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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 2-8779109-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=8779109&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "2",
"pos": 8779109,
"ref": "T",
"alt": "C",
"effect": "missense_variant",
"transcript": "ENST00000256707.8",
"consequences": [
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIDINS220",
"gene_hgnc_id": 29508,
"hgvs_c": "c.2401A>G",
"hgvs_p": "p.Ile801Val",
"transcript": "NM_020738.4",
"protein_id": "NP_065789.1",
"transcript_support_level": null,
"aa_start": 801,
"aa_end": null,
"aa_length": 1771,
"cds_start": 2401,
"cds_end": null,
"cds_length": 5316,
"cdna_start": 2571,
"cdna_end": null,
"cdna_length": 7348,
"mane_select": "ENST00000256707.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIDINS220",
"gene_hgnc_id": 29508,
"hgvs_c": "c.2401A>G",
"hgvs_p": "p.Ile801Val",
"transcript": "ENST00000256707.8",
"protein_id": "ENSP00000256707.4",
"transcript_support_level": 1,
"aa_start": 801,
"aa_end": null,
"aa_length": 1771,
"cds_start": 2401,
"cds_end": null,
"cds_length": 5316,
"cdna_start": 2571,
"cdna_end": null,
"cdna_length": 7348,
"mane_select": "NM_020738.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIDINS220",
"gene_hgnc_id": 29508,
"hgvs_c": "c.2404A>G",
"hgvs_p": "p.Ile802Val",
"transcript": "ENST00000319688.5",
"protein_id": "ENSP00000319947.5",
"transcript_support_level": 1,
"aa_start": 802,
"aa_end": null,
"aa_length": 1031,
"cds_start": 2404,
"cds_end": null,
"cds_length": 3096,
"cdna_start": 2561,
"cdna_end": null,
"cdna_length": 3765,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIDINS220",
"gene_hgnc_id": 29508,
"hgvs_c": "n.*2461A>G",
"hgvs_p": null,
"transcript": "ENST00000488729.5",
"protein_id": "ENSP00000417390.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5988,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIDINS220",
"gene_hgnc_id": 29508,
"hgvs_c": "n.*2461A>G",
"hgvs_p": null,
"transcript": "ENST00000488729.5",
"protein_id": "ENSP00000417390.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5988,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIDINS220",
"gene_hgnc_id": 29508,
"hgvs_c": "c.2404A>G",
"hgvs_p": "p.Ile802Val",
"transcript": "NM_001348729.2",
"protein_id": "NP_001335658.1",
"transcript_support_level": null,
"aa_start": 802,
"aa_end": null,
"aa_length": 1772,
"cds_start": 2404,
"cds_end": null,
"cds_length": 5319,
"cdna_start": 2574,
"cdna_end": null,
"cdna_length": 7351,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIDINS220",
"gene_hgnc_id": 29508,
"hgvs_c": "c.2404A>G",
"hgvs_p": "p.Ile802Val",
"transcript": "ENST00000691030.1",
"protein_id": "ENSP00000510148.1",
"transcript_support_level": null,
"aa_start": 802,
"aa_end": null,
"aa_length": 1764,
"cds_start": 2404,
"cds_end": null,
"cds_length": 5295,
"cdna_start": 2574,
"cdna_end": null,
"cdna_length": 7254,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIDINS220",
"gene_hgnc_id": 29508,
"hgvs_c": "c.2404A>G",
"hgvs_p": "p.Ile802Val",
"transcript": "NM_001348731.2",
"protein_id": "NP_001335660.1",
"transcript_support_level": null,
"aa_start": 802,
"aa_end": null,
"aa_length": 1753,
"cds_start": 2404,
"cds_end": null,
"cds_length": 5262,
"cdna_start": 2574,
"cdna_end": null,
"cdna_length": 7294,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIDINS220",
"gene_hgnc_id": 29508,
"hgvs_c": "c.2401A>G",
"hgvs_p": "p.Ile801Val",
"transcript": "NM_001348732.2",
"protein_id": "NP_001335661.1",
"transcript_support_level": null,
"aa_start": 801,
"aa_end": null,
"aa_length": 1752,
"cds_start": 2401,
"cds_end": null,
"cds_length": 5259,
"cdna_start": 2571,
"cdna_end": null,
"cdna_length": 7291,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIDINS220",
"gene_hgnc_id": 29508,
"hgvs_c": "c.2401A>G",
"hgvs_p": "p.Ile801Val",
"transcript": "ENST00000473731.5",
"protein_id": "ENSP00000418974.1",
"transcript_support_level": 5,
"aa_start": 801,
"aa_end": null,
"aa_length": 1752,
"cds_start": 2401,
"cds_end": null,
"cds_length": 5259,
"cdna_start": 2599,
"cdna_end": null,
"cdna_length": 7248,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIDINS220",
"gene_hgnc_id": 29508,
"hgvs_c": "c.2404A>G",
"hgvs_p": "p.Ile802Val",
"transcript": "NM_001348734.2",
"protein_id": "NP_001335663.1",
"transcript_support_level": null,
"aa_start": 802,
"aa_end": null,
"aa_length": 1715,
"cds_start": 2404,
"cds_end": null,
"cds_length": 5148,
"cdna_start": 2574,
"cdna_end": null,
"cdna_length": 7180,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIDINS220",
"gene_hgnc_id": 29508,
"hgvs_c": "c.2401A>G",
