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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 22-41220782-A-G (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=22&pos=41220782&ref=A&alt=G&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "22",
      "pos": 41220782,
      "ref": "A",
      "alt": "G",
      "effect": "missense_variant",
      "transcript": "NM_031488.5",
      "consequences": [
        {
          "aa_ref": "H",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "L3MBTL2",
          "gene_hgnc_id": 18594,
          "hgvs_c": "c.767A>G",
          "hgvs_p": "p.His256Arg",
          "transcript": "NM_031488.5",
          "protein_id": "NP_113676.2",
          "transcript_support_level": null,
          "aa_start": 256,
          "aa_end": null,
          "aa_length": 705,
          "cds_start": 767,
          "cds_end": null,
          "cds_length": 2118,
          "cdna_start": 818,
          "cdna_end": null,
          "cdna_length": 3189,
          "mane_select": "ENST00000216237.10",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_031488.5"
        },
        {
          "aa_ref": "H",
          "aa_alt": "R",
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "L3MBTL2",
          "gene_hgnc_id": 18594,
          "hgvs_c": "c.767A>G",
          "hgvs_p": "p.His256Arg",
          "transcript": "ENST00000216237.10",
          "protein_id": "ENSP00000216237.5",
          "transcript_support_level": 1,
          "aa_start": 256,
          "aa_end": null,
          "aa_length": 705,
          "cds_start": 767,
          "cds_end": null,
          "cds_length": 2118,
          "cdna_start": 818,
          "cdna_end": null,
          "cdna_length": 3189,
          "mane_select": "NM_031488.5",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000216237.10"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "L3MBTL2",
          "gene_hgnc_id": 18594,
          "hgvs_c": "n.821A>G",
          "hgvs_p": null,
          "transcript": "ENST00000466589.5",
          "protein_id": null,
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3055,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000466589.5"
        },
        {
          "aa_ref": "H",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "L3MBTL2",
          "gene_hgnc_id": 18594,
          "hgvs_c": "c.767A>G",
          "hgvs_p": "p.His256Arg",
          "transcript": "ENST00000892682.1",
          "protein_id": "ENSP00000562741.1",
          "transcript_support_level": null,
          "aa_start": 256,
          "aa_end": null,
          "aa_length": 739,
          "cds_start": 767,
          "cds_end": null,
          "cds_length": 2220,
          "cdna_start": 822,
          "cdna_end": null,
          "cdna_length": 3295,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000892682.1"
        },
        {
          "aa_ref": "H",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "L3MBTL2",
          "gene_hgnc_id": 18594,
          "hgvs_c": "c.767A>G",
          "hgvs_p": "p.His256Arg",
          "transcript": "ENST00000969172.1",
          "protein_id": "ENSP00000639231.1",
          "transcript_support_level": null,
          "aa_start": 256,
          "aa_end": null,
          "aa_length": 713,
          "cds_start": 767,
          "cds_end": null,
          "cds_length": 2142,
          "cdna_start": 794,
          "cdna_end": null,
          "cdna_length": 3188,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000969172.1"
        },
        {
          "aa_ref": "H",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "L3MBTL2",
          "gene_hgnc_id": 18594,
          "hgvs_c": "c.779A>G",
          "hgvs_p": "p.His260Arg",
          "transcript": "ENST00000922934.1",
          "protein_id": "ENSP00000592993.1",
          "transcript_support_level": null,
          "aa_start": 260,
          "aa_end": null,
          "aa_length": 709,
          "cds_start": 779,
          "cds_end": null,
          "cds_length": 2130,
          "cdna_start": 816,
          "cdna_end": null,
          "cdna_length": 3187,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000922934.1"
        },
        {
          "aa_ref": "H",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "L3MBTL2",
          "gene_hgnc_id": 18594,
          "hgvs_c": "c.764A>G",
          "hgvs_p": "p.His255Arg",
          "transcript": "ENST00000969169.1",
          "protein_id": "ENSP00000639228.1",
          "transcript_support_level": null,
          "aa_start": 255,
          "aa_end": null,
          "aa_length": 704,
          "cds_start": 764,
          "cds_end": null,
          "cds_length": 2115,
          "cdna_start": 820,
          "cdna_end": null,
          "cdna_length": 3190,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000969169.1"
        },
        {
          "aa_ref": "H",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "L3MBTL2",
          "gene_hgnc_id": 18594,
          "hgvs_c": "c.767A>G",
          "hgvs_p": "p.His256Arg",
          "transcript": "ENST00000969170.1",
          "protein_id": "ENSP00000639229.1",
          "transcript_support_level": null,
          "aa_start": 256,
          "aa_end": null,
          "aa_length": 692,
          "cds_start": 767,
          "cds_end": null,
          "cds_length": 2079,
          "cdna_start": 818,
          "cdna_end": null,
          "cdna_length": 3149,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000969170.1"
        },
        {
          "aa_ref": "H",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "L3MBTL2",
          "gene_hgnc_id": 18594,
          "hgvs_c": "c.767A>G",
          "hgvs_p": "p.His256Arg",
