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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 22-27982301-C-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=22&pos=27982301&ref=C&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "22",
      "pos": 27982301,
      "ref": "C",
      "alt": "A",
      "effect": "missense_variant",
      "transcript": "NM_001145418.2",
      "consequences": [
        {
          "aa_ref": "A",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 23,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TTC28",
          "gene_hgnc_id": 29179,
          "hgvs_c": "c.7366G>T",
          "hgvs_p": "p.Ala2456Ser",
          "transcript": "NM_001145418.2",
          "protein_id": "NP_001138890.1",
          "transcript_support_level": null,
          "aa_start": 2456,
          "aa_end": null,
          "aa_length": 2481,
          "cds_start": 7366,
          "cds_end": null,
          "cds_length": 7446,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000397906.7",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001145418.2"
        },
        {
          "aa_ref": "A",
          "aa_alt": "S",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 23,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TTC28",
          "gene_hgnc_id": 29179,
          "hgvs_c": "c.7366G>T",
          "hgvs_p": "p.Ala2456Ser",
          "transcript": "ENST00000397906.7",
          "protein_id": "ENSP00000381003.2",
          "transcript_support_level": 1,
          "aa_start": 2456,
          "aa_end": null,
          "aa_length": 2481,
          "cds_start": 7366,
          "cds_end": null,
          "cds_length": 7446,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_001145418.2",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000397906.7"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "TTC28-AS1",
          "gene_hgnc_id": 29336,
          "hgvs_c": "n.146-3391C>A",
          "hgvs_p": null,
          "transcript": "ENST00000419253.1",
          "protein_id": null,
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "ENST00000419253.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "TTC28-AS1",
          "gene_hgnc_id": 29336,
          "hgvs_c": "n.206-12172C>A",
          "hgvs_p": null,
          "transcript": "ENST00000454741.5",
          "protein_id": null,
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "ENST00000454741.5"
        },
        {
          "aa_ref": "A",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 22,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TTC28",
          "gene_hgnc_id": 29179,
          "hgvs_c": "c.7342G>T",
          "hgvs_p": "p.Ala2448Ser",
          "transcript": "NM_001393403.1",
          "protein_id": "NP_001380332.1",
          "transcript_support_level": null,
          "aa_start": 2448,
          "aa_end": null,
          "aa_length": 2473,
          "cds_start": 7342,
          "cds_end": null,
          "cds_length": 7422,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001393403.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 22,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TTC28",
          "gene_hgnc_id": 29179,
          "hgvs_c": "c.7012G>T",
          "hgvs_p": "p.Ala2338Ser",
          "transcript": "NM_001393404.1",
          "protein_id": "NP_001380333.1",
          "transcript_support_level": null,
          "aa_start": 2338,
          "aa_end": null,
          "aa_length": 2363,
          "cds_start": 7012,
          "cds_end": null,
          "cds_length": 7092,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001393404.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TTC28",
          "gene_hgnc_id": 29179,
          "hgvs_c": "c.6988G>T",
          "hgvs_p": "p.Ala2330Ser",
          "transcript": "NM_001393405.1",
          "protein_id": "NP_001380334.1",
          "transcript_support_level": null,
          "aa_start": 2330,
          "aa_end": null,
          "aa_length": 2355,
          "cds_start": 6988,
          "cds_end": null,
          "cds_length": 7068,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001393405.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TTC28",
          "gene_hgnc_id": 29179,
          "hgvs_c": "c.6985G>T",
          "hgvs_p": "p.Ala2329Ser",
          "transcript": "ENST00000612946.4",
          "protein_id": "ENSP00000479834.1",
          "transcript_support_level": 5,
          "aa_start": 2329,
          "aa_end": null,
          "aa_length": 2354,
          "cds_start": 6985,
          "cds_end": null,
          "cds_length": 7065,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000612946.4"
        },
        {
          "aa_ref": "A",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 23,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TTC28",
          "gene_hgnc_id": 29179,
          "hgvs_c": "c.7288G>T",
          "hgvs_p": "p.Ala2430Ser",
          "transcript": "XM_011530018.4",
          "protein_id": "XP_011528320.1",
