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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 22-31625772-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=22&pos=31625772&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "22",
"pos": 31625772,
"ref": "G",
"alt": "T",
"effect": "intron_variant",
"transcript": "ENST00000439502.7",
"consequences": [
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PISD",
"gene_hgnc_id": 8999,
"hgvs_c": "c.44C>A",
"hgvs_p": "p.Ala15Glu",
"transcript": "ENST00000266095.9",
"protein_id": "ENSP00000266095.5",
"transcript_support_level": 1,
"aa_start": 15,
"aa_end": null,
"aa_length": 375,
"cds_start": 44,
"cds_end": null,
"cds_length": 1128,
"cdna_start": 474,
"cdna_end": null,
"cdna_length": 2655,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "PISD",
"gene_hgnc_id": 8999,
"hgvs_c": "c.322-3887C>A",
"hgvs_p": null,
"transcript": "NM_001326411.2",
"protein_id": "NP_001313340.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 409,
"cds_start": -4,
"cds_end": null,
"cds_length": 1230,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2358,
"mane_select": "ENST00000439502.7",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "PISD",
"gene_hgnc_id": 8999,
"hgvs_c": "c.322-3887C>A",
"hgvs_p": null,
"transcript": "ENST00000439502.7",
"protein_id": "ENSP00000391739.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 409,
"cds_start": -4,
"cds_end": null,
"cds_length": 1230,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2358,
"mane_select": "NM_001326411.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "PISD",
"gene_hgnc_id": 8999,
"hgvs_c": "n.329-3887C>A",
"hgvs_p": null,
"transcript": "ENST00000460723.5",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2534,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PISD",
"gene_hgnc_id": 8999,
"hgvs_c": "c.44C>A",
"hgvs_p": "p.Ala15Glu",
"transcript": "NM_001326415.2",
"protein_id": "NP_001313344.1",
"transcript_support_level": null,
"aa_start": 15,
"aa_end": null,
"aa_length": 375,
"cds_start": 44,
"cds_end": null,
"cds_length": 1128,
"cdna_start": 493,
"cdna_end": null,
"cdna_length": 2698,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PISD",
"gene_hgnc_id": 8999,
"hgvs_c": "c.44C>A",
"hgvs_p": "p.Ala15Glu",
"transcript": "NM_001326416.2",
"protein_id": "NP_001313345.1",
"transcript_support_level": null,
"aa_start": 15,
"aa_end": null,
"aa_length": 375,
"cds_start": 44,
"cds_end": null,
"cds_length": 1128,
"cdna_start": 682,
"cdna_end": null,
"cdna_length": 2887,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PISD",
"gene_hgnc_id": 8999,
"hgvs_c": "c.44C>A",
"hgvs_p": "p.Ala15Glu",
"transcript": "NM_001326417.2",
"protein_id": "NP_001313346.1",
"transcript_support_level": null,
"aa_start": 15,
"aa_end": null,
"aa_length": 375,
"cds_start": 44,
"cds_end": null,
"cds_length": 1128,
"cdna_start": 573,
"cdna_end": null,
"cdna_length": 2778,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PISD",
"gene_hgnc_id": 8999,
"hgvs_c": "c.44C>A",
"hgvs_p": "p.Ala15Glu",
"transcript": "NM_014338.4",
"protein_id": "NP_055153.1",
"transcript_support_level": null,
"aa_start": 15,
"aa_end": null,
"aa_length": 375,
"cds_start": 44,
"cds_end": null,
"cds_length": 1128,
"cdna_start": 485,
"cdna_end": null,
"cdna_length": 2690,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PISD",
"gene_hgnc_id": 8999,
"hgvs_c": "c.44C>A",
"hgvs_p": "p.Ala15Glu",
"transcript": "NM_178022.2",
"protein_id": "NP_821141.1",
"transcript_support_level": null,
"aa_start": 15,
"aa_end": null,
"aa_length": 375,
"cds_start": 44,
"cds_end": null,
"cds_length": 1128,
"cdna_start": 403,
"cdna_end": null,
"cdna_length": 2608,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PISD",
"gene_hgnc_id": 8999,
"hgvs_c": "c.44C>A",
"hgvs_p": "p.Ala15Glu",
"transcript": "ENST00000382151.6",
"protein_id": "ENSP00000371586.2",
"transcript_support_level": 5,
"aa_start": 15,
"aa_end": null,
"aa_length": 375,
"cds_start": 44,
"cds_end": null,
"cds_length": 1128,
"cdna_start": 464,
"cdna_end": null,
"cdna_length": 2669,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PISD",
"gene_hgnc_id": 8999,
"hgvs_c": "c.44C>A",
"hgvs_p": "p.Ala15Glu",
"transcript": "NM_001326419.2",
"protein_id": "NP_001313348.1",
"transcript_support_level": null,
"aa_start": 15,
"aa_end": null,
