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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 22-47004963-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=22&pos=47004963&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "22",
"pos": 47004963,
"ref": "T",
"alt": "C",
"effect": "intron_variant",
"transcript": "NM_014346.5",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "TBC1D22A",
"gene_hgnc_id": 1309,
"hgvs_c": "c.1201+7254T>C",
"hgvs_p": null,
"transcript": "NM_014346.5",
"protein_id": "NP_055161.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 517,
"cds_start": null,
"cds_end": null,
"cds_length": 1554,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3758,
"mane_select": "ENST00000337137.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_014346.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "TBC1D22A",
"gene_hgnc_id": 1309,
"hgvs_c": "c.1201+7254T>C",
"hgvs_p": null,
"transcript": "ENST00000337137.9",
"protein_id": "ENSP00000336724.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 517,
"cds_start": null,
"cds_end": null,
"cds_length": 1554,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3758,
"mane_select": "NM_014346.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000337137.9"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "TBC1D22A",
"gene_hgnc_id": 1309,
"hgvs_c": "c.1111+7254T>C",
"hgvs_p": null,
"transcript": "ENST00000380995.5",
"protein_id": "ENSP00000370383.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 487,
"cds_start": null,
"cds_end": null,
"cds_length": 1464,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3934,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000380995.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "TBC1D22A",
"gene_hgnc_id": 1309,
"hgvs_c": "c.967+7254T>C",
"hgvs_p": null,
"transcript": "ENST00000355704.7",
"protein_id": "ENSP00000347932.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 439,
"cds_start": null,
"cds_end": null,
"cds_length": 1320,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1886,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000355704.7"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "TBC1D22A",
"gene_hgnc_id": 1309,
"hgvs_c": "c.1297+7254T>C",
"hgvs_p": null,
"transcript": "ENST00000859791.1",
"protein_id": "ENSP00000529850.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 549,
"cds_start": null,
"cds_end": null,
"cds_length": 1650,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3870,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000859791.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "TBC1D22A",
"gene_hgnc_id": 1309,
"hgvs_c": "c.1228+7254T>C",
"hgvs_p": null,
"transcript": "ENST00000859794.1",
"protein_id": "ENSP00000529853.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 526,
"cds_start": null,
"cds_end": null,
"cds_length": 1581,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2156,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000859794.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "TBC1D22A",
"gene_hgnc_id": 1309,
"hgvs_c": "c.1192+7254T>C",
"hgvs_p": null,
"transcript": "ENST00000859792.1",
"protein_id": "ENSP00000529851.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 514,
"cds_start": null,
"cds_end": null,
"cds_length": 1545,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2158,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000859792.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "TBC1D22A",
"gene_hgnc_id": 1309,
"hgvs_c": "c.1138+7254T>C",
"hgvs_p": null,
"transcript": "ENST00000954015.1",
"protein_id": "ENSP00000624074.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 496,
"cds_start": null,
"cds_end": null,
"cds_length": 1491,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3688,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000954015.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "TBC1D22A",
"gene_hgnc_id": 1309,
"hgvs_c": "c.1111+7254T>C",
"hgvs_p": null,
"transcript": "NM_001284304.2",
"protein_id": "NP_001271233.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 487,
"cds_start": null,
"cds_end": null,
"cds_length": 1464,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3895,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001284304.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "TBC1D22A",
"gene_hgnc_id": 1309,
"hgvs_c": "c.1060+7254T>C",
"hgvs_p": null,
"transcript": "NM_001284305.2",
"protein_id": "NP_001271234.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 470,
"cds_start": null,
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"cds_length": 1413,
"cdna_start": null,
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"cdna_length": 3697,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001284305.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 13,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "TBC1D22A",
"gene_hgnc_id": 1309,
"hgvs_c": "c.1060+7254T>C",
"hgvs_p": null,
"transcript": "ENST00000406733.1",
"protein_id": "ENSP00000385634.1",
"transcript_support_level": 2,
"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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},
{
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"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"intron_rank": 9,
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"gene_symbol": "TBC1D22A",
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"hgvs_c": "c.1024+7254T>C",
"hgvs_p": null,
"transcript": "NM_001410803.1",
"protein_id": "NP_001397732.1",
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"aa_start": null,
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"cds_start": null,
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"biotype": "protein_coding",
"feature": "NM_001410803.1"
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 12,
"intron_rank": 9,
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"gene_symbol": "TBC1D22A",
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"hgvs_c": "c.1024+7254T>C",
"hgvs_p": null,
"transcript": "ENST00000407381.7",
"protein_id": "ENSP00000384036.3",
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"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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},
{
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"strand": true,
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],
"exon_rank": null,
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"gene_symbol": "TBC1D22A",
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 11,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "TBC1D22A",
"gene_hgnc_id": 1309,
"hgvs_c": "c.1009+7254T>C",
"hgvs_p": null,
"transcript": "ENST00000859789.1",
"protein_id": "ENSP00000529848.1",
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},
{
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],
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"gene_symbol": "TBC1D22A",
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"feature": "NM_001284303.2"
},
{
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"strand": true,
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],
"exon_rank": null,
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"intron_rank": 6,
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"gene_symbol": "TBC1D22A",
"gene_hgnc_id": 1309,
"hgvs_c": "c.823+7254T>C",
"hgvs_p": null,
"transcript": "ENST00000859793.1",
"protein_id": "ENSP00000529852.1",
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},
{
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"protein_coding": true,
"strand": true,
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],
"exon_rank": null,
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"exon_count": 9,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "TBC1D22A",
"gene_hgnc_id": 1309,
"hgvs_c": "c.784+7254T>C",
"hgvs_p": null,
"transcript": "ENST00000918112.1",
"protein_id": "ENSP00000588171.1",
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},
{
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],
"exon_rank": null,
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"intron_rank": 11,
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"gene_symbol": "TBC1D22A",
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},
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],
"exon_rank": null,
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"gene_symbol": "TBC1D22A",
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"hgvs_c": "c.1297+7254T>C",
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},
{
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"strand": true,
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],
"exon_rank": null,
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"intron_rank": 10,
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"gene_symbol": "TBC1D22A",
"gene_hgnc_id": 1309,
"hgvs_c": "c.1201+7254T>C",
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"transcript": "XM_017028743.3",
"protein_id": "XP_016884232.1",
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "XM_017028743.3"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "TBC1D22A",
"gene_hgnc_id": 1309,
"hgvs_c": "c.1297+7254T>C",
"hgvs_p": null,
"transcript": "XM_047441307.1",
"protein_id": "XP_047297263.1",
"transcript_support_level": null,
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"cds_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "XM_047441307.1"
},
{
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}
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}