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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 22-41249337-C-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=22&pos=41249337&ref=C&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "22",
"pos": 41249337,
"ref": "C",
"alt": "G",
"effect": "missense_variant",
"transcript": "NM_002883.4",
"consequences": [
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RANGAP1",
"gene_hgnc_id": 9854,
"hgvs_c": "c.1687G>C",
"hgvs_p": "p.Val563Leu",
"transcript": "NM_002883.4",
"protein_id": "NP_002874.1",
"transcript_support_level": null,
"aa_start": 563,
"aa_end": null,
"aa_length": 587,
"cds_start": 1687,
"cds_end": null,
"cds_length": 1764,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000356244.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_002883.4"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RANGAP1",
"gene_hgnc_id": 9854,
"hgvs_c": "c.1687G>C",
"hgvs_p": "p.Val563Leu",
"transcript": "ENST00000356244.8",
"protein_id": "ENSP00000348577.3",
"transcript_support_level": 1,
"aa_start": 563,
"aa_end": null,
"aa_length": 587,
"cds_start": 1687,
"cds_end": null,
"cds_length": 1764,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_002883.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000356244.8"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RANGAP1",
"gene_hgnc_id": 9854,
"hgvs_c": "c.1687G>C",
"hgvs_p": "p.Val563Leu",
"transcript": "ENST00000405486.5",
"protein_id": "ENSP00000385866.1",
"transcript_support_level": 1,
"aa_start": 563,
"aa_end": null,
"aa_length": 587,
"cds_start": 1687,
"cds_end": null,
"cds_length": 1764,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000405486.5"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RANGAP1",
"gene_hgnc_id": 9854,
"hgvs_c": "c.1687G>C",
"hgvs_p": "p.Val563Leu",
"transcript": "ENST00000455915.6",
"protein_id": "ENSP00000401470.2",
"transcript_support_level": 1,
"aa_start": 563,
"aa_end": null,
"aa_length": 587,
"cds_start": 1687,
"cds_end": null,
"cds_length": 1764,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000455915.6"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RANGAP1",
"gene_hgnc_id": 9854,
"hgvs_c": "c.1789G>C",
"hgvs_p": "p.Val597Leu",
"transcript": "ENST00000932888.1",
"protein_id": "ENSP00000602947.1",
"transcript_support_level": null,
"aa_start": 597,
"aa_end": null,
"aa_length": 621,
"cds_start": 1789,
"cds_end": null,
"cds_length": 1866,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000932888.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RANGAP1",
"gene_hgnc_id": 9854,
"hgvs_c": "c.1756G>C",
"hgvs_p": "p.Val586Leu",
"transcript": "ENST00000898490.1",
"protein_id": "ENSP00000568549.1",
"transcript_support_level": null,
"aa_start": 586,
"aa_end": null,
"aa_length": 610,
"cds_start": 1756,
"cds_end": null,
"cds_length": 1833,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898490.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RANGAP1",
"gene_hgnc_id": 9854,
"hgvs_c": "c.1714G>C",
"hgvs_p": "p.Val572Leu",
"transcript": "ENST00000962603.1",
"protein_id": "ENSP00000632662.1",
"transcript_support_level": null,
"aa_start": 572,
"aa_end": null,
"aa_length": 596,
"cds_start": 1714,
"cds_end": null,
"cds_length": 1791,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000962603.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RANGAP1",
"gene_hgnc_id": 9854,
"hgvs_c": "c.1690G>C",
"hgvs_p": "p.Val564Leu",
"transcript": "ENST00000898497.1",
"protein_id": "ENSP00000568556.1",
"transcript_support_level": null,
"aa_start": 564,
"aa_end": null,
"aa_length": 588,
"cds_start": 1690,
"cds_end": null,
"cds_length": 1767,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898497.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RANGAP1",
"gene_hgnc_id": 9854,
"hgvs_c": "c.1690G>C",
"hgvs_p": "p.Val564Leu",
"transcript": "ENST00000932880.1",
"protein_id": "ENSP00000602939.1",
"transcript_support_level": null,
"aa_start": 564,
"aa_end": null,
"aa_length": 588,
"cds_start": 1690,
"cds_end": null,
"cds_length": 1767,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000932880.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RANGAP1",
"gene_hgnc_id": 9854,
"hgvs_c": "c.1690G>C",
"hgvs_p": "p.Val564Leu",
"transcript": "ENST00000932889.1",
"protein_id": "ENSP00000602948.1",
"transcript_support_level": null,
"aa_start": 564,
"aa_end": null,
"aa_length": 588,
"cds_start": 1690,
"cds_end": null,
"cds_length": 1767,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000932889.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RANGAP1",
"gene_hgnc_id": 9854,
"hgvs_c": "c.1690G>C",
"hgvs_p": "p.Val564Leu",
