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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 20-35003168-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=20&pos=35003168&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "20",
"pos": 35003168,
"ref": "T",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_015638.3",
"consequences": [
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC4AP",
"gene_hgnc_id": 16181,
"hgvs_c": "c.2372A>G",
"hgvs_p": "p.Asp791Gly",
"transcript": "NM_015638.3",
"protein_id": "NP_056453.1",
"transcript_support_level": null,
"aa_start": 791,
"aa_end": null,
"aa_length": 797,
"cds_start": 2372,
"cds_end": null,
"cds_length": 2394,
"cdna_start": 2398,
"cdna_end": null,
"cdna_length": 3162,
"mane_select": "ENST00000252015.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_015638.3"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC4AP",
"gene_hgnc_id": 16181,
"hgvs_c": "c.2372A>G",
"hgvs_p": "p.Asp791Gly",
"transcript": "ENST00000252015.3",
"protein_id": "ENSP00000252015.2",
"transcript_support_level": 1,
"aa_start": 791,
"aa_end": null,
"aa_length": 797,
"cds_start": 2372,
"cds_end": null,
"cds_length": 2394,
"cdna_start": 2398,
"cdna_end": null,
"cdna_length": 3162,
"mane_select": "NM_015638.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000252015.3"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC4AP",
"gene_hgnc_id": 16181,
"hgvs_c": "c.2666A>G",
"hgvs_p": "p.Asp889Gly",
"transcript": "ENST00000970992.1",
"protein_id": "ENSP00000641051.1",
"transcript_support_level": null,
"aa_start": 889,
"aa_end": null,
"aa_length": 895,
"cds_start": 2666,
"cds_end": null,
"cds_length": 2688,
"cdna_start": 2681,
"cdna_end": null,
"cdna_length": 3444,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000970992.1"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC4AP",
"gene_hgnc_id": 16181,
"hgvs_c": "c.2498A>G",
"hgvs_p": "p.Asp833Gly",
"transcript": "ENST00000888656.1",
"protein_id": "ENSP00000558715.1",
"transcript_support_level": null,
"aa_start": 833,
"aa_end": null,
"aa_length": 839,
"cds_start": 2498,
"cds_end": null,
"cds_length": 2520,
"cdna_start": 2524,
"cdna_end": null,
"cdna_length": 3260,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000888656.1"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC4AP",
"gene_hgnc_id": 16181,
"hgvs_c": "c.2474A>G",
"hgvs_p": "p.Asp825Gly",
"transcript": "ENST00000888655.1",
"protein_id": "ENSP00000558714.1",
"transcript_support_level": null,
"aa_start": 825,
"aa_end": null,
"aa_length": 831,
"cds_start": 2474,
"cds_end": null,
"cds_length": 2496,
"cdna_start": 2486,
"cdna_end": null,
"cdna_length": 3242,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000888655.1"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC4AP",
"gene_hgnc_id": 16181,
"hgvs_c": "c.2432A>G",
"hgvs_p": "p.Asp811Gly",
"transcript": "ENST00000937644.1",
"protein_id": "ENSP00000607703.1",
"transcript_support_level": null,
"aa_start": 811,
"aa_end": null,
"aa_length": 817,
"cds_start": 2432,
"cds_end": null,
"cds_length": 2454,
"cdna_start": 2458,
"cdna_end": null,
"cdna_length": 3219,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000937644.1"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC4AP",
"gene_hgnc_id": 16181,
"hgvs_c": "c.2408A>G",
"hgvs_p": "p.Asp803Gly",
"transcript": "ENST00000970995.1",
"protein_id": "ENSP00000641054.1",
"transcript_support_level": null,
"aa_start": 803,
"aa_end": null,
"aa_length": 809,
"cds_start": 2408,
"cds_end": null,
"cds_length": 2430,
"cdna_start": 2416,
"cdna_end": null,
"cdna_length": 3172,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000970995.1"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC4AP",
"gene_hgnc_id": 16181,
"hgvs_c": "c.2372A>G",
"hgvs_p": "p.Asp791Gly",
"transcript": "ENST00000888645.1",
"protein_id": "ENSP00000558704.1",
"transcript_support_level": null,
"aa_start": 791,
"aa_end": null,
"aa_length": 797,
"cds_start": 2372,
"cds_end": null,
"cds_length": 2394,
"cdna_start": 2459,
"cdna_end": null,
"cdna_length": 2774,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000888645.1"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC4AP",
"gene_hgnc_id": 16181,
"hgvs_c": "c.2369A>G",
"hgvs_p": "p.Asp790Gly",
"transcript": "ENST00000937641.1",
"protein_id": "ENSP00000607700.1",
"transcript_support_level": null,
"aa_start": 790,
"aa_end": null,
"aa_length": 796,
"cds_start": 2369,
"cds_end": null,
"cds_length": 2391,
"cdna_start": 2394,
"cdna_end": null,
"cdna_length": 3158,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000937641.1"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC4AP",
"gene_hgnc_id": 16181,
"hgvs_c": "c.2369A>G",
"hgvs_p": "p.Asp790Gly",
"transcript": "ENST00000970990.1",
"protein_id": "ENSP00000641049.1",
"transcript_support_level": null,
"aa_start": 790,
"aa_end": null,
"aa_length": 796,
"cds_start": 2369,
"cds_end": null,
"cds_length": 2391,
"cdna_start": 2395,
"cdna_end": null,
"cdna_length": 3158,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000970990.1"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC4AP",
"gene_hgnc_id": 16181,
"hgvs_c": "c.2366A>G",
"hgvs_p": "p.Asp789Gly",
"transcript": "ENST00000888647.1",
"protein_id": "ENSP00000558706.1",
