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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 20-63285688-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=20&pos=63285688&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "20",
"pos": 63285688,
"ref": "G",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_018209.4",
"consequences": [
{
"aa_ref": "S",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP1",
"gene_hgnc_id": 15852,
"hgvs_c": "c.809G>C",
"hgvs_p": "p.Ser270Thr",
"transcript": "NM_018209.4",
"protein_id": "NP_060679.1",
"transcript_support_level": null,
"aa_start": 270,
"aa_end": null,
"aa_length": 406,
"cds_start": 809,
"cds_end": null,
"cds_length": 1221,
"cdna_start": 921,
"cdna_end": null,
"cdna_length": 3250,
"mane_select": "ENST00000370283.9",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "T",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP1",
"gene_hgnc_id": 15852,
"hgvs_c": "c.809G>C",
"hgvs_p": "p.Ser270Thr",
"transcript": "ENST00000370283.9",
"protein_id": "ENSP00000359306.4",
"transcript_support_level": 1,
"aa_start": 270,
"aa_end": null,
"aa_length": 406,
"cds_start": 809,
"cds_end": null,
"cds_length": 1221,
"cdna_start": 921,
"cdna_end": null,
"cdna_length": 3250,
"mane_select": "NM_018209.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP1",
"gene_hgnc_id": 15852,
"hgvs_c": "c.839G>C",
"hgvs_p": "p.Ser280Thr",
"transcript": "ENST00000353546.7",
"protein_id": "ENSP00000314615.3",
"transcript_support_level": 1,
"aa_start": 280,
"aa_end": null,
"aa_length": 414,
"cds_start": 839,
"cds_end": null,
"cds_length": 1245,
"cdna_start": 899,
"cdna_end": null,
"cdna_length": 2776,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP1",
"gene_hgnc_id": 15852,
"hgvs_c": "c.809G>C",
"hgvs_p": "p.Ser270Thr",
"transcript": "ENST00000370275.8",
"protein_id": "ENSP00000359298.4",
"transcript_support_level": 1,
"aa_start": 270,
"aa_end": null,
"aa_length": 403,
"cds_start": 809,
"cds_end": null,
"cds_length": 1212,
"cdna_start": 901,
"cdna_end": null,
"cdna_length": 3467,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP1",
"gene_hgnc_id": 15852,
"hgvs_c": "n.843G>C",
"hgvs_p": null,
"transcript": "ENST00000518794.6",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2727,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP1",
"gene_hgnc_id": 15852,
"hgvs_c": "c.839G>C",
"hgvs_p": "p.Ser280Thr",
"transcript": "NM_175609.3",
"protein_id": "NP_783202.1",
"transcript_support_level": null,
"aa_start": 280,
"aa_end": null,
"aa_length": 414,
"cds_start": 839,
"cds_end": null,
"cds_length": 1245,
"cdna_start": 951,
"cdna_end": null,
"cdna_length": 3274,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP1",
"gene_hgnc_id": 15852,
"hgvs_c": "c.809G>C",
"hgvs_p": "p.Ser270Thr",
"transcript": "NM_001281482.2",
"protein_id": "NP_001268411.1",
"transcript_support_level": null,
"aa_start": 270,
"aa_end": null,
"aa_length": 403,
"cds_start": 809,
"cds_end": null,
"cds_length": 1212,
"cdna_start": 921,
"cdna_end": null,
"cdna_length": 3489,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP1",
"gene_hgnc_id": 15852,
"hgvs_c": "c.680G>C",
"hgvs_p": "p.Ser227Thr",
"transcript": "NM_001281483.2",
"protein_id": "NP_001268412.1",
"transcript_support_level": null,
"aa_start": 227,
"aa_end": null,
"aa_length": 361,
"cds_start": 680,
"cds_end": null,
"cds_length": 1086,
"cdna_start": 841,
"cdna_end": null,
"cdna_length": 3164,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP1",
"gene_hgnc_id": 15852,
"hgvs_c": "c.680G>C",
"hgvs_p": "p.Ser227Thr",
"transcript": "ENST00000519604.5",
"protein_id": "ENSP00000430500.1",
"transcript_support_level": 2,
"aa_start": 227,
"aa_end": null,
"aa_length": 361,
"cds_start": 680,
"cds_end": null,
"cds_length": 1086,
"cdna_start": 869,
"cdna_end": null,
"cdna_length": 3191,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP1",
"gene_hgnc_id": 15852,
"hgvs_c": "c.617G>C",
"hgvs_p": "p.Ser206Thr",
"transcript": "ENST00000547204.5",
"protein_id": "ENSP00000449800.1",
"transcript_support_level": 2,
"aa_start": 206,
"aa_end": null,
"aa_length": 340,
"cds_start": 617,
"cds_end": null,
"cds_length": 1023,
"cdna_start": 857,
"cdna_end": null,
"cdna_length": 1327,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP1",
"gene_hgnc_id": 15852,
"hgvs_c": "c.470G>C",
"hgvs_p": "p.Ser157Thr",
"transcript": "NM_001281484.2",
"protein_id": "NP_001268413.1",
