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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 20-36897876-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=20&pos=36897876&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "20",
"pos": 36897876,
"ref": "G",
"alt": "A",
"effect": "synonymous_variant",
"transcript": "NM_015474.4",
"consequences": [
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SAMHD1",
"gene_hgnc_id": 15925,
"hgvs_c": "c.1692C>T",
"hgvs_p": "p.Ala564Ala",
"transcript": "NM_015474.4",
"protein_id": "NP_056289.2",
"transcript_support_level": null,
"aa_start": 564,
"aa_end": null,
"aa_length": 626,
"cds_start": 1692,
"cds_end": null,
"cds_length": 1881,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000646673.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_015474.4"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SAMHD1",
"gene_hgnc_id": 15925,
"hgvs_c": "c.1692C>T",
"hgvs_p": "p.Ala564Ala",
"transcript": "ENST00000646673.2",
"protein_id": "ENSP00000493536.2",
"transcript_support_level": null,
"aa_start": 564,
"aa_end": null,
"aa_length": 626,
"cds_start": 1692,
"cds_end": null,
"cds_length": 1881,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_015474.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000646673.2"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SAMHD1",
"gene_hgnc_id": 15925,
"hgvs_c": "c.1587C>T",
"hgvs_p": "p.Ala529Ala",
"transcript": "ENST00000262878.5",
"protein_id": "ENSP00000262878.5",
"transcript_support_level": 1,
"aa_start": 529,
"aa_end": null,
"aa_length": 591,
"cds_start": 1587,
"cds_end": null,
"cds_length": 1776,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000262878.5"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SAMHD1",
"gene_hgnc_id": 15925,
"hgvs_c": "c.1830C>T",
"hgvs_p": "p.Ala610Ala",
"transcript": "ENST00000866371.1",
"protein_id": "ENSP00000536430.1",
"transcript_support_level": null,
"aa_start": 610,
"aa_end": null,
"aa_length": 672,
"cds_start": 1830,
"cds_end": null,
"cds_length": 2019,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000866371.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SAMHD1",
"gene_hgnc_id": 15925,
"hgvs_c": "c.1734C>T",
"hgvs_p": "p.Ala578Ala",
"transcript": "ENST00000866370.1",
"protein_id": "ENSP00000536429.1",
"transcript_support_level": null,
"aa_start": 578,
"aa_end": null,
"aa_length": 640,
"cds_start": 1734,
"cds_end": null,
"cds_length": 1923,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000866370.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SAMHD1",
"gene_hgnc_id": 15925,
"hgvs_c": "c.1689C>T",
"hgvs_p": "p.Ala563Ala",
"transcript": "ENST00000970830.1",
"protein_id": "ENSP00000640889.1",
"transcript_support_level": null,
"aa_start": 563,
"aa_end": null,
"aa_length": 625,
"cds_start": 1689,
"cds_end": null,
"cds_length": 1878,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000970830.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SAMHD1",
"gene_hgnc_id": 15925,
"hgvs_c": "c.1614C>T",
"hgvs_p": "p.Ala538Ala",
"transcript": "ENST00000866373.1",
"protein_id": "ENSP00000536432.1",
"transcript_support_level": null,
"aa_start": 538,
"aa_end": null,
"aa_length": 600,
"cds_start": 1614,
"cds_end": null,
"cds_length": 1803,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000866373.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SAMHD1",
"gene_hgnc_id": 15925,
"hgvs_c": "c.1587C>T",
"hgvs_p": "p.Ala529Ala",
"transcript": "NM_001363729.2",
"protein_id": "NP_001350658.1",
"transcript_support_level": null,
"aa_start": 529,
"aa_end": null,
"aa_length": 591,
"cds_start": 1587,
"cds_end": null,
"cds_length": 1776,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001363729.2"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SAMHD1",
"gene_hgnc_id": 15925,
"hgvs_c": "c.1692C>T",
"hgvs_p": "p.Ala564Ala",
"transcript": "NM_001363733.2",
"protein_id": "NP_001350662.1",
"transcript_support_level": null,
"aa_start": 564,
"aa_end": null,
"aa_length": 589,
"cds_start": 1692,
"cds_end": null,
"cds_length": 1770,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001363733.2"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SAMHD1",
"gene_hgnc_id": 15925,
"hgvs_c": "c.1692C>T",
"hgvs_p": "p.Ala564Ala",
"transcript": "ENST00000643918.1",
"protein_id": "ENSP00000493928.1",
"transcript_support_level": null,
"aa_start": 564,
"aa_end": null,
