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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 21-43658154-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=21&pos=43658154&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "21",
"pos": 43658154,
"ref": "C",
"alt": "T",
"effect": "5_prime_UTR_premature_start_codon_gain_variant",
"transcript": "ENST00000291560.7",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HSF2BP",
"gene_hgnc_id": 5226,
"hgvs_c": "c.-58G>A",
"hgvs_p": null,
"transcript": "NM_007031.2",
"protein_id": "NP_008962.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 334,
"cds_start": -4,
"cds_end": null,
"cds_length": 1005,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1900,
"mane_select": "ENST00000291560.7",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HSF2BP",
"gene_hgnc_id": 5226,
"hgvs_c": "c.-58G>A",
"hgvs_p": null,
"transcript": "ENST00000291560.7",
"protein_id": "ENSP00000291560.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 334,
"cds_start": -4,
"cds_end": null,
"cds_length": 1005,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1900,
"mane_select": "NM_007031.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HSF2BP",
"gene_hgnc_id": 5226,
"hgvs_c": "c.-58G>A",
"hgvs_p": null,
"transcript": "NM_007031.2",
"protein_id": "NP_008962.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 334,
"cds_start": -4,
"cds_end": null,
"cds_length": 1005,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1900,
"mane_select": "ENST00000291560.7",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HSF2BP",
"gene_hgnc_id": 5226,
"hgvs_c": "c.-58G>A",
"hgvs_p": null,
"transcript": "ENST00000291560.7",
"protein_id": "ENSP00000291560.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 334,
"cds_start": -4,
"cds_end": null,
"cds_length": 1005,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1900,
"mane_select": "NM_007031.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HSF2BP",
"gene_hgnc_id": 5226,
"hgvs_c": "c.-58G>A",
"hgvs_p": null,
"transcript": "ENST00000443485.1",
"protein_id": "ENSP00000409585.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 225,
"cds_start": -4,
"cds_end": null,
"cds_length": 680,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 989,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HSF2BP",
"gene_hgnc_id": 5226,
"hgvs_c": "c.-58G>A",
"hgvs_p": null,
"transcript": "XM_011529443.3",
"protein_id": "XP_011527745.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 348,
"cds_start": -4,
"cds_end": null,
"cds_length": 1047,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1826,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HSF2BP",
"gene_hgnc_id": 5226,
"hgvs_c": "c.-58G>A",
"hgvs_p": null,
"transcript": "XM_047440674.1",
"protein_id": "XP_047296630.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 348,
"cds_start": -4,
"cds_end": null,
"cds_length": 1047,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2891,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HSF2BP",
"gene_hgnc_id": 5226,
"hgvs_c": "c.-58G>A",
"hgvs_p": null,
"transcript": "XM_017028267.2",
"protein_id": "XP_016883756.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 345,
"cds_start": -4,
"cds_end": null,
"cds_length": 1038,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1934,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HSF2BP",
"gene_hgnc_id": 5226,
"hgvs_c": "c.-58G>A",
"hgvs_p": null,
"transcript": "XM_047440675.1",
"protein_id": "XP_047296631.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 345,
"cds_start": -4,
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"cds_length": 1038,
"cdna_start": null,
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"cdna_length": 2873,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HSF2BP",
"gene_hgnc_id": 5226,
"hgvs_c": "c.-58G>A",
"hgvs_p": null,
"transcript": "XM_017028268.2",
"protein_id": "XP_016883757.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 342,
"cds_start": -4,
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"cds_length": 1029,
"cdna_start": null,
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"cdna_length": 3342,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 2,
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"exon_count": 10,
"intron_rank": null,
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"gene_symbol": "HSF2BP",
"gene_hgnc_id": 5226,
"hgvs_c": "c.-58G>A",
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"transcript": "XM_017028269.2",
"protein_id": "XP_016883758.1",
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"cds_start": -4,
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"cdna_start": null,
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},
{
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"strand": false,
"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 1,
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"exon_count": 8,
"intron_rank": null,
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"gene_symbol": "HSF2BP",
"gene_hgnc_id": 5226,
"hgvs_c": "c.-58G>A",
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"transcript": "XM_047440676.1",
"protein_id": "XP_047296632.1",
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
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"strand": false,
"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 2,
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"exon_count": 8,
"intron_rank": null,
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"gene_symbol": "HSF2BP",
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"hgvs_c": "c.-58G>A",
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"transcript": "XM_017028270.2",
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"cds_start": -4,
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},
{
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],
"exon_rank": 2,
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"intron_rank": null,
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"gene_symbol": "HSF2BP",
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},
{
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"strand": false,
"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
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"gene_symbol": "HSF2BP",
"gene_hgnc_id": 5226,
"hgvs_c": "c.-58G>A",
"hgvs_p": null,
"transcript": "XM_011529447.3",
"protein_id": "XP_011527749.1",
"transcript_support_level": null,
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},
{
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"protein_coding": true,
"strand": false,
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"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 2,
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"intron_rank": null,
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"gene_symbol": "HSF2BP",
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
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"gene_symbol": "HSF2BP",
"gene_hgnc_id": 5226,
"hgvs_c": "c.-58G>A",
"hgvs_p": null,
"transcript": "XM_047440679.1",
"protein_id": "XP_047296635.1",
"transcript_support_level": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HSF2BP",
"gene_hgnc_id": 5226,
"hgvs_c": "n.270G>A",
"hgvs_p": null,
"transcript": "XR_007067780.1",
"protein_id": null,
"transcript_support_level": null,
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},
{
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"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HSF2BP",
"gene_hgnc_id": 5226,
"hgvs_c": "n.270G>A",
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"transcript": "XR_007067781.1",
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},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HSF2BP",
"gene_hgnc_id": 5226,
"hgvs_c": "n.270G>A",
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"transcript": "XR_007067782.1",
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},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 2,
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"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HSF2BP",
"gene_hgnc_id": 5226,
"hgvs_c": "c.-58G>A",
"hgvs_p": null,
"transcript": "ENST00000443485.1",
"protein_id": "ENSP00000409585.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 225,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HSF2BP",
"gene_hgnc_id": 5226,
"hgvs_c": "c.-58G>A",
"hgvs_p": null,
"transcript": "XM_011529443.3",
"protein_id": "XP_011527745.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 348,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
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