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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 22-41653610-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=22&pos=41653610&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "22",
"pos": 41653610,
"ref": "G",
"alt": "A",
"effect": "missense_variant",
"transcript": "NM_001469.5",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XRCC6",
"gene_hgnc_id": 4055,
"hgvs_c": "c.1211G>A",
"hgvs_p": "p.Arg404Lys",
"transcript": "NM_001469.5",
"protein_id": "NP_001460.1",
"transcript_support_level": null,
"aa_start": 404,
"aa_end": null,
"aa_length": 609,
"cds_start": 1211,
"cds_end": null,
"cds_length": 1830,
"cdna_start": 1277,
"cdna_end": null,
"cdna_length": 2122,
"mane_select": "ENST00000360079.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001469.5"
},
{
"aa_ref": "R",
"aa_alt": "K",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XRCC6",
"gene_hgnc_id": 4055,
"hgvs_c": "c.1211G>A",
"hgvs_p": "p.Arg404Lys",
"transcript": "ENST00000360079.8",
"protein_id": "ENSP00000353192.3",
"transcript_support_level": 1,
"aa_start": 404,
"aa_end": null,
"aa_length": 609,
"cds_start": 1211,
"cds_end": null,
"cds_length": 1830,
"cdna_start": 1277,
"cdna_end": null,
"cdna_length": 2122,
"mane_select": "NM_001469.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000360079.8"
},
{
"aa_ref": "R",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XRCC6",
"gene_hgnc_id": 4055,
"hgvs_c": "c.1211G>A",
"hgvs_p": "p.Arg404Lys",
"transcript": "ENST00000359308.8",
"protein_id": "ENSP00000352257.4",
"transcript_support_level": 1,
"aa_start": 404,
"aa_end": null,
"aa_length": 609,
"cds_start": 1211,
"cds_end": null,
"cds_length": 1830,
"cdna_start": 1866,
"cdna_end": null,
"cdna_length": 2709,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000359308.8"
},
{
"aa_ref": "R",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XRCC6",
"gene_hgnc_id": 4055,
"hgvs_c": "c.1286G>A",
"hgvs_p": "p.Arg429Lys",
"transcript": "ENST00000938034.1",
"protein_id": "ENSP00000608093.1",
"transcript_support_level": null,
"aa_start": 429,
"aa_end": null,
"aa_length": 634,
"cds_start": 1286,
"cds_end": null,
"cds_length": 1905,
"cdna_start": 1356,
"cdna_end": null,
"cdna_length": 2199,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000938034.1"
},
{
"aa_ref": "R",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XRCC6",
"gene_hgnc_id": 4055,
"hgvs_c": "c.1247G>A",
"hgvs_p": "p.Arg416Lys",
"transcript": "ENST00000892848.1",
"protein_id": "ENSP00000562907.1",
"transcript_support_level": null,
"aa_start": 416,
"aa_end": null,
"aa_length": 621,
"cds_start": 1247,
"cds_end": null,
"cds_length": 1866,
"cdna_start": 1302,
"cdna_end": null,
"cdna_length": 2145,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892848.1"
},
{
"aa_ref": "R",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XRCC6",
"gene_hgnc_id": 4055,
"hgvs_c": "c.1211G>A",
"hgvs_p": "p.Arg404Lys",
"transcript": "ENST00000970533.1",
"protein_id": "ENSP00000640592.1",
"transcript_support_level": null,
"aa_start": 404,
"aa_end": null,
"aa_length": 620,
"cds_start": 1211,
"cds_end": null,
"cds_length": 1863,
"cdna_start": 1279,
"cdna_end": null,
"cdna_length": 2156,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000970533.1"
},
{
"aa_ref": "R",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XRCC6",
"gene_hgnc_id": 4055,
"hgvs_c": "c.1211G>A",
"hgvs_p": "p.Arg404Lys",
"transcript": "NM_001288976.2",
"protein_id": "NP_001275905.1",
"transcript_support_level": null,
"aa_start": 404,
"aa_end": null,
"aa_length": 609,
"cds_start": 1211,
"cds_end": null,
"cds_length": 1830,
