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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 22-30019748-ACC-GCG (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=22&pos=30019748&ref=ACC&alt=GCG&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 0,
          "criteria": [],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "MTMR3",
          "hgnc_id": 7451,
          "hgvs_c": "c.2089_2091delACCinsGCG",
          "hgvs_p": "p.Thr697Ala",
          "inheritance_mode": "AR",
          "pathogenic_score": 0,
          "score": 0,
          "transcript": "NM_021090.4",
          "verdict": "Uncertain_significance"
        },
        {
          "benign_score": 0,
          "criteria": [],
          "effects": [
            "intron_variant"
          ],
          "gene_symbol": "HORMAD2-AS1",
          "hgnc_id": 50729,
          "hgvs_c": "n.416-1021_416-1019delGGTinsCGC",
          "hgvs_p": null,
          "inheritance_mode": "",
          "pathogenic_score": 0,
          "score": 0,
          "transcript": "ENST00000429350.6",
          "verdict": "Uncertain_significance"
        }
      ],
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "",
      "acmg_score": 0,
      "allele_count_reference_population": 0,
      "alphamissense_prediction": null,
      "alphamissense_score": null,
      "alt": "GCG",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": null,
      "bayesdelnoaf_score": null,
      "chr": "22",
      "clinvar_classification": "",
      "clinvar_disease": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "computational_prediction_selected": null,
      "computational_score_selected": null,
      "computational_source_selected": null,
      "consequences": [
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1198,
          "aa_ref": "T",
          "aa_start": 697,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 8987,
          "cdna_start": 2412,
          "cds_end": null,
          "cds_length": 3597,
          "cds_start": 2089,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 20,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_021090.4",
          "gene_hgnc_id": 7451,
          "gene_symbol": "MTMR3",
          "hgvs_c": "c.2089_2091delACCinsGCG",
          "hgvs_p": "p.Thr697Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000401950.7",
          "protein_coding": true,
          "protein_id": "NP_066576.1",
          "strand": true,
          "transcript": "NM_021090.4",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1198,
          "aa_ref": "T",
          "aa_start": 697,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 8987,
          "cdna_start": 2412,
          "cds_end": null,
          "cds_length": 3597,
          "cds_start": 2089,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 20,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000401950.7",
          "gene_hgnc_id": 7451,
          "gene_symbol": "MTMR3",
          "hgvs_c": "c.2089_2091delACCinsGCG",
          "hgvs_p": "p.Thr697Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_021090.4",
          "protein_coding": true,
          "protein_id": "ENSP00000384651.3",
          "strand": true,
          "transcript": "ENST00000401950.7",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1161,
          "aa_ref": "T",
          "aa_start": 697,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4464,
          "cdna_start": 2373,
          "cds_end": null,
          "cds_length": 3486,
          "cds_start": 2089,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 19,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000351488.7",
          "gene_hgnc_id": 7451,
          "gene_symbol": "MTMR3",
          "hgvs_c": "c.2089_2091delACCinsGCG",
          "hgvs_p": "p.Thr697Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000307271.6",
          "strand": true,
          "transcript": "ENST00000351488.7",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1232,
          "aa_ref": "T",
          "aa_start": 731,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4088,
          "cdna_start": 2501,
          "cds_end": null,
          "cds_length": 3699,
          "cds_start": 2191,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 21,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000956491.1",
          "gene_hgnc_id": 7451,
          "gene_symbol": "MTMR3",
          "hgvs_c": "c.2191_2193delACCinsGCG",
          "hgvs_p": "p.Thr731Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000626550.1",
          "strand": true,
          "transcript": "ENST00000956491.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1207,
          "aa_ref": "T",
          "aa_start": 697,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 9017,
          "cdna_start": 2431,
          "cds_end": null,
          "cds_length": 3624,
          "cds_start": 2089,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 21,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000908090.1",
          "gene_hgnc_id": 7451,
          "gene_symbol": "MTMR3",
          "hgvs_c": "c.2089_2091delACCinsGCG",
          "hgvs_p": "p.Thr697Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000578149.1",
          "strand": true,
          "transcript": "ENST00000908090.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1207,
          "aa_ref": "T",
          "aa_start": 697,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6103,
          "cdna_start": 2510,
          "cds_end": null,
          "cds_length": 3624,
          "cds_start": 2089,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 22,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000908091.1",
          "gene_hgnc_id": 7451,
          "gene_symbol": "MTMR3",
          "hgvs_c": "c.2089_2091delACCinsGCG",
          "hgvs_p": "p.Thr697Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000578150.1",
          "strand": true,
          "transcript": "ENST00000908091.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1206,
          "aa_ref": "T",
          "aa_start": 697,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5961,
          "cdna_start": 2380,
          "cds_end": null,
          "cds_length": 3621,
          "cds_start": 2089,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 21,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000956489.1",
          "gene_hgnc_id": 7451,
          "gene_symbol": "MTMR3",
          "hgvs_c": "c.2089_2091delACCinsGCG",
          "hgvs_p": "p.Thr697Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000626548.1",
          "strand": true,
          "transcript": "ENST00000956489.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1204,
          "aa_ref": "T",
          "aa_start": 731,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5995,
          "cdna_start": 2514,
          "cds_end": null,
          "cds_length": 3615,
          "cds_start": 2191,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 21,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000956488.1",
          "gene_hgnc_id": 7451,
          "gene_symbol": "MTMR3",
          "hgvs_c": "c.2191_2193delACCinsGCG",
          "hgvs_p": "p.Thr731Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000626547.1",
