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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 21-38299349-A-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=21&pos=38299349&ref=A&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "21",
"pos": 38299349,
"ref": "A",
"alt": "C",
"effect": "missense_variant",
"transcript": "ENST00000398938.7",
"consequences": [
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNJ15",
"gene_hgnc_id": 6261,
"hgvs_c": "c.88A>C",
"hgvs_p": "p.Met30Leu",
"transcript": "NM_170736.3",
"protein_id": "NP_733932.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 375,
"cds_start": 88,
"cds_end": null,
"cds_length": 1128,
"cdna_start": 399,
"cdna_end": null,
"cdna_length": 8407,
"mane_select": "ENST00000398938.7",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNJ15",
"gene_hgnc_id": 6261,
"hgvs_c": "c.88A>C",
"hgvs_p": "p.Met30Leu",
"transcript": "ENST00000398938.7",
"protein_id": "ENSP00000381911.2",
"transcript_support_level": 1,
"aa_start": 30,
"aa_end": null,
"aa_length": 375,
"cds_start": 88,
"cds_end": null,
"cds_length": 1128,
"cdna_start": 399,
"cdna_end": null,
"cdna_length": 8407,
"mane_select": "NM_170736.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNJ15",
"gene_hgnc_id": 6261,
"hgvs_c": "c.88A>C",
"hgvs_p": "p.Met30Leu",
"transcript": "ENST00000328656.8",
"protein_id": "ENSP00000331698.3",
"transcript_support_level": 1,
"aa_start": 30,
"aa_end": null,
"aa_length": 375,
"cds_start": 88,
"cds_end": null,
"cds_length": 1128,
"cdna_start": 391,
"cdna_end": null,
"cdna_length": 8399,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNJ15",
"gene_hgnc_id": 6261,
"hgvs_c": "c.88A>C",
"hgvs_p": "p.Met30Leu",
"transcript": "NM_001276435.2",
"protein_id": "NP_001263364.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 375,
"cds_start": 88,
"cds_end": null,
"cds_length": 1128,
"cdna_start": 530,
"cdna_end": null,
"cdna_length": 8538,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNJ15",
"gene_hgnc_id": 6261,
"hgvs_c": "c.88A>C",
"hgvs_p": "p.Met30Leu",
"transcript": "NM_001276436.2",
"protein_id": "NP_001263365.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 375,
"cds_start": 88,
"cds_end": null,
"cds_length": 1128,
"cdna_start": 533,
"cdna_end": null,
"cdna_length": 8541,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNJ15",
"gene_hgnc_id": 6261,
"hgvs_c": "c.88A>C",
"hgvs_p": "p.Met30Leu",
"transcript": "NM_001276437.2",
"protein_id": "NP_001263366.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 375,
"cds_start": 88,
"cds_end": null,
"cds_length": 1128,
"cdna_start": 384,
"cdna_end": null,
"cdna_length": 8392,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNJ15",
"gene_hgnc_id": 6261,
"hgvs_c": "c.88A>C",
"hgvs_p": "p.Met30Leu",
"transcript": "NM_001276438.2",
"protein_id": "NP_001263367.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 375,
"cds_start": 88,
"cds_end": null,
"cds_length": 1128,
"cdna_start": 302,
"cdna_end": null,
"cdna_length": 8310,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNJ15",
"gene_hgnc_id": 6261,
"hgvs_c": "c.88A>C",
"hgvs_p": "p.Met30Leu",
"transcript": "NM_001276439.2",
"protein_id": "NP_001263368.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 375,
"cds_start": 88,
"cds_end": null,
"cds_length": 1128,
"cdna_start": 442,
"cdna_end": null,
"cdna_length": 8450,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNJ15",
"gene_hgnc_id": 6261,
"hgvs_c": "c.88A>C",
"hgvs_p": "p.Met30Leu",
"transcript": "NM_002243.5",
"protein_id": "NP_002234.2",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 375,
"cds_start": 88,
"cds_end": null,
"cds_length": 1128,
"cdna_start": 391,
"cdna_end": null,
"cdna_length": 8399,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNJ15",
"gene_hgnc_id": 6261,
"hgvs_c": "c.88A>C",
"hgvs_p": "p.Met30Leu",
"transcript": "NM_170737.3",
"protein_id": "NP_733933.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 375,
"cds_start": 88,
"cds_end": null,
"cds_length": 1128,
"cdna_start": 254,
"cdna_end": null,
"cdna_length": 8262,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNJ15",
"gene_hgnc_id": 6261,
"hgvs_c": "c.88A>C",
"hgvs_p": "p.Met30Leu",
"transcript": "ENST00000398930.5",
"protein_id": "ENSP00000381904.1",
"transcript_support_level": 5,
"aa_start": 30,
"aa_end": null,
"aa_length": 375,
"cds_start": 88,
"cds_end": null,
"cds_length": 1128,
"cdna_start": 442,
"cdna_end": null,
"cdna_length": 2914,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNJ15",
"gene_hgnc_id": 6261,
"hgvs_c": "c.88A>C",
