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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 22-37808082-C-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=22&pos=37808082&ref=C&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "22",
"pos": 37808082,
"ref": "C",
"alt": "G",
"effect": "missense_variant",
"transcript": "NM_001171690.2",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCAT",
"gene_hgnc_id": 4188,
"hgvs_c": "c.115C>G",
"hgvs_p": "p.Arg39Gly",
"transcript": "NM_014291.4",
"protein_id": "NP_055106.1",
"transcript_support_level": null,
"aa_start": 39,
"aa_end": null,
"aa_length": 419,
"cds_start": 115,
"cds_end": null,
"cds_length": 1260,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000248924.11",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_014291.4"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCAT",
"gene_hgnc_id": 4188,
"hgvs_c": "c.115C>G",
"hgvs_p": "p.Arg39Gly",
"transcript": "ENST00000248924.11",
"protein_id": "ENSP00000248924.6",
"transcript_support_level": 1,
"aa_start": 39,
"aa_end": null,
"aa_length": 419,
"cds_start": 115,
"cds_end": null,
"cds_length": 1260,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_014291.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000248924.11"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCAT",
"gene_hgnc_id": 4188,
"hgvs_c": "c.115C>G",
"hgvs_p": "p.Arg39Gly",
"transcript": "ENST00000892369.1",
"protein_id": "ENSP00000562428.1",
"transcript_support_level": null,
"aa_start": 39,
"aa_end": null,
"aa_length": 499,
"cds_start": 115,
"cds_end": null,
"cds_length": 1500,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892369.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCAT",
"gene_hgnc_id": 4188,
"hgvs_c": "c.115C>G",
"hgvs_p": "p.Arg39Gly",
"transcript": "ENST00000892367.1",
"protein_id": "ENSP00000562426.1",
"transcript_support_level": null,
"aa_start": 39,
"aa_end": null,
"aa_length": 494,
"cds_start": 115,
"cds_end": null,
"cds_length": 1485,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892367.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCAT",
"gene_hgnc_id": 4188,
"hgvs_c": "c.115C>G",
"hgvs_p": "p.Arg39Gly",
"transcript": "ENST00000892362.1",
"protein_id": "ENSP00000562421.1",
"transcript_support_level": null,
"aa_start": 39,
"aa_end": null,
"aa_length": 459,
"cds_start": 115,
"cds_end": null,
"cds_length": 1380,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892362.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCAT",
"gene_hgnc_id": 4188,
"hgvs_c": "c.115C>G",
"hgvs_p": "p.Arg39Gly",
"transcript": "NM_001171690.2",
"protein_id": "NP_001165161.1",
"transcript_support_level": null,
"aa_start": 39,
"aa_end": null,
"aa_length": 445,
"cds_start": 115,
"cds_end": null,
"cds_length": 1338,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001171690.2"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCAT",
"gene_hgnc_id": 4188,
"hgvs_c": "c.115C>G",
"hgvs_p": "p.Arg39Gly",
"transcript": "ENST00000323205.10",
"protein_id": "ENSP00000371110.3",
"transcript_support_level": 2,
"aa_start": 39,
"aa_end": null,
"aa_length": 445,
"cds_start": 115,
"cds_end": null,
"cds_length": 1338,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000323205.10"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCAT",
"gene_hgnc_id": 4188,
"hgvs_c": "c.115C>G",
"hgvs_p": "p.Arg39Gly",
"transcript": "ENST00000892361.1",
"protein_id": "ENSP00000562420.1",
"transcript_support_level": null,
"aa_start": 39,
"aa_end": null,
"aa_length": 445,
"cds_start": 115,
"cds_end": null,
"cds_length": 1338,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892361.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCAT",
"gene_hgnc_id": 4188,
"hgvs_c": "c.115C>G",
"hgvs_p": "p.Arg39Gly",
"transcript": "ENST00000892368.1",
"protein_id": "ENSP00000562427.1",
"transcript_support_level": null,
"aa_start": 39,
"aa_end": null,
"aa_length": 445,
"cds_start": 115,
"cds_end": null,
"cds_length": 1338,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892368.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCAT",
"gene_hgnc_id": 4188,
"hgvs_c": "c.115C>G",
"hgvs_p": "p.Arg39Gly",
"transcript": "ENST00000892366.1",
"protein_id": "ENSP00000562425.1",
"transcript_support_level": null,
"aa_start": 39,
"aa_end": null,
"aa_length": 437,
"cds_start": 115,
"cds_end": null,
"cds_length": 1314,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892366.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCAT",
"gene_hgnc_id": 4188,
"hgvs_c": "c.115C>G",
"hgvs_p": "p.Arg39Gly",
"transcript": "ENST00000892359.1",
"protein_id": "ENSP00000562418.1",
