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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 22-46104002-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=22&pos=46104002&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "22",
"pos": 46104002,
"ref": "G",
"alt": "A",
"effect": "missense_variant",
"transcript": "XM_047441694.1",
"consequences": [
{
"aa_ref": "G",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LOC124905135",
"gene_hgnc_id": null,
"hgvs_c": "c.523G>A",
"hgvs_p": "p.Gly175Arg",
"transcript": "XM_047441694.1",
"protein_id": "XP_047297650.1",
"transcript_support_level": null,
"aa_start": 175,
"aa_end": null,
"aa_length": 369,
"cds_start": 523,
"cds_end": null,
"cds_length": 1110,
"cdna_start": 6241,
"cdna_end": null,
"cdna_length": 16167,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LOC124905135",
"gene_hgnc_id": null,
"hgvs_c": "c.523G>A",
"hgvs_p": "p.Gly175Arg",
"transcript": "XM_047441695.1",
"protein_id": "XP_047297651.1",
"transcript_support_level": null,
"aa_start": 175,
"aa_end": null,
"aa_length": 369,
"cds_start": 523,
"cds_end": null,
"cds_length": 1110,
"cdna_start": 7011,
"cdna_end": null,
"cdna_length": 16937,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LOC124905135",
"gene_hgnc_id": null,
"hgvs_c": "c.523G>A",
"hgvs_p": "p.Gly175Arg",
"transcript": "XM_047441696.1",
"protein_id": "XP_047297652.1",
"transcript_support_level": null,
"aa_start": 175,
"aa_end": null,
"aa_length": 369,
"cds_start": 523,
"cds_end": null,
"cds_length": 1110,
"cdna_start": 6441,
"cdna_end": null,
"cdna_length": 16367,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LOC124905135",
"gene_hgnc_id": null,
"hgvs_c": "c.523G>A",
"hgvs_p": "p.Gly175Arg",
"transcript": "XM_047441697.1",
"protein_id": "XP_047297653.1",
"transcript_support_level": null,
"aa_start": 175,
"aa_end": null,
"aa_length": 369,
"cds_start": 523,
"cds_end": null,
"cds_length": 1110,
"cdna_start": 6443,
"cdna_end": null,
"cdna_length": 16369,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "MIRLET7BHG",
"gene_hgnc_id": 37189,
"hgvs_c": "n.309-5265G>A",
"hgvs_p": null,
"transcript": "ENST00000360737.4",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4560,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "MIRLET7BHG",
"gene_hgnc_id": 37189,
"hgvs_c": "n.349+753G>A",
"hgvs_p": null,
"transcript": "ENST00000381051.7",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1013,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "MIRLET7BHG",
"gene_hgnc_id": 37189,
"hgvs_c": "n.372+753G>A",
"hgvs_p": null,
"transcript": "ENST00000435439.5",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
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"cds_length": null,
"cdna_start": null,
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"cdna_length": 2264,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "MIRLET7BHG",
"gene_hgnc_id": 37189,
"hgvs_c": "n.552+753G>A",
"hgvs_p": null,
"transcript": "ENST00000443490.6",
"protein_id": null,
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1212,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "MIRLET7BHG",
"gene_hgnc_id": 37189,
"hgvs_c": "n.286+749G>A",
"hgvs_p": null,
"transcript": "ENST00000686090.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 941,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "MIRLET7BHG",
"gene_hgnc_id": 37189,
"hgvs_c": "n.591+753G>A",
"hgvs_p": null,
"transcript": "ENST00000686767.2",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
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"aa_length": null,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 1253,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "MIRLET7BHG",
"gene_hgnc_id": 37189,
"hgvs_c": "n.252+753G>A",
"hgvs_p": null,
"transcript": "ENST00000687637.2",
"protein_id": null,
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"aa_start": null,
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"cdna_start": null,
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"feature": null
},
{
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"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 5,
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"gene_symbol": "MIRLET7BHG",
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"hgvs_c": "n.620+753G>A",
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"transcript": "ENST00000691934.3",
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},
{
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"canonical": false,
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 6,
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"gene_symbol": "MIRLET7BHG",
"gene_hgnc_id": 37189,
"hgvs_c": "n.224-5265G>A",
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"transcript": "ENST00000794298.1",
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},
{
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"strand": true,
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],
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"gene_symbol": "MIRLET7BHG",
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"hgvs_c": "n.262+753G>A",
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},
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],
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"gene_symbol": "MIRLET7BHG",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 3,
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"gene_symbol": "MIRLET7BHG",
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"hgvs_c": "n.203-5265G>A",
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},
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],
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},
{
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],
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"intron_rank": 5,
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"gene_symbol": "MIRLET7BHG",
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"transcript": "ENST00000794303.1",
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},
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"strand": true,
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],
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"exon_count": 6,
"intron_rank": 3,
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"gene_symbol": "MIRLET7BHG",
"gene_hgnc_id": 37189,
"hgvs_c": "n.368-5265G>A",
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],
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],
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},
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],
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 5,
"intron_rank": 4,
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"gene_symbol": "MIRLET7BHG",
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"hgvs_c": "n.560+753G>A",
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"transcript": "ENST00000794309.1",
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},
{
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],
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{
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{
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],
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}
],
"message": null
}