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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 20-45897769-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=20&pos=45897769&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "20",
"pos": 45897769,
"ref": "T",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_000308.4",
"consequences": [
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "c.1217T>C",
"hgvs_p": "p.Met406Thr",
"transcript": "NM_000308.4",
"protein_id": "NP_000299.3",
"transcript_support_level": null,
"aa_start": 406,
"aa_end": null,
"aa_length": 480,
"cds_start": 1217,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 1262,
"cdna_end": null,
"cdna_length": 1858,
"mane_select": "ENST00000646241.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_000308.4"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "c.1217T>C",
"hgvs_p": "p.Met406Thr",
"transcript": "ENST00000646241.3",
"protein_id": "ENSP00000493613.2",
"transcript_support_level": null,
"aa_start": 406,
"aa_end": null,
"aa_length": 480,
"cds_start": 1217,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 1262,
"cdna_end": null,
"cdna_length": 1858,
"mane_select": "NM_000308.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000646241.3"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "c.1271T>C",
"hgvs_p": "p.Met424Thr",
"transcript": "ENST00000372484.8",
"protein_id": "ENSP00000361562.3",
"transcript_support_level": 1,
"aa_start": 424,
"aa_end": null,
"aa_length": 498,
"cds_start": 1271,
"cds_end": null,
"cds_length": 1497,
"cdna_start": 2343,
"cdna_end": null,
"cdna_length": 2939,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000372484.8"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "c.1217T>C",
"hgvs_p": "p.Met406Thr",
"transcript": "ENST00000191018.9",
"protein_id": "ENSP00000191018.5",
"transcript_support_level": 1,
"aa_start": 406,
"aa_end": null,
"aa_length": 480,
"cds_start": 1217,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 1302,
"cdna_end": null,
"cdna_length": 1898,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000191018.9"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "c.1217T>C",
"hgvs_p": "p.Met406Thr",
"transcript": "ENST00000372459.7",
"protein_id": "ENSP00000361537.2",
"transcript_support_level": 1,
"aa_start": 406,
"aa_end": null,
"aa_length": 480,
"cds_start": 1217,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 1400,
"cdna_end": null,
"cdna_length": 1996,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000372459.7"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "n.3774T>C",
"hgvs_p": null,
"transcript": "ENST00000484855.4",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4697,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000484855.4"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "c.1370T>C",
"hgvs_p": "p.Met457Thr",
"transcript": "ENST00000958428.1",
"protein_id": "ENSP00000628487.1",
"transcript_support_level": null,
"aa_start": 457,
"aa_end": null,
"aa_length": 531,
"cds_start": 1370,
"cds_end": null,
"cds_length": 1596,
"cdna_start": 1397,
"cdna_end": null,
"cdna_length": 1990,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000958428.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "c.1334T>C",
"hgvs_p": "p.Met445Thr",
"transcript": "ENST00000867522.1",
"protein_id": "ENSP00000537581.1",
"transcript_support_level": null,
"aa_start": 445,
"aa_end": null,
"aa_length": 519,
"cds_start": 1334,
"cds_end": null,
"cds_length": 1560,
"cdna_start": 1334,
"cdna_end": null,
"cdna_length": 1930,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867522.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "c.1271T>C",
"hgvs_p": "p.Met424Thr",
"transcript": "ENST00000677394.1",
"protein_id": "ENSP00000504790.1",
"transcript_support_level": null,
"aa_start": 424,
"aa_end": null,
"aa_length": 498,
"cds_start": 1271,
"cds_end": null,
"cds_length": 1497,
"cdna_start": 2197,
"cdna_end": null,
"cdna_length": 2774,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000677394.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "c.1217T>C",
"hgvs_p": "p.Met406Thr",
"transcript": "NM_001127695.3",
"protein_id": "NP_001121167.1",
"transcript_support_level": null,
"aa_start": 406,
"aa_end": null,
"aa_length": 480,
"cds_start": 1217,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 1308,
"cdna_end": null,
"cdna_length": 1904,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001127695.3"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "c.1217T>C",
"hgvs_p": "p.Met406Thr",
"transcript": "ENST00000607482.6",
"protein_id": "ENSP00000475524.2",
"transcript_support_level": 3,
"aa_start": 406,
"aa_end": null,
"aa_length": 480,
"cds_start": 1217,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 1291,
"cdna_end": null,
"cdna_length": 1887,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000607482.6"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "c.1217T>C",