          "transcript_support_level": null,
          "aa_start": 2430,
          "aa_end": null,
          "aa_length": 2455,
          "cds_start": 7288,
          "cds_end": null,
          "cds_length": 7368,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_011530018.4"
        },
        {
          "aa_ref": "A",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 23,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TTC28",
          "gene_hgnc_id": 29179,
          "hgvs_c": "c.7276G>T",
          "hgvs_p": "p.Ala2426Ser",
          "transcript": "XM_017028673.3",
          "protein_id": "XP_016884162.1",
          "transcript_support_level": null,
          "aa_start": 2426,
          "aa_end": null,
          "aa_length": 2451,
          "cds_start": 7276,
          "cds_end": null,
          "cds_length": 7356,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_017028673.3"
        },
        {
          "aa_ref": "A",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 22,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TTC28",
          "gene_hgnc_id": 29179,
          "hgvs_c": "c.7264G>T",
          "hgvs_p": "p.Ala2422Ser",
          "transcript": "XM_047441214.1",
          "protein_id": "XP_047297170.1",
          "transcript_support_level": null,
          "aa_start": 2422,
          "aa_end": null,
          "aa_length": 2447,
          "cds_start": 7264,
          "cds_end": null,
          "cds_length": 7344,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047441214.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 23,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TTC28",
          "gene_hgnc_id": 29179,
          "hgvs_c": "c.7060G>T",
          "hgvs_p": "p.Ala2354Ser",
          "transcript": "XM_047441215.1",
          "protein_id": "XP_047297171.1",
          "transcript_support_level": null,
          "aa_start": 2354,
          "aa_end": null,
          "aa_length": 2379,
          "cds_start": 7060,
          "cds_end": null,
          "cds_length": 7140,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047441215.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "TTC28-AS1",
          "gene_hgnc_id": 29336,
          "hgvs_c": "n.239-15110C>A",
          "hgvs_p": null,
          "transcript": "ENST00000417497.6",
          "protein_id": null,
          "transcript_support_level": 3,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "ENST00000417497.6"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "TTC28-AS1",
          "gene_hgnc_id": 29336,
          "hgvs_c": "n.155-12172C>A",
          "hgvs_p": null,
          "transcript": "ENST00000424161.6",
          "protein_id": null,
          "transcript_support_level": 4,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "ENST00000424161.6"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "TTC28-AS1",
          "gene_hgnc_id": 29336,
          "hgvs_c": "n.359-3391C>A",
          "hgvs_p": null,
          "transcript": "ENST00000425112.3",
          "protein_id": null,
          "transcript_support_level": 3,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "ENST00000425112.3"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "TTC28-AS1",
          "gene_hgnc_id": 29336,
          "hgvs_c": "n.251-7581C>A",
          "hgvs_p": null,
          "transcript": "ENST00000430853.5",
          "protein_id": null,
          "transcript_support_level": 4,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "ENST00000430853.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "TTC28-AS1",
          "gene_hgnc_id": 29336,
          "hgvs_c": "n.159-10823C>A",
          "hgvs_p": null,
          "transcript": "ENST00000434221.6",
          "protein_id": null,
          "transcript_support_level": 3,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "ENST00000434221.6"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "TTC28-AS1",
          "gene_hgnc_id": 29336,
          "hgvs_c": "n.322-15110C>A",
          "hgvs_p": null,
          "transcript": "ENST00000435348.6",
          "protein_id": null,
          "transcript_support_level": 4,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "ENST00000435348.6"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "TTC28-AS1",
          "gene_hgnc_id": 29336,
          "hgvs_c": "n.136-15110C>A",
          "hgvs_p": null,
          "transcript": "ENST00000452612.5",
          "protein_id": null,
          "transcript_support_level": 3,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "ENST00000452612.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "TTC28-AS1",
          "gene_hgnc_id": 29336,
          "hgvs_c": "n.204-15110C>A",
          "hgvs_p": null,
          "transcript": "ENST00000453632.6",
          "protein_id": null,
          "transcript_support_level": 4,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "ENST00000453632.6"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
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