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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 20-25511554-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=20&pos=25511554&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "20",
"pos": 25511554,
"ref": "C",
"alt": "T",
"effect": "intron_variant",
"transcript": "NM_025176.6",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "NINL",
"gene_hgnc_id": 29163,
"hgvs_c": "c.451-814G>A",
"hgvs_p": null,
"transcript": "NM_025176.6",
"protein_id": "NP_079452.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1382,
"cds_start": null,
"cds_end": null,
"cds_length": 4149,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000278886.11",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_025176.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "NINL",
"gene_hgnc_id": 29163,
"hgvs_c": "c.451-814G>A",
"hgvs_p": null,
"transcript": "ENST00000278886.11",
"protein_id": "ENSP00000278886.6",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1382,
"cds_start": null,
"cds_end": null,
"cds_length": 4149,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_025176.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000278886.11"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "NINL",
"gene_hgnc_id": 29163,
"hgvs_c": "c.451-814G>A",
"hgvs_p": null,
"transcript": "ENST00000960977.1",
"protein_id": "ENSP00000631036.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1449,
"cds_start": null,
"cds_end": null,
"cds_length": 4350,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000960977.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "NINL",
"gene_hgnc_id": 29163,
"hgvs_c": "c.451-814G>A",
"hgvs_p": null,
"transcript": "ENST00000889360.1",
"protein_id": "ENSP00000559419.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1387,
"cds_start": null,
"cds_end": null,
"cds_length": 4164,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000889360.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "NINL",
"gene_hgnc_id": 29163,
"hgvs_c": "c.451-814G>A",
"hgvs_p": null,
"transcript": "ENST00000889365.1",
"protein_id": "ENSP00000559424.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1387,
"cds_start": null,
"cds_end": null,
"cds_length": 4164,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000889365.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "NINL",
"gene_hgnc_id": 29163,
"hgvs_c": "c.451-814G>A",
"hgvs_p": null,
"transcript": "ENST00000889363.1",
"protein_id": "ENSP00000559422.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1382,
"cds_start": null,
"cds_end": null,
"cds_length": 4149,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000889363.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "NINL",
"gene_hgnc_id": 29163,
"hgvs_c": "c.451-814G>A",
"hgvs_p": null,
"transcript": "ENST00000889364.1",
"protein_id": "ENSP00000559423.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1382,
"cds_start": null,
"cds_end": null,
"cds_length": 4149,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000889364.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "NINL",
"gene_hgnc_id": 29163,
"hgvs_c": "c.451-814G>A",
"hgvs_p": null,
"transcript": "ENST00000924903.1",
"protein_id": "ENSP00000594962.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1382,
"cds_start": null,
"cds_end": null,
"cds_length": 4149,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000924903.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "NINL",
"gene_hgnc_id": 29163,
"hgvs_c": "c.451-814G>A",
"hgvs_p": null,
"transcript": "ENST00000924905.1",
"protein_id": "ENSP00000594964.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1382,
"cds_start": null,
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"cds_length": 4149,
"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000924905.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 24,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "NINL",
"gene_hgnc_id": 29163,
"hgvs_c": "c.451-814G>A",
"hgvs_p": null,
"transcript": "ENST00000960979.1",
"protein_id": "ENSP00000631038.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1343,
"cds_start": null,
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"cds_length": 4032,
"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000960979.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 23,
"intron_rank": 4,
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"gene_symbol": "NINL",
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"hgvs_c": "c.451-814G>A",
"hgvs_p": null,
"transcript": "ENST00000960980.1",
"protein_id": "ENSP00000631039.1",
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"cdna_start": null,
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},
{
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"consequences": [
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],
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"gene_symbol": "NINL",
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"hgvs_c": "c.451-814G>A",
"hgvs_p": null,
"transcript": "ENST00000889361.1",
"protein_id": "ENSP00000559420.1",
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"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"feature": "ENST00000889361.1"
},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 23,
"intron_rank": 4,
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"gene_symbol": "NINL",
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"hgvs_c": "c.451-814G>A",
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"transcript": "NM_001318226.2",
"protein_id": "NP_001305155.1",
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"feature": "NM_001318226.2"
},
{
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],
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"gene_symbol": "NINL",
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},
{
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],
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"intron_rank": 4,
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"gene_symbol": "NINL",
"gene_hgnc_id": 29163,
"hgvs_c": "c.451-814G>A",
"hgvs_p": null,
"transcript": "ENST00000924904.1",
"protein_id": "ENSP00000594963.1",
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},
{
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],
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"gene_symbol": "NINL",
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},
{
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],
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"intron_rank": 4,
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"gene_symbol": "NINL",
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"hgvs_c": "c.451-814G>A",
"hgvs_p": null,
"transcript": "ENST00000960978.1",
"protein_id": "ENSP00000631037.1",
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"feature": "ENST00000960978.1"
},
{
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"strand": false,
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],
"exon_rank": null,
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"exon_count": 25,
"intron_rank": 4,
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"gene_symbol": "NINL",
"gene_hgnc_id": 29163,
"hgvs_c": "c.499-814G>A",
"hgvs_p": null,
"transcript": "XM_011529186.3",
"protein_id": "XP_011527488.1",
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},
{
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],
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},
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],
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},
{
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],
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"biotype": "protein_coding",
"feature": "XM_047440020.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 25,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "NINL",
"gene_hgnc_id": 29163,
"hgvs_c": "c.451-814G>A",
"hgvs_p": null,
"transcript": "XM_011529188.1",
"protein_id": "XP_011527490.1",
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"aa_start": null,
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"feature": "XM_011529188.1"
},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 25,
"intron_rank": 4,
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