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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 22-42871457-G-C (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=22&pos=42871457&ref=G&alt=C&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "22",
      "pos": 42871457,
      "ref": "G",
      "alt": "C",
      "effect": "missense_variant",
      "transcript": "NM_001349969.2",
      "consequences": [
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PACSIN2",
          "gene_hgnc_id": 8571,
          "hgvs_c": "c.1361C>G",
          "hgvs_p": "p.Thr454Ser",
          "transcript": "NM_001184970.3",
          "protein_id": "NP_001171899.1",
          "transcript_support_level": null,
          "aa_start": 454,
          "aa_end": null,
          "aa_length": 486,
          "cds_start": 1361,
          "cds_end": null,
          "cds_length": 1461,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000263246.8",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001184970.3"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PACSIN2",
          "gene_hgnc_id": 8571,
          "hgvs_c": "c.1361C>G",
          "hgvs_p": "p.Thr454Ser",
          "transcript": "ENST00000263246.8",
          "protein_id": "ENSP00000263246.3",
          "transcript_support_level": 1,
          "aa_start": 454,
          "aa_end": null,
          "aa_length": 486,
          "cds_start": 1361,
          "cds_end": null,
          "cds_length": 1461,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_001184970.3",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000263246.8"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PACSIN2",
          "gene_hgnc_id": 8571,
          "hgvs_c": "c.1361C>G",
          "hgvs_p": "p.Thr454Ser",
          "transcript": "ENST00000403744.7",
          "protein_id": "ENSP00000385372.3",
          "transcript_support_level": 1,
          "aa_start": 454,
          "aa_end": null,
          "aa_length": 486,
          "cds_start": 1361,
          "cds_end": null,
          "cds_length": 1461,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000403744.7"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PACSIN2",
          "gene_hgnc_id": 8571,
          "hgvs_c": "c.1238C>G",
          "hgvs_p": "p.Thr413Ser",
          "transcript": "ENST00000407585.5",
          "protein_id": "ENSP00000385952.1",
          "transcript_support_level": 1,
          "aa_start": 413,
          "aa_end": null,
          "aa_length": 445,
          "cds_start": 1238,
          "cds_end": null,
          "cds_length": 1338,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000407585.5"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PACSIN2",
          "gene_hgnc_id": 8571,
          "hgvs_c": "c.1502C>G",
          "hgvs_p": "p.Thr501Ser",
          "transcript": "ENST00000859857.1",
          "protein_id": "ENSP00000529916.1",
          "transcript_support_level": null,
          "aa_start": 501,
          "aa_end": null,
          "aa_length": 533,
          "cds_start": 1502,
          "cds_end": null,
          "cds_length": 1602,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000859857.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PACSIN2",
          "gene_hgnc_id": 8571,
          "hgvs_c": "c.1379C>G",
          "hgvs_p": "p.Thr460Ser",
          "transcript": "ENST00000971203.1",
          "protein_id": "ENSP00000641262.1",
          "transcript_support_level": null,
          "aa_start": 460,
          "aa_end": null,
          "aa_length": 492,
          "cds_start": 1379,
          "cds_end": null,
          "cds_length": 1479,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000971203.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PACSIN2",
          "gene_hgnc_id": 8571,
          "hgvs_c": "c.1367C>G",
          "hgvs_p": "p.Thr456Ser",
          "transcript": "NM_001349969.2",
          "protein_id": "NP_001336898.1",
          "transcript_support_level": null,
          "aa_start": 456,
          "aa_end": null,
          "aa_length": 488,
          "cds_start": 1367,
          "cds_end": null,
          "cds_length": 1467,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001349969.2"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PACSIN2",
          "gene_hgnc_id": 8571,
          "hgvs_c": "c.1367C>G",
          "hgvs_p": "p.Thr456Ser",
          "transcript": "NM_001349970.2",
          "protein_id": "NP_001336899.1",
          "transcript_support_level": null,
          "aa_start": 456,
          "aa_end": null,
          "aa_length": 488,
          "cds_start": 1367,
          "cds_end": null,
          "cds_length": 1467,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001349970.2"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PACSIN2",
          "gene_hgnc_id": 8571,
          "hgvs_c": "c.1361C>G",
          "hgvs_p": "p.Thr454Ser",
          "transcript": "NM_007229.3",
          "protein_id": "NP_009160.2",
          "transcript_support_level": null,
          "aa_start": 454,
          "aa_end": null,
          "aa_length": 486,
          "cds_start": 1361,
          "cds_end": null,
          "cds_length": 1461,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_007229.3"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PACSIN2",
          "gene_hgnc_id": 8571,
          "hgvs_c": "c.1361C>G",