"hgvs_p": "p.Met30Leu",
"transcript": "ENST00000398932.5",
"protein_id": "ENSP00000381905.1",
"transcript_support_level": 5,
"aa_start": 30,
"aa_end": null,
"aa_length": 375,
"cds_start": 88,
"cds_end": null,
"cds_length": 1128,
"cdna_start": 606,
"cdna_end": null,
"cdna_length": 2747,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNJ15",
"gene_hgnc_id": 6261,
"hgvs_c": "c.88A>C",
"hgvs_p": "p.Met30Leu",
"transcript": "ENST00000398934.5",
"protein_id": "ENSP00000381907.1",
"transcript_support_level": 3,
"aa_start": 30,
"aa_end": null,
"aa_length": 375,
"cds_start": 88,
"cds_end": null,
"cds_length": 1128,
"cdna_start": 342,
"cdna_end": null,
"cdna_length": 2815,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNJ15",
"gene_hgnc_id": 6261,
"hgvs_c": "c.88A>C",
"hgvs_p": "p.Met30Leu",
"transcript": "ENST00000612702.4",
"protein_id": "ENSP00000484960.1",
"transcript_support_level": 4,
"aa_start": 30,
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"cds_start": 88,
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"cdna_start": 573,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNJ15",
"gene_hgnc_id": 6261,
"hgvs_c": "c.88A>C",
"hgvs_p": "p.Met30Leu",
"transcript": "ENST00000613499.4",
"protein_id": "ENSP00000479100.1",
"transcript_support_level": 4,
"aa_start": 30,
"aa_end": null,
"aa_length": 375,
"cds_start": 88,
"cds_end": null,
"cds_length": 1128,
"cdna_start": 576,
"cdna_end": null,
"cdna_length": 3049,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNJ15",
"gene_hgnc_id": 6261,
"hgvs_c": "c.88A>C",
"hgvs_p": "p.Met30Leu",
"transcript": "ENST00000438657.5",
"protein_id": "ENSP00000414487.1",
"transcript_support_level": 3,
"aa_start": 30,
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"cds_start": 88,
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"cdna_start": 467,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNJ15",
"gene_hgnc_id": 6261,
"hgvs_c": "c.88A>C",
"hgvs_p": "p.Met30Leu",
"transcript": "ENST00000398927.1",
"protein_id": "ENSP00000381901.1",
"transcript_support_level": 3,
"aa_start": 30,
"aa_end": null,
"aa_length": 155,
"cds_start": 88,
"cds_end": null,
"cds_length": 470,
"cdna_start": 283,
"cdna_end": null,
"cdna_length": 665,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNJ15",
"gene_hgnc_id": 6261,
"hgvs_c": "c.88A>C",
"hgvs_p": "p.Met30Leu",
"transcript": "ENST00000398928.5",
"protein_id": "ENSP00000381902.1",
"transcript_support_level": 5,
"aa_start": 30,
"aa_end": null,
"aa_length": 155,
"cds_start": 88,
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"cds_length": 470,
"cdna_start": 333,
"cdna_end": null,
"cdna_length": 715,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNJ15",
"gene_hgnc_id": 6261,
"hgvs_c": "c.88A>C",
"hgvs_p": "p.Met30Leu",
"transcript": "ENST00000419868.1",
"protein_id": "ENSP00000400849.1",
"transcript_support_level": 3,
"aa_start": 30,
"aa_end": null,
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"cdna_start": 192,
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"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNJ15",
"gene_hgnc_id": 6261,
"hgvs_c": "c.88A>C",
"hgvs_p": "p.Met30Leu",
"transcript": "ENST00000398925.5",
"protein_id": "ENSP00000381899.1",
"transcript_support_level": 5,
"aa_start": 30,
"aa_end": null,
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"mane_select": null,
"mane_plus": null,
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"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNJ15",
"gene_hgnc_id": 6261,
"hgvs_c": "c.88A>C",
"hgvs_p": "p.Met30Leu",
"transcript": "ENST00000547341.5",
"protein_id": "ENSP00000447111.1",
"transcript_support_level": 3,
"aa_start": 30,
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"cds_start": 88,
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"cdna_start": 538,
"cdna_end": null,
"cdna_length": 595,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNJ15",
"gene_hgnc_id": 6261,
"hgvs_c": "c.88A>C",
"hgvs_p": "p.Met30Leu",
"transcript": "ENST00000547595.5",
"protein_id": "ENSP00000450254.1",
"transcript_support_level": 2,
"aa_start": 30,
"aa_end": null,
"aa_length": 47,
"cds_start": 88,
"cds_end": null,
"cds_length": 145,
"cdna_start": 256,
"cdna_end": null,
"cdna_length": 313,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "M",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KCNJ15",
"gene_hgnc_id": 6261,
"hgvs_c": "c.88A>C",
"hgvs_p": "p.Met30Leu",
"transcript": "ENST00000548700.5",
"protein_id": "ENSP00000448886.1",
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}
],
"message": null
}