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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 20-9433994-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=20&pos=9433994&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "20",
"pos": 9433994,
"ref": "G",
"alt": "A",
"effect": "intron_variant",
"transcript": "NM_001377142.1",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 40,
"intron_rank": 28,
"intron_rank_end": null,
"gene_symbol": "PLCB4",
"gene_hgnc_id": 9059,
"hgvs_c": "c.2525-1566G>A",
"hgvs_p": null,
"transcript": "NM_001377142.1",
"protein_id": "NP_001364071.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1206,
"cds_start": null,
"cds_end": null,
"cds_length": 3621,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000378473.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001377142.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 40,
"intron_rank": 28,
"intron_rank_end": null,
"gene_symbol": "PLCB4",
"gene_hgnc_id": 9059,
"hgvs_c": "c.2525-1566G>A",
"hgvs_p": null,
"transcript": "ENST00000378473.9",
"protein_id": "ENSP00000367734.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1206,
"cds_start": null,
"cds_end": null,
"cds_length": 3621,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001377142.1",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000378473.9"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 36,
"intron_rank": 25,
"intron_rank_end": null,
"gene_symbol": "PLCB4",
"gene_hgnc_id": 9059,
"hgvs_c": "c.2435-1566G>A",
"hgvs_p": null,
"transcript": "ENST00000278655.9",
"protein_id": "ENSP00000278655.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1157,
"cds_start": null,
"cds_end": null,
"cds_length": 3474,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000278655.9"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": 18,
"intron_rank_end": null,
"gene_symbol": "PLCB4",
"gene_hgnc_id": 9059,
"hgvs_c": "n.2266-1566G>A",
"hgvs_p": null,
"transcript": "ENST00000464199.5",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "pseudogene",
"feature": "ENST00000464199.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 40,
"intron_rank": 28,
"intron_rank_end": null,
"gene_symbol": "PLCB4",
"gene_hgnc_id": 9059,
"hgvs_c": "c.2537-1566G>A",
"hgvs_p": null,
"transcript": "ENST00000946820.1",
"protein_id": "ENSP00000616879.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1210,
"cds_start": null,
"cds_end": null,
"cds_length": 3633,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000946820.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": 28,
"intron_rank_end": null,
"gene_symbol": "PLCB4",
"gene_hgnc_id": 9059,
"hgvs_c": "c.2525-1566G>A",
"hgvs_p": null,
"transcript": "ENST00000685298.1",
"protein_id": "ENSP00000509390.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1209,
"cds_start": null,
"cds_end": null,
"cds_length": 3630,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000685298.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": 27,
"intron_rank_end": null,
"gene_symbol": "PLCB4",
"gene_hgnc_id": 9059,
"hgvs_c": "c.2525-1566G>A",
"hgvs_p": null,
"transcript": "NM_001377143.1",
"protein_id": "NP_001364072.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1206,
"cds_start": null,
"cds_end": null,
"cds_length": 3621,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001377143.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": 27,
"intron_rank_end": null,
"gene_symbol": "PLCB4",
"gene_hgnc_id": 9059,
"hgvs_c": "c.2525-1566G>A",
"hgvs_p": null,
"transcript": "ENST00000685568.1",
"protein_id": "ENSP00000508726.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1206,
"cds_start": null,
"cds_end": null,
"cds_length": 3621,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000685568.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 40,
"intron_rank": 28,
"intron_rank_end": null,
"gene_symbol": "PLCB4",
"gene_hgnc_id": 9059,
"hgvs_c": "c.2525-1566G>A",
"hgvs_p": null,
"transcript": "ENST00000920652.1",
"protein_id": "ENSP00000590711.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1206,
"cds_start": null,
"cds_end": null,
"cds_length": 3621,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000920652.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 41,
"intron_rank": 29,
"intron_rank_end": null,
"gene_symbol": "PLCB4",
"gene_hgnc_id": 9059,
"hgvs_c": "c.2525-1566G>A",
"hgvs_p": null,
"transcript": "ENST00000946818.1",
"protein_id": "ENSP00000616877.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1206,
"cds_start": null,
"cds_end": null,
"cds_length": 3621,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000946818.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 41,
"intron_rank": 29,
"intron_rank_end": null,
"gene_symbol": "PLCB4",
"gene_hgnc_id": 9059,
"hgvs_c": "c.2525-1566G>A",
"hgvs_p": null,
"transcript": "ENST00000946821.1",
"protein_id": "ENSP00000616880.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1206,
