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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 20-37316410-C-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=20&pos=37316410&ref=C&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "20",
"pos": 37316410,
"ref": "C",
"alt": "G",
"effect": "missense_variant",
"transcript": "NM_022077.4",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MANBAL",
"gene_hgnc_id": 15799,
"hgvs_c": "c.253C>G",
"hgvs_p": "p.Arg85Gly",
"transcript": "NM_001003897.2",
"protein_id": "NP_001003897.1",
"transcript_support_level": null,
"aa_start": 85,
"aa_end": null,
"aa_length": 85,
"cds_start": 253,
"cds_end": null,
"cds_length": 258,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000373606.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001003897.2"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MANBAL",
"gene_hgnc_id": 15799,
"hgvs_c": "c.253C>G",
"hgvs_p": "p.Arg85Gly",
"transcript": "ENST00000373606.8",
"protein_id": "ENSP00000362708.3",
"transcript_support_level": 1,
"aa_start": 85,
"aa_end": null,
"aa_length": 85,
"cds_start": 253,
"cds_end": null,
"cds_length": 258,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001003897.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000373606.8"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MANBAL",
"gene_hgnc_id": 15799,
"hgvs_c": "c.253C>G",
"hgvs_p": "p.Arg85Gly",
"transcript": "ENST00000397152.7",
"protein_id": "ENSP00000380339.3",
"transcript_support_level": 1,
"aa_start": 85,
"aa_end": null,
"aa_length": 85,
"cds_start": 253,
"cds_end": null,
"cds_length": 258,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000397152.7"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MANBAL",
"gene_hgnc_id": 15799,
"hgvs_c": "c.253C>G",
"hgvs_p": "p.Arg85Gly",
"transcript": "NM_001369742.1",
"protein_id": "NP_001356671.1",
"transcript_support_level": null,
"aa_start": 85,
"aa_end": null,
"aa_length": 85,
"cds_start": 253,
"cds_end": null,
"cds_length": 258,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001369742.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MANBAL",
"gene_hgnc_id": 15799,
"hgvs_c": "c.253C>G",
"hgvs_p": "p.Arg85Gly",
"transcript": "NM_001369743.1",
"protein_id": "NP_001356672.1",
"transcript_support_level": null,
"aa_start": 85,
"aa_end": null,
"aa_length": 85,
"cds_start": 253,
"cds_end": null,
"cds_length": 258,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001369743.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MANBAL",
"gene_hgnc_id": 15799,
"hgvs_c": "c.253C>G",
"hgvs_p": "p.Arg85Gly",
"transcript": "NM_001376529.1",
"protein_id": "NP_001363458.1",
"transcript_support_level": null,
"aa_start": 85,
"aa_end": null,
"aa_length": 85,
"cds_start": 253,
"cds_end": null,
"cds_length": 258,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001376529.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MANBAL",
"gene_hgnc_id": 15799,
"hgvs_c": "c.253C>G",
"hgvs_p": "p.Arg85Gly",
"transcript": "NM_001376530.1",
"protein_id": "NP_001363459.1",
"transcript_support_level": null,
"aa_start": 85,
"aa_end": null,
"aa_length": 85,
"cds_start": 253,
"cds_end": null,
"cds_length": 258,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001376530.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MANBAL",
"gene_hgnc_id": 15799,
"hgvs_c": "c.253C>G",
"hgvs_p": "p.Arg85Gly",
"transcript": "NM_001376531.1",
"protein_id": "NP_001363460.1",
"transcript_support_level": null,
"aa_start": 85,
"aa_end": null,
"aa_length": 85,
"cds_start": 253,
"cds_end": null,
"cds_length": 258,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001376531.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MANBAL",
"gene_hgnc_id": 15799,
"hgvs_c": "c.253C>G",
"hgvs_p": "p.Arg85Gly",
"transcript": "NM_001376532.1",
"protein_id": "NP_001363461.1",
"transcript_support_level": null,
"aa_start": 85,
"aa_end": null,
"aa_length": 85,
"cds_start": 253,
"cds_end": null,
"cds_length": 258,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001376532.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MANBAL",
"gene_hgnc_id": 15799,
"hgvs_c": "c.253C>G",
"hgvs_p": "p.Arg85Gly",
"transcript": "NM_001376533.1",
"protein_id": "NP_001363462.1",
"transcript_support_level": null,
"aa_start": 85,
"aa_end": null,
"aa_length": 85,
"cds_start": 253,
"cds_end": null,
"cds_length": 258,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001376533.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MANBAL",
"gene_hgnc_id": 15799,
"hgvs_c": "c.253C>G",
"hgvs_p": "p.Arg85Gly",
"transcript": "NM_001387335.1",
"protein_id": "NP_001374264.1",
"transcript_support_level": null,
