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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 20-13534052-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=20&pos=13534052&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"message": null,
"variants": [
{
"acmg_by_gene": [
{
"benign_score": 12,
"criteria": [
"BP4_Moderate",
"BP6",
"BP7",
"BS1",
"BS2"
],
"effects": [
"synonymous_variant"
],
"gene_symbol": "TASP1",
"hgnc_id": 15859,
"hgvs_c": "c.765G>A",
"hgvs_p": "p.Leu255Leu",
"inheritance_mode": "AR",
"pathogenic_score": 0,
"score": -12,
"transcript": "NM_017714.3",
"verdict": "Benign"
}
],
"acmg_classification": "Benign",
"acmg_criteria": "BP4_Moderate,BP6,BP7,BS1,BS2",
"acmg_score": -12,
"allele_count_reference_population": 5995,
"alphamissense_prediction": null,
"alphamissense_score": null,
"alt": "T",
"apogee2_prediction": null,
"apogee2_score": null,
"bayesdelnoaf_prediction": "Benign",
"bayesdelnoaf_score": -0.35,
"chr": "20",
"clinvar_classification": "Benign",
"clinvar_disease": "TASP1-related disorder",
"clinvar_review_status": "no assertion criteria provided",
"clinvar_submissions_summary": "null",
"computational_prediction_selected": "Benign",
"computational_score_selected": -0.3499999940395355,
"computational_source_selected": "BayesDel_noAF",
"consequences": [
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 420,
"aa_ref": "L",
"aa_start": 255,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2342,
"cdna_start": 878,
"cds_end": null,
"cds_length": 1263,
"cds_start": 765,
"consequences": [
"synonymous_variant"
],
"exon_count": 14,
"exon_rank": 9,
"exon_rank_end": null,
"feature": "NM_017714.3",
"gene_hgnc_id": 15859,
"gene_symbol": "TASP1",
"hgvs_c": "c.765G>A",
"hgvs_p": "p.Leu255Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": "ENST00000337743.9",
"protein_coding": true,
"protein_id": "NP_060184.2",
"strand": false,
"transcript": "NM_017714.3",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 420,
"aa_ref": "L",
"aa_start": 255,
"biotype": "protein_coding",
"canonical": true,
"cdna_end": null,
"cdna_length": 2342,
"cdna_start": 878,
"cds_end": null,
"cds_length": 1263,
"cds_start": 765,
"consequences": [
"synonymous_variant"
],
"exon_count": 14,
"exon_rank": 9,
"exon_rank_end": null,
"feature": "ENST00000337743.9",
"gene_hgnc_id": 15859,
"gene_symbol": "TASP1",
"hgvs_c": "c.765G>A",
"hgvs_p": "p.Leu255Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": "NM_017714.3",
"protein_coding": true,
"protein_id": "ENSP00000338624.4",
"strand": false,
"transcript": "ENST00000337743.9",
"transcript_support_level": 1
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 450,
"aa_ref": "L",
"aa_start": 255,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2393,
"cdna_start": 839,
"cds_end": null,
"cds_length": 1353,
"cds_start": 765,
"consequences": [
"synonymous_variant"
],
"exon_count": 14,
"exon_rank": 8,
"exon_rank_end": null,
"feature": "ENST00000961261.1",
"gene_hgnc_id": 15859,
"gene_symbol": "TASP1",
"hgvs_c": "c.765G>A",
"hgvs_p": "p.Leu255Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000631320.1",
"strand": false,
"transcript": "ENST00000961261.1",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 420,
"aa_ref": "L",
"aa_start": 255,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2951,
"cdna_start": 984,
"cds_end": null,
"cds_length": 1263,
"cds_start": 765,
"consequences": [
"synonymous_variant"
],
"exon_count": 15,
"exon_rank": 10,
"exon_rank_end": null,
"feature": "ENST00000861004.1",
"gene_hgnc_id": 15859,
"gene_symbol": "TASP1",
"hgvs_c": "c.765G>A",
"hgvs_p": "p.Leu255Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000531063.1",
"strand": false,
"transcript": "ENST00000861004.1",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 420,
"aa_ref": "L",
"aa_start": 255,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2652,
"cdna_start": 1191,
"cds_end": null,
"cds_length": 1263,
"cds_start": 765,
"consequences": [
"synonymous_variant"
],
"exon_count": 14,
"exon_rank": 9,
"exon_rank_end": null,
"feature": "ENST00000861007.1",
"gene_hgnc_id": 15859,
"gene_symbol": "TASP1",
"hgvs_c": "c.765G>A",
"hgvs_p": "p.Leu255Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000531066.1",
"strand": false,
"transcript": "ENST00000861007.1",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 420,
"aa_ref": "L",
