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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 20-37403347-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=20&pos=37403347&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "20",
"pos": 37403347,
"ref": "G",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_005417.5",
"consequences": [
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SRC",
"gene_hgnc_id": 11283,
"hgvs_c": "c.1579G>C",
"hgvs_p": "p.Glu527Gln",
"transcript": "NM_198291.3",
"protein_id": "NP_938033.1",
"transcript_support_level": null,
"aa_start": 527,
"aa_end": null,
"aa_length": 536,
"cds_start": 1579,
"cds_end": null,
"cds_length": 1611,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000373578.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_198291.3"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SRC",
"gene_hgnc_id": 11283,
"hgvs_c": "c.1579G>C",
"hgvs_p": "p.Glu527Gln",
"transcript": "ENST00000373578.7",
"protein_id": "ENSP00000362680.2",
"transcript_support_level": 5,
"aa_start": 527,
"aa_end": null,
"aa_length": 536,
"cds_start": 1579,
"cds_end": null,
"cds_length": 1611,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_198291.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000373578.7"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SRC",
"gene_hgnc_id": 11283,
"hgvs_c": "c.1630G>C",
"hgvs_p": "p.Glu544Gln",
"transcript": "ENST00000358208.9",
"protein_id": "ENSP00000350941.5",
"transcript_support_level": 1,
"aa_start": 544,
"aa_end": null,
"aa_length": 553,
"cds_start": 1630,
"cds_end": null,
"cds_length": 1662,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000358208.9"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SRC",
"gene_hgnc_id": 11283,
"hgvs_c": "c.1579G>C",
"hgvs_p": "p.Glu527Gln",
"transcript": "ENST00000373567.6",
"protein_id": "ENSP00000362668.2",
"transcript_support_level": 1,
"aa_start": 527,
"aa_end": null,
"aa_length": 536,
"cds_start": 1579,
"cds_end": null,
"cds_length": 1611,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000373567.6"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SRC",
"gene_hgnc_id": 11283,
"hgvs_c": "c.1654G>C",
"hgvs_p": "p.Glu552Gln",
"transcript": "ENST00000876231.1",
"protein_id": "ENSP00000546290.1",
"transcript_support_level": null,
"aa_start": 552,
"aa_end": null,
"aa_length": 561,
"cds_start": 1654,
"cds_end": null,
"cds_length": 1686,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876231.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SRC",
"gene_hgnc_id": 11283,
"hgvs_c": "c.1612G>C",
"hgvs_p": "p.Glu538Gln",
"transcript": "ENST00000876235.1",
"protein_id": "ENSP00000546294.1",
"transcript_support_level": null,
"aa_start": 538,
"aa_end": null,
"aa_length": 547,
"cds_start": 1612,
"cds_end": null,
"cds_length": 1644,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876235.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SRC",
"gene_hgnc_id": 11283,
"hgvs_c": "c.1597G>C",
"hgvs_p": "p.Glu533Gln",
"transcript": "ENST00000373558.2",
"protein_id": "ENSP00000362659.2",
"transcript_support_level": 5,
"aa_start": 533,
"aa_end": null,
"aa_length": 542,
"cds_start": 1597,
"cds_end": null,
"cds_length": 1629,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000373558.2"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SRC",
"gene_hgnc_id": 11283,
"hgvs_c": "c.1579G>C",
"hgvs_p": "p.Glu527Gln",
"transcript": "NM_005417.5",
"protein_id": "NP_005408.1",
"transcript_support_level": null,
"aa_start": 527,
"aa_end": null,
"aa_length": 536,
"cds_start": 1579,
"cds_end": null,
"cds_length": 1611,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_005417.5"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SRC",
"gene_hgnc_id": 11283,
"hgvs_c": "c.1579G>C",
"hgvs_p": "p.Glu527Gln",
"transcript": "ENST00000692112.1",
"protein_id": "ENSP00000508666.1",
"transcript_support_level": null,
"aa_start": 527,
"aa_end": null,
"aa_length": 536,
"cds_start": 1579,
"cds_end": null,
"cds_length": 1611,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000692112.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SRC",
"gene_hgnc_id": 11283,
"hgvs_c": "c.1579G>C",
"hgvs_p": "p.Glu527Gln",
"transcript": "ENST00000692423.1",
"protein_id": "ENSP00000509325.1",
"transcript_support_level": null,
"aa_start": 527,
"aa_end": null,
"aa_length": 536,
"cds_start": 1579,
"cds_end": null,
"cds_length": 1611,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000692423.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SRC",
"gene_hgnc_id": 11283,
"hgvs_c": "c.1579G>C",
"hgvs_p": "p.Glu527Gln",
"transcript": "ENST00000876226.1",
"protein_id": "ENSP00000546285.1",
"transcript_support_level": null,
"aa_start": 527,
"aa_end": null,
"aa_length": 536,
"cds_start": 1579,
"cds_end": null,