"transcript_support_level": null,
"aa_start": 39,
"aa_end": null,
"aa_length": 433,
"cds_start": 115,
"cds_end": null,
"cds_length": 1302,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892359.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCAT",
"gene_hgnc_id": 4188,
"hgvs_c": "c.115C>G",
"hgvs_p": "p.Arg39Gly",
"transcript": "ENST00000892360.1",
"protein_id": "ENSP00000562419.1",
"transcript_support_level": null,
"aa_start": 39,
"aa_end": null,
"aa_length": 433,
"cds_start": 115,
"cds_end": null,
"cds_length": 1302,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892360.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCAT",
"gene_hgnc_id": 4188,
"hgvs_c": "c.115C>G",
"hgvs_p": "p.Arg39Gly",
"transcript": "ENST00000892370.1",
"protein_id": "ENSP00000562429.1",
"transcript_support_level": null,
"aa_start": 39,
"aa_end": null,
"aa_length": 432,
"cds_start": 115,
"cds_end": null,
"cds_length": 1299,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892370.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCAT",
"gene_hgnc_id": 4188,
"hgvs_c": "c.115C>G",
"hgvs_p": "p.Arg39Gly",
"transcript": "ENST00000945451.1",
"protein_id": "ENSP00000615510.1",
"transcript_support_level": null,
"aa_start": 39,
"aa_end": null,
"aa_length": 432,
"cds_start": 115,
"cds_end": null,
"cds_length": 1299,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000945451.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCAT",
"gene_hgnc_id": 4188,
"hgvs_c": "c.115C>G",
"hgvs_p": "p.Arg39Gly",
"transcript": "ENST00000892357.1",
"protein_id": "ENSP00000562416.1",
"transcript_support_level": null,
"aa_start": 39,
"aa_end": null,
"aa_length": 419,
"cds_start": 115,
"cds_end": null,
"cds_length": 1260,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892357.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCAT",
"gene_hgnc_id": 4188,
"hgvs_c": "c.115C>G",
"hgvs_p": "p.Arg39Gly",
"transcript": "ENST00000892358.1",
"protein_id": "ENSP00000562417.1",
"transcript_support_level": null,
"aa_start": 39,
"aa_end": null,
"aa_length": 418,
"cds_start": 115,
"cds_end": null,
"cds_length": 1257,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892358.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCAT",
"gene_hgnc_id": 4188,
"hgvs_c": "c.115C>G",
"hgvs_p": "p.Arg39Gly",
"transcript": "ENST00000892363.1",
"protein_id": "ENSP00000562422.1",
"transcript_support_level": null,
"aa_start": 39,
"aa_end": null,
"aa_length": 418,
"cds_start": 115,
"cds_end": null,
"cds_length": 1257,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892363.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCAT",
"gene_hgnc_id": 4188,
"hgvs_c": "c.115C>G",
"hgvs_p": "p.Arg39Gly",
"transcript": "ENST00000912828.1",
"protein_id": "ENSP00000582887.1",
"transcript_support_level": null,
"aa_start": 39,
"aa_end": null,
"aa_length": 395,
"cds_start": 115,
"cds_end": null,
"cds_length": 1188,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000912828.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCAT",
"gene_hgnc_id": 4188,
"hgvs_c": "c.115C>G",
"hgvs_p": "p.Arg39Gly",
"transcript": "ENST00000892365.1",
"protein_id": "ENSP00000562424.1",
"transcript_support_level": null,
"aa_start": 39,
"aa_end": null,
"aa_length": 388,
"cds_start": 115,
"cds_end": null,
"cds_length": 1167,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892365.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCAT",
"gene_hgnc_id": 4188,
"hgvs_c": "c.115C>G",
"hgvs_p": "p.Arg39Gly",
"transcript": "ENST00000945452.1",
"protein_id": "ENSP00000615511.1",
"transcript_support_level": null,
"aa_start": 39,
"aa_end": null,
"aa_length": 386,
"cds_start": 115,
"cds_end": null,
"cds_length": 1161,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000945452.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCAT",
"gene_hgnc_id": 4188,
"hgvs_c": "c.115C>G",
"hgvs_p": "p.Arg39Gly",
"transcript": "ENST00000912827.1",
"protein_id": "ENSP00000582886.1",
"transcript_support_level": null,
"aa_start": 39,
"aa_end": null,
"aa_length": 370,
"cds_start": 115,
"cds_end": null,
"cds_length": 1113,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000912827.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCAT",
"gene_hgnc_id": 4188,
"hgvs_c": "c.115C>G",
"hgvs_p": "p.Arg39Gly",
"transcript": "ENST00000892364.1",
"protein_id": "ENSP00000562423.1",
"transcript_support_level": null,
"aa_start": 39,
"aa_end": null,
"aa_length": 336,
"cds_start": 115,
"cds_end": null,
"cds_length": 1011,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892364.1"
},
{
"aa_ref": "R",
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}