"aa_start": 255,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2926,
"cdna_start": 1462,
"cds_end": null,
"cds_length": 1263,
"cds_start": 765,
"consequences": [
"synonymous_variant"
],
"exon_count": 14,
"exon_rank": 9,
"exon_rank_end": null,
"feature": "ENST00000861008.1",
"gene_hgnc_id": 15859,
"gene_symbol": "TASP1",
"hgvs_c": "c.765G>A",
"hgvs_p": "p.Leu255Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000531067.1",
"strand": false,
"transcript": "ENST00000861008.1",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 383,
"aa_ref": "L",
"aa_start": 255,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2233,
"cdna_start": 882,
"cds_end": null,
"cds_length": 1152,
"cds_start": 765,
"consequences": [
"synonymous_variant"
],
"exon_count": 13,
"exon_rank": 9,
"exon_rank_end": null,
"feature": "ENST00000939534.1",
"gene_hgnc_id": 15859,
"gene_symbol": "TASP1",
"hgvs_c": "c.765G>A",
"hgvs_p": "p.Leu255Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000609593.1",
"strand": false,
"transcript": "ENST00000939534.1",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 365,
"aa_ref": "L",
"aa_start": 200,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2177,
"cdna_start": 713,
"cds_end": null,
"cds_length": 1098,
"cds_start": 600,
"consequences": [
"synonymous_variant"
],
"exon_count": 12,
"exon_rank": 7,
"exon_rank_end": null,
"feature": "ENST00000939535.1",
"gene_hgnc_id": 15859,
"gene_symbol": "TASP1",
"hgvs_c": "c.600G>A",
"hgvs_p": "p.Leu200Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000609594.1",
"strand": false,
"transcript": "ENST00000939535.1",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 353,
"aa_ref": "L",
"aa_start": 188,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2132,
"cdna_start": 664,
"cds_end": null,
"cds_length": 1062,
"cds_start": 564,
"consequences": [
"synonymous_variant"
],
"exon_count": 12,
"exon_rank": 7,
"exon_rank_end": null,
"feature": "ENST00000961257.1",
"gene_hgnc_id": 15859,
"gene_symbol": "TASP1",
"hgvs_c": "c.564G>A",
"hgvs_p": "p.Leu188Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000631316.1",
"strand": false,
"transcript": "ENST00000961257.1",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 318,
"aa_ref": "L",
"aa_start": 153,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2609,
"cdna_start": 1145,
"cds_end": null,
"cds_length": 957,
"cds_start": 459,
"consequences": [
"synonymous_variant"
],
"exon_count": 15,
"exon_rank": 10,
"exon_rank_end": null,
"feature": "NM_001323603.2",
"gene_hgnc_id": 15859,
"gene_symbol": "TASP1",
"hgvs_c": "c.459G>A",
"hgvs_p": "p.Leu153Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "NP_001310532.1",
"strand": false,
"transcript": "NM_001323603.2",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 318,
"aa_ref": "L",
"aa_start": 153,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2417,
"cdna_start": 953,
"cds_end": null,
"cds_length": 957,
"cds_start": 459,
"consequences": [
"synonymous_variant"
],
"exon_count": 15,
"exon_rank": 10,
"exon_rank_end": null,
"feature": "NM_001323604.2",
"gene_hgnc_id": 15859,
"gene_symbol": "TASP1",
"hgvs_c": "c.459G>A",
"hgvs_p": "p.Leu153Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "NP_001310533.1",
"strand": false,
"transcript": "NM_001323604.2",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 304,
"aa_ref": "L",
"aa_start": 232,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1000,
"cdna_start": 780,
"cds_end": null,
"cds_length": 916,
"cds_start": 696,
"consequences": [
"synonymous_variant"
],
"exon_count": 10,
"exon_rank": 8,
"exon_rank_end": null,
"feature": "ENST00000455532.5",
"gene_hgnc_id": 15859,
"gene_symbol": "TASP1",
"hgvs_c": "c.696G>A",
"hgvs_p": "p.Leu232Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000400580.1",
"strand": false,
"transcript": "ENST00000455532.5",
"transcript_support_level": 5
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 289,
"aa_ref": "L",
"aa_start": 124,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1949,
"cdna_start": 485,
"cds_end": null,
"cds_length": 870,
"cds_start": 372,
"consequences": [
"synonymous_variant"
],
"exon_count": 10,
"exon_rank": 5,
"exon_rank_end": null,
"feature": "NM_001323602.2",
"gene_hgnc_id": 15859,
"gene_symbol": "TASP1",
"hgvs_c": "c.372G>A",
"hgvs_p": "p.Leu124Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "NP_001310531.1",
"strand": false,
