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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 21-44230070-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=21&pos=44230070&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "21",
"pos": 44230070,
"ref": "C",
"alt": "T",
"effect": "synonymous_variant",
"transcript": "NM_001283050.2",
"consequences": [
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ICOSLG",
"gene_hgnc_id": 17087,
"hgvs_c": "c.882G>A",
"hgvs_p": "p.Pro294Pro",
"transcript": "NM_015259.6",
"protein_id": "NP_056074.1",
"transcript_support_level": null,
"aa_start": 294,
"aa_end": null,
"aa_length": 302,
"cds_start": 882,
"cds_end": null,
"cds_length": 909,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000407780.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_015259.6"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ICOSLG",
"gene_hgnc_id": 17087,
"hgvs_c": "c.882G>A",
"hgvs_p": "p.Pro294Pro",
"transcript": "ENST00000407780.8",
"protein_id": "ENSP00000384432.3",
"transcript_support_level": 1,
"aa_start": 294,
"aa_end": null,
"aa_length": 302,
"cds_start": 882,
"cds_end": null,
"cds_length": 909,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_015259.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000407780.8"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ICOSLG",
"gene_hgnc_id": 17087,
"hgvs_c": "c.882G>A",
"hgvs_p": "p.Pro294Pro",
"transcript": "ENST00000400379.8",
"protein_id": "ENSP00000383230.3",
"transcript_support_level": 1,
"aa_start": 294,
"aa_end": null,
"aa_length": 473,
"cds_start": 882,
"cds_end": null,
"cds_length": 1422,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000400379.8"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ICOSLG",
"gene_hgnc_id": 17087,
"hgvs_c": "c.882G>A",
"hgvs_p": "p.Pro294Pro",
"transcript": "ENST00000344330.9",
"protein_id": "ENSP00000339477.4",
"transcript_support_level": 1,
"aa_start": 294,
"aa_end": null,
"aa_length": 309,
"cds_start": 882,
"cds_end": null,
"cds_length": 930,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000344330.9"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ICOSLG",
"gene_hgnc_id": 17087,
"hgvs_c": "c.882G>A",
"hgvs_p": "p.Pro294Pro",
"transcript": "ENST00000643466.2",
"protein_id": "ENSP00000494882.2",
"transcript_support_level": null,
"aa_start": 294,
"aa_end": null,
"aa_length": 361,
"cds_start": 882,
"cds_end": null,
"cds_length": 1086,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000643466.2"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ICOSLG",
"gene_hgnc_id": 17087,
"hgvs_c": "c.918G>A",
"hgvs_p": "p.Pro306Pro",
"transcript": "ENST00000867614.1",
"protein_id": "ENSP00000537673.1",
"transcript_support_level": null,
"aa_start": 306,
"aa_end": null,
"aa_length": 314,
"cds_start": 918,
"cds_end": null,
"cds_length": 945,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867614.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ICOSLG",
"gene_hgnc_id": 17087,
"hgvs_c": "c.882G>A",
"hgvs_p": "p.Pro294Pro",
"transcript": "NM_001283050.2",
"protein_id": "NP_001269979.1",
"transcript_support_level": null,
"aa_start": 294,
"aa_end": null,
"aa_length": 309,
"cds_start": 882,
"cds_end": null,
"cds_length": 930,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001283050.2"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ICOSLG",
"gene_hgnc_id": 17087,
"hgvs_c": "c.882G>A",
"hgvs_p": "p.Pro294Pro",
"transcript": "NM_001395918.1",
"protein_id": "NP_001382847.1",
"transcript_support_level": null,
"aa_start": 294,
"aa_end": null,
"aa_length": 304,
"cds_start": 882,
"cds_end": null,
"cds_length": 915,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001395918.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ICOSLG",
"gene_hgnc_id": 17087,
"hgvs_c": "c.882G>A",
"hgvs_p": "p.Pro294Pro",
"transcript": "ENST00000700355.1",
"protein_id": "ENSP00000514957.1",
"transcript_support_level": null,
"aa_start": 294,
"aa_end": null,
"aa_length": 304,
"cds_start": 882,
"cds_end": null,
"cds_length": 915,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000700355.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ICOSLG",
"gene_hgnc_id": 17087,
"hgvs_c": "c.801G>A",
"hgvs_p": "p.Pro267Pro",
"transcript": "NM_001365759.2",
"protein_id": "NP_001352688.1",
"transcript_support_level": null,
"aa_start": 267,
"aa_end": null,
"aa_length": 275,
"cds_start": 801,
"cds_end": null,
"cds_length": 828,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001365759.2"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ICOSLG",
"gene_hgnc_id": 17087,
"hgvs_c": "c.759G>A",
"hgvs_p": "p.Pro253Pro",
"transcript": "ENST00000700352.1",
"protein_id": "ENSP00000514956.1",