          "transcript": "ENST00000969168.1",
          "protein_id": "ENSP00000639227.1",
          "transcript_support_level": null,
          "aa_start": 256,
          "aa_end": null,
          "aa_length": 670,
          "cds_start": 767,
          "cds_end": null,
          "cds_length": 2013,
          "cdna_start": 822,
          "cdna_end": null,
          "cdna_length": 3090,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000969168.1"
        },
        {
          "aa_ref": "H",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "L3MBTL2",
          "gene_hgnc_id": 18594,
          "hgvs_c": "c.767A>G",
          "hgvs_p": "p.His256Arg",
          "transcript": "ENST00000892680.1",
          "protein_id": "ENSP00000562739.1",
          "transcript_support_level": null,
          "aa_start": 256,
          "aa_end": null,
          "aa_length": 666,
          "cds_start": 767,
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          "cds_length": 2001,
          "cdna_start": 823,
          "cdna_end": null,
          "cdna_length": 3077,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000892680.1"
        },
        {
          "aa_ref": "H",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "L3MBTL2",
          "gene_hgnc_id": 18594,
          "hgvs_c": "c.587A>G",
          "hgvs_p": "p.His196Arg",
          "transcript": "ENST00000922932.1",
          "protein_id": "ENSP00000592991.1",
          "transcript_support_level": null,
          "aa_start": 196,
          "aa_end": null,
          "aa_length": 645,
          "cds_start": 587,
          "cds_end": null,
          "cds_length": 1938,
          "cdna_start": 643,
          "cdna_end": null,
          "cdna_length": 3014,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000922932.1"
        },
        {
          "aa_ref": "H",
          "aa_alt": "R",
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          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
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          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "L3MBTL2",
          "gene_hgnc_id": 18594,
          "hgvs_c": "c.563A>G",
          "hgvs_p": "p.His188Arg",
          "transcript": "ENST00000922933.1",
          "protein_id": "ENSP00000592992.1",
          "transcript_support_level": null,
          "aa_start": 188,
          "aa_end": null,
          "aa_length": 637,
          "cds_start": 563,
          "cds_end": null,
          "cds_length": 1914,
          "cdna_start": 614,
          "cdna_end": null,
          "cdna_length": 2985,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000922933.1"
        },
        {
          "aa_ref": "H",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
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          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "L3MBTL2",
          "gene_hgnc_id": 18594,
          "hgvs_c": "c.515A>G",
          "hgvs_p": "p.His172Arg",
          "transcript": "ENST00000892681.1",
          "protein_id": "ENSP00000562740.1",
          "transcript_support_level": null,
          "aa_start": 172,
          "aa_end": null,
          "aa_length": 621,
          "cds_start": 515,
          "cds_end": null,
          "cds_length": 1866,
          "cdna_start": 571,
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          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000892681.1"
        },
        {
          "aa_ref": "H",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "L3MBTL2",
          "gene_hgnc_id": 18594,
          "hgvs_c": "c.515A>G",
          "hgvs_p": "p.His172Arg",
          "transcript": "ENST00000969171.1",
          "protein_id": "ENSP00000639230.1",
          "transcript_support_level": null,
          "aa_start": 172,
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          "aa_length": 582,
          "cds_start": 515,
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        },
        {
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          ],
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          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "L3MBTL2",
          "gene_hgnc_id": 18594,
          "hgvs_c": "c.608A>G",
          "hgvs_p": "p.His203Arg",
          "transcript": "ENST00000449635.5",
          "protein_id": "ENSP00000399405.1",
          "transcript_support_level": 3,
          "aa_start": 203,
          "aa_end": null,
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          "cds_start": 608,
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          "cds_length": 863,
          "cdna_start": 609,
          "cdna_end": null,
          "cdna_length": 864,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000449635.5"
        },
        {
          "aa_ref": "H",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "L3MBTL2",
          "gene_hgnc_id": 18594,
          "hgvs_c": "c.767A>G",
          "hgvs_p": "p.His256Arg",
          "transcript": "XM_047441536.1",
          "protein_id": "XP_047297492.1",
          "transcript_support_level": null,
          "aa_start": 256,
          "aa_end": null,
          "aa_length": 631,
          "cds_start": 767,
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          "cds_length": 1896,
          "cdna_start": 818,
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          "cdna_length": 1969,
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          "biotype": "protein_coding",
          "feature": "XM_047441536.1"
        },
        {
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          "protein_coding": true,
