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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 22-20465035-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=22&pos=20465035&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "22",
"pos": 20465035,
"ref": "G",
"alt": "A",
"effect": "missense_variant",
"transcript": "NM_032775.4",
"consequences": [
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL22",
"gene_hgnc_id": 25888,
"hgvs_c": "c.935C>T",
"hgvs_p": "p.Thr312Ile",
"transcript": "NM_032775.4",
"protein_id": "NP_116164.2",
"transcript_support_level": null,
"aa_start": 312,
"aa_end": null,
"aa_length": 634,
"cds_start": 935,
"cds_end": null,
"cds_length": 1905,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000328879.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_032775.4"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL22",
"gene_hgnc_id": 25888,
"hgvs_c": "c.935C>T",
"hgvs_p": "p.Thr312Ile",
"transcript": "ENST00000328879.9",
"protein_id": "ENSP00000331682.4",
"transcript_support_level": 1,
"aa_start": 312,
"aa_end": null,
"aa_length": 634,
"cds_start": 935,
"cds_end": null,
"cds_length": 1905,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_032775.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000328879.9"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL22",
"gene_hgnc_id": 25888,
"hgvs_c": "c.935C>T",
"hgvs_p": "p.Thr312Ile",
"transcript": "ENST00000871932.1",
"protein_id": "ENSP00000541991.1",
"transcript_support_level": null,
"aa_start": 312,
"aa_end": null,
"aa_length": 634,
"cds_start": 935,
"cds_end": null,
"cds_length": 1905,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000871932.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL22",
"gene_hgnc_id": 25888,
"hgvs_c": "c.935C>T",
"hgvs_p": "p.Thr312Ile",
"transcript": "ENST00000871933.1",
"protein_id": "ENSP00000541992.1",
"transcript_support_level": null,
"aa_start": 312,
"aa_end": null,
"aa_length": 634,
"cds_start": 935,
"cds_end": null,
"cds_length": 1905,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000871933.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL22",
"gene_hgnc_id": 25888,
"hgvs_c": "c.935C>T",
"hgvs_p": "p.Thr312Ile",
"transcript": "ENST00000871934.1",
"protein_id": "ENSP00000541993.1",
"transcript_support_level": null,
"aa_start": 312,
"aa_end": null,
"aa_length": 634,
"cds_start": 935,
"cds_end": null,
"cds_length": 1905,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000871934.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL22",
"gene_hgnc_id": 25888,
"hgvs_c": "c.935C>T",
"hgvs_p": "p.Thr312Ile",
"transcript": "ENST00000871935.1",
"protein_id": "ENSP00000541994.1",
"transcript_support_level": null,
"aa_start": 312,
"aa_end": null,
"aa_length": 634,
"cds_start": 935,
"cds_end": null,
"cds_length": 1905,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000871935.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL22",
"gene_hgnc_id": 25888,
"hgvs_c": "c.935C>T",
"hgvs_p": "p.Thr312Ile",
"transcript": "ENST00000871937.1",
"protein_id": "ENSP00000541996.1",
"transcript_support_level": null,
"aa_start": 312,
"aa_end": null,
"aa_length": 634,
"cds_start": 935,
"cds_end": null,
"cds_length": 1905,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000871937.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL22",
"gene_hgnc_id": 25888,
"hgvs_c": "c.935C>T",
"hgvs_p": "p.Thr312Ile",
"transcript": "ENST00000871938.1",
"protein_id": "ENSP00000541997.1",
"transcript_support_level": null,
"aa_start": 312,
"aa_end": null,
"aa_length": 634,
"cds_start": 935,
"cds_end": null,
"cds_length": 1905,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000871938.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL22",
"gene_hgnc_id": 25888,
"hgvs_c": "c.935C>T",
"hgvs_p": "p.Thr312Ile",
"transcript": "ENST00000871939.1",
"protein_id": "ENSP00000541998.1",
"transcript_support_level": null,
"aa_start": 312,
"aa_end": null,
"aa_length": 634,
"cds_start": 935,
"cds_end": null,
"cds_length": 1905,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000871939.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL22",
"gene_hgnc_id": 25888,
"hgvs_c": "c.935C>T",
"hgvs_p": "p.Thr312Ile",
"transcript": "ENST00000871940.1",
"protein_id": "ENSP00000541999.1",
"transcript_support_level": null,
"aa_start": 312,
"aa_end": null,
"aa_length": 634,
"cds_start": 935,
"cds_end": null,
"cds_length": 1905,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000871940.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL22",
"gene_hgnc_id": 25888,
"hgvs_c": "c.935C>T",
"hgvs_p": "p.Thr312Ile",
"transcript": "ENST00000912749.1",
"protein_id": "ENSP00000582808.1",
