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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 20-34708786-C-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=20&pos=34708786&ref=C&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "20",
"pos": 34708786,
"ref": "C",
"alt": "G",
"effect": "missense_variant",
"transcript": "NM_021202.3",
"consequences": [
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TP53INP2",
"gene_hgnc_id": 16104,
"hgvs_c": "c.47C>G",
"hgvs_p": "p.Pro16Arg",
"transcript": "NM_021202.3",
"protein_id": "NP_067025.1",
"transcript_support_level": null,
"aa_start": 16,
"aa_end": null,
"aa_length": 220,
"cds_start": 47,
"cds_end": null,
"cds_length": 663,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000374810.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_021202.3"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TP53INP2",
"gene_hgnc_id": 16104,
"hgvs_c": "c.47C>G",
"hgvs_p": "p.Pro16Arg",
"transcript": "ENST00000374810.8",
"protein_id": "ENSP00000363943.3",
"transcript_support_level": 1,
"aa_start": 16,
"aa_end": null,
"aa_length": 220,
"cds_start": 47,
"cds_end": null,
"cds_length": 663,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_021202.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000374810.8"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TP53INP2",
"gene_hgnc_id": 16104,
"hgvs_c": "c.47C>G",
"hgvs_p": "p.Pro16Arg",
"transcript": "NM_001329429.2",
"protein_id": "NP_001316358.1",
"transcript_support_level": null,
"aa_start": 16,
"aa_end": null,
"aa_length": 220,
"cds_start": 47,
"cds_end": null,
"cds_length": 663,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001329429.2"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TP53INP2",
"gene_hgnc_id": 16104,
"hgvs_c": "c.47C>G",
"hgvs_p": "p.Pro16Arg",
"transcript": "NM_001329430.2",
"protein_id": "NP_001316359.1",
"transcript_support_level": null,
"aa_start": 16,
"aa_end": null,
"aa_length": 220,
"cds_start": 47,
"cds_end": null,
"cds_length": 663,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001329430.2"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TP53INP2",
"gene_hgnc_id": 16104,
"hgvs_c": "c.47C>G",
"hgvs_p": "p.Pro16Arg",
"transcript": "NM_001329431.2",
"protein_id": "NP_001316360.1",
"transcript_support_level": null,
"aa_start": 16,
"aa_end": null,
"aa_length": 220,
"cds_start": 47,
"cds_end": null,
"cds_length": 663,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001329431.2"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TP53INP2",
"gene_hgnc_id": 16104,
"hgvs_c": "c.47C>G",
"hgvs_p": "p.Pro16Arg",
"transcript": "ENST00000374809.6",
"protein_id": "ENSP00000363942.2",
"transcript_support_level": 5,
"aa_start": 16,
"aa_end": null,
"aa_length": 220,
"cds_start": 47,
"cds_end": null,
"cds_length": 663,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000374809.6"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TP53INP2",
"gene_hgnc_id": 16104,
"hgvs_c": "c.47C>G",
"hgvs_p": "p.Pro16Arg",
"transcript": "ENST00000894582.1",
"protein_id": "ENSP00000564641.1",
"transcript_support_level": null,
"aa_start": 16,
"aa_end": null,
"aa_length": 220,
"cds_start": 47,
"cds_end": null,
"cds_length": 663,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894582.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TP53INP2",
"gene_hgnc_id": 16104,
"hgvs_c": "c.47C>G",
"hgvs_p": "p.Pro16Arg",
"transcript": "ENST00000894583.1",
"protein_id": "ENSP00000564642.1",
"transcript_support_level": null,
"aa_start": 16,
"aa_end": null,
"aa_length": 220,
"cds_start": 47,
"cds_end": null,
"cds_length": 663,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894583.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TP53INP2",
"gene_hgnc_id": 16104,
"hgvs_c": "c.47C>G",
"hgvs_p": "p.Pro16Arg",
"transcript": "ENST00000894584.1",
"protein_id": "ENSP00000564643.1",
"transcript_support_level": null,
"aa_start": 16,
"aa_end": null,
"aa_length": 220,
"cds_start": 47,
"cds_end": null,
"cds_length": 663,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894584.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TP53INP2",
"gene_hgnc_id": 16104,
"hgvs_c": "c.47C>G",
"hgvs_p": "p.Pro16Arg",
"transcript": "ENST00000894585.1",
"protein_id": "ENSP00000564644.1",
"transcript_support_level": null,
"aa_start": 16,
"aa_end": null,
"aa_length": 220,
"cds_start": 47,
"cds_end": null,
"cds_length": 663,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894585.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TP53INP2",
"gene_hgnc_id": 16104,
"hgvs_c": "c.47C>G",
"hgvs_p": "p.Pro16Arg",
"transcript": "ENST00000894586.1",
"protein_id": "ENSP00000564645.1",
