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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 20-3015777-T-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=20&pos=3015777&ref=T&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "20",
"pos": 3015777,
"ref": "T",
"alt": "A",
"effect": "intron_variant",
"transcript": "ENST00000399903.7",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "PTPRA",
"gene_hgnc_id": 9664,
"hgvs_c": "c.907-72T>A",
"hgvs_p": null,
"transcript": "NM_001385305.1",
"protein_id": "NP_001372234.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 802,
"cds_start": -4,
"cds_end": null,
"cds_length": 2409,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3353,
"mane_select": "ENST00000399903.7",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "PTPRA",
"gene_hgnc_id": 9664,
"hgvs_c": "c.907-72T>A",
"hgvs_p": null,
"transcript": "ENST00000399903.7",
"protein_id": "ENSP00000382787.2",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 802,
"cds_start": -4,
"cds_end": null,
"cds_length": 2409,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3353,
"mane_select": "NM_001385305.1",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "PTPRA",
"gene_hgnc_id": 9664,
"hgvs_c": "c.880-72T>A",
"hgvs_p": null,
"transcript": "ENST00000216877.10",
"protein_id": "ENSP00000216877.6",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 793,
"cds_start": -4,
"cds_end": null,
"cds_length": 2382,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3725,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "PTPRA",
"gene_hgnc_id": 9664,
"hgvs_c": "c.880-72T>A",
"hgvs_p": null,
"transcript": "ENST00000356147.3",
"protein_id": "ENSP00000348468.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 793,
"cds_start": -4,
"cds_end": null,
"cds_length": 2382,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3135,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "PTPRA",
"gene_hgnc_id": 9664,
"hgvs_c": "c.940-72T>A",
"hgvs_p": null,
"transcript": "NM_001385302.1",
"protein_id": "NP_001372231.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 813,
"cds_start": -4,
"cds_end": null,
"cds_length": 2442,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3403,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "PTPRA",
"gene_hgnc_id": 9664,
"hgvs_c": "c.940-72T>A",
"hgvs_p": null,
"transcript": "NM_001385303.1",
"protein_id": "NP_001372232.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 813,
"cds_start": -4,
"cds_end": null,
"cds_length": 2442,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3310,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "PTPRA",
"gene_hgnc_id": 9664,
"hgvs_c": "c.913-72T>A",
"hgvs_p": null,
"transcript": "NM_001385304.1",
"protein_id": "NP_001372233.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 804,
"cds_start": -4,
"cds_end": null,
"cds_length": 2415,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3283,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "PTPRA",
"gene_hgnc_id": 9664,
"hgvs_c": "c.907-72T>A",
"hgvs_p": null,
"transcript": "NM_001385306.1",
"protein_id": "NP_001372235.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 802,
"cds_start": -4,
"cds_end": null,
"cds_length": 2409,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3446,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "PTPRA",
"gene_hgnc_id": 9664,
"hgvs_c": "c.907-72T>A",
"hgvs_p": null,
"transcript": "NM_001385307.1",
"protein_id": "NP_001372236.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 802,
"cds_start": -4,
"cds_end": null,
"cds_length": 2409,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3274,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "PTPRA",
"gene_hgnc_id": 9664,
"hgvs_c": "c.907-72T>A",
"hgvs_p": null,
"transcript": "NM_001385308.1",
"protein_id": "NP_001372237.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 802,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 25,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "PTPRA",
"gene_hgnc_id": 9664,
"hgvs_c": "c.907-72T>A",
"hgvs_p": null,
"transcript": "NM_001388320.1",
"protein_id": "NP_001375249.1",
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},
{
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"consequences": [
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],
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"gene_symbol": "PTPRA",
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"transcript": "NM_002836.4",
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},
{
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"consequences": [
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],
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"gene_symbol": "PTPRA",
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"hgvs_c": "c.913-72T>A",
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"transcript": "NM_001385310.1",
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},
{
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],
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"gene_symbol": "PTPRA",
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"hgvs_c": "c.880-72T>A",
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"transcript": "NM_001385311.1",
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},
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],
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"gene_symbol": "PTPRA",
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"transcript": "NM_001388321.1",
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},
{
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],
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"intron_rank": 10,
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"gene_symbol": "PTPRA",
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"hgvs_c": "c.880-72T>A",
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},
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],
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"gene_symbol": "PTPRA",
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"hgvs_c": "c.880-72T>A",
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"transcript": "NM_080841.3",
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},
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],
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"gene_symbol": "PTPRA",
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"hgvs_c": "c.880-72T>A",
"hgvs_p": null,
"transcript": "ENST00000318266.9",
"protein_id": "ENSP00000314568.5",
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],
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"intron_rank": 10,
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"gene_symbol": "PTPRA",
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},
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],
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"gene_symbol": "PTPRA",
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},
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],
"exon_rank": null,
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"gene_symbol": "PTPRA",
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"hgvs_c": "c.880-72T>A",
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"transcript": "NM_001385315.1",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 22,
"intron_rank": 9,
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"gene_symbol": "PTPRA",
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"hgvs_c": "c.562-72T>A",
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},
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}