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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 20-31777542-C-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=20&pos=31777542&ref=C&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "20",
"pos": 31777542,
"ref": "C",
"alt": "A",
"effect": "missense_variant",
"transcript": "NM_012112.5",
"consequences": [
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TPX2",
"gene_hgnc_id": 1249,
"hgvs_c": "c.786C>A",
"hgvs_p": "p.Phe262Leu",
"transcript": "NM_012112.5",
"protein_id": "NP_036244.2",
"transcript_support_level": null,
"aa_start": 262,
"aa_end": null,
"aa_length": 747,
"cds_start": 786,
"cds_end": null,
"cds_length": 2244,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000300403.11",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_012112.5"
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TPX2",
"gene_hgnc_id": 1249,
"hgvs_c": "c.786C>A",
"hgvs_p": "p.Phe262Leu",
"transcript": "ENST00000300403.11",
"protein_id": "ENSP00000300403.6",
"transcript_support_level": 1,
"aa_start": 262,
"aa_end": null,
"aa_length": 747,
"cds_start": 786,
"cds_end": null,
"cds_length": 2244,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_012112.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000300403.11"
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TPX2",
"gene_hgnc_id": 1249,
"hgvs_c": "c.786C>A",
"hgvs_p": "p.Phe262Leu",
"transcript": "ENST00000340513.4",
"protein_id": "ENSP00000341145.4",
"transcript_support_level": 1,
"aa_start": 262,
"aa_end": null,
"aa_length": 783,
"cds_start": 786,
"cds_end": null,
"cds_length": 2352,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000340513.4"
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TPX2",
"gene_hgnc_id": 1249,
"hgvs_c": "c.786C>A",
"hgvs_p": "p.Phe262Leu",
"transcript": "ENST00000934062.1",
"protein_id": "ENSP00000604121.1",
"transcript_support_level": null,
"aa_start": 262,
"aa_end": null,
"aa_length": 783,
"cds_start": 786,
"cds_end": null,
"cds_length": 2352,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000934062.1"
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TPX2",
"gene_hgnc_id": 1249,
"hgvs_c": "c.786C>A",
"hgvs_p": "p.Phe262Leu",
"transcript": "ENST00000934061.1",
"protein_id": "ENSP00000604120.1",
"transcript_support_level": null,
"aa_start": 262,
"aa_end": null,
"aa_length": 776,
"cds_start": 786,
"cds_end": null,
"cds_length": 2331,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000934061.1"
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TPX2",
"gene_hgnc_id": 1249,
"hgvs_c": "c.786C>A",
"hgvs_p": "p.Phe262Leu",
"transcript": "ENST00000934060.1",
"protein_id": "ENSP00000604119.1",
"transcript_support_level": null,
"aa_start": 262,
"aa_end": null,
"aa_length": 748,
"cds_start": 786,
"cds_end": null,
"cds_length": 2247,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000934060.1"
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TPX2",
"gene_hgnc_id": 1249,
"hgvs_c": "c.786C>A",
"hgvs_p": "p.Phe262Leu",
"transcript": "ENST00000853940.1",
"protein_id": "ENSP00000523999.1",
"transcript_support_level": null,
"aa_start": 262,
"aa_end": null,
"aa_length": 747,
"cds_start": 786,
"cds_end": null,
"cds_length": 2244,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853940.1"
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TPX2",
"gene_hgnc_id": 1249,
"hgvs_c": "c.786C>A",
"hgvs_p": "p.Phe262Leu",
"transcript": "ENST00000853941.1",
"protein_id": "ENSP00000524000.1",
"transcript_support_level": null,
"aa_start": 262,
"aa_end": null,
"aa_length": 747,
"cds_start": 786,
"cds_end": null,
"cds_length": 2244,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853941.1"
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TPX2",
"gene_hgnc_id": 1249,
"hgvs_c": "c.786C>A",
"hgvs_p": "p.Phe262Leu",
"transcript": "ENST00000853948.1",
"protein_id": "ENSP00000524007.1",
"transcript_support_level": null,
"aa_start": 262,
"aa_end": null,
"aa_length": 747,
"cds_start": 786,
"cds_end": null,
"cds_length": 2244,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853948.1"
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TPX2",
"gene_hgnc_id": 1249,
"hgvs_c": "c.786C>A",
"hgvs_p": "p.Phe262Leu",
"transcript": "ENST00000853949.1",
"protein_id": "ENSP00000524008.1",
"transcript_support_level": null,
"aa_start": 262,
"aa_end": null,
"aa_length": 747,
"cds_start": 786,
"cds_end": null,
"cds_length": 2244,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853949.1"
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TPX2",
"gene_hgnc_id": 1249,
"hgvs_c": "c.786C>A",
"hgvs_p": "p.Phe262Leu",
