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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 21-15831466-A-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=21&pos=15831466&ref=A&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "21",
"pos": 15831466,
"ref": "A",
"alt": "T",
"effect": "synonymous_variant",
"transcript": "NM_001283041.3",
"consequences": [
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP25",
"gene_hgnc_id": 12624,
"hgvs_c": "c.1830A>T",
"hgvs_p": "p.Ala610Ala",
"transcript": "NM_001283041.3",
"protein_id": "NP_001269970.1",
"transcript_support_level": null,
"aa_start": 610,
"aa_end": null,
"aa_length": 1125,
"cds_start": 1830,
"cds_end": null,
"cds_length": 3378,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000400183.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001283041.3"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP25",
"gene_hgnc_id": 12624,
"hgvs_c": "c.1830A>T",
"hgvs_p": "p.Ala610Ala",
"transcript": "ENST00000400183.7",
"protein_id": "ENSP00000383044.2",
"transcript_support_level": 1,
"aa_start": 610,
"aa_end": null,
"aa_length": 1125,
"cds_start": 1830,
"cds_end": null,
"cds_length": 3378,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001283041.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000400183.7"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP25",
"gene_hgnc_id": 12624,
"hgvs_c": "c.1830A>T",
"hgvs_p": "p.Ala610Ala",
"transcript": "ENST00000285681.6",
"protein_id": "ENSP00000285681.2",
"transcript_support_level": 1,
"aa_start": 610,
"aa_end": null,
"aa_length": 1087,
"cds_start": 1830,
"cds_end": null,
"cds_length": 3264,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000285681.6"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP25",
"gene_hgnc_id": 12624,
"hgvs_c": "c.1830A>T",
"hgvs_p": "p.Ala610Ala",
"transcript": "ENST00000285679.10",
"protein_id": "ENSP00000285679.6",
"transcript_support_level": 1,
"aa_start": 610,
"aa_end": null,
"aa_length": 1055,
"cds_start": 1830,
"cds_end": null,
"cds_length": 3168,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000285679.10"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "USP25",
"gene_hgnc_id": 12624,
"hgvs_c": "c.780+26208A>T",
"hgvs_p": null,
"transcript": "ENST00000351097.9",
"protein_id": "ENSP00000299574.6",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 450,
"cds_start": null,
"cds_end": null,
"cds_length": 1353,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000351097.9"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP25",
"gene_hgnc_id": 12624,
"hgvs_c": "c.1830A>T",
"hgvs_p": "p.Ala610Ala",
"transcript": "ENST00000941969.1",
"protein_id": "ENSP00000612028.1",
"transcript_support_level": null,
"aa_start": 610,
"aa_end": null,
"aa_length": 1133,
"cds_start": 1830,
"cds_end": null,
"cds_length": 3402,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000941969.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP25",
"gene_hgnc_id": 12624,
"hgvs_c": "c.1830A>T",
"hgvs_p": "p.Ala610Ala",
"transcript": "ENST00000941973.1",
"protein_id": "ENSP00000612032.1",
"transcript_support_level": null,
"aa_start": 610,
"aa_end": null,
"aa_length": 1113,
"cds_start": 1830,
"cds_end": null,
"cds_length": 3342,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000941973.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP25",
"gene_hgnc_id": 12624,
"hgvs_c": "c.1830A>T",
"hgvs_p": "p.Ala610Ala",
"transcript": "ENST00000941966.1",
"protein_id": "ENSP00000612025.1",
"transcript_support_level": null,
"aa_start": 610,
"aa_end": null,
"aa_length": 1093,
"cds_start": 1830,
"cds_end": null,
"cds_length": 3282,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000941966.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP25",
"gene_hgnc_id": 12624,
"hgvs_c": "c.1833A>T",
"hgvs_p": "p.Ala611Ala",
"transcript": "ENST00000926093.1",
"protein_id": "ENSP00000596152.1",
"transcript_support_level": null,
"aa_start": 611,
"aa_end": null,
"aa_length": 1088,
"cds_start": 1833,
"cds_end": null,
"cds_length": 3267,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000926093.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP25",
"gene_hgnc_id": 12624,
"hgvs_c": "c.1830A>T",
"hgvs_p": "p.Ala610Ala",
"transcript": "NM_001283042.3",
"protein_id": "NP_001269971.1",
"transcript_support_level": null,
"aa_start": 610,
"aa_end": null,
"aa_length": 1087,
"cds_start": 1830,
"cds_end": null,
"cds_length": 3264,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001283042.3"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP25",
"gene_hgnc_id": 12624,
"hgvs_c": "c.1830A>T",
"hgvs_p": "p.Ala610Ala",
"transcript": "ENST00000941967.1",
"protein_id": "ENSP00000612026.1",
