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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 22-50246704-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=22&pos=50246704&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "22",
"pos": 50246704,
"ref": "G",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_032019.6",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HDAC10",
"gene_hgnc_id": 18128,
"hgvs_c": "c.1546C>G",
"hgvs_p": "p.Arg516Gly",
"transcript": "NM_032019.6",
"protein_id": "NP_114408.3",
"transcript_support_level": null,
"aa_start": 516,
"aa_end": null,
"aa_length": 669,
"cds_start": 1546,
"cds_end": null,
"cds_length": 2010,
"cdna_start": 1779,
"cdna_end": null,
"cdna_length": 2567,
"mane_select": "ENST00000216271.10",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_032019.6"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HDAC10",
"gene_hgnc_id": 18128,
"hgvs_c": "c.1546C>G",
"hgvs_p": "p.Arg516Gly",
"transcript": "ENST00000216271.10",
"protein_id": "ENSP00000216271.5",
"transcript_support_level": 1,
"aa_start": 516,
"aa_end": null,
"aa_length": 669,
"cds_start": 1546,
"cds_end": null,
"cds_length": 2010,
"cdna_start": 1779,
"cdna_end": null,
"cdna_length": 2567,
"mane_select": "NM_032019.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000216271.10"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HDAC10",
"gene_hgnc_id": 18128,
"hgvs_c": "c.1486C>G",
"hgvs_p": "p.Arg496Gly",
"transcript": "ENST00000349505.4",
"protein_id": "ENSP00000343540.4",
"transcript_support_level": 1,
"aa_start": 496,
"aa_end": null,
"aa_length": 649,
"cds_start": 1486,
"cds_end": null,
"cds_length": 1950,
"cdna_start": 1486,
"cdna_end": null,
"cdna_length": 1950,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000349505.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HDAC10",
"gene_hgnc_id": 18128,
"hgvs_c": "n.*1067C>G",
"hgvs_p": null,
"transcript": "ENST00000415993.5",
"protein_id": "ENSP00000397517.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2375,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000415993.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HDAC10",
"gene_hgnc_id": 18128,
"hgvs_c": "n.*730C>G",
"hgvs_p": null,
"transcript": "ENST00000429374.5",
"protein_id": "ENSP00000407640.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1634,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000429374.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HDAC10",
"gene_hgnc_id": 18128,
"hgvs_c": "n.*1067C>G",
"hgvs_p": null,
"transcript": "ENST00000415993.5",
"protein_id": "ENSP00000397517.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2375,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000415993.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HDAC10",
"gene_hgnc_id": 18128,
"hgvs_c": "n.*730C>G",
"hgvs_p": null,
"transcript": "ENST00000429374.5",
"protein_id": "ENSP00000407640.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1634,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000429374.5"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HDAC10",
"gene_hgnc_id": 18128,
"hgvs_c": "c.1546C>G",
"hgvs_p": "p.Arg516Gly",
"transcript": "ENST00000895908.1",
"protein_id": "ENSP00000565967.1",
"transcript_support_level": null,
"aa_start": 516,
"aa_end": null,
"aa_length": 668,
"cds_start": 1546,
"cds_end": null,
"cds_length": 2007,
"cdna_start": 1750,
"cdna_end": null,
"cdna_length": 2535,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000895908.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HDAC10",
"gene_hgnc_id": 18128,
"hgvs_c": "c.1546C>G",
"hgvs_p": "p.Arg516Gly",
"transcript": "ENST00000895903.1",
"protein_id": "ENSP00000565962.1",
"transcript_support_level": null,
"aa_start": 516,
"aa_end": null,
"aa_length": 664,
"cds_start": 1546,
"cds_end": null,
"cds_length": 1995,
"cdna_start": 1779,
"cdna_end": null,
"cdna_length": 2552,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000895903.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HDAC10",
"gene_hgnc_id": 18128,
"hgvs_c": "c.1522C>G",
"hgvs_p": "p.Arg508Gly",
"transcript": "ENST00000895906.1",
"protein_id": "ENSP00000565965.1",
"transcript_support_level": null,
"aa_start": 508,
"aa_end": null,
"aa_length": 661,
"cds_start": 1522,
"cds_end": null,
"cds_length": 1986,
"cdna_start": 1736,
"cdna_end": null,
"cdna_length": 2524,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000895906.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HDAC10",
"gene_hgnc_id": 18128,
"hgvs_c": "c.1510C>G",
"hgvs_p": "p.Arg504Gly",
"transcript": "ENST00000895900.1",
"protein_id": "ENSP00000565959.1",
"transcript_support_level": null,
"aa_start": 504,
"aa_end": null,
"aa_length": 657,
"cds_start": 1510,
"cds_end": null,
"cds_length": 1974,
"cdna_start": 1832,
"cdna_end": null,