          "hgvs_p": "p.Thr454Ser",
          "transcript": "ENST00000402229.5",
          "protein_id": "ENSP00000385040.1",
          "transcript_support_level": 5,
          "aa_start": 454,
          "aa_end": null,
          "aa_length": 486,
          "cds_start": 1361,
          "cds_end": null,
          "cds_length": 1461,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000402229.5"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PACSIN2",
          "gene_hgnc_id": 8571,
          "hgvs_c": "c.1361C>G",
          "hgvs_p": "p.Thr454Ser",
          "transcript": "ENST00000859849.1",
          "protein_id": "ENSP00000529908.1",
          "transcript_support_level": null,
          "aa_start": 454,
          "aa_end": null,
          "aa_length": 486,
          "cds_start": 1361,
          "cds_end": null,
          "cds_length": 1461,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000859849.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PACSIN2",
          "gene_hgnc_id": 8571,
          "hgvs_c": "c.1361C>G",
          "hgvs_p": "p.Thr454Ser",
          "transcript": "ENST00000859852.1",
          "protein_id": "ENSP00000529911.1",
          "transcript_support_level": null,
          "aa_start": 454,
          "aa_end": null,
          "aa_length": 486,
          "cds_start": 1361,
          "cds_end": null,
          "cds_length": 1461,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000859852.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PACSIN2",
          "gene_hgnc_id": 8571,
          "hgvs_c": "c.1361C>G",
          "hgvs_p": "p.Thr454Ser",
          "transcript": "ENST00000859853.1",
          "protein_id": "ENSP00000529912.1",
          "transcript_support_level": null,
          "aa_start": 454,
          "aa_end": null,
          "aa_length": 486,
          "cds_start": 1361,
          "cds_end": null,
          "cds_length": 1461,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000859853.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PACSIN2",
          "gene_hgnc_id": 8571,
          "hgvs_c": "c.1361C>G",
          "hgvs_p": "p.Thr454Ser",
          "transcript": "ENST00000859854.1",
          "protein_id": "ENSP00000529913.1",
          "transcript_support_level": null,
          "aa_start": 454,
          "aa_end": null,
          "aa_length": 486,
          "cds_start": 1361,
          "cds_end": null,
          "cds_length": 1461,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000859854.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PACSIN2",
          "gene_hgnc_id": 8571,
          "hgvs_c": "c.1361C>G",
          "hgvs_p": "p.Thr454Ser",
          "transcript": "ENST00000859856.1",
          "protein_id": "ENSP00000529915.1",
          "transcript_support_level": null,
          "aa_start": 454,
          "aa_end": null,
          "aa_length": 486,
          "cds_start": 1361,
          "cds_end": null,
          "cds_length": 1461,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000859856.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PACSIN2",
          "gene_hgnc_id": 8571,
          "hgvs_c": "c.1361C>G",
          "hgvs_p": "p.Thr454Ser",
          "transcript": "ENST00000859858.1",
          "protein_id": "ENSP00000529917.1",
          "transcript_support_level": null,
          "aa_start": 454,
          "aa_end": null,
          "aa_length": 486,
          "cds_start": 1361,
          "cds_end": null,
          "cds_length": 1461,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000859858.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PACSIN2",
          "gene_hgnc_id": 8571,
          "hgvs_c": "c.1361C>G",
          "hgvs_p": "p.Thr454Ser",
          "transcript": "ENST00000859859.1",
          "protein_id": "ENSP00000529918.1",
          "transcript_support_level": null,
          "aa_start": 454,
          "aa_end": null,
          "aa_length": 486,
          "cds_start": 1361,
          "cds_end": null,
          "cds_length": 1461,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000859859.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PACSIN2",
          "gene_hgnc_id": 8571,
          "hgvs_c": "c.1361C>G",
          "hgvs_p": "p.Thr454Ser",
          "transcript": "ENST00000859860.1",
          "protein_id": "ENSP00000529919.1",
          "transcript_support_level": null,
          "aa_start": 454,
          "aa_end": null,
          "aa_length": 486,
          "cds_start": 1361,
          "cds_end": null,
          "cds_length": 1461,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000859860.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PACSIN2",
          "gene_hgnc_id": 8571,
          "hgvs_c": "c.1361C>G",
          "hgvs_p": "p.Thr454Ser",
          "transcript": "ENST00000859863.1",
          "protein_id": "ENSP00000529922.1",
          "transcript_support_level": null,
          "aa_start": 454,
          "aa_end": null,
          "aa_length": 486,
          "cds_start": 1361,
          "cds_end": null,
          "cds_length": 1461,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000859863.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PACSIN2",
          "gene_hgnc_id": 8571,
          "hgvs_c": "c.1361C>G",
          "hgvs_p": "p.Thr454Ser",
          "transcript": "ENST00000859864.1",
          "protein_id": "ENSP00000529923.1",
