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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 2-88182739-G-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=88182739&ref=G&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "2",
      "pos": 88182739,
      "ref": "G",
      "alt": "A",
      "effect": "synonymous_variant",
      "transcript": "ENST00000674334.2",
      "consequences": [
        {
          "aa_ref": "L",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "THNSL2",
          "gene_hgnc_id": 25602,
          "hgvs_c": "c.843G>A",
          "hgvs_p": "p.Leu281Leu",
          "transcript": "NM_018271.5",
          "protein_id": "NP_060741.3",
          "transcript_support_level": null,
          "aa_start": 281,
          "aa_end": null,
          "aa_length": 484,
          "cds_start": 843,
          "cds_end": null,
          "cds_length": 1455,
          "cdna_start": 966,
          "cdna_end": null,
          "cdna_length": 2082,
          "mane_select": "ENST00000674334.2",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "L",
          "aa_alt": "L",
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "THNSL2",
          "gene_hgnc_id": 25602,
          "hgvs_c": "c.843G>A",
          "hgvs_p": "p.Leu281Leu",
          "transcript": "ENST00000674334.2",
          "protein_id": "ENSP00000501453.1",
          "transcript_support_level": null,
          "aa_start": 281,
          "aa_end": null,
          "aa_length": 484,
          "cds_start": 843,
          "cds_end": null,
          "cds_length": 1455,
          "cdna_start": 966,
          "cdna_end": null,
          "cdna_length": 2082,
          "mane_select": "NM_018271.5",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "L",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "THNSL2",
          "gene_hgnc_id": 25602,
          "hgvs_c": "c.843G>A",
          "hgvs_p": "p.Leu281Leu",
          "transcript": "ENST00000324166.7",
          "protein_id": "ENSP00000327323.5",
          "transcript_support_level": 1,
          "aa_start": 281,
          "aa_end": null,
          "aa_length": 484,
          "cds_start": 843,
          "cds_end": null,
          "cds_length": 1455,
          "cdna_start": 855,
          "cdna_end": null,
          "cdna_length": 1980,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "L",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "THNSL2",
          "gene_hgnc_id": 25602,
          "hgvs_c": "c.843G>A",
          "hgvs_p": "p.Leu281Leu",
          "transcript": "ENST00000343544.8",
          "protein_id": "ENSP00000339563.4",
          "transcript_support_level": 1,
          "aa_start": 281,
          "aa_end": null,
          "aa_length": 405,
          "cds_start": 843,
          "cds_end": null,
          "cds_length": 1218,
          "cdna_start": 914,
          "cdna_end": null,
          "cdna_length": 2052,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "L",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "THNSL2",
          "gene_hgnc_id": 25602,
          "hgvs_c": "c.843G>A",
          "hgvs_p": "p.Leu281Leu",
          "transcript": "NM_001244676.2",
          "protein_id": "NP_001231605.1",
          "transcript_support_level": null,
          "aa_start": 281,
          "aa_end": null,
          "aa_length": 405,
          "cds_start": 843,
          "cds_end": null,
          "cds_length": 1218,
          "cdna_start": 966,
          "cdna_end": null,
          "cdna_length": 2104,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "L",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "THNSL2",
          "gene_hgnc_id": 25602,
          "hgvs_c": "c.843G>A",
          "hgvs_p": "p.Leu281Leu",
          "transcript": "NM_001384383.1",
          "protein_id": "NP_001371312.1",
          "transcript_support_level": null,
          "aa_start": 281,
          "aa_end": null,
          "aa_length": 384,
          "cds_start": 843,
          "cds_end": null,
          "cds_length": 1155,
          "cdna_start": 3648,
          "cdna_end": null,
          "cdna_length": 4612,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "L",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "THNSL2",
          "gene_hgnc_id": 25602,
          "hgvs_c": "c.843G>A",
          "hgvs_p": "p.Leu281Leu",
          "transcript": "ENST00000496844.6",
          "protein_id": "ENSP00000501447.1",
          "transcript_support_level": 5,
          "aa_start": 281,
          "aa_end": null,
          "aa_length": 384,
          "cds_start": 843,
          "cds_end": null,
          "cds_length": 1155,
          "cdna_start": 883,
          "cdna_end": null,
          "cdna_length": 1678,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "L",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "THNSL2",
          "gene_hgnc_id": 25602,
          "hgvs_c": "c.369G>A",
          "hgvs_p": "p.Leu123Leu",
          "transcript": "NM_001244678.2",
          "protein_id": "NP_001231607.1",
          "transcript_support_level": null,
          "aa_start": 123,
          "aa_end": null,
          "aa_length": 226,
          "cds_start": 369,
          "cds_end": null,
          "cds_length": 681,
          "cdna_start": 536,
          "cdna_end": null,
          "cdna_length": 1500,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "L",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "THNSL2",
          "gene_hgnc_id": 25602,
          "hgvs_c": "c.369G>A",
          "hgvs_p": "p.Leu123Leu",
          "transcript": "NM_001384382.1",
          "protein_id": "NP_001371311.1",
          "transcript_support_level": null,
          "aa_start": 123,
          "aa_end": null,
          "aa_length": 226,
          "cds_start": 369,
          "cds_end": null,
          "cds_length": 681,
          "cdna_start": 731,
          "cdna_end": null,
          "cdna_length": 1695,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "L",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "THNSL2",
          "gene_hgnc_id": 25602,
          "hgvs_c": "c.369G>A",
          "hgvs_p": "p.Leu123Leu",
          "transcript": "ENST00000377254.7",
          "protein_id": "ENSP00000366464.4",
          "transcript_support_level": 2,
          "aa_start": 123,
          "aa_end": null,
          "aa_length": 226,
          "cds_start": 369,
          "cds_end": null,
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          "cdna_start": 587,
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          "cdna_length": 1560,
          "mane_select": null,
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        {
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          ],
          "exon_rank": 6,
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          "gene_symbol": "THNSL2",
          "gene_hgnc_id": 25602,
          "hgvs_c": "c.843G>A",
          "hgvs_p": "p.Leu281Leu",
          "transcript": "XM_005264401.6",
          "protein_id": "XP_005264458.1",
          "transcript_support_level": null,
          "aa_start": 281,
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          "aa_length": 484,
          "cds_start": 843,
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          "cdna_start": 1520,
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          "mane_select": null,
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        {
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          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
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          "exon_rank": 6,
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          "exon_count": 9,
          "intron_rank": null,
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          "gene_symbol": "THNSL2",
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          "hgvs_c": "c.843G>A",
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        {
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          "transcript": "XM_047444896.1",
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        {
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          "gene_symbol": "THNSL2",
          "gene_hgnc_id": 25602,
          "hgvs_c": "c.843G>A",
          "hgvs_p": "p.Leu281Leu",
          "transcript": "XM_011532953.3",
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        {
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        {
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          "gene_symbol": "THNSL2",
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          "transcript": "XM_005264402.4",
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        {
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        {
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        {
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        {
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          "gene_symbol": "THNSL2",
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          "hgvs_p": "p.Leu281Leu",
          "transcript": "XM_047444898.1",
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        },
        {
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      "clinvar_classification": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
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      "custom_annotations": null
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  "message": null
}