"cdna_start": 1342,
"cdna_end": null,
"cdna_length": 2187,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001288976.2"
},
{
"aa_ref": "R",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XRCC6",
"gene_hgnc_id": 4055,
"hgvs_c": "c.1211G>A",
"hgvs_p": "p.Arg404Lys",
"transcript": "ENST00000405878.5",
"protein_id": "ENSP00000384257.1",
"transcript_support_level": 5,
"aa_start": 404,
"aa_end": null,
"aa_length": 609,
"cds_start": 1211,
"cds_end": null,
"cds_length": 1830,
"cdna_start": 1357,
"cdna_end": null,
"cdna_length": 2200,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000405878.5"
},
{
"aa_ref": "R",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XRCC6",
"gene_hgnc_id": 4055,
"hgvs_c": "c.1211G>A",
"hgvs_p": "p.Arg404Lys",
"transcript": "ENST00000892843.1",
"protein_id": "ENSP00000562902.1",
"transcript_support_level": null,
"aa_start": 404,
"aa_end": null,
"aa_length": 609,
"cds_start": 1211,
"cds_end": null,
"cds_length": 1830,
"cdna_start": 1272,
"cdna_end": null,
"cdna_length": 2115,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892843.1"
},
{
"aa_ref": "R",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XRCC6",
"gene_hgnc_id": 4055,
"hgvs_c": "c.1211G>A",
"hgvs_p": "p.Arg404Lys",
"transcript": "ENST00000892849.1",
"protein_id": "ENSP00000562908.1",
"transcript_support_level": null,
"aa_start": 404,
"aa_end": null,
"aa_length": 609,
"cds_start": 1211,
"cds_end": null,
"cds_length": 1830,
"cdna_start": 1298,
"cdna_end": null,
"cdna_length": 2143,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892849.1"
},
{
"aa_ref": "R",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XRCC6",
"gene_hgnc_id": 4055,
"hgvs_c": "c.1211G>A",
"hgvs_p": "p.Arg404Lys",
"transcript": "ENST00000892850.1",
"protein_id": "ENSP00000562909.1",
"transcript_support_level": null,
"aa_start": 404,
"aa_end": null,
"aa_length": 609,
"cds_start": 1211,
"cds_end": null,
"cds_length": 1830,
"cdna_start": 1333,
"cdna_end": null,
"cdna_length": 2176,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892850.1"
},
{
"aa_ref": "R",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XRCC6",
"gene_hgnc_id": 4055,
"hgvs_c": "c.1211G>A",
"hgvs_p": "p.Arg404Lys",
"transcript": "ENST00000892852.1",
"protein_id": "ENSP00000562911.1",
"transcript_support_level": null,
"aa_start": 404,
"aa_end": null,
"aa_length": 609,
"cds_start": 1211,
"cds_end": null,
"cds_length": 1830,
"cdna_start": 1282,
"cdna_end": null,
"cdna_length": 2123,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892852.1"
},
{
"aa_ref": "R",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XRCC6",
"gene_hgnc_id": 4055,
"hgvs_c": "c.1211G>A",
"hgvs_p": "p.Arg404Lys",
"transcript": "ENST00000892853.1",
"protein_id": "ENSP00000562912.1",
"transcript_support_level": null,
"aa_start": 404,
"aa_end": null,
"aa_length": 609,
"cds_start": 1211,
"cds_end": null,
"cds_length": 1830,
"cdna_start": 1454,
"cdna_end": null,
"cdna_length": 2297,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892853.1"
},
{
"aa_ref": "R",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XRCC6",
"gene_hgnc_id": 4055,
"hgvs_c": "c.1211G>A",
"hgvs_p": "p.Arg404Lys",
"transcript": "ENST00000938028.1",
"protein_id": "ENSP00000608087.1",
"transcript_support_level": null,
"aa_start": 404,
"aa_end": null,
"aa_length": 609,
"cds_start": 1211,
"cds_end": null,
"cds_length": 1830,
"cdna_start": 1473,
"cdna_end": null,
"cdna_length": 2318,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000938028.1"
},
{
"aa_ref": "R",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XRCC6",
"gene_hgnc_id": 4055,
"hgvs_c": "c.1211G>A",