"transcript": "ENST00000962601.1",
"protein_id": "ENSP00000632660.1",
"transcript_support_level": null,
"aa_start": 564,
"aa_end": null,
"aa_length": 588,
"cds_start": 1690,
"cds_end": null,
"cds_length": 1767,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000962601.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RANGAP1",
"gene_hgnc_id": 9854,
"hgvs_c": "c.1687G>C",
"hgvs_p": "p.Val563Leu",
"transcript": "NM_001278651.2",
"protein_id": "NP_001265580.1",
"transcript_support_level": null,
"aa_start": 563,
"aa_end": null,
"aa_length": 587,
"cds_start": 1687,
"cds_end": null,
"cds_length": 1764,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001278651.2"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RANGAP1",
"gene_hgnc_id": 9854,
"hgvs_c": "c.1687G>C",
"hgvs_p": "p.Val563Leu",
"transcript": "NM_001317930.2",
"protein_id": "NP_001304859.1",
"transcript_support_level": null,
"aa_start": 563,
"aa_end": null,
"aa_length": 587,
"cds_start": 1687,
"cds_end": null,
"cds_length": 1764,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001317930.2"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RANGAP1",
"gene_hgnc_id": 9854,
"hgvs_c": "c.1687G>C",
"hgvs_p": "p.Val563Leu",
"transcript": "ENST00000705116.1",
"protein_id": "ENSP00000516069.1",
"transcript_support_level": null,
"aa_start": 563,
"aa_end": null,
"aa_length": 587,
"cds_start": 1687,
"cds_end": null,
"cds_length": 1764,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000705116.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RANGAP1",
"gene_hgnc_id": 9854,
"hgvs_c": "c.1687G>C",
"hgvs_p": "p.Val563Leu",
"transcript": "ENST00000898474.1",
"protein_id": "ENSP00000568533.1",
"transcript_support_level": null,
"aa_start": 563,
"aa_end": null,
"aa_length": 587,
"cds_start": 1687,
"cds_end": null,
"cds_length": 1764,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898474.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RANGAP1",
"gene_hgnc_id": 9854,
"hgvs_c": "c.1687G>C",
"hgvs_p": "p.Val563Leu",
"transcript": "ENST00000898475.1",
"protein_id": "ENSP00000568534.1",
"transcript_support_level": null,
"aa_start": 563,
"aa_end": null,
"aa_length": 587,
"cds_start": 1687,
"cds_end": null,
"cds_length": 1764,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898475.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RANGAP1",
"gene_hgnc_id": 9854,
"hgvs_c": "c.1687G>C",
"hgvs_p": "p.Val563Leu",
"transcript": "ENST00000898476.1",
"protein_id": "ENSP00000568535.1",
"transcript_support_level": null,
"aa_start": 563,
"aa_end": null,
"aa_length": 587,
"cds_start": 1687,
"cds_end": null,
"cds_length": 1764,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898476.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RANGAP1",
"gene_hgnc_id": 9854,
"hgvs_c": "c.1687G>C",
"hgvs_p": "p.Val563Leu",
"transcript": "ENST00000898477.1",
"protein_id": "ENSP00000568536.1",
"transcript_support_level": null,
"aa_start": 563,
"aa_end": null,
"aa_length": 587,
"cds_start": 1687,
"cds_end": null,
"cds_length": 1764,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898477.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RANGAP1",
"gene_hgnc_id": 9854,
"hgvs_c": "c.1687G>C",
"hgvs_p": "p.Val563Leu",
"transcript": "ENST00000898478.1",
"protein_id": "ENSP00000568537.1",
"transcript_support_level": null,
"aa_start": 563,
"aa_end": null,
"aa_length": 587,
"cds_start": 1687,
"cds_end": null,
"cds_length": 1764,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898478.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RANGAP1",
"gene_hgnc_id": 9854,
"hgvs_c": "c.1687G>C",
"hgvs_p": "p.Val563Leu",
"transcript": "ENST00000898479.1",
"protein_id": "ENSP00000568538.1",
"transcript_support_level": null,
"aa_start": 563,
"aa_end": null,
"aa_length": 587,
"cds_start": 1687,
"cds_end": null,
"cds_length": 1764,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898479.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RANGAP1",
"gene_hgnc_id": 9854,
"hgvs_c": "c.1687G>C",
"hgvs_p": "p.Val563Leu",
"transcript": "ENST00000898480.1",
"protein_id": "ENSP00000568539.1",
"transcript_support_level": null,
"aa_start": 563,
"aa_end": null,
"aa_length": 587,
"cds_start": 1687,
"cds_end": null,
"cds_length": 1764,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898480.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RANGAP1",
"gene_hgnc_id": 9854,
"hgvs_c": "c.1687G>C",
"hgvs_p": "p.Val563Leu",
"transcript": "ENST00000898482.1",
"protein_id": "ENSP00000568541.1",
"transcript_support_level": null,
"aa_start": 563,
"aa_end": null,
"aa_length": 587,
"cds_start": 1687,
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}