"aa_start": 85,
"aa_end": null,
"aa_length": 85,
"cds_start": 253,
"cds_end": null,
"cds_length": 258,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001387335.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MANBAL",
"gene_hgnc_id": 15799,
"hgvs_c": "c.253C>G",
"hgvs_p": "p.Arg85Gly",
"transcript": "NM_022077.4",
"protein_id": "NP_071360.1",
"transcript_support_level": null,
"aa_start": 85,
"aa_end": null,
"aa_length": 85,
"cds_start": 253,
"cds_end": null,
"cds_length": 258,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_022077.4"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MANBAL",
"gene_hgnc_id": 15799,
"hgvs_c": "c.253C>G",
"hgvs_p": "p.Arg85Gly",
"transcript": "ENST00000373605.7",
"protein_id": "ENSP00000362707.3",
"transcript_support_level": 2,
"aa_start": 85,
"aa_end": null,
"aa_length": 85,
"cds_start": 253,
"cds_end": null,
"cds_length": 258,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000373605.7"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MANBAL",
"gene_hgnc_id": 15799,
"hgvs_c": "c.253C>G",
"hgvs_p": "p.Arg85Gly",
"transcript": "ENST00000397151.1",
"protein_id": "ENSP00000380338.1",
"transcript_support_level": 3,
"aa_start": 85,
"aa_end": null,
"aa_length": 85,
"cds_start": 253,
"cds_end": null,
"cds_length": 258,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000397151.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MANBAL",
"gene_hgnc_id": 15799,
"hgvs_c": "c.253C>G",
"hgvs_p": "p.Arg85Gly",
"transcript": "ENST00000910092.1",
"protein_id": "ENSP00000580151.1",
"transcript_support_level": null,
"aa_start": 85,
"aa_end": null,
"aa_length": 85,
"cds_start": 253,
"cds_end": null,
"cds_length": 258,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000910092.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MANBAL",
"gene_hgnc_id": 15799,
"hgvs_c": "c.253C>G",
"hgvs_p": "p.Arg85Gly",
"transcript": "ENST00000910093.1",
"protein_id": "ENSP00000580152.1",
"transcript_support_level": null,
"aa_start": 85,
"aa_end": null,
"aa_length": 85,
"cds_start": 253,
"cds_end": null,
"cds_length": 258,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000910093.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MANBAL",
"gene_hgnc_id": 15799,
"hgvs_c": "c.253C>G",
"hgvs_p": "p.Arg85Gly",
"transcript": "ENST00000910094.1",
"protein_id": "ENSP00000580153.1",
"transcript_support_level": null,
"aa_start": 85,
"aa_end": null,
"aa_length": 85,
"cds_start": 253,
"cds_end": null,
"cds_length": 258,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000910094.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MANBAL",
"gene_hgnc_id": 15799,
"hgvs_c": "c.253C>G",
"hgvs_p": "p.Arg85Gly",
"transcript": "ENST00000910095.1",
"protein_id": "ENSP00000580154.1",
"transcript_support_level": null,
"aa_start": 85,
"aa_end": null,
"aa_length": 85,
"cds_start": 253,
"cds_end": null,
"cds_length": 258,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000910095.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MANBAL",
"gene_hgnc_id": 15799,
"hgvs_c": "c.253C>G",
"hgvs_p": "p.Arg85Gly",
"transcript": "ENST00000910096.1",
"protein_id": "ENSP00000580155.1",
"transcript_support_level": null,
"aa_start": 85,
"aa_end": null,
"aa_length": 85,
"cds_start": 253,
"cds_end": null,
"cds_length": 258,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000910096.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MANBAL",
"gene_hgnc_id": 15799,
"hgvs_c": "c.253C>G",
"hgvs_p": "p.Arg85Gly",
"transcript": "ENST00000910097.1",
"protein_id": "ENSP00000580156.1",
"transcript_support_level": null,
"aa_start": 85,
"aa_end": null,
"aa_length": 85,
"cds_start": 253,
"cds_end": null,
"cds_length": 258,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000910097.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MANBAL",
"gene_hgnc_id": 15799,
"hgvs_c": "c.253C>G",
"hgvs_p": "p.Arg85Gly",
"transcript": "ENST00000910098.1",
"protein_id": "ENSP00000580157.1",
"transcript_support_level": null,
"aa_start": 85,
"aa_end": null,
"aa_length": 85,
"cds_start": 253,
"cds_end": null,
"cds_length": 258,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000910098.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MANBAL",
"gene_hgnc_id": 15799,
"hgvs_c": "c.253C>G",
"hgvs_p": "p.Arg85Gly",
"transcript": "ENST00000910099.1",
"protein_id": "ENSP00000580158.1",
"transcript_support_level": null,
"aa_start": 85,
"aa_end": null,
"aa_length": 85,
"cds_start": 253,
"cds_end": null,
"cds_length": 258,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000910099.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
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