"transcript": "ENST00000853951.1",
"protein_id": "ENSP00000524010.1",
"transcript_support_level": null,
"aa_start": 262,
"aa_end": null,
"aa_length": 747,
"cds_start": 786,
"cds_end": null,
"cds_length": 2244,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853951.1"
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TPX2",
"gene_hgnc_id": 1249,
"hgvs_c": "c.786C>A",
"hgvs_p": "p.Phe262Leu",
"transcript": "ENST00000853953.1",
"protein_id": "ENSP00000524012.1",
"transcript_support_level": null,
"aa_start": 262,
"aa_end": null,
"aa_length": 747,
"cds_start": 786,
"cds_end": null,
"cds_length": 2244,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853953.1"
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TPX2",
"gene_hgnc_id": 1249,
"hgvs_c": "c.786C>A",
"hgvs_p": "p.Phe262Leu",
"transcript": "ENST00000934051.1",
"protein_id": "ENSP00000604110.1",
"transcript_support_level": null,
"aa_start": 262,
"aa_end": null,
"aa_length": 747,
"cds_start": 786,
"cds_end": null,
"cds_length": 2244,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000934051.1"
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TPX2",
"gene_hgnc_id": 1249,
"hgvs_c": "c.786C>A",
"hgvs_p": "p.Phe262Leu",
"transcript": "ENST00000934053.1",
"protein_id": "ENSP00000604112.1",
"transcript_support_level": null,
"aa_start": 262,
"aa_end": null,
"aa_length": 747,
"cds_start": 786,
"cds_end": null,
"cds_length": 2244,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000934053.1"
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TPX2",
"gene_hgnc_id": 1249,
"hgvs_c": "c.786C>A",
"hgvs_p": "p.Phe262Leu",
"transcript": "ENST00000934056.1",
"protein_id": "ENSP00000604115.1",
"transcript_support_level": null,
"aa_start": 262,
"aa_end": null,
"aa_length": 747,
"cds_start": 786,
"cds_end": null,
"cds_length": 2244,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000934056.1"
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TPX2",
"gene_hgnc_id": 1249,
"hgvs_c": "c.786C>A",
"hgvs_p": "p.Phe262Leu",
"transcript": "ENST00000934058.1",
"protein_id": "ENSP00000604117.1",
"transcript_support_level": null,
"aa_start": 262,
"aa_end": null,
"aa_length": 747,
"cds_start": 786,
"cds_end": null,
"cds_length": 2244,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000934058.1"
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TPX2",
"gene_hgnc_id": 1249,
"hgvs_c": "c.786C>A",
"hgvs_p": "p.Phe262Leu",
"transcript": "ENST00000934064.1",
"protein_id": "ENSP00000604123.1",
"transcript_support_level": null,
"aa_start": 262,
"aa_end": null,
"aa_length": 747,
"cds_start": 786,
"cds_end": null,
"cds_length": 2244,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000934064.1"
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TPX2",
"gene_hgnc_id": 1249,
"hgvs_c": "c.783C>A",
"hgvs_p": "p.Phe261Leu",
"transcript": "ENST00000853944.1",
"protein_id": "ENSP00000524003.1",
"transcript_support_level": null,
"aa_start": 261,
"aa_end": null,
"aa_length": 746,
"cds_start": 783,
"cds_end": null,
"cds_length": 2241,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853944.1"
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TPX2",
"gene_hgnc_id": 1249,
"hgvs_c": "c.783C>A",
"hgvs_p": "p.Phe261Leu",
"transcript": "ENST00000853945.1",
"protein_id": "ENSP00000524004.1",
"transcript_support_level": null,
"aa_start": 261,
"aa_end": null,
"aa_length": 746,
"cds_start": 783,
"cds_end": null,
"cds_length": 2241,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853945.1"
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TPX2",
"gene_hgnc_id": 1249,
"hgvs_c": "c.783C>A",
"hgvs_p": "p.Phe261Leu",
"transcript": "ENST00000853952.1",
"protein_id": "ENSP00000524011.1",
"transcript_support_level": null,
"aa_start": 261,
"aa_end": null,
"aa_length": 746,
"cds_start": 783,
"cds_end": null,
"cds_length": 2241,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853952.1"
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TPX2",
"gene_hgnc_id": 1249,
"hgvs_c": "c.783C>A",
"hgvs_p": "p.Phe261Leu",
"transcript": "ENST00000934057.1",
"protein_id": "ENSP00000604116.1",
"transcript_support_level": null,
"aa_start": 261,
"aa_end": null,
"aa_length": 746,
"cds_start": 783,
"cds_end": null,
"cds_length": 2241,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000934057.1"
},
{
"aa_ref": "F",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TPX2",
"gene_hgnc_id": 1249,
"hgvs_c": "c.783C>A",
"hgvs_p": "p.Phe261Leu",
"transcript": "ENST00000934063.1",
"protein_id": "ENSP00000604122.1",
"transcript_support_level": null,
"aa_start": 261,
"aa_end": null,
"aa_length": 746,
"cds_start": 783,
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}