          "strand": true,
          "consequences": [
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          ],
          "exon_rank": 5,
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          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "L3MBTL2",
          "gene_hgnc_id": 18594,
          "hgvs_c": "c.515A>G",
          "hgvs_p": "p.His172Arg",
          "transcript": "XM_017028976.2",
          "protein_id": "XP_016884465.1",
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          "cds_start": 515,
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        },
        {
          "aa_ref": "H",
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          "strand": true,
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          ],
          "exon_rank": 3,
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          "exon_count": 13,
          "intron_rank": null,
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          "gene_symbol": "L3MBTL2",
          "gene_hgnc_id": 18594,
          "hgvs_c": "c.437A>G",
          "hgvs_p": "p.His146Arg",
          "transcript": "XM_017028977.2",
          "protein_id": "XP_016884466.1",
          "transcript_support_level": null,
          "aa_start": 146,
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          "cds_start": 437,
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          "cds_length": 1788,
          "cdna_start": 531,
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          "cdna_length": 2902,
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          "biotype": "protein_coding",
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        },
        {
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          "protein_coding": true,
          "strand": true,
          "consequences": [
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          ],
          "exon_rank": 3,
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          "exon_count": 13,
          "intron_rank": null,
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          "gene_symbol": "L3MBTL2",
          "gene_hgnc_id": 18594,
          "hgvs_c": "c.137A>G",
          "hgvs_p": "p.His46Arg",
          "transcript": "XM_047441537.1",
          "protein_id": "XP_047297493.1",
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          "aa_length": 495,
          "cds_start": 137,
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          "cdna_start": 467,
          "cdna_end": null,
          "cdna_length": 2838,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047441537.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "L3MBTL2",
          "gene_hgnc_id": 18594,
          "hgvs_c": "n.625A>G",
          "hgvs_p": null,
          "transcript": "ENST00000450939.1",
          "protein_id": "ENSP00000403767.1",
          "transcript_support_level": 5,
          "aa_start": null,
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          "cds_start": null,
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          "cds_length": null,
          "cdna_start": null,
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        {
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        {
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          "gene_symbol": "L3MBTL2",
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        {
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          "biotype": "pseudogene",
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      ],
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      "gnomad_genomes_ac": null,
      "gnomad_exomes_homalt": null,
      "gnomad_genomes_homalt": null,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.3850218951702118,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": 0.138,
      "revel_prediction": "Benign",
      "alphamissense_score": 0.0828,
      "alphamissense_prediction": "Benign",
      "bayesdelnoaf_score": -0.38,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": 2.927,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
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      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
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      "mitotip_score": null,
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      "acmg_score": 1,
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PM2,BP4",
      "acmg_by_gene": [
        {
          "score": 1,
          "benign_score": 1,
          "pathogenic_score": 2,
          "criteria": [
            "PM2",
            "BP4"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "NM_031488.5",
          "gene_symbol": "L3MBTL2",
          "hgnc_id": 18594,
          "effects": [
            "missense_variant"
          ],
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        {
          "score": 1,
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          "pathogenic_score": 2,
          "criteria": [
            "PM2",
            "BP4"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "ENST00000657161.1",
          "gene_symbol": "L3MBTL2-AS1",
          "hgnc_id": 40847,
          "effects": [
            "intron_variant"
          ],
          "inheritance_mode": "",
          "hgvs_c": "n.227+7492T>C",
          "hgvs_p": null
        }
      ],
      "clinvar_disease": "",
      "clinvar_classification": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "phenotype_combined": null,
      "pathogenicity_classification_combined": null,
      "custom_annotations": null
    }
  ],
  "message": null
}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.