"transcript_support_level": null,
"aa_start": 16,
"aa_end": null,
"aa_length": 220,
"cds_start": 47,
"cds_end": null,
"cds_length": 663,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894586.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TP53INP2",
"gene_hgnc_id": 16104,
"hgvs_c": "c.47C>G",
"hgvs_p": "p.Pro16Arg",
"transcript": "ENST00000894588.1",
"protein_id": "ENSP00000564647.1",
"transcript_support_level": null,
"aa_start": 16,
"aa_end": null,
"aa_length": 220,
"cds_start": 47,
"cds_end": null,
"cds_length": 663,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894588.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TP53INP2",
"gene_hgnc_id": 16104,
"hgvs_c": "c.47C>G",
"hgvs_p": "p.Pro16Arg",
"transcript": "ENST00000894589.1",
"protein_id": "ENSP00000564648.1",
"transcript_support_level": null,
"aa_start": 16,
"aa_end": null,
"aa_length": 220,
"cds_start": 47,
"cds_end": null,
"cds_length": 663,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894589.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TP53INP2",
"gene_hgnc_id": 16104,
"hgvs_c": "c.47C>G",
"hgvs_p": "p.Pro16Arg",
"transcript": "ENST00000894590.1",
"protein_id": "ENSP00000564649.1",
"transcript_support_level": null,
"aa_start": 16,
"aa_end": null,
"aa_length": 220,
"cds_start": 47,
"cds_end": null,
"cds_length": 663,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894590.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TP53INP2",
"gene_hgnc_id": 16104,
"hgvs_c": "c.47C>G",
"hgvs_p": "p.Pro16Arg",
"transcript": "ENST00000894591.1",
"protein_id": "ENSP00000564650.1",
"transcript_support_level": null,
"aa_start": 16,
"aa_end": null,
"aa_length": 220,
"cds_start": 47,
"cds_end": null,
"cds_length": 663,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894591.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TP53INP2",
"gene_hgnc_id": 16104,
"hgvs_c": "c.47C>G",
"hgvs_p": "p.Pro16Arg",
"transcript": "ENST00000894592.1",
"protein_id": "ENSP00000564651.1",
"transcript_support_level": null,
"aa_start": 16,
"aa_end": null,
"aa_length": 220,
"cds_start": 47,
"cds_end": null,
"cds_length": 663,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894592.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TP53INP2",
"gene_hgnc_id": 16104,
"hgvs_c": "c.47C>G",
"hgvs_p": "p.Pro16Arg",
"transcript": "ENST00000894593.1",
"protein_id": "ENSP00000564652.1",
"transcript_support_level": null,
"aa_start": 16,
"aa_end": null,
"aa_length": 220,
"cds_start": 47,
"cds_end": null,
"cds_length": 663,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894593.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TP53INP2",
"gene_hgnc_id": 16104,
"hgvs_c": "c.47C>G",
"hgvs_p": "p.Pro16Arg",
"transcript": "ENST00000894594.1",
"protein_id": "ENSP00000564653.1",
"transcript_support_level": null,
"aa_start": 16,
"aa_end": null,
"aa_length": 220,
"cds_start": 47,
"cds_end": null,
"cds_length": 663,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894594.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TP53INP2",
"gene_hgnc_id": 16104,
"hgvs_c": "c.47C>G",
"hgvs_p": "p.Pro16Arg",
"transcript": "ENST00000894595.1",
"protein_id": "ENSP00000564654.1",
"transcript_support_level": null,
"aa_start": 16,
"aa_end": null,
"aa_length": 220,
"cds_start": 47,
"cds_end": null,
"cds_length": 663,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894595.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TP53INP2",
"gene_hgnc_id": 16104,
"hgvs_c": "c.47C>G",
"hgvs_p": "p.Pro16Arg",
"transcript": "ENST00000894596.1",
"protein_id": "ENSP00000564655.1",
"transcript_support_level": null,
"aa_start": 16,
"aa_end": null,
"aa_length": 220,
"cds_start": 47,
"cds_end": null,
"cds_length": 663,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894596.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TP53INP2",
"gene_hgnc_id": 16104,
"hgvs_c": "c.47C>G",
"hgvs_p": "p.Pro16Arg",
"transcript": "ENST00000894597.1",
"protein_id": "ENSP00000564656.1",
"transcript_support_level": null,
"aa_start": 16,
"aa_end": null,
"aa_length": 220,
"cds_start": 47,
"cds_end": null,
"cds_length": 663,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894597.1"
},
{
"aa_ref": "P",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TP53INP2",
"gene_hgnc_id": 16104,
"hgvs_c": "c.47C>G",
"hgvs_p": "p.Pro16Arg",
"transcript": "ENST00000894598.1",
"protein_id": "ENSP00000564657.1",
"transcript_support_level": null,
"aa_start": 16,
"aa_end": null,
"aa_length": 220,
"cds_start": 47,
"cds_end": null,
"cds_length": 663,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
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}
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}