"cds_length": 1611,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876226.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SRC",
"gene_hgnc_id": 11283,
"hgvs_c": "c.1579G>C",
"hgvs_p": "p.Glu527Gln",
"transcript": "ENST00000876227.1",
"protein_id": "ENSP00000546286.1",
"transcript_support_level": null,
"aa_start": 527,
"aa_end": null,
"aa_length": 536,
"cds_start": 1579,
"cds_end": null,
"cds_length": 1611,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876227.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SRC",
"gene_hgnc_id": 11283,
"hgvs_c": "c.1579G>C",
"hgvs_p": "p.Glu527Gln",
"transcript": "ENST00000876228.1",
"protein_id": "ENSP00000546287.1",
"transcript_support_level": null,
"aa_start": 527,
"aa_end": null,
"aa_length": 536,
"cds_start": 1579,
"cds_end": null,
"cds_length": 1611,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876228.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SRC",
"gene_hgnc_id": 11283,
"hgvs_c": "c.1579G>C",
"hgvs_p": "p.Glu527Gln",
"transcript": "ENST00000876229.1",
"protein_id": "ENSP00000546288.1",
"transcript_support_level": null,
"aa_start": 527,
"aa_end": null,
"aa_length": 536,
"cds_start": 1579,
"cds_end": null,
"cds_length": 1611,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876229.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SRC",
"gene_hgnc_id": 11283,
"hgvs_c": "c.1579G>C",
"hgvs_p": "p.Glu527Gln",
"transcript": "ENST00000876230.1",
"protein_id": "ENSP00000546289.1",
"transcript_support_level": null,
"aa_start": 527,
"aa_end": null,
"aa_length": 536,
"cds_start": 1579,
"cds_end": null,
"cds_length": 1611,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876230.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SRC",
"gene_hgnc_id": 11283,
"hgvs_c": "c.1579G>C",
"hgvs_p": "p.Glu527Gln",
"transcript": "ENST00000876232.1",
"protein_id": "ENSP00000546291.1",
"transcript_support_level": null,
"aa_start": 527,
"aa_end": null,
"aa_length": 536,
"cds_start": 1579,
"cds_end": null,
"cds_length": 1611,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876232.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SRC",
"gene_hgnc_id": 11283,
"hgvs_c": "c.1579G>C",
"hgvs_p": "p.Glu527Gln",
"transcript": "ENST00000876233.1",
"protein_id": "ENSP00000546292.1",
"transcript_support_level": null,
"aa_start": 527,
"aa_end": null,
"aa_length": 536,
"cds_start": 1579,
"cds_end": null,
"cds_length": 1611,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876233.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SRC",
"gene_hgnc_id": 11283,
"hgvs_c": "c.1579G>C",
"hgvs_p": "p.Glu527Gln",
"transcript": "ENST00000876234.1",
"protein_id": "ENSP00000546293.1",
"transcript_support_level": null,
"aa_start": 527,
"aa_end": null,
"aa_length": 536,
"cds_start": 1579,
"cds_end": null,
"cds_length": 1611,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876234.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SRC",
"gene_hgnc_id": 11283,
"hgvs_c": "c.1579G>C",
"hgvs_p": "p.Glu527Gln",
"transcript": "ENST00000876236.1",
"protein_id": "ENSP00000546295.1",
"transcript_support_level": null,
"aa_start": 527,
"aa_end": null,
"aa_length": 536,
"cds_start": 1579,
"cds_end": null,
"cds_length": 1611,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876236.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SRC",
"gene_hgnc_id": 11283,
"hgvs_c": "c.1579G>C",
"hgvs_p": "p.Glu527Gln",
"transcript": "ENST00000876237.1",
"protein_id": "ENSP00000546296.1",
"transcript_support_level": null,
"aa_start": 527,
"aa_end": null,
"aa_length": 536,
"cds_start": 1579,
"cds_end": null,
"cds_length": 1611,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876237.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SRC",
"gene_hgnc_id": 11283,
"hgvs_c": "c.1579G>C",
"hgvs_p": "p.Glu527Gln",
"transcript": "ENST00000921683.1",
"protein_id": "ENSP00000591742.1",
"transcript_support_level": null,
"aa_start": 527,
"aa_end": null,
"aa_length": 536,
"cds_start": 1579,
"cds_end": null,
"cds_length": 1611,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000921683.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SRC",
"gene_hgnc_id": 11283,
"hgvs_c": "c.1579G>C",
"hgvs_p": "p.Glu527Gln",
"transcript": "ENST00000921684.1",
"protein_id": "ENSP00000591743.1",
"transcript_support_level": null,
"aa_start": 527,
"aa_end": null,
"aa_length": 536,
"cds_start": 1579,
"cds_end": null,
"cds_length": 1611,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000921684.1"
},
{
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"clinvar_disease": "",
"clinvar_classification": "",
"clinvar_review_status": "",
"clinvar_submissions_summary": "",
"phenotype_combined": null,
"pathogenicity_classification_combined": null,
"custom_annotations": null
}
],
"message": null
}