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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 20-34876675-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=20&pos=34876675&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "20",
"pos": 34876675,
"ref": "C",
"alt": "T",
"effect": "synonymous_variant",
"transcript": "NM_001076552.3",
"consequences": [
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACSS2",
"gene_hgnc_id": 15814,
"hgvs_c": "c.30C>T",
"hgvs_p": "p.Ser10Ser",
"transcript": "NM_018677.4",
"protein_id": "NP_061147.1",
"transcript_support_level": null,
"aa_start": 10,
"aa_end": null,
"aa_length": 701,
"cds_start": 30,
"cds_end": null,
"cds_length": 2106,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000360596.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_018677.4"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACSS2",
"gene_hgnc_id": 15814,
"hgvs_c": "c.30C>T",
"hgvs_p": "p.Ser10Ser",
"transcript": "ENST00000360596.7",
"protein_id": "ENSP00000353804.2",
"transcript_support_level": 1,
"aa_start": 10,
"aa_end": null,
"aa_length": 701,
"cds_start": 30,
"cds_end": null,
"cds_length": 2106,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_018677.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000360596.7"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACSS2",
"gene_hgnc_id": 15814,
"hgvs_c": "c.30C>T",
"hgvs_p": "p.Ser10Ser",
"transcript": "ENST00000484354.1",
"protein_id": "ENSP00000419167.1",
"transcript_support_level": 5,
"aa_start": 10,
"aa_end": null,
"aa_length": 146,
"cds_start": 30,
"cds_end": null,
"cds_length": 443,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000484354.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACSS2",
"gene_hgnc_id": 15814,
"hgvs_c": "c.30C>T",
"hgvs_p": "p.Ser10Ser",
"transcript": "ENST00000871370.1",
"protein_id": "ENSP00000541429.1",
"transcript_support_level": null,
"aa_start": 10,
"aa_end": null,
"aa_length": 724,
"cds_start": 30,
"cds_end": null,
"cds_length": 2175,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000871370.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACSS2",
"gene_hgnc_id": 15814,
"hgvs_c": "c.30C>T",
"hgvs_p": "p.Ser10Ser",
"transcript": "ENST00000957800.1",
"protein_id": "ENSP00000627859.1",
"transcript_support_level": null,
"aa_start": 10,
"aa_end": null,
"aa_length": 723,
"cds_start": 30,
"cds_end": null,
"cds_length": 2172,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000957800.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACSS2",
"gene_hgnc_id": 15814,
"hgvs_c": "c.30C>T",
"hgvs_p": "p.Ser10Ser",
"transcript": "ENST00000957795.1",
"protein_id": "ENSP00000627854.1",
"transcript_support_level": null,
"aa_start": 10,
"aa_end": null,
"aa_length": 720,
"cds_start": 30,
"cds_end": null,
"cds_length": 2163,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000957795.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACSS2",
"gene_hgnc_id": 15814,
"hgvs_c": "c.30C>T",
"hgvs_p": "p.Ser10Ser",
"transcript": "ENST00000871376.1",
"protein_id": "ENSP00000541435.1",
"transcript_support_level": null,
"aa_start": 10,
"aa_end": null,
"aa_length": 718,
"cds_start": 30,
"cds_end": null,
"cds_length": 2157,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000871376.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACSS2",
"gene_hgnc_id": 15814,
"hgvs_c": "c.30C>T",
"hgvs_p": "p.Ser10Ser",
"transcript": "NM_001076552.3",
"protein_id": "NP_001070020.2",
"transcript_support_level": null,
"aa_start": 10,
"aa_end": null,
"aa_length": 714,
"cds_start": 30,
"cds_end": null,
"cds_length": 2145,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001076552.3"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACSS2",
"gene_hgnc_id": 15814,
"hgvs_c": "c.30C>T",
"hgvs_p": "p.Ser10Ser",
"transcript": "ENST00000253382.5",
"protein_id": "ENSP00000253382.5",
"transcript_support_level": 2,
"aa_start": 10,
"aa_end": null,
"aa_length": 714,
"cds_start": 30,
"cds_end": null,
"cds_length": 2145,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000253382.5"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACSS2",
"gene_hgnc_id": 15814,
"hgvs_c": "c.30C>T",
"hgvs_p": "p.Ser10Ser",
"transcript": "ENST00000871368.1",
"protein_id": "ENSP00000541427.1",
"transcript_support_level": null,
"aa_start": 10,
"aa_end": null,
"aa_length": 711,
"cds_start": 30,
"cds_end": null,
"cds_length": 2136,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000871368.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACSS2",
"gene_hgnc_id": 15814,
"hgvs_c": "c.30C>T",
"hgvs_p": "p.Ser10Ser",
"transcript": "ENST00000871379.1",
"protein_id": "ENSP00000541438.1",
