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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 20-35633233-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=20&pos=35633233&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "20",
"pos": 35633233,
"ref": "G",
"alt": "T",
"effect": "intron_variant",
"transcript": "ENST00000437340.5",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "CPNE1",
"gene_hgnc_id": 2314,
"hgvs_c": "c.1-310C>A",
"hgvs_p": null,
"transcript": "NM_152925.3",
"protein_id": "NP_690902.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 537,
"cds_start": -4,
"cds_end": null,
"cds_length": 1614,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1952,
"mane_select": "ENST00000397443.7",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "CPNE1",
"gene_hgnc_id": 2314,
"hgvs_c": "c.1-310C>A",
"hgvs_p": null,
"transcript": "ENST00000397443.7",
"protein_id": "ENSP00000380585.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 537,
"cds_start": -4,
"cds_end": null,
"cds_length": 1614,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1952,
"mane_select": "NM_152925.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "CPNE1",
"gene_hgnc_id": 2314,
"hgvs_c": "c.16-310C>A",
"hgvs_p": null,
"transcript": "ENST00000317677.9",
"protein_id": "ENSP00000317257.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 542,
"cds_start": -4,
"cds_end": null,
"cds_length": 1629,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1961,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "CPNE1",
"gene_hgnc_id": 2314,
"hgvs_c": "c.1-310C>A",
"hgvs_p": null,
"transcript": "ENST00000352393.8",
"protein_id": "ENSP00000336945.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 537,
"cds_start": -4,
"cds_end": null,
"cds_length": 1614,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2147,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "CPNE1",
"gene_hgnc_id": 2314,
"hgvs_c": "c.1-310C>A",
"hgvs_p": null,
"transcript": "ENST00000437340.5",
"protein_id": "ENSP00000415597.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 532,
"cds_start": -4,
"cds_end": null,
"cds_length": 1600,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1755,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "ENSG00000272897",
"gene_hgnc_id": null,
"hgvs_c": "n.*33-310C>A",
"hgvs_p": null,
"transcript": "ENST00000541176.2",
"protein_id": "ENSP00000443983.2",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 872,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "CPNE1",
"gene_hgnc_id": 2314,
"hgvs_c": "c.16-310C>A",
"hgvs_p": null,
"transcript": "NM_003915.6",
"protein_id": "NP_003906.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 542,
"cds_start": -4,
"cds_end": null,
"cds_length": 1629,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2193,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "CPNE1",
"gene_hgnc_id": 2314,
"hgvs_c": "c.1-310C>A",
"hgvs_p": null,
"transcript": "NM_152926.3",
"protein_id": "NP_690903.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 537,
"cds_start": -4,
"cds_end": null,
"cds_length": 1614,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1910,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "CPNE1",
"gene_hgnc_id": 2314,
"hgvs_c": "c.1-310C>A",
"hgvs_p": null,
"transcript": "NM_152927.3",
"protein_id": "NP_690904.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 537,
"cds_start": -4,
"cds_end": null,
"cds_length": 1614,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2037,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "CPNE1",
"gene_hgnc_id": 2314,
"hgvs_c": "c.1-310C>A",
"hgvs_p": null,
"transcript": "NM_152928.3",
"protein_id": "NP_690905.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 537,
"cds_start": -4,
"cds_end": null,
"cds_length": 1614,
"cdna_start": null,
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"cdna_length": 2005,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "CPNE1",
"gene_hgnc_id": 2314,
"hgvs_c": "c.1-310C>A",
"hgvs_p": null,
"transcript": "NM_001198863.2",
"protein_id": "NP_001185792.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 16,
"intron_rank": 1,
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"gene_symbol": "CPNE1",
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"hgvs_c": "c.1-310C>A",
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"transcript": "ENST00000397442.5",
"protein_id": "ENSP00000380584.1",
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 13,
"intron_rank": 1,
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"gene_symbol": "CPNE1",
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"hgvs_c": "c.1-310C>A",
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"transcript": "ENST00000430570.5",
"protein_id": "ENSP00000390626.1",
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"cds_start": -4,
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},
{
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"strand": false,
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],
"exon_rank": null,
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"gene_symbol": "CPNE1",
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"hgvs_c": "c.1-310C>A",
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"transcript": "ENST00000412056.5",
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},
{
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],
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"transcript": "ENST00000414664.5",
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 8,
"intron_rank": 1,
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"gene_symbol": "CPNE1",
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"hgvs_c": "c.1-310C>A",
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"transcript": "ENST00000439806.6",
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},
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],
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"gene_symbol": "CPNE1",
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"hgvs_c": "c.1-310C>A",
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"transcript": "ENST00000416778.5",
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},
{
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],
"exon_rank": null,
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"intron_rank": 2,
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"gene_symbol": "CPNE1",
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"hgvs_c": "c.1-310C>A",
"hgvs_p": null,
"transcript": "ENST00000420363.5",
"protein_id": "ENSP00000401915.1",
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},
{
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"strand": false,
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],
"exon_rank": null,
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"exon_count": 8,
"intron_rank": 2,
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"gene_symbol": "CPNE1",
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"hgvs_c": "c.1-310C>A",
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"transcript": "ENST00000434795.5",
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},
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],
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],
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},
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],
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"gene_symbol": "CPNE1",
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"hgvs_c": "c.1-310C>A",
"hgvs_p": null,
"transcript": "ENST00000458038.5",
"protein_id": "ENSP00000390141.1",
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "CPNE1",
"gene_hgnc_id": 2314,
"hgvs_c": "c.1-310C>A",
"hgvs_p": null,
"transcript": "ENST00000414711.5",
"protein_id": "ENSP00000409955.1",
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},
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}
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}