"aa_length": 337,
"cds_start": 44,
"cds_end": null,
"cds_length": 1014,
"cdna_start": 573,
"cdna_end": null,
"cdna_length": 2664,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PISD",
"gene_hgnc_id": 8999,
"hgvs_c": "c.44C>A",
"hgvs_p": "p.Ala15Glu",
"transcript": "ENST00000397500.5",
"protein_id": "ENSP00000380637.1",
"transcript_support_level": 5,
"aa_start": 15,
"aa_end": null,
"aa_length": 262,
"cds_start": 44,
"cds_end": null,
"cds_length": 789,
"cdna_start": 273,
"cdna_end": null,
"cdna_length": 2194,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PISD",
"gene_hgnc_id": 8999,
"hgvs_c": "c.44C>A",
"hgvs_p": "p.Ala15Glu",
"transcript": "ENST00000422020.5",
"protein_id": "ENSP00000412169.1",
"transcript_support_level": 5,
"aa_start": 15,
"aa_end": null,
"aa_length": 227,
"cds_start": 44,
"cds_end": null,
"cds_length": 684,
"cdna_start": 375,
"cdna_end": null,
"cdna_length": 1015,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PISD",
"gene_hgnc_id": 8999,
"hgvs_c": "c.44C>A",
"hgvs_p": "p.Ala15Glu",
"transcript": "ENST00000442379.1",
"protein_id": "ENSP00000399818.1",
"transcript_support_level": 2,
"aa_start": 15,
"aa_end": null,
"aa_length": 80,
"cds_start": 44,
"cds_end": null,
"cds_length": 243,
"cdna_start": 523,
"cdna_end": null,
"cdna_length": 722,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PISD",
"gene_hgnc_id": 8999,
"hgvs_c": "c.44C>A",
"hgvs_p": "p.Ala15Glu",
"transcript": "ENST00000429683.1",
"protein_id": "ENSP00000396002.1",
"transcript_support_level": 3,
"aa_start": 15,
"aa_end": null,
"aa_length": 72,
"cds_start": 44,
"cds_end": null,
"cds_length": 219,
"cdna_start": 434,
"cdna_end": null,
"cdna_length": 609,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "E",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PISD",
"gene_hgnc_id": 8999,
"hgvs_c": "c.44C>A",
"hgvs_p": "p.Ala15Glu",
"transcript": "ENST00000431201.5",
"protein_id": "ENSP00000401606.1",
"transcript_support_level": 4,
"aa_start": 15,
"aa_end": null,
"aa_length": 72,
"cds_start": 44,
"cds_end": null,
"cds_length": 219,
"cdna_start": 285,
"cdna_end": null,
"cdna_length": 460,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PISD",
"gene_hgnc_id": 8999,
"hgvs_c": "n.15C>A",
"hgvs_p": null,
"transcript": "ENST00000478893.5",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1056,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "PISD",
"gene_hgnc_id": 8999,
"hgvs_c": "c.322-3950C>A",
"hgvs_p": null,
"transcript": "NM_001326412.1",
"protein_id": "NP_001313341.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 388,
"cds_start": -4,
"cds_end": null,
"cds_length": 1167,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2644,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "PISD",
"gene_hgnc_id": 8999,
"hgvs_c": "c.93-1923C>A",
"hgvs_p": null,
"transcript": "NM_001326413.2",
"protein_id": "NP_001313342.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 388,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 2444,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "PISD",
"gene_hgnc_id": 8999,
"hgvs_c": "c.93-1923C>A",
"hgvs_p": null,
"transcript": "NM_001326414.2",
"protein_id": "NP_001313343.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 388,
"cds_start": -4,
"cds_end": null,
"cds_length": 1167,
"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "PISD",
"gene_hgnc_id": 8999,
"hgvs_c": "c.292-3887C>A",
"hgvs_p": null,
"transcript": "ENST00000435900.5",
"protein_id": "ENSP00000414395.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 361,
"cds_start": -4,
"cds_end": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "PISD",
"gene_hgnc_id": 8999,
"hgvs_c": "c.142-3887C>A",
"hgvs_p": null,
"transcript": "NM_001326418.2",
"protein_id": "NP_001313347.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 349,
"cds_start": -4,
"cds_end": null,
"cds_length": 1050,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2278,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "PISD",
"gene_hgnc_id": 8999,
"hgvs_c": "c.142-3887C>A",
"hgvs_p": null,
"transcript": "NM_001326420.2",
"protein_id": "NP_001313349.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 311,
"cds_start": -4,
"cds_end": null,
"cds_length": 936,
"cdna_start": null,
"cdna_end": null,
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}