"hgvs_p": "p.Arg404Lys",
"transcript": "ENST00000938030.1",
"protein_id": "ENSP00000608089.1",
"transcript_support_level": null,
"aa_start": 404,
"aa_end": null,
"aa_length": 609,
"cds_start": 1211,
"cds_end": null,
"cds_length": 1830,
"cdna_start": 1300,
"cdna_end": null,
"cdna_length": 2191,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000938030.1"
},
{
"aa_ref": "R",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XRCC6",
"gene_hgnc_id": 4055,
"hgvs_c": "c.1211G>A",
"hgvs_p": "p.Arg404Lys",
"transcript": "ENST00000938031.1",
"protein_id": "ENSP00000608090.1",
"transcript_support_level": null,
"aa_start": 404,
"aa_end": null,
"aa_length": 609,
"cds_start": 1211,
"cds_end": null,
"cds_length": 1830,
"cdna_start": 1294,
"cdna_end": null,
"cdna_length": 2139,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000938031.1"
},
{
"aa_ref": "R",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XRCC6",
"gene_hgnc_id": 4055,
"hgvs_c": "c.1211G>A",
"hgvs_p": "p.Arg404Lys",
"transcript": "ENST00000938039.1",
"protein_id": "ENSP00000608098.1",
"transcript_support_level": null,
"aa_start": 404,
"aa_end": null,
"aa_length": 609,
"cds_start": 1211,
"cds_end": null,
"cds_length": 1830,
"cdna_start": 1471,
"cdna_end": null,
"cdna_length": 2316,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000938039.1"
},
{
"aa_ref": "R",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XRCC6",
"gene_hgnc_id": 4055,
"hgvs_c": "c.1211G>A",
"hgvs_p": "p.Arg404Lys",
"transcript": "ENST00000892844.1",
"protein_id": "ENSP00000562903.1",
"transcript_support_level": null,
"aa_start": 404,
"aa_end": null,
"aa_length": 608,
"cds_start": 1211,
"cds_end": null,
"cds_length": 1827,
"cdna_start": 1277,
"cdna_end": null,
"cdna_length": 2118,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892844.1"
},
{
"aa_ref": "R",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XRCC6",
"gene_hgnc_id": 4055,
"hgvs_c": "c.1208G>A",
"hgvs_p": "p.Arg403Lys",
"transcript": "ENST00000938029.1",
"protein_id": "ENSP00000608088.1",
"transcript_support_level": null,
"aa_start": 403,
"aa_end": null,
"aa_length": 608,
"cds_start": 1208,
"cds_end": null,
"cds_length": 1827,
"cdna_start": 1344,
"cdna_end": null,
"cdna_length": 2196,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000938029.1"
},
{
"aa_ref": "R",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XRCC6",
"gene_hgnc_id": 4055,
"hgvs_c": "c.1211G>A",
"hgvs_p": "p.Arg404Lys",
"transcript": "ENST00000938040.1",
"protein_id": "ENSP00000608099.1",
"transcript_support_level": null,
"aa_start": 404,
"aa_end": null,
"aa_length": 608,
"cds_start": 1211,
"cds_end": null,
"cds_length": 1827,
"cdna_start": 1294,
"cdna_end": null,
"cdna_length": 2136,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000938040.1"
},
{
"aa_ref": "R",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XRCC6",
"gene_hgnc_id": 4055,
"hgvs_c": "c.1208G>A",
"hgvs_p": "p.Arg403Lys",
"transcript": "ENST00000970532.1",
"protein_id": "ENSP00000640591.1",
"transcript_support_level": null,
"aa_start": 403,
"aa_end": null,
"aa_length": 608,
"cds_start": 1208,
"cds_end": null,
"cds_length": 1827,
"cdna_start": 1278,
"cdna_end": null,
"cdna_length": 2122,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000970532.1"
},
{
"aa_ref": "R",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "XRCC6",
"gene_hgnc_id": 4055,
"hgvs_c": "c.1211G>A",
"hgvs_p": "p.Arg404Lys",
"transcript": "ENST00000938032.1",
"protein_id": "ENSP00000608091.1",
"transcript_support_level": null,
"aa_start": 404,
"aa_end": null,
"aa_length": 606,
"cds_start": 1211,
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