"cds_start": null,
"cds_end": null,
"cds_length": 3621,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000946821.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": 27,
"intron_rank_end": null,
"gene_symbol": "PLCB4",
"gene_hgnc_id": 9059,
"hgvs_c": "c.2501-1566G>A",
"hgvs_p": null,
"transcript": "ENST00000946817.1",
"protein_id": "ENSP00000616876.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1198,
"cds_start": null,
"cds_end": null,
"cds_length": 3597,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000946817.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": 27,
"intron_rank_end": null,
"gene_symbol": "PLCB4",
"gene_hgnc_id": 9059,
"hgvs_c": "c.2489-1566G>A",
"hgvs_p": null,
"transcript": "NM_000933.4",
"protein_id": "NP_000924.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1194,
"cds_start": null,
"cds_end": null,
"cds_length": 3585,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_000933.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": 27,
"intron_rank_end": null,
"gene_symbol": "PLCB4",
"gene_hgnc_id": 9059,
"hgvs_c": "c.2489-1566G>A",
"hgvs_p": null,
"transcript": "NM_001377134.2",
"protein_id": "NP_001364063.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1194,
"cds_start": null,
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"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001377134.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 38,
"intron_rank": 26,
"intron_rank_end": null,
"gene_symbol": "PLCB4",
"gene_hgnc_id": 9059,
"hgvs_c": "c.2489-1566G>A",
"hgvs_p": null,
"transcript": "NM_001377135.1",
"protein_id": "NP_001364064.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1194,
"cds_start": null,
"cds_end": null,
"cds_length": 3585,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001377135.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 38,
"intron_rank": 26,
"intron_rank_end": null,
"gene_symbol": "PLCB4",
"gene_hgnc_id": 9059,
"hgvs_c": "c.2489-1566G>A",
"hgvs_p": null,
"transcript": "ENST00000378501.3",
"protein_id": "ENSP00000367762.2",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 1194,
"cds_start": null,
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"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000378501.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 38,
"intron_rank": 26,
"intron_rank_end": null,
"gene_symbol": "PLCB4",
"gene_hgnc_id": 9059,
"hgvs_c": "c.2489-1566G>A",
"hgvs_p": null,
"transcript": "ENST00000686313.1",
"protein_id": "ENSP00000508595.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1194,
"cds_start": null,
"cds_end": null,
"cds_length": 3585,
"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000686313.1"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": 27,
"intron_rank_end": null,
"gene_symbol": "PLCB4",
"gene_hgnc_id": 9059,
"hgvs_c": "c.2489-1566G>A",
"hgvs_p": null,
"transcript": "ENST00000686871.1",
"protein_id": "ENSP00000510118.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1194,
"cds_start": null,
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"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000686871.1"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": 27,
"intron_rank_end": null,
"gene_symbol": "PLCB4",
"gene_hgnc_id": 9059,
"hgvs_c": "c.2489-1566G>A",
"hgvs_p": null,
"transcript": "ENST00000686976.1",
"protein_id": "ENSP00000508600.1",
"transcript_support_level": null,
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"aa_end": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000686976.1"
},
{
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"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 38,
"intron_rank": 26,
"intron_rank_end": null,
"gene_symbol": "PLCB4",
"gene_hgnc_id": 9059,
"hgvs_c": "c.2489-1566G>A",
"hgvs_p": null,
"transcript": "ENST00000693752.1",
"protein_id": "ENSP00000508677.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 1194,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000693752.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": 27,
"intron_rank_end": null,
"gene_symbol": "PLCB4",
"gene_hgnc_id": 9059,
"hgvs_c": "c.2489-1566G>A",
"hgvs_p": null,
"transcript": "ENST00000920653.1",
"protein_id": "ENSP00000590712.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1194,
"cds_start": null,
"cds_end": null,
"cds_length": 3585,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000920653.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": 27,
"intron_rank_end": null,
"gene_symbol": "PLCB4",
"gene_hgnc_id": 9059,
"hgvs_c": "c.2489-1566G>A",
"hgvs_p": null,
"transcript": "ENST00000920654.1",
"protein_id": "ENSP00000590713.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1194,
"cds_start": null,
"cds_end": null,
"cds_length": 3585,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000920654.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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}