"transcript_support_level": null,
"aa_start": 312,
"aa_end": null,
"aa_length": 634,
"cds_start": 935,
"cds_end": null,
"cds_length": 1905,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000912749.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL22",
"gene_hgnc_id": 25888,
"hgvs_c": "c.935C>T",
"hgvs_p": "p.Thr312Ile",
"transcript": "ENST00000912751.1",
"protein_id": "ENSP00000582810.1",
"transcript_support_level": null,
"aa_start": 312,
"aa_end": null,
"aa_length": 634,
"cds_start": 935,
"cds_end": null,
"cds_length": 1905,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000912751.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL22",
"gene_hgnc_id": 25888,
"hgvs_c": "c.935C>T",
"hgvs_p": "p.Thr312Ile",
"transcript": "ENST00000957182.1",
"protein_id": "ENSP00000627241.1",
"transcript_support_level": null,
"aa_start": 312,
"aa_end": null,
"aa_length": 634,
"cds_start": 935,
"cds_end": null,
"cds_length": 1905,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000957182.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL22",
"gene_hgnc_id": 25888,
"hgvs_c": "c.935C>T",
"hgvs_p": "p.Thr312Ile",
"transcript": "ENST00000957183.1",
"protein_id": "ENSP00000627242.1",
"transcript_support_level": null,
"aa_start": 312,
"aa_end": null,
"aa_length": 634,
"cds_start": 935,
"cds_end": null,
"cds_length": 1905,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000957183.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL22",
"gene_hgnc_id": 25888,
"hgvs_c": "c.935C>T",
"hgvs_p": "p.Thr312Ile",
"transcript": "ENST00000957184.1",
"protein_id": "ENSP00000627243.1",
"transcript_support_level": null,
"aa_start": 312,
"aa_end": null,
"aa_length": 634,
"cds_start": 935,
"cds_end": null,
"cds_length": 1905,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000957184.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL22",
"gene_hgnc_id": 25888,
"hgvs_c": "c.935C>T",
"hgvs_p": "p.Thr312Ile",
"transcript": "ENST00000957185.1",
"protein_id": "ENSP00000627244.1",
"transcript_support_level": null,
"aa_start": 312,
"aa_end": null,
"aa_length": 634,
"cds_start": 935,
"cds_end": null,
"cds_length": 1905,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000957185.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL22",
"gene_hgnc_id": 25888,
"hgvs_c": "c.935C>T",
"hgvs_p": "p.Thr312Ile",
"transcript": "ENST00000957186.1",
"protein_id": "ENSP00000627245.1",
"transcript_support_level": null,
"aa_start": 312,
"aa_end": null,
"aa_length": 634,
"cds_start": 935,
"cds_end": null,
"cds_length": 1905,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000957186.1"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL22",
"gene_hgnc_id": 25888,
"hgvs_c": "c.1079C>T",
"hgvs_p": "p.Thr360Ile",
"transcript": "XM_017029019.3",
"protein_id": "XP_016884508.1",
"transcript_support_level": null,
"aa_start": 360,
"aa_end": null,
"aa_length": 682,
"cds_start": 1079,
"cds_end": null,
"cds_length": 2049,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017029019.3"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL22",
"gene_hgnc_id": 25888,
"hgvs_c": "c.1031C>T",
"hgvs_p": "p.Thr344Ile",
"transcript": "XM_017029020.3",
"protein_id": "XP_016884509.1",
"transcript_support_level": null,
"aa_start": 344,
"aa_end": null,
"aa_length": 666,
"cds_start": 1031,
"cds_end": null,
"cds_length": 2001,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017029020.3"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL22",
"gene_hgnc_id": 25888,
"hgvs_c": "c.935C>T",
"hgvs_p": "p.Thr312Ile",
"transcript": "XM_017029021.3",
"protein_id": "XP_016884510.1",
"transcript_support_level": null,
"aa_start": 312,
"aa_end": null,
"aa_length": 634,
"cds_start": 935,
"cds_end": null,
"cds_length": 1905,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017029021.3"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL22",
"gene_hgnc_id": 25888,
"hgvs_c": "c.881C>T",
"hgvs_p": "p.Thr294Ile",
"transcript": "XM_017029022.2",
"protein_id": "XP_016884511.1",
"transcript_support_level": null,
"aa_start": 294,
"aa_end": null,
"aa_length": 616,
"cds_start": 881,
"cds_end": null,
"cds_length": 1851,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017029022.2"
},
{
"aa_ref": "T",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "KLHL22",
"gene_hgnc_id": 25888,
"hgvs_c": "c.833C>T",
"hgvs_p": "p.Thr278Ile",
"transcript": "XM_017029023.2",
"protein_id": "XP_016884512.1",
"transcript_support_level": null,
"aa_start": 278,
"aa_end": null,
"aa_length": 600,
"cds_start": 833,
"cds_end": null,
"cds_length": 1803,
"cdna_start": null,
"cdna_end": null,
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}
],
"message": null
}