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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 20-36653614-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=20&pos=36653614&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "20",
"pos": 36653614,
"ref": "C",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_032013.4",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NDRG3",
"gene_hgnc_id": 14462,
"hgvs_c": "c.1034G>A",
"hgvs_p": "p.Arg345Gln",
"transcript": "NM_032013.4",
"protein_id": "NP_114402.1",
"transcript_support_level": null,
"aa_start": 345,
"aa_end": null,
"aa_length": 375,
"cds_start": 1034,
"cds_end": null,
"cds_length": 1128,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000349004.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_032013.4"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NDRG3",
"gene_hgnc_id": 14462,
"hgvs_c": "c.1034G>A",
"hgvs_p": "p.Arg345Gln",
"transcript": "ENST00000349004.6",
"protein_id": "ENSP00000345292.1",
"transcript_support_level": 1,
"aa_start": 345,
"aa_end": null,
"aa_length": 375,
"cds_start": 1034,
"cds_end": null,
"cds_length": 1128,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_032013.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000349004.6"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NDRG3",
"gene_hgnc_id": 14462,
"hgvs_c": "c.998G>A",
"hgvs_p": "p.Arg333Gln",
"transcript": "ENST00000359675.6",
"protein_id": "ENSP00000352703.2",
"transcript_support_level": 1,
"aa_start": 333,
"aa_end": null,
"aa_length": 363,
"cds_start": 998,
"cds_end": null,
"cds_length": 1092,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000359675.6"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NDRG3",
"gene_hgnc_id": 14462,
"hgvs_c": "c.749G>A",
"hgvs_p": "p.Arg250Gln",
"transcript": "ENST00000373773.7",
"protein_id": "ENSP00000362878.3",
"transcript_support_level": 1,
"aa_start": 250,
"aa_end": null,
"aa_length": 280,
"cds_start": 749,
"cds_end": null,
"cds_length": 843,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000373773.7"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NDRG3",
"gene_hgnc_id": 14462,
"hgvs_c": "c.1166G>A",
"hgvs_p": "p.Arg389Gln",
"transcript": "ENST00000930948.1",
"protein_id": "ENSP00000601007.1",
"transcript_support_level": null,
"aa_start": 389,
"aa_end": null,
"aa_length": 419,
"cds_start": 1166,
"cds_end": null,
"cds_length": 1260,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000930948.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NDRG3",
"gene_hgnc_id": 14462,
"hgvs_c": "c.1160G>A",
"hgvs_p": "p.Arg387Gln",
"transcript": "ENST00000956895.1",
"protein_id": "ENSP00000626954.1",
"transcript_support_level": null,
"aa_start": 387,
"aa_end": null,
"aa_length": 417,
"cds_start": 1160,
"cds_end": null,
"cds_length": 1254,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000956895.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NDRG3",
"gene_hgnc_id": 14462,
"hgvs_c": "c.1073G>A",
"hgvs_p": "p.Arg358Gln",
"transcript": "ENST00000373803.6",
"protein_id": "ENSP00000362909.2",
"transcript_support_level": 5,
"aa_start": 358,
"aa_end": null,
"aa_length": 388,
"cds_start": 1073,
"cds_end": null,
"cds_length": 1167,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000373803.6"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NDRG3",
"gene_hgnc_id": 14462,
"hgvs_c": "c.1073G>A",
"hgvs_p": "p.Arg358Gln",
"transcript": "ENST00000956896.1",
"protein_id": "ENSP00000626955.1",
"transcript_support_level": null,
"aa_start": 358,
"aa_end": null,
"aa_length": 388,
"cds_start": 1073,
"cds_end": null,
"cds_length": 1167,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000956896.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NDRG3",
"gene_hgnc_id": 14462,
"hgvs_c": "c.1037G>A",
"hgvs_p": "p.Arg346Gln",
"transcript": "ENST00000956892.1",
"protein_id": "ENSP00000626951.1",
"transcript_support_level": null,
"aa_start": 346,
"aa_end": null,
"aa_length": 376,
"cds_start": 1037,
"cds_end": null,
"cds_length": 1131,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000956892.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NDRG3",
"gene_hgnc_id": 14462,
"hgvs_c": "c.1034G>A",
"hgvs_p": "p.Arg345Gln",
"transcript": "ENST00000855486.1",
"protein_id": "ENSP00000525545.1",
"transcript_support_level": null,
"aa_start": 345,
"aa_end": null,
"aa_length": 375,
"cds_start": 1034,
"cds_end": null,
"cds_length": 1128,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000855486.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NDRG3",
"gene_hgnc_id": 14462,
"hgvs_c": "c.1034G>A",
"hgvs_p": "p.Arg345Gln",
"transcript": "ENST00000855487.1",
"protein_id": "ENSP00000525546.1",
"transcript_support_level": null,
"aa_start": 345,
"aa_end": null,
"aa_length": 375,
"cds_start": 1034,
"cds_end": null,