"cdna_length": 2620,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000895900.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HDAC10",
"gene_hgnc_id": 18128,
"hgvs_c": "c.1486C>G",
"hgvs_p": "p.Arg496Gly",
"transcript": "NM_001159286.2",
"protein_id": "NP_001152758.1",
"transcript_support_level": null,
"aa_start": 496,
"aa_end": null,
"aa_length": 649,
"cds_start": 1486,
"cds_end": null,
"cds_length": 1950,
"cdna_start": 1719,
"cdna_end": null,
"cdna_length": 2507,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001159286.2"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HDAC10",
"gene_hgnc_id": 18128,
"hgvs_c": "c.1480C>G",
"hgvs_p": "p.Arg494Gly",
"transcript": "ENST00000895901.1",
"protein_id": "ENSP00000565960.1",
"transcript_support_level": null,
"aa_start": 494,
"aa_end": null,
"aa_length": 647,
"cds_start": 1480,
"cds_end": null,
"cds_length": 1944,
"cdna_start": 1740,
"cdna_end": null,
"cdna_length": 2525,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000895901.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HDAC10",
"gene_hgnc_id": 18128,
"hgvs_c": "c.1450C>G",
"hgvs_p": "p.Arg484Gly",
"transcript": "ENST00000895907.1",
"protein_id": "ENSP00000565966.1",
"transcript_support_level": null,
"aa_start": 484,
"aa_end": null,
"aa_length": 637,
"cds_start": 1450,
"cds_end": null,
"cds_length": 1914,
"cdna_start": 1660,
"cdna_end": null,
"cdna_length": 2448,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000895907.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HDAC10",
"gene_hgnc_id": 18128,
"hgvs_c": "c.1432C>G",
"hgvs_p": "p.Arg478Gly",
"transcript": "ENST00000948609.1",
"protein_id": "ENSP00000618668.1",
"transcript_support_level": null,
"aa_start": 478,
"aa_end": null,
"aa_length": 631,
"cds_start": 1432,
"cds_end": null,
"cds_length": 1896,
"cdna_start": 1642,
"cdna_end": null,
"cdna_length": 2427,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000948609.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HDAC10",
"gene_hgnc_id": 18128,
"hgvs_c": "c.1420C>G",
"hgvs_p": "p.Arg474Gly",
"transcript": "ENST00000895902.1",
"protein_id": "ENSP00000565961.1",
"transcript_support_level": null,
"aa_start": 474,
"aa_end": null,
"aa_length": 627,
"cds_start": 1420,
"cds_end": null,
"cds_length": 1884,
"cdna_start": 1672,
"cdna_end": null,
"cdna_length": 2460,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000895902.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HDAC10",
"gene_hgnc_id": 18128,
"hgvs_c": "c.1408C>G",
"hgvs_p": "p.Arg470Gly",
"transcript": "ENST00000895905.1",
"protein_id": "ENSP00000565964.1",
"transcript_support_level": null,
"aa_start": 470,
"aa_end": null,
"aa_length": 623,
"cds_start": 1408,
"cds_end": null,
"cds_length": 1872,
"cdna_start": 1635,
"cdna_end": null,
"cdna_length": 2423,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000895905.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HDAC10",
"gene_hgnc_id": 18128,
"hgvs_c": "c.1396C>G",
"hgvs_p": "p.Arg466Gly",
"transcript": "ENST00000448072.5",
"protein_id": "ENSP00000397542.1",
"transcript_support_level": 5,
"aa_start": 466,
"aa_end": null,
"aa_length": 619,
"cds_start": 1396,
"cds_end": null,
"cds_length": 1860,
"cdna_start": 1604,
"cdna_end": null,
"cdna_length": 2133,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000448072.5"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HDAC10",
"gene_hgnc_id": 18128,
"hgvs_c": "c.1351C>G",
"hgvs_p": "p.Arg451Gly",
"transcript": "ENST00000895904.1",
"protein_id": "ENSP00000565963.1",
"transcript_support_level": null,
"aa_start": 451,
"aa_end": null,
"aa_length": 604,
"cds_start": 1351,
"cds_end": null,
"cds_length": 1815,
"cdna_start": 1584,
"cdna_end": null,
"cdna_length": 2367,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000895904.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HDAC10",
"gene_hgnc_id": 18128,
"hgvs_c": "c.1135C>G",
"hgvs_p": "p.Arg379Gly",
"transcript": "ENST00000948608.1",
"protein_id": "ENSP00000618667.1",
"transcript_support_level": null,
"aa_start": 379,
"aa_end": null,
"aa_length": 532,
"cds_start": 1135,
"cds_end": null,
"cds_length": 1599,
"cdna_start": 1357,
"cdna_end": null,
"cdna_length": 2142,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000948608.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HDAC10",
"gene_hgnc_id": 18128,
"hgvs_c": "n.*120C>G",
"hgvs_p": null,
"transcript": "ENST00000454936.5",
"protein_id": "ENSP00000406150.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1922,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000454936.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HDAC10",
"gene_hgnc_id": 18128,
"hgvs_c": "n.855C>G",
"hgvs_p": null,
"transcript": "ENST00000471375.5",
"protein_id": null,
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
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}