"hgvs_p": "p.Ile801Val",
"transcript": "NM_001348735.2",
"protein_id": "NP_001335664.1",
"transcript_support_level": null,
"aa_start": 801,
"aa_end": null,
"aa_length": 1714,
"cds_start": 2401,
"cds_end": null,
"cds_length": 5145,
"cdna_start": 2571,
"cdna_end": null,
"cdna_length": 7177,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIDINS220",
"gene_hgnc_id": 29508,
"hgvs_c": "c.2275A>G",
"hgvs_p": "p.Ile759Val",
"transcript": "NM_001348736.2",
"protein_id": "NP_001335665.1",
"transcript_support_level": null,
"aa_start": 759,
"aa_end": null,
"aa_length": 1672,
"cds_start": 2275,
"cds_end": null,
"cds_length": 5019,
"cdna_start": 2742,
"cdna_end": null,
"cdna_length": 7348,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIDINS220",
"gene_hgnc_id": 29508,
"hgvs_c": "c.2275A>G",
"hgvs_p": "p.Ile759Val",
"transcript": "ENST00000685097.1",
"protein_id": "ENSP00000510510.1",
"transcript_support_level": null,
"aa_start": 759,
"aa_end": null,
"aa_length": 1672,
"cds_start": 2275,
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"cdna_start": 2422,
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"cdna_length": 7008,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIDINS220",
"gene_hgnc_id": 29508,
"hgvs_c": "c.2077A>G",
"hgvs_p": "p.Ile693Val",
"transcript": "ENST00000687912.1",
"protein_id": "ENSP00000508455.1",
"transcript_support_level": null,
"aa_start": 693,
"aa_end": null,
"aa_length": 1606,
"cds_start": 2077,
"cds_end": null,
"cds_length": 4821,
"cdna_start": 2229,
"cdna_end": null,
"cdna_length": 6815,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIDINS220",
"gene_hgnc_id": 29508,
"hgvs_c": "c.2401A>G",
"hgvs_p": "p.Ile801Val",
"transcript": "ENST00000693432.1",
"protein_id": "ENSP00000510486.1",
"transcript_support_level": null,
"aa_start": 801,
"aa_end": null,
"aa_length": 1373,
"cds_start": 2401,
"cds_end": null,
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"cdna_start": 2573,
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"cdna_length": 5843,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIDINS220",
"gene_hgnc_id": 29508,
"hgvs_c": "c.2401A>G",
"hgvs_p": "p.Ile801Val",
"transcript": "NM_001348738.2",
"protein_id": "NP_001335667.1",
"transcript_support_level": null,
"aa_start": 801,
"aa_end": null,
"aa_length": 1348,
"cds_start": 2401,
"cds_end": null,
"cds_length": 4047,
"cdna_start": 2571,
"cdna_end": null,
"cdna_length": 8742,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIDINS220",
"gene_hgnc_id": 29508,
"hgvs_c": "c.2401A>G",
"hgvs_p": "p.Ile801Val",
"transcript": "ENST00000689852.1",
"protein_id": "ENSP00000510537.1",
"transcript_support_level": null,
"aa_start": 801,
"aa_end": null,
"aa_length": 1321,
"cds_start": 2401,
"cds_end": null,
"cds_length": 3966,
"cdna_start": 2573,
"cdna_end": null,
"cdna_length": 8526,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIDINS220",
"gene_hgnc_id": 29508,
"hgvs_c": "c.2404A>G",
"hgvs_p": "p.Ile802Val",
"transcript": "NM_001348739.2",
"protein_id": "NP_001335668.1",
"transcript_support_level": null,
"aa_start": 802,
"aa_end": null,
"aa_length": 1311,
"cds_start": 2404,
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"cdna_start": 2574,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIDINS220",
"gene_hgnc_id": 29508,
"hgvs_c": "c.2404A>G",
"hgvs_p": "p.Ile802Val",
"transcript": "NM_001348740.2",
"protein_id": "NP_001335669.1",
"transcript_support_level": null,
"aa_start": 802,
"aa_end": null,
"aa_length": 1311,
"cds_start": 2404,
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"cdna_start": 2574,
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"cdna_length": 6391,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIDINS220",
"gene_hgnc_id": 29508,
"hgvs_c": "c.2401A>G",
"hgvs_p": "p.Ile801Val",
"transcript": "NM_001348741.2",
"protein_id": "NP_001335670.1",
"transcript_support_level": null,
"aa_start": 801,
"aa_end": null,
"aa_length": 1310,
"cds_start": 2401,
"cds_end": null,
"cds_length": 3933,
"cdna_start": 2571,
"cdna_end": null,
"cdna_length": 8628,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KIDINS220",
"gene_hgnc_id": 29508,
"hgvs_c": "c.2401A>G",
"hgvs_p": "p.Ile801Val",
"transcript": "NM_001348742.2",
"protein_id": "NP_001335671.1",
"transcript_support_level": null,
"aa_start": 801,
"aa_end": null,
"aa_length": 1310,
"cds_start": 2401,
"cds_end": null,
"cds_length": 3933,
"cdna_start": 2571,
"cdna_end": null,
"cdna_length": 6388,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "I",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
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}