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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 20-33412343-G-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=20&pos=33412343&ref=G&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 10,
          "criteria": [
            "BP4_Strong",
            "BP6",
            "BP7",
            "BS2"
          ],
          "effects": [
            "synonymous_variant"
          ],
          "gene_symbol": "SNTA1",
          "hgnc_id": 11167,
          "hgvs_c": "c.993C>T",
          "hgvs_p": "p.Arg331Arg",
          "inheritance_mode": "AD",
          "pathogenic_score": 0,
          "score": -10,
          "transcript": "NM_003098.3",
          "verdict": "Benign"
        },
        {
          "benign_score": 5,
          "criteria": [
            "BP4_Strong",
            "BP6"
          ],
          "effects": [
            "non_coding_transcript_exon_variant"
          ],
          "gene_symbol": "LOC124904889",
          "hgnc_id": null,
          "hgvs_c": "n.2385G>A",
          "hgvs_p": null,
          "inheritance_mode": "",
          "pathogenic_score": 0,
          "score": -5,
          "transcript": "XR_007067567.1",
          "verdict": "Likely_benign"
        },
        {
          "benign_score": 5,
          "criteria": [
            "BP4_Strong",
            "BP6"
          ],
          "effects": [
            "intron_variant"
          ],
          "gene_symbol": "ENSG00000288878",
          "hgnc_id": null,
          "hgvs_c": "n.224+2109G>A",
          "hgvs_p": null,
          "inheritance_mode": "",
          "pathogenic_score": 0,
          "score": -5,
          "transcript": "ENST00000785672.1",
          "verdict": "Likely_benign"
        }
      ],
      "acmg_classification": "Benign",
      "acmg_criteria": "BP4_Strong,BP6,BP7,BS2",
      "acmg_score": -10,
      "allele_count_reference_population": 364,
      "alphamissense_prediction": null,
      "alphamissense_score": null,
      "alt": "A",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Benign",
      "bayesdelnoaf_score": -0.74,
      "chr": "20",
      "clinvar_classification": "Conflicting classifications of pathogenicity",
      "clinvar_disease": "Cardiovascular phenotype,Congenital long QT syndrome,Long QT syndrome,Long QT syndrome 12,not provided,not specified",
      "clinvar_review_status": "criteria provided, conflicting classifications",
      "clinvar_submissions_summary": "US:1 LB:4 B:2",
      "computational_prediction_selected": "Benign",
      "computational_score_selected": -0.7400000095367432,
      "computational_source_selected": "BayesDel_noAF",
      "consequences": [
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 505,
          "aa_ref": "R",
          "aa_start": 331,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2211,
          "cdna_start": 1136,
          "cds_end": null,
          "cds_length": 1518,
          "cds_start": 993,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 8,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "NM_003098.3",
          "gene_hgnc_id": 11167,
          "gene_symbol": "SNTA1",
          "hgvs_c": "c.993C>T",
          "hgvs_p": "p.Arg331Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000217381.3",
          "protein_coding": true,
          "protein_id": "NP_003089.1",
          "strand": false,
          "transcript": "NM_003098.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 505,
          "aa_ref": "R",
          "aa_start": 331,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 2211,
          "cdna_start": 1136,
          "cds_end": null,
          "cds_length": 1518,
          "cds_start": 993,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 8,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000217381.3",
          "gene_hgnc_id": 11167,
          "gene_symbol": "SNTA1",
          "hgvs_c": "c.993C>T",
          "hgvs_p": "p.Arg331Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_003098.3",
          "protein_coding": true,
          "protein_id": "ENSP00000217381.2",
          "strand": false,
          "transcript": "ENST00000217381.3",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 546,
          "aa_ref": "R",
          "aa_start": 372,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2251,
          "cdna_start": 1186,
          "cds_end": null,
          "cds_length": 1641,
          "cds_start": 1116,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 9,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "ENST00000953204.1",
          "gene_hgnc_id": 11167,
          "gene_symbol": "SNTA1",
          "hgvs_c": "c.1116C>T",
          "hgvs_p": "p.Arg372Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000623263.1",
          "strand": false,
          "transcript": "ENST00000953204.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 528,
          "aa_ref": "R",
          "aa_start": 354,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2179,
          "cdna_start": 1113,
          "cds_end": null,
          "cds_length": 1587,
          "cds_start": 1062,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 9,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "ENST00000953205.1",
          "gene_hgnc_id": 11167,
          "gene_symbol": "SNTA1",
          "hgvs_c": "c.1062C>T",
          "hgvs_p": "p.Arg354Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000623264.1",
          "strand": false,
          "transcript": "ENST00000953205.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 515,
          "aa_ref": "R",
          "aa_start": 341,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2164,
          "cdna_start": 1095,
          "cds_end": null,
          "cds_length": 1548,
          "cds_start": 1023,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 8,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000953203.1",
          "gene_hgnc_id": 11167,
          "gene_symbol": "SNTA1",
          "hgvs_c": "c.1023C>T",
          "hgvs_p": "p.Arg341Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000623262.1",
          "strand": false,
          "transcript": "ENST00000953203.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 512,
          "aa_ref": "R",
          "aa_start": 331,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1685,
          "cdna_start": 1003,
          "cds_end": null,
          "cds_length": 1539,
          "cds_start": 993,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 8,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000880503.1",
          "gene_hgnc_id": 11167,
          "gene_symbol": "SNTA1",
          "hgvs_c": "c.993C>T",
          "hgvs_p": "p.Arg331Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000550562.1",
          "strand": false,
          "transcript": "ENST00000880503.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 511,
          "aa_ref": "R",
          "aa_start": 331,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2172,
          "cdna_start": 1081,
          "cds_end": null,
          "cds_length": 1536,
          "cds_start": 993,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 8,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000953201.1",
          "gene_hgnc_id": 11167,
          "gene_symbol": "SNTA1",
          "hgvs_c": "c.993C>T",
          "hgvs_p": "p.Arg331Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000623260.1",