"transcript_support_level": null,
"aa_start": 253,
"aa_end": null,
"aa_length": 261,
"cds_start": 759,
"cds_end": null,
"cds_length": 786,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000700352.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ICOSLG",
"gene_hgnc_id": 17087,
"hgvs_c": "c.627G>A",
"hgvs_p": "p.Pro209Pro",
"transcript": "NM_001283052.2",
"protein_id": "NP_001269981.1",
"transcript_support_level": null,
"aa_start": 209,
"aa_end": null,
"aa_length": 217,
"cds_start": 627,
"cds_end": null,
"cds_length": 654,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001283052.2"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ICOSLG",
"gene_hgnc_id": 17087,
"hgvs_c": "c.627G>A",
"hgvs_p": "p.Pro209Pro",
"transcript": "ENST00000700358.1",
"protein_id": "ENSP00000514960.1",
"transcript_support_level": null,
"aa_start": 209,
"aa_end": null,
"aa_length": 217,
"cds_start": 627,
"cds_end": null,
"cds_length": 654,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000700358.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ICOSLG",
"gene_hgnc_id": 17087,
"hgvs_c": "c.627G>A",
"hgvs_p": "p.Pro209Pro",
"transcript": "ENST00000700360.1",
"protein_id": "ENSP00000514962.1",
"transcript_support_level": null,
"aa_start": 209,
"aa_end": null,
"aa_length": 213,
"cds_start": 627,
"cds_end": null,
"cds_length": 643,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000700360.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ICOSLG",
"gene_hgnc_id": 17087,
"hgvs_c": "c.531G>A",
"hgvs_p": "p.Pro177Pro",
"transcript": "NM_001283051.2",
"protein_id": "NP_001269980.1",
"transcript_support_level": null,
"aa_start": 177,
"aa_end": null,
"aa_length": 185,
"cds_start": 531,
"cds_end": null,
"cds_length": 558,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001283051.2"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ICOSLG",
"gene_hgnc_id": 17087,
"hgvs_c": "c.531G>A",
"hgvs_p": "p.Pro177Pro",
"transcript": "ENST00000400377.4",
"protein_id": "ENSP00000383228.3",
"transcript_support_level": 2,
"aa_start": 177,
"aa_end": null,
"aa_length": 185,
"cds_start": 531,
"cds_end": null,
"cds_length": 558,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000400377.4"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ICOSLG",
"gene_hgnc_id": 17087,
"hgvs_c": "c.240G>A",
"hgvs_p": "p.Pro80Pro",
"transcript": "ENST00000867615.1",
"protein_id": "ENSP00000537674.1",
"transcript_support_level": null,
"aa_start": 80,
"aa_end": null,
"aa_length": 88,
"cds_start": 240,
"cds_end": null,
"cds_length": 267,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867615.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ICOSLG",
"gene_hgnc_id": 17087,
"hgvs_c": "c.885G>A",
"hgvs_p": "p.Pro295Pro",
"transcript": "XM_047440729.1",
"protein_id": "XP_047296685.1",
"transcript_support_level": null,
"aa_start": 295,
"aa_end": null,
"aa_length": 362,
"cds_start": 885,
"cds_end": null,
"cds_length": 1089,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047440729.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ICOSLG",
"gene_hgnc_id": 17087,
"hgvs_c": "c.882G>A",
"hgvs_p": "p.Pro294Pro",
"transcript": "XM_011529514.4",
"protein_id": "XP_011527816.1",
"transcript_support_level": null,
"aa_start": 294,
"aa_end": null,
"aa_length": 361,
"cds_start": 882,
"cds_end": null,
"cds_length": 1086,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011529514.4"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ICOSLG",
"gene_hgnc_id": 17087,
"hgvs_c": "c.801G>A",
"hgvs_p": "p.Pro267Pro",
"transcript": "XM_011529516.4",
"protein_id": "XP_011527818.1",
"transcript_support_level": null,
"aa_start": 267,
"aa_end": null,
"aa_length": 334,
"cds_start": 801,
"cds_end": null,
"cds_length": 1005,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011529516.4"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ICOSLG",
"gene_hgnc_id": 17087,
"hgvs_c": "c.801G>A",
"hgvs_p": "p.Pro267Pro",
"transcript": "XM_047440730.1",
"protein_id": "XP_047296686.1",
"transcript_support_level": null,
"aa_start": 267,
"aa_end": null,
"aa_length": 334,
"cds_start": 801,
"cds_end": null,
"cds_length": 1005,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047440730.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ICOSLG",
"gene_hgnc_id": 17087,
"hgvs_c": "c.885G>A",
"hgvs_p": "p.Pro295Pro",
"transcript": "XM_047440731.1",
"protein_id": "XP_047296687.1",
"transcript_support_level": null,
"aa_start": 295,
"aa_end": null,
"aa_length": 303,
"cds_start": 885,
"cds_end": null,
"cds_length": 912,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047440731.1"
},
{
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}
],
"message": null
}