"hgvs_p": "p.Met406Thr",
"transcript": "ENST00000867515.1",
"protein_id": "ENSP00000537574.1",
"transcript_support_level": null,
"aa_start": 406,
"aa_end": null,
"aa_length": 480,
"cds_start": 1217,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 1262,
"cdna_end": null,
"cdna_length": 1858,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867515.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "c.1217T>C",
"hgvs_p": "p.Met406Thr",
"transcript": "ENST00000867518.1",
"protein_id": "ENSP00000537577.1",
"transcript_support_level": null,
"aa_start": 406,
"aa_end": null,
"aa_length": 480,
"cds_start": 1217,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 1363,
"cdna_end": null,
"cdna_length": 1959,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867518.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "c.1217T>C",
"hgvs_p": "p.Met406Thr",
"transcript": "ENST00000958426.1",
"protein_id": "ENSP00000628485.1",
"transcript_support_level": null,
"aa_start": 406,
"aa_end": null,
"aa_length": 480,
"cds_start": 1217,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 1279,
"cdna_end": null,
"cdna_length": 1871,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000958426.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "c.1211T>C",
"hgvs_p": "p.Met404Thr",
"transcript": "ENST00000867516.1",
"protein_id": "ENSP00000537575.1",
"transcript_support_level": null,
"aa_start": 404,
"aa_end": null,
"aa_length": 478,
"cds_start": 1211,
"cds_end": null,
"cds_length": 1437,
"cdna_start": 1253,
"cdna_end": null,
"cdna_length": 1849,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867516.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "c.1217T>C",
"hgvs_p": "p.Met406Thr",
"transcript": "ENST00000958422.1",
"protein_id": "ENSP00000628481.1",
"transcript_support_level": null,
"aa_start": 406,
"aa_end": null,
"aa_length": 478,
"cds_start": 1217,
"cds_end": null,
"cds_length": 1437,
"cdna_start": 1282,
"cdna_end": null,
"cdna_length": 1872,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000958422.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "c.1211T>C",
"hgvs_p": "p.Met404Thr",
"transcript": "ENST00000958423.1",
"protein_id": "ENSP00000628482.1",
"transcript_support_level": null,
"aa_start": 404,
"aa_end": null,
"aa_length": 478,
"cds_start": 1211,
"cds_end": null,
"cds_length": 1437,
"cdna_start": 1269,
"cdna_end": null,
"cdna_length": 1865,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000958423.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "c.1208T>C",
"hgvs_p": "p.Met403Thr",
"transcript": "ENST00000867514.1",
"protein_id": "ENSP00000537573.1",
"transcript_support_level": null,
"aa_start": 403,
"aa_end": null,
"aa_length": 477,
"cds_start": 1208,
"cds_end": null,
"cds_length": 1434,
"cdna_start": 1260,
"cdna_end": null,
"cdna_length": 1856,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867514.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "c.1178T>C",
"hgvs_p": "p.Met393Thr",
"transcript": "ENST00000867517.1",
"protein_id": "ENSP00000537576.1",
"transcript_support_level": null,
"aa_start": 393,
"aa_end": null,
"aa_length": 467,
"cds_start": 1178,
"cds_end": null,
"cds_length": 1404,
"cdna_start": 1216,
"cdna_end": null,
"cdna_length": 1812,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867517.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "c.1178T>C",
"hgvs_p": "p.Met393Thr",
"transcript": "ENST00000958432.1",
"protein_id": "ENSP00000628491.1",
"transcript_support_level": null,
"aa_start": 393,
"aa_end": null,
"aa_length": 467,
"cds_start": 1178,
"cds_end": null,
"cds_length": 1404,
"cdna_start": 1228,
"cdna_end": null,
"cdna_length": 1821,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000958432.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "c.1166T>C",
"hgvs_p": "p.Met389Thr",
"transcript": "NM_001167594.3",
"protein_id": "NP_001161066.2",
"transcript_support_level": null,
"aa_start": 389,
"aa_end": null,
"aa_length": 463,
"cds_start": 1166,
"cds_end": null,
"cds_length": 1392,
"cdna_start": 1211,
"cdna_end": null,
"cdna_length": 1807,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001167594.3"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CTSA",
"gene_hgnc_id": 9251,
"hgvs_c": "c.1166T>C",
"hgvs_p": "p.Met389Thr",
"transcript": "ENST00000354880.9",
"protein_id": "ENSP00000346952.5",
"transcript_support_level": 2,
"aa_start": 389,
"aa_end": null,
"aa_length": 463,
"cds_start": 1166,
"cds_end": null,
"cds_length": 1392,
"cdna_start": 1224,
"cdna_end": null,
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"clinvar_classification": "Pathogenic",
"clinvar_review_status": "no assertion criteria provided",
"clinvar_submissions_summary": "null",
"phenotype_combined": "Galactosialidosis, late infantile",
"pathogenicity_classification_combined": "Pathogenic",
"custom_annotations": null
}
],
"message": null
}