          "strand": false,
          "transcript": "ENST00000953201.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 510,
          "aa_ref": "R",
          "aa_start": 331,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2120,
          "cdna_start": 1030,
          "cds_end": null,
          "cds_length": 1533,
          "cds_start": 993,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 8,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000953206.1",
          "gene_hgnc_id": 11167,
          "gene_symbol": "SNTA1",
          "hgvs_c": "c.993C>T",
          "hgvs_p": "p.Arg331Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000623265.1",
          "strand": false,
          "transcript": "ENST00000953206.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 509,
          "aa_ref": "R",
          "aa_start": 331,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2199,
          "cdna_start": 1119,
          "cds_end": null,
          "cds_length": 1530,
          "cds_start": 993,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 8,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000953198.1",
          "gene_hgnc_id": 11167,
          "gene_symbol": "SNTA1",
          "hgvs_c": "c.993C>T",
          "hgvs_p": "p.Arg331Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000623257.1",
          "strand": false,
          "transcript": "ENST00000953198.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 504,
          "aa_ref": "R",
          "aa_start": 331,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2208,
          "cdna_start": 1136,
          "cds_end": null,
          "cds_length": 1515,
          "cds_start": 993,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 8,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "NM_001424413.1",
          "gene_hgnc_id": 11167,
          "gene_symbol": "SNTA1",
          "hgvs_c": "c.993C>T",
          "hgvs_p": "p.Arg331Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001411342.1",
          "strand": false,
          "transcript": "NM_001424413.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 504,
          "aa_ref": "R",
          "aa_start": 331,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2332,
          "cdna_start": 1258,
          "cds_end": null,
          "cds_length": 1515,
          "cds_start": 993,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 8,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000880497.1",
          "gene_hgnc_id": 11167,
          "gene_symbol": "SNTA1",
          "hgvs_c": "c.993C>T",
          "hgvs_p": "p.Arg331Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000550556.1",
          "strand": false,
          "transcript": "ENST00000880497.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 498,
          "aa_ref": "R",
          "aa_start": 331,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2144,
          "cdna_start": 1093,
          "cds_end": null,
          "cds_length": 1497,
          "cds_start": 993,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 8,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000880499.1",
          "gene_hgnc_id": 11167,
          "gene_symbol": "SNTA1",
          "hgvs_c": "c.993C>T",
          "hgvs_p": "p.Arg331Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000550558.1",
          "strand": false,
          "transcript": "ENST00000880499.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 496,
          "aa_ref": "R",
          "aa_start": 331,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2243,
          "cdna_start": 1136,
          "cds_end": null,
          "cds_length": 1491,
          "cds_start": 993,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 8,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "NM_001424414.1",
          "gene_hgnc_id": 11167,
          "gene_symbol": "SNTA1",
          "hgvs_c": "c.993C>T",
          "hgvs_p": "p.Arg331Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001411343.1",
          "strand": false,
          "transcript": "NM_001424414.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 489,
          "aa_ref": "R",
          "aa_start": 315,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2071,
          "cdna_start": 996,
          "cds_end": null,
          "cds_length": 1470,
          "cds_start": 945,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 8,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000880502.1",
          "gene_hgnc_id": 11167,
          "gene_symbol": "SNTA1",
          "hgvs_c": "c.945C>T",
          "hgvs_p": "p.Arg315Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000550561.1",
          "strand": false,
          "transcript": "ENST00000880502.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 476,
          "aa_ref": "R",
          "aa_start": 331,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2071,
          "cdna_start": 1081,
          "cds_end": null,
          "cds_length": 1431,
          "cds_start": 993,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 7,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000880500.1",
          "gene_hgnc_id": 11167,
          "gene_symbol": "SNTA1",
          "hgvs_c": "c.993C>T",
          "hgvs_p": "p.Arg331Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000550559.1",
          "strand": false,
          "transcript": "ENST00000880500.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 475,
          "aa_ref": "R",
          "aa_start": 331,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2067,
          "cdna_start": 1081,
          "cds_end": null,
          "cds_length": 1428,
          "cds_start": 993,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 7,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000953199.1",
          "gene_hgnc_id": 11167,
          "gene_symbol": "SNTA1",
          "hgvs_c": "c.993C>T",
          "hgvs_p": "p.Arg331Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000623258.1",
          "strand": false,
          "transcript": "ENST00000953199.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 470,
          "aa_ref": "R",
          "aa_start": 331,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2080,
          "cdna_start": 1110,
          "cds_end": null,
          "cds_length": 1413,
          "cds_start": 993,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 8,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000880498.1",
          "gene_hgnc_id": 11167,
          "gene_symbol": "SNTA1",
          "hgvs_c": "c.993C>T",
          "hgvs_p": "p.Arg331Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000550557.1",
          "strand": false,
          "transcript": "ENST00000880498.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 469,
          "aa_ref": "R",
          "aa_start": 331,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2093,
          "cdna_start": 1130,
          "cds_end": null,
          "cds_length": 1410,
          "cds_start": 993,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 8,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000953197.1",
          "gene_hgnc_id": 11167,
          "gene_symbol": "SNTA1",
          "hgvs_c": "c.993C>T",
          "hgvs_p": "p.Arg331Arg",
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For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.