          "transcript_support_level": null,
          "aa_start": 454,
          "aa_end": null,
          "aa_length": 486,
          "cds_start": 1361,
          "cds_end": null,
          "cds_length": 1461,
          "cdna_start": null,
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        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
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          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
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          "gene_symbol": "ENSG00000307798",
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          "hgvs_c": "n.385G>C",
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        },
        {
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          "protein_coding": false,
          "strand": true,
          "consequences": [
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          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LOC101927393",
          "gene_hgnc_id": null,
          "hgvs_c": "n.44G>C",
          "hgvs_p": null,
          "transcript": "XR_001755575.2",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
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          "aa_length": null,
          "cds_start": null,
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          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
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          "biotype": "pseudogene",
          "feature": "XR_001755575.2"
        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LOC101927393",
          "gene_hgnc_id": null,
          "hgvs_c": "n.44G>C",
          "hgvs_p": null,
          "transcript": "XR_244440.4",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
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          "cds_length": null,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "XR_244440.4"
        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
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          "exon_count": 4,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "PACSIN2",
          "gene_hgnc_id": 8571,
          "hgvs_c": "n.70+4680C>G",
          "hgvs_p": null,
          "transcript": "ENST00000507586.1",
          "protein_id": "ENSP00000422788.1",
          "transcript_support_level": 3,
          "aa_start": null,
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          "cds_start": null,
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          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000507586.1"
        }
      ],
      "gene_symbol": "PACSIN2",
      "gene_hgnc_id": 8571,
      "dbsnp": null,
      "frequency_reference_population": null,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 0,
      "gnomad_exomes_af": null,
      "gnomad_genomes_af": null,
      "gnomad_exomes_ac": null,
      "gnomad_genomes_ac": null,
      "gnomad_exomes_homalt": null,
      "gnomad_genomes_homalt": null,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.439444363117218,
      "computational_prediction_selected": "Uncertain_significance",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": 0.106,
      "revel_prediction": "Benign",
      "alphamissense_score": 0.2072,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.21,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": 5.428,
      "phylop100way_prediction": "Uncertain_significance",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": 2,
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PM2",
      "acmg_by_gene": [
        {
          "score": 2,
          "benign_score": 0,
          "pathogenic_score": 2,
          "criteria": [
            "PM2"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "NM_001349969.2",
          "gene_symbol": "PACSIN2",
          "hgnc_id": 8571,
          "effects": [
            "missense_variant"
          ],
          "inheritance_mode": "",
          "hgvs_c": "c.1367C>G",
          "hgvs_p": "p.Thr456Ser"
        },
        {
          "score": 2,
          "benign_score": 0,
          "pathogenic_score": 2,
          "criteria": [
            "PM2"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "ENST00000828835.1",
          "gene_symbol": "ENSG00000307798",
          "hgnc_id": null,
          "effects": [
            "non_coding_transcript_exon_variant"
          ],
          "inheritance_mode": "",
          "hgvs_c": "n.379G>C",
          "hgvs_p": null
        },
        {
          "score": 2,
          "benign_score": 0,
          "pathogenic_score": 2,
          "criteria": [
            "PM2"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "XR_244440.4",
          "gene_symbol": "LOC101927393",
          "hgnc_id": null,
          "effects": [
            "non_coding_transcript_exon_variant"
          ],
          "inheritance_mode": "",
          "hgvs_c": "n.44G>C",
          "hgvs_p": null
        }
      ],
      "clinvar_disease": "Myoepithelial tumor",
      "clinvar_classification": "Uncertain significance",
      "clinvar_review_status": "no assertion criteria provided",
      "clinvar_submissions_summary": "null",
      "phenotype_combined": "Myoepithelial tumor",
      "pathogenicity_classification_combined": "Uncertain significance",
      "custom_annotations": null
    }
  ],
  "message": null
}