"aa_length": 589,
"cds_start": 1692,
"cds_end": null,
"cds_length": 1770,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000643918.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SAMHD1",
"gene_hgnc_id": 15925,
"hgvs_c": "c.1536C>T",
"hgvs_p": "p.Ala512Ala",
"transcript": "ENST00000866372.1",
"protein_id": "ENSP00000536431.1",
"transcript_support_level": null,
"aa_start": 512,
"aa_end": null,
"aa_length": 574,
"cds_start": 1536,
"cds_end": null,
"cds_length": 1725,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000866372.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SAMHD1",
"gene_hgnc_id": 15925,
"hgvs_c": "c.1482C>T",
"hgvs_p": "p.Ala494Ala",
"transcript": "ENST00000646066.1",
"protein_id": "ENSP00000495432.1",
"transcript_support_level": null,
"aa_start": 494,
"aa_end": null,
"aa_length": 556,
"cds_start": 1482,
"cds_end": null,
"cds_length": 1671,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000646066.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SAMHD1",
"gene_hgnc_id": 15925,
"hgvs_c": "c.1458C>T",
"hgvs_p": "p.Ala486Ala",
"transcript": "ENST00000926798.1",
"protein_id": "ENSP00000596857.1",
"transcript_support_level": null,
"aa_start": 486,
"aa_end": null,
"aa_length": 548,
"cds_start": 1458,
"cds_end": null,
"cds_length": 1647,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000926798.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SAMHD1",
"gene_hgnc_id": 15925,
"hgvs_c": "c.1377C>T",
"hgvs_p": "p.Ala459Ala",
"transcript": "ENST00000970831.1",
"protein_id": "ENSP00000640890.1",
"transcript_support_level": null,
"aa_start": 459,
"aa_end": null,
"aa_length": 521,
"cds_start": 1377,
"cds_end": null,
"cds_length": 1566,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000970831.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SAMHD1",
"gene_hgnc_id": 15925,
"hgvs_c": "c.315C>T",
"hgvs_p": "p.Ala105Ala",
"transcript": "ENST00000643825.1",
"protein_id": "ENSP00000495448.1",
"transcript_support_level": null,
"aa_start": 105,
"aa_end": null,
"aa_length": 139,
"cds_start": 315,
"cds_end": null,
"cds_length": 420,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000643825.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SAMHD1",
"gene_hgnc_id": 15925,
"hgvs_c": "c.207C>T",
"hgvs_p": "p.Ala69Ala",
"transcript": "ENST00000465985.2",
"protein_id": "ENSP00000496075.1",
"transcript_support_level": 3,
"aa_start": 69,
"aa_end": null,
"aa_length": 103,
"cds_start": 207,
"cds_end": null,
"cds_length": 312,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000465985.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SAMHD1",
"gene_hgnc_id": 15925,
"hgvs_c": "n.*1996C>T",
"hgvs_p": null,
"transcript": "ENST00000642186.1",
"protein_id": "ENSP00000494436.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000642186.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SAMHD1",
"gene_hgnc_id": 15925,
"hgvs_c": "n.*1371C>T",
"hgvs_p": null,
"transcript": "ENST00000642246.1",
"protein_id": "ENSP00000494979.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000642246.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SAMHD1",
"gene_hgnc_id": 15925,
"hgvs_c": "n.*145C>T",
"hgvs_p": null,
"transcript": "ENST00000644114.2",
"protein_id": "ENSP00000494354.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000644114.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SAMHD1",
"gene_hgnc_id": 15925,
"hgvs_c": "n.1587C>T",
"hgvs_p": null,
"transcript": "ENST00000644250.2",
"protein_id": "ENSP00000493810.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000644250.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SAMHD1",
"gene_hgnc_id": 15925,
"hgvs_c": "n.*869C>T",
"hgvs_p": null,
"transcript": "ENST00000645033.1",
"protein_id": "ENSP00000494520.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000645033.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SAMHD1",
"gene_hgnc_id": 15925,
"hgvs_c": "n.1692C>T",
"hgvs_p": null,
"transcript": "ENST00000646869.1",
"protein_id": "ENSP00000495667.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
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"biotype": "nonsense_mediated_decay",
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"clinvar_review_status": "criteria provided, multiple submitters, no conflicts",
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"custom_annotations": null
}
],
"message": null
}