
"cdna_length": 2602,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942084.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GGCX",
"gene_hgnc_id": 4247,
"hgvs_c": "c.726C>G",
"hgvs_p": "p.Thr242Thr",
"transcript": "ENST00000896462.1",
"protein_id": "ENSP00000566521.1",
"transcript_support_level": null,
"aa_start": 242,
"aa_end": null,
"aa_length": 586,
"cds_start": 726,
"cds_end": null,
"cds_length": 1761,
"cdna_start": 763,
"cdna_end": null,
"cdna_length": 2376,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000896462.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GGCX",
"gene_hgnc_id": 4247,
"hgvs_c": "c.567C>G",
"hgvs_p": "p.Thr189Thr",
"transcript": "ENST00000690595.1",
"protein_id": "ENSP00000508979.1",
"transcript_support_level": null,
"aa_start": 189,
"aa_end": null,
"aa_length": 533,
"cds_start": 567,
"cds_end": null,
"cds_length": 1602,
"cdna_start": 640,
"cdna_end": null,
"cdna_length": 2520,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000690595.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GGCX",
"gene_hgnc_id": 4247,
"hgvs_c": "c.558C>G",
"hgvs_p": "p.Thr186Thr",
"transcript": "ENST00000693287.1",
"protein_id": "ENSP00000510264.1",
"transcript_support_level": null,
"aa_start": 186,
"aa_end": null,
"aa_length": 530,
"cds_start": 558,
"cds_end": null,
"cds_length": 1593,
"cdna_start": 732,
"cdna_end": null,
"cdna_length": 2619,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000693287.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GGCX",
"gene_hgnc_id": 4247,
"hgvs_c": "c.555C>G",
"hgvs_p": "p.Thr185Thr",
"transcript": "ENST00000693681.1",
"protein_id": "ENSP00000510789.1",
"transcript_support_level": null,
"aa_start": 185,
"aa_end": null,
"aa_length": 529,
"cds_start": 555,
"cds_end": null,
"cds_length": 1590,
"cdna_start": 650,
"cdna_end": null,
"cdna_length": 2530,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000693681.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GGCX",
"gene_hgnc_id": 4247,
"hgvs_c": "c.396C>G",
"hgvs_p": "p.Thr132Thr",
"transcript": "ENST00000896460.1",
"protein_id": "ENSP00000566519.1",
"transcript_support_level": null,
"aa_start": 132,
"aa_end": null,
"aa_length": 476,
"cds_start": 396,
"cds_end": null,
"cds_length": 1431,
"cdna_start": 468,
"cdna_end": null,
"cdna_length": 2365,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000896460.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GGCX",
"gene_hgnc_id": 4247,
"hgvs_c": "c.396C>G",
"hgvs_p": "p.Thr132Thr",
"transcript": "ENST00000942082.1",
"protein_id": "ENSP00000612141.1",
"transcript_support_level": null,
"aa_start": 132,
"aa_end": null,
"aa_length": 474,
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