"transcript_support_level": null,
"aa_start": 157,
"aa_end": null,
"aa_length": 293,
"cds_start": 470,
"cds_end": null,
"cds_length": 882,
"cdna_start": 820,
"cdna_end": null,
"cdna_length": 3149,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP1",
"gene_hgnc_id": 15852,
"hgvs_c": "c.470G>C",
"hgvs_p": "p.Ser157Thr",
"transcript": "ENST00000519273.6",
"protein_id": "ENSP00000443716.1",
"transcript_support_level": 2,
"aa_start": 157,
"aa_end": null,
"aa_length": 293,
"cds_start": 470,
"cds_end": null,
"cds_length": 882,
"cdna_start": 848,
"cdna_end": null,
"cdna_length": 3176,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP1",
"gene_hgnc_id": 15852,
"hgvs_c": "c.587G>C",
"hgvs_p": "p.Ser196Thr",
"transcript": "ENST00000549047.5",
"protein_id": "ENSP00000447037.1",
"transcript_support_level": 5,
"aa_start": 196,
"aa_end": null,
"aa_length": 270,
"cds_start": 587,
"cds_end": null,
"cds_length": 814,
"cdna_start": 813,
"cdna_end": null,
"cdna_length": 1040,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP1",
"gene_hgnc_id": 15852,
"hgvs_c": "c.674G>C",
"hgvs_p": "p.Ser225Thr",
"transcript": "ENST00000518601.6",
"protein_id": "ENSP00000429674.2",
"transcript_support_level": 5,
"aa_start": 225,
"aa_end": null,
"aa_length": 243,
"cds_start": 674,
"cds_end": null,
"cds_length": 732,
"cdna_start": 847,
"cdna_end": null,
"cdna_length": 905,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP1",
"gene_hgnc_id": 15852,
"hgvs_c": "c.77G>C",
"hgvs_p": "p.Ser26Thr",
"transcript": "ENST00000523460.5",
"protein_id": "ENSP00000429770.1",
"transcript_support_level": 4,
"aa_start": 26,
"aa_end": null,
"aa_length": 152,
"cds_start": 77,
"cds_end": null,
"cds_length": 460,
"cdna_start": 189,
"cdna_end": null,
"cdna_length": 572,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP1",
"gene_hgnc_id": 15852,
"hgvs_c": "c.839G>C",
"hgvs_p": "p.Ser280Thr",
"transcript": "XM_011528901.2",
"protein_id": "XP_011527203.1",
"transcript_support_level": null,
"aa_start": 280,
"aa_end": null,
"aa_length": 416,
"cds_start": 839,
"cds_end": null,
"cds_length": 1251,
"cdna_start": 951,
"cdna_end": null,
"cdna_length": 3280,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP1",
"gene_hgnc_id": 15852,
"hgvs_c": "c.839G>C",
"hgvs_p": "p.Ser280Thr",
"transcript": "XM_017027950.2",
"protein_id": "XP_016883439.1",
"transcript_support_level": null,
"aa_start": 280,
"aa_end": null,
"aa_length": 416,
"cds_start": 839,
"cds_end": null,
"cds_length": 1251,
"cdna_start": 970,
"cdna_end": null,
"cdna_length": 3299,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP1",
"gene_hgnc_id": 15852,
"hgvs_c": "c.809G>C",
"hgvs_p": "p.Ser270Thr",
"transcript": "XM_047440287.1",
"protein_id": "XP_047296243.1",
"transcript_support_level": null,
"aa_start": 270,
"aa_end": null,
"aa_length": 406,
"cds_start": 809,
"cds_end": null,
"cds_length": 1221,
"cdna_start": 1411,
"cdna_end": null,
"cdna_length": 3740,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP1",
"gene_hgnc_id": 15852,
"hgvs_c": "c.809G>C",
"hgvs_p": "p.Ser270Thr",
"transcript": "XM_006723823.3",
"protein_id": "XP_006723886.1",
"transcript_support_level": null,
"aa_start": 270,
"aa_end": null,
"aa_length": 404,
"cds_start": 809,
"cds_end": null,
"cds_length": 1215,
"cdna_start": 921,
"cdna_end": null,
"cdna_length": 3244,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP1",
"gene_hgnc_id": 15852,
"hgvs_c": "c.809G>C",
"hgvs_p": "p.Ser270Thr",
"transcript": "XM_047440288.1",
"protein_id": "XP_047296244.1",
"transcript_support_level": null,
"aa_start": 270,
"aa_end": null,
"aa_length": 404,
"cds_start": 809,
"cds_end": null,
"cds_length": 1215,
"cdna_start": 1411,
"cdna_end": null,
"cdna_length": 3734,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP1",
"gene_hgnc_id": 15852,
"hgvs_c": "n.313G>C",
"hgvs_p": null,
"transcript": "ENST00000468975.6",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2640,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP1",
"gene_hgnc_id": 15852,
"hgvs_c": "n.203G>C",
"hgvs_p": null,
"transcript": "ENST00000518618.2",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1244,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARFGAP1",
"gene_hgnc_id": 15852,
"hgvs_c": "n.523G>C",
"hgvs_p": null,
"transcript": "ENST00000518691.1",
"protein_id": null,
"transcript_support_level": 2,
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}