"transcript_support_level": null,
"aa_start": 789,
"aa_end": null,
"aa_length": 795,
"cds_start": 2366,
"cds_end": null,
"cds_length": 2388,
"cdna_start": 2392,
"cdna_end": null,
"cdna_length": 3156,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000888647.1"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC4AP",
"gene_hgnc_id": 16181,
"hgvs_c": "c.2348A>G",
"hgvs_p": "p.Asp783Gly",
"transcript": "NM_199368.2",
"protein_id": "NP_955400.1",
"transcript_support_level": null,
"aa_start": 783,
"aa_end": null,
"aa_length": 789,
"cds_start": 2348,
"cds_end": null,
"cds_length": 2370,
"cdna_start": 2374,
"cdna_end": null,
"cdna_length": 3138,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_199368.2"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC4AP",
"gene_hgnc_id": 16181,
"hgvs_c": "c.2348A>G",
"hgvs_p": "p.Asp783Gly",
"transcript": "ENST00000451813.6",
"protein_id": "ENSP00000400614.1",
"transcript_support_level": 2,
"aa_start": 783,
"aa_end": null,
"aa_length": 789,
"cds_start": 2348,
"cds_end": null,
"cds_length": 2370,
"cdna_start": 2374,
"cdna_end": null,
"cdna_length": 3138,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000451813.6"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC4AP",
"gene_hgnc_id": 16181,
"hgvs_c": "c.2348A>G",
"hgvs_p": "p.Asp783Gly",
"transcript": "ENST00000970988.1",
"protein_id": "ENSP00000641047.1",
"transcript_support_level": null,
"aa_start": 783,
"aa_end": null,
"aa_length": 789,
"cds_start": 2348,
"cds_end": null,
"cds_length": 2370,
"cdna_start": 2429,
"cdna_end": null,
"cdna_length": 3732,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000970988.1"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC4AP",
"gene_hgnc_id": 16181,
"hgvs_c": "c.2345A>G",
"hgvs_p": "p.Asp782Gly",
"transcript": "ENST00000937646.1",
"protein_id": "ENSP00000607705.1",
"transcript_support_level": null,
"aa_start": 782,
"aa_end": null,
"aa_length": 788,
"cds_start": 2345,
"cds_end": null,
"cds_length": 2367,
"cdna_start": 2363,
"cdna_end": null,
"cdna_length": 3124,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000937646.1"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC4AP",
"gene_hgnc_id": 16181,
"hgvs_c": "c.2345A>G",
"hgvs_p": "p.Asp782Gly",
"transcript": "ENST00000970994.1",
"protein_id": "ENSP00000641053.1",
"transcript_support_level": null,
"aa_start": 782,
"aa_end": null,
"aa_length": 788,
"cds_start": 2345,
"cds_end": null,
"cds_length": 2367,
"cdna_start": 2360,
"cdna_end": null,
"cdna_length": 3116,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000970994.1"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC4AP",
"gene_hgnc_id": 16181,
"hgvs_c": "c.2342A>G",
"hgvs_p": "p.Asp781Gly",
"transcript": "ENST00000888654.1",
"protein_id": "ENSP00000558713.1",
"transcript_support_level": null,
"aa_start": 781,
"aa_end": null,
"aa_length": 787,
"cds_start": 2342,
"cds_end": null,
"cds_length": 2364,
"cdna_start": 2368,
"cdna_end": null,
"cdna_length": 3129,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000888654.1"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC4AP",
"gene_hgnc_id": 16181,
"hgvs_c": "c.2342A>G",
"hgvs_p": "p.Asp781Gly",
"transcript": "ENST00000888657.1",
"protein_id": "ENSP00000558716.1",
"transcript_support_level": null,
"aa_start": 781,
"aa_end": null,
"aa_length": 787,
"cds_start": 2342,
"cds_end": null,
"cds_length": 2364,
"cdna_start": 2368,
"cdna_end": null,
"cdna_length": 3098,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000888657.1"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC4AP",
"gene_hgnc_id": 16181,
"hgvs_c": "c.2321A>G",
"hgvs_p": "p.Asp774Gly",
"transcript": "ENST00000970989.1",
"protein_id": "ENSP00000641048.1",
"transcript_support_level": null,
"aa_start": 774,
"aa_end": null,
"aa_length": 780,
"cds_start": 2321,
"cds_end": null,
"cds_length": 2343,
"cdna_start": 2394,
"cdna_end": null,
"cdna_length": 3150,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000970989.1"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC4AP",
"gene_hgnc_id": 16181,
"hgvs_c": "c.2312A>G",
"hgvs_p": "p.Asp771Gly",
"transcript": "ENST00000970991.1",
"protein_id": "ENSP00000641050.1",
"transcript_support_level": null,
"aa_start": 771,
"aa_end": null,
"aa_length": 777,
"cds_start": 2312,
"cds_end": null,
"cds_length": 2334,
"cdna_start": 2338,
"cdna_end": null,
"cdna_length": 3099,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000970991.1"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC4AP",
"gene_hgnc_id": 16181,
"hgvs_c": "c.2309A>G",
"hgvs_p": "p.Asp770Gly",
"transcript": "ENST00000937648.1",
"protein_id": "ENSP00000607707.1",
"transcript_support_level": null,
"aa_start": 770,
"aa_end": null,
"aa_length": 776,
"cds_start": 2309,
"cds_end": null,
"cds_length": 2331,
"cdna_start": 2319,
"cdna_end": null,
"cdna_length": 3080,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000937648.1"
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPC4AP",
"gene_hgnc_id": 16181,
"hgvs_c": "c.2258A>G",
"hgvs_p": "p.Asp753Gly",
"transcript": "ENST00000888650.1",
"protein_id": "ENSP00000558709.1",
"transcript_support_level": null,
"aa_start": 753,
"aa_end": null,
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}
],
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}