"transcript_support_level": null,
"aa_start": 610,
"aa_end": null,
"aa_length": 1075,
"cds_start": 1830,
"cds_end": null,
"cds_length": 3228,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000941967.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP25",
"gene_hgnc_id": 12624,
"hgvs_c": "c.1833A>T",
"hgvs_p": "p.Ala611Ala",
"transcript": "ENST00000926090.1",
"protein_id": "ENSP00000596149.1",
"transcript_support_level": null,
"aa_start": 611,
"aa_end": null,
"aa_length": 1056,
"cds_start": 1833,
"cds_end": null,
"cds_length": 3171,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000926090.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP25",
"gene_hgnc_id": 12624,
"hgvs_c": "c.1830A>T",
"hgvs_p": "p.Ala610Ala",
"transcript": "NM_013396.6",
"protein_id": "NP_037528.3",
"transcript_support_level": null,
"aa_start": 610,
"aa_end": null,
"aa_length": 1055,
"cds_start": 1830,
"cds_end": null,
"cds_length": 3168,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_013396.6"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP25",
"gene_hgnc_id": 12624,
"hgvs_c": "c.1830A>T",
"hgvs_p": "p.Ala610Ala",
"transcript": "ENST00000941970.1",
"protein_id": "ENSP00000612029.1",
"transcript_support_level": null,
"aa_start": 610,
"aa_end": null,
"aa_length": 1054,
"cds_start": 1830,
"cds_end": null,
"cds_length": 3165,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000941970.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP25",
"gene_hgnc_id": 12624,
"hgvs_c": "c.1752A>T",
"hgvs_p": "p.Ala584Ala",
"transcript": "ENST00000941972.1",
"protein_id": "ENSP00000612031.1",
"transcript_support_level": null,
"aa_start": 584,
"aa_end": null,
"aa_length": 1029,
"cds_start": 1752,
"cds_end": null,
"cds_length": 3090,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000941972.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP25",
"gene_hgnc_id": 12624,
"hgvs_c": "c.1743A>T",
"hgvs_p": "p.Ala581Ala",
"transcript": "ENST00000941968.1",
"protein_id": "ENSP00000612027.1",
"transcript_support_level": null,
"aa_start": 581,
"aa_end": null,
"aa_length": 1026,
"cds_start": 1743,
"cds_end": null,
"cds_length": 3081,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000941968.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP25",
"gene_hgnc_id": 12624,
"hgvs_c": "c.1734A>T",
"hgvs_p": "p.Ala578Ala",
"transcript": "ENST00000926091.1",
"protein_id": "ENSP00000596150.1",
"transcript_support_level": null,
"aa_start": 578,
"aa_end": null,
"aa_length": 1023,
"cds_start": 1734,
"cds_end": null,
"cds_length": 3072,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000926091.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP25",
"gene_hgnc_id": 12624,
"hgvs_c": "c.1830A>T",
"hgvs_p": "p.Ala610Ala",
"transcript": "ENST00000926092.1",
"protein_id": "ENSP00000596151.1",
"transcript_support_level": null,
"aa_start": 610,
"aa_end": null,
"aa_length": 988,
"cds_start": 1830,
"cds_end": null,
"cds_length": 2967,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000926092.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP25",
"gene_hgnc_id": 12624,
"hgvs_c": "c.1167A>T",
"hgvs_p": "p.Ala389Ala",
"transcript": "NM_001352560.2",
"protein_id": "NP_001339489.1",
"transcript_support_level": null,
"aa_start": 389,
"aa_end": null,
"aa_length": 834,
"cds_start": 1167,
"cds_end": null,
"cds_length": 2505,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001352560.2"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP25",
"gene_hgnc_id": 12624,
"hgvs_c": "c.1167A>T",
"hgvs_p": "p.Ala389Ala",
"transcript": "NM_001388299.1",
"protein_id": "NP_001375228.1",
"transcript_support_level": null,
"aa_start": 389,
"aa_end": null,
"aa_length": 834,
"cds_start": 1167,
"cds_end": null,
"cds_length": 2505,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001388299.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP25",
"gene_hgnc_id": 12624,
"hgvs_c": "c.618A>T",
"hgvs_p": "p.Ala206Ala",
"transcript": "NM_001352561.2",
"protein_id": "NP_001339490.1",
"transcript_support_level": null,
"aa_start": 206,
"aa_end": null,
"aa_length": 651,
"cds_start": 618,
"cds_end": null,
"cds_length": 1956,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001352561.2"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "USP25",
"gene_hgnc_id": 12624,
"hgvs_c": "c.618A>T",
"hgvs_p": "p.Ala206Ala",
"transcript": "NM_001388300.1",
"protein_id": "NP_001375229.1",
"transcript_support_level": null,
"aa_start": 206,
"aa_end": null,
"aa_length": 651,
"cds_start": 618,
"cds_end": null,
"cds_length": 1956,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001388300.1"
},
{
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}
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}