"transcript": "NM_001323602.2",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 289,
"aa_ref": "L",
"aa_start": 124,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1965,
"cdna_start": 499,
"cds_end": null,
"cds_length": 870,
"cds_start": 372,
"consequences": [
"synonymous_variant"
],
"exon_count": 10,
"exon_rank": 5,
"exon_rank_end": null,
"feature": "ENST00000861005.1",
"gene_hgnc_id": 15859,
"gene_symbol": "TASP1",
"hgvs_c": "c.372G>A",
"hgvs_p": "p.Leu124Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000531064.1",
"strand": false,
"transcript": "ENST00000861005.1",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 289,
"aa_ref": "L",
"aa_start": 124,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1973,
"cdna_start": 562,
"cds_end": null,
"cds_length": 870,
"cds_start": 372,
"consequences": [
"synonymous_variant"
],
"exon_count": 10,
"exon_rank": 5,
"exon_rank_end": null,
"feature": "ENST00000939537.1",
"gene_hgnc_id": 15859,
"gene_symbol": "TASP1",
"hgvs_c": "c.372G>A",
"hgvs_p": "p.Leu124Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000609596.1",
"strand": false,
"transcript": "ENST00000939537.1",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 289,
"aa_ref": "L",
"aa_start": 124,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1934,
"cdna_start": 525,
"cds_end": null,
"cds_length": 870,
"cds_start": 372,
"consequences": [
"synonymous_variant"
],
"exon_count": 10,
"exon_rank": 5,
"exon_rank_end": null,
"feature": "ENST00000961260.1",
"gene_hgnc_id": 15859,
"gene_symbol": "TASP1",
"hgvs_c": "c.372G>A",
"hgvs_p": "p.Leu124Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000631319.1",
"strand": false,
"transcript": "ENST00000961260.1",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 420,
"aa_ref": "L",
"aa_start": 255,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2971,
"cdna_start": 1507,
"cds_end": null,
"cds_length": 1263,
"cds_start": 765,
"consequences": [
"synonymous_variant"
],
"exon_count": 14,
"exon_rank": 9,
"exon_rank_end": null,
"feature": "XM_047440267.1",
"gene_hgnc_id": 15859,
"gene_symbol": "TASP1",
"hgvs_c": "c.765G>A",
"hgvs_p": "p.Leu255Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "XP_047296223.1",
"strand": false,
"transcript": "XM_047440267.1",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 420,
"aa_ref": "L",
"aa_start": 255,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2681,
"cdna_start": 1217,
"cds_end": null,
"cds_length": 1263,
"cds_start": 765,
"consequences": [
"synonymous_variant"
],
"exon_count": 14,
"exon_rank": 9,
"exon_rank_end": null,
"feature": "XM_047440268.1",
"gene_hgnc_id": 15859,
"gene_symbol": "TASP1",
"hgvs_c": "c.765G>A",
"hgvs_p": "p.Leu255Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "XP_047296224.1",
"strand": false,
"transcript": "XM_047440268.1",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 397,
"aa_ref": "L",
"aa_start": 255,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 16860,
"cdna_start": 878,
"cds_end": null,
"cds_length": 1194,
"cds_start": 765,
"consequences": [
"synonymous_variant"
],
"exon_count": 14,
"exon_rank": 9,
"exon_rank_end": null,
"feature": "XM_047440269.1",
"gene_hgnc_id": 15859,
"gene_symbol": "TASP1",
"hgvs_c": "c.765G>A",
"hgvs_p": "p.Leu255Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "XP_047296225.1",
"strand": false,
"transcript": "XM_047440269.1",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 350,
"aa_ref": "L",
"aa_start": 255,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1230,
"cdna_start": 878,
"cds_end": null,
"cds_length": 1053,
"cds_start": 765,
"consequences": [
"synonymous_variant"
],
"exon_count": 13,
"exon_rank": 9,
"exon_rank_end": null,
"feature": "XM_047440270.1",
"gene_hgnc_id": 15859,
"gene_symbol": "TASP1",
"hgvs_c": "c.765G>A",
"hgvs_p": "p.Leu255Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "XP_047296226.1",
"strand": false,
"transcript": "XM_047440270.1",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 338,
"aa_ref": "L",
"aa_start": 255,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1194,
"cdna_start": 878,
"cds_end": null,
"cds_length": 1017,
"cds_start": 765,
"consequences": [
"synonymous_variant"
],
"exon_count": 12,
"exon_rank": 9,
"exon_rank_end": null,
"feature": "XM_047440271.1",
"gene_hgnc_id": 15859,
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