"transcript_support_level": null,
"aa_start": 10,
"aa_end": null,
"aa_length": 710,
"cds_start": 30,
"cds_end": null,
"cds_length": 2133,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000871379.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACSS2",
"gene_hgnc_id": 15814,
"hgvs_c": "c.30C>T",
"hgvs_p": "p.Ser10Ser",
"transcript": "ENST00000871374.1",
"protein_id": "ENSP00000541433.1",
"transcript_support_level": null,
"aa_start": 10,
"aa_end": null,
"aa_length": 707,
"cds_start": 30,
"cds_end": null,
"cds_length": 2124,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000871374.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACSS2",
"gene_hgnc_id": 15814,
"hgvs_c": "c.30C>T",
"hgvs_p": "p.Ser10Ser",
"transcript": "ENST00000957796.1",
"protein_id": "ENSP00000627855.1",
"transcript_support_level": null,
"aa_start": 10,
"aa_end": null,
"aa_length": 700,
"cds_start": 30,
"cds_end": null,
"cds_length": 2103,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000957796.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACSS2",
"gene_hgnc_id": 15814,
"hgvs_c": "c.30C>T",
"hgvs_p": "p.Ser10Ser",
"transcript": "ENST00000957799.1",
"protein_id": "ENSP00000627858.1",
"transcript_support_level": null,
"aa_start": 10,
"aa_end": null,
"aa_length": 694,
"cds_start": 30,
"cds_end": null,
"cds_length": 2085,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000957799.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACSS2",
"gene_hgnc_id": 15814,
"hgvs_c": "c.30C>T",
"hgvs_p": "p.Ser10Ser",
"transcript": "ENST00000957794.1",
"protein_id": "ENSP00000627853.1",
"transcript_support_level": null,
"aa_start": 10,
"aa_end": null,
"aa_length": 682,
"cds_start": 30,
"cds_end": null,
"cds_length": 2049,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000957794.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACSS2",
"gene_hgnc_id": 15814,
"hgvs_c": "c.30C>T",
"hgvs_p": "p.Ser10Ser",
"transcript": "ENST00000957797.1",
"protein_id": "ENSP00000627856.1",
"transcript_support_level": null,
"aa_start": 10,
"aa_end": null,
"aa_length": 682,
"cds_start": 30,
"cds_end": null,
"cds_length": 2049,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000957797.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACSS2",
"gene_hgnc_id": 15814,
"hgvs_c": "c.30C>T",
"hgvs_p": "p.Ser10Ser",
"transcript": "ENST00000871373.1",
"protein_id": "ENSP00000541432.1",
"transcript_support_level": null,
"aa_start": 10,
"aa_end": null,
"aa_length": 674,
"cds_start": 30,
"cds_end": null,
"cds_length": 2025,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000871373.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACSS2",
"gene_hgnc_id": 15814,
"hgvs_c": "c.30C>T",
"hgvs_p": "p.Ser10Ser",
"transcript": "ENST00000871378.1",
"protein_id": "ENSP00000541437.1",
"transcript_support_level": null,
"aa_start": 10,
"aa_end": null,
"aa_length": 674,
"cds_start": 30,
"cds_end": null,
"cds_length": 2025,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000871378.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACSS2",
"gene_hgnc_id": 15814,
"hgvs_c": "c.30C>T",
"hgvs_p": "p.Ser10Ser",
"transcript": "ENST00000871380.1",
"protein_id": "ENSP00000541439.1",
"transcript_support_level": null,
"aa_start": 10,
"aa_end": null,
"aa_length": 670,
"cds_start": 30,
"cds_end": null,
"cds_length": 2013,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000871380.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACSS2",
"gene_hgnc_id": 15814,
"hgvs_c": "c.30C>T",
"hgvs_p": "p.Ser10Ser",
"transcript": "ENST00000871372.1",
"protein_id": "ENSP00000541431.1",
"transcript_support_level": null,
"aa_start": 10,
"aa_end": null,
"aa_length": 657,
"cds_start": 30,
"cds_end": null,
"cds_length": 1974,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000871372.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACSS2",
"gene_hgnc_id": 15814,
"hgvs_c": "c.30C>T",
"hgvs_p": "p.Ser10Ser",
"transcript": "ENST00000871371.1",
"protein_id": "ENSP00000541430.1",
"transcript_support_level": null,
"aa_start": 10,
"aa_end": null,
"aa_length": 655,
"cds_start": 30,
"cds_end": null,
"cds_length": 1968,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000871371.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ACSS2",
"gene_hgnc_id": 15814,
"hgvs_c": "c.30C>T",
"hgvs_p": "p.Ser10Ser",
"transcript": "ENST00000918464.1",
"protein_id": "ENSP00000588523.1",
"transcript_support_level": null,
"aa_start": 10,
"aa_end": null,
"aa_length": 652,
"cds_start": 30,
"cds_end": null,
"cds_length": 1959,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000918464.1"
},
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}