          "strand": true,
          "transcript": "ENST00000956488.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1198,
          "aa_ref": "T",
          "aa_start": 697,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4286,
          "cdna_start": 2531,
          "cds_end": null,
          "cds_length": 3597,
          "cds_start": 2089,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 21,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000908094.1",
          "gene_hgnc_id": 7451,
          "gene_symbol": "MTMR3",
          "hgvs_c": "c.2089_2091delACCinsGCG",
          "hgvs_p": "p.Thr697Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000578153.1",
          "strand": true,
          "transcript": "ENST00000908094.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1198,
          "aa_ref": "T",
          "aa_start": 697,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4272,
          "cdna_start": 2528,
          "cds_end": null,
          "cds_length": 3597,
          "cds_start": 2089,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 21,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000908095.1",
          "gene_hgnc_id": 7451,
          "gene_symbol": "MTMR3",
          "hgvs_c": "c.2089_2091delACCinsGCG",
          "hgvs_p": "p.Thr697Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000578154.1",
          "strand": true,
          "transcript": "ENST00000908095.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1198,
          "aa_ref": "T",
          "aa_start": 697,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4374,
          "cdna_start": 2619,
          "cds_end": null,
          "cds_length": 3597,
          "cds_start": 2089,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 20,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000908096.1",
          "gene_hgnc_id": 7451,
          "gene_symbol": "MTMR3",
          "hgvs_c": "c.2089_2091delACCinsGCG",
          "hgvs_p": "p.Thr697Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000578155.1",
          "strand": true,
          "transcript": "ENST00000908096.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1198,
          "aa_ref": "T",
          "aa_start": 697,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5919,
          "cdna_start": 2355,
          "cds_end": null,
          "cds_length": 3597,
          "cds_start": 2089,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 18,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000908097.1",
          "gene_hgnc_id": 7451,
          "gene_symbol": "MTMR3",
          "hgvs_c": "c.2089_2091delACCinsGCG",
          "hgvs_p": "p.Thr697Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000578156.1",
          "strand": true,
          "transcript": "ENST00000908097.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1170,
          "aa_ref": "T",
          "aa_start": 697,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 8903,
          "cdna_start": 2412,
          "cds_end": null,
          "cds_length": 3513,
          "cds_start": 2089,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 20,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_153050.3",
          "gene_hgnc_id": 7451,
          "gene_symbol": "MTMR3",
          "hgvs_c": "c.2089_2091delACCinsGCG",
          "hgvs_p": "p.Thr697Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_694690.1",
          "strand": true,
          "transcript": "NM_153050.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1170,
          "aa_ref": "T",
          "aa_start": 697,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 8906,
          "cdna_start": 2417,
          "cds_end": null,
          "cds_length": 3513,
          "cds_start": 2089,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 20,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000333027.7",
          "gene_hgnc_id": 7451,
          "gene_symbol": "MTMR3",
          "hgvs_c": "c.2089_2091delACCinsGCG",
          "hgvs_p": "p.Thr697Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000331649.3",
          "strand": true,
          "transcript": "ENST00000333027.7",
          "transcript_support_level": 5
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1170,
          "aa_ref": "T",
          "aa_start": 697,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3758,
          "cdna_start": 2098,
          "cds_end": null,
          "cds_length": 3513,
          "cds_start": 2089,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 18,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000406629.1",
          "gene_hgnc_id": 7451,
          "gene_symbol": "MTMR3",
          "hgvs_c": "c.2089_2091delACCinsGCG",
          "hgvs_p": "p.Thr697Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000384077.1",
          "strand": true,
          "transcript": "ENST00000406629.1",
          "transcript_support_level": 5
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1161,
          "aa_ref": "T",
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          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 8876,
          "cdna_start": 2412,
          "cds_end": null,
          "cds_length": 3486,
          "cds_start": 2089,
          "consequences": [
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          ],
          "exon_count": 19,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_153051.3",
          "gene_hgnc_id": 7451,
          "gene_symbol": "MTMR3",
          "hgvs_c": "c.2089_2091delACCinsGCG",
          "hgvs_p": "p.Thr697Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_694691.1",
          "strand": true,
          "transcript": "NM_153051.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1161,
          "aa_ref": "T",
          "aa_start": 697,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6011,
          "cdna_start": 2556,
          "cds_end": null,
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          "cds_start": 2089,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 20,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000940445.1",
          "gene_hgnc_id": 7451,
          "gene_symbol": "MTMR3",
          "hgvs_c": "c.2089_2091delACCinsGCG",
          "hgvs_p": "p.Thr697Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000610504.1",
          "strand": true,
          "transcript": "ENST00000940445.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1160,
          "aa_ref": "T",
          "aa_start": 659,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5796,
          "cdna_start": 2271,
          "cds_end": null,
          "cds_length": 3483,
          "cds_start": 1975,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 19,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000908093.1",
          "gene_hgnc_id": 7451,
          "gene_symbol": "MTMR3",
          "hgvs_c": "c.1975_1977delACCinsGCG",
          "hgvs_p": "p.Thr659Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000578152.1",
          "strand": true,
          "transcript": "ENST00000908093.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1153,
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For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.