"cds_length": 1128,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000855487.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NDRG3",
"gene_hgnc_id": 14462,
"hgvs_c": "c.1034G>A",
"hgvs_p": "p.Arg345Gln",
"transcript": "ENST00000855488.1",
"protein_id": "ENSP00000525547.1",
"transcript_support_level": null,
"aa_start": 345,
"aa_end": null,
"aa_length": 375,
"cds_start": 1034,
"cds_end": null,
"cds_length": 1128,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000855488.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NDRG3",
"gene_hgnc_id": 14462,
"hgvs_c": "c.1034G>A",
"hgvs_p": "p.Arg345Gln",
"transcript": "ENST00000930946.1",
"protein_id": "ENSP00000601005.1",
"transcript_support_level": null,
"aa_start": 345,
"aa_end": null,
"aa_length": 375,
"cds_start": 1034,
"cds_end": null,
"cds_length": 1128,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000930946.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NDRG3",
"gene_hgnc_id": 14462,
"hgvs_c": "c.1034G>A",
"hgvs_p": "p.Arg345Gln",
"transcript": "ENST00000956894.1",
"protein_id": "ENSP00000626953.1",
"transcript_support_level": null,
"aa_start": 345,
"aa_end": null,
"aa_length": 375,
"cds_start": 1034,
"cds_end": null,
"cds_length": 1128,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000956894.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NDRG3",
"gene_hgnc_id": 14462,
"hgvs_c": "c.1034G>A",
"hgvs_p": "p.Arg345Gln",
"transcript": "ENST00000956898.1",
"protein_id": "ENSP00000626957.1",
"transcript_support_level": null,
"aa_start": 345,
"aa_end": null,
"aa_length": 375,
"cds_start": 1034,
"cds_end": null,
"cds_length": 1128,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000956898.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NDRG3",
"gene_hgnc_id": 14462,
"hgvs_c": "c.1031G>A",
"hgvs_p": "p.Arg344Gln",
"transcript": "ENST00000956893.1",
"protein_id": "ENSP00000626952.1",
"transcript_support_level": null,
"aa_start": 344,
"aa_end": null,
"aa_length": 374,
"cds_start": 1031,
"cds_end": null,
"cds_length": 1125,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000956893.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NDRG3",
"gene_hgnc_id": 14462,
"hgvs_c": "c.1025G>A",
"hgvs_p": "p.Arg342Gln",
"transcript": "ENST00000956897.1",
"protein_id": "ENSP00000626956.1",
"transcript_support_level": null,
"aa_start": 342,
"aa_end": null,
"aa_length": 372,
"cds_start": 1025,
"cds_end": null,
"cds_length": 1119,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000956897.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NDRG3",
"gene_hgnc_id": 14462,
"hgvs_c": "c.998G>A",
"hgvs_p": "p.Arg333Gln",
"transcript": "NM_022477.4",
"protein_id": "NP_071922.2",
"transcript_support_level": null,
"aa_start": 333,
"aa_end": null,
"aa_length": 363,
"cds_start": 998,
"cds_end": null,
"cds_length": 1092,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_022477.4"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NDRG3",
"gene_hgnc_id": 14462,
"hgvs_c": "c.986G>A",
"hgvs_p": "p.Arg329Gln",
"transcript": "ENST00000855485.1",
"protein_id": "ENSP00000525544.1",
"transcript_support_level": null,
"aa_start": 329,
"aa_end": null,
"aa_length": 359,
"cds_start": 986,
"cds_end": null,
"cds_length": 1080,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000855485.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NDRG3",
"gene_hgnc_id": 14462,
"hgvs_c": "c.986G>A",
"hgvs_p": "p.Arg329Gln",
"transcript": "ENST00000930947.1",
"protein_id": "ENSP00000601006.1",
"transcript_support_level": null,
"aa_start": 329,
"aa_end": null,
"aa_length": 359,
"cds_start": 986,
"cds_end": null,
"cds_length": 1080,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000930947.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NDRG3",
"gene_hgnc_id": 14462,
"hgvs_c": "c.977G>A",
"hgvs_p": "p.Arg326Gln",
"transcript": "ENST00000930944.1",
"protein_id": "ENSP00000601003.1",
"transcript_support_level": null,
"aa_start": 326,
"aa_end": null,
"aa_length": 356,
"cds_start": 977,
"cds_end": null,
"cds_length": 1071,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000930944.1"
},
{
"aa_ref": "R",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NDRG3",
"gene_hgnc_id": 14462,
"hgvs_c": "c.950G>A",
"hgvs_p": "p.Arg317Gln",
"transcript": "ENST00000930945.1",
"protein_id": "ENSP00000601004.1",
"transcript_support_level": null,
"aa_start": 317,
"aa_end": null,
"aa_length": 347,
"cds_start": 950,
"cds_end": null,
"cds_length": 1044,
"cdna_start": null,
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{
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],
"clinvar_disease": "not specified",
"clinvar_classification": "Uncertain significance",
"clinvar_review_status": "criteria provided, single submitter",
"clinvar_submissions_summary": "US:1",
"phenotype_combined": "not specified",
"pathogenicity_classification_combined": "Uncertain significance",
"custom_annotations": null
}
],
"message": null
}