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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 3-101685871-G-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=101685871&ref=G&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "3",
      "pos": 101685871,
      "ref": "G",
      "alt": "A",
      "effect": "missense_variant",
      "transcript": "NM_000986.4",
      "consequences": [
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RPL24",
          "gene_hgnc_id": 10325,
          "hgvs_c": "c.139C>T",
          "hgvs_p": "p.Arg47Trp",
          "transcript": "NM_000986.4",
          "protein_id": "NP_000977.1",
          "transcript_support_level": null,
          "aa_start": 47,
          "aa_end": null,
          "aa_length": 157,
          "cds_start": 139,
          "cds_end": null,
          "cds_length": 474,
          "cdna_start": 181,
          "cdna_end": null,
          "cdna_length": 560,
          "mane_select": "ENST00000394077.8",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_000986.4"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RPL24",
          "gene_hgnc_id": 10325,
          "hgvs_c": "c.139C>T",
          "hgvs_p": "p.Arg47Trp",
          "transcript": "ENST00000394077.8",
          "protein_id": "ENSP00000377640.3",
          "transcript_support_level": 1,
          "aa_start": 47,
          "aa_end": null,
          "aa_length": 157,
          "cds_start": 139,
          "cds_end": null,
          "cds_length": 474,
          "cdna_start": 181,
          "cdna_end": null,
          "cdna_length": 560,
          "mane_select": "NM_000986.4",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000394077.8"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RPL24",
          "gene_hgnc_id": 10325,
          "hgvs_c": "n.289C>T",
          "hgvs_p": null,
          "transcript": "ENST00000464595.1",
          "protein_id": null,
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 668,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "ENST00000464595.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RPL24",
          "gene_hgnc_id": 10325,
          "hgvs_c": "c.139C>T",
          "hgvs_p": "p.Arg47Trp",
          "transcript": "ENST00000915208.1",
          "protein_id": "ENSP00000585267.1",
          "transcript_support_level": null,
          "aa_start": 47,
          "aa_end": null,
          "aa_length": 157,
          "cds_start": 139,
          "cds_end": null,
          "cds_length": 474,
          "cdna_start": 220,
          "cdna_end": null,
          "cdna_length": 599,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000915208.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RPL24",
          "gene_hgnc_id": 10325,
          "hgvs_c": "c.124C>T",
          "hgvs_p": "p.Arg42Trp",
          "transcript": "ENST00000889763.1",
          "protein_id": "ENSP00000559822.1",
          "transcript_support_level": null,
          "aa_start": 42,
          "aa_end": null,
          "aa_length": 152,
          "cds_start": 124,
          "cds_end": null,
          "cds_length": 459,
          "cdna_start": 166,
          "cdna_end": null,
          "cdna_length": 544,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000889763.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RPL24",
          "gene_hgnc_id": 10325,
          "hgvs_c": "c.139C>T",
          "hgvs_p": "p.Arg47Trp",
          "transcript": "ENST00000915209.1",
          "protein_id": "ENSP00000585268.1",
          "transcript_support_level": null,
          "aa_start": 47,
          "aa_end": null,
          "aa_length": 152,
          "cds_start": 139,
          "cds_end": null,
          "cds_length": 459,
          "cdna_start": 185,
          "cdna_end": null,
          "cdna_length": 549,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000915209.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RPL24",
          "gene_hgnc_id": 10325,
          "hgvs_c": "c.139C>T",
          "hgvs_p": "p.Arg47Trp",
          "transcript": "ENST00000469605.2",
          "protein_id": "ENSP00000420380.1",
          "transcript_support_level": 2,
          "aa_start": 47,
          "aa_end": null,
          "aa_length": 150,
          "cds_start": 139,
          "cds_end": null,
          "cds_length": 453,
          "cdna_start": 177,
          "cdna_end": null,
          "cdna_length": 1755,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000469605.2"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RPL24",
          "gene_hgnc_id": 10325,
          "hgvs_c": "c.139C>T",
          "hgvs_p": "p.Arg47Trp",
          "transcript": "ENST00000915213.1",
          "protein_id": "ENSP00000585272.1",
          "transcript_support_level": null,
          "aa_start": 47,
          "aa_end": null,
          "aa_length": 146,
          "cds_start": 139,
          "cds_end": null,
          "cds_length": 441,
          "cdna_start": 159,
          "cdna_end": null,
          "cdna_length": 505,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000915213.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RPL24",
          "gene_hgnc_id": 10325,
          "hgvs_c": "c.91C>T",
          "hgvs_p": "p.Arg31Trp",
          "transcript": "ENST00000915212.1",
          "protein_id": "ENSP00000585271.1",
          "transcript_support_level": null,
          "aa_start": 31,
          "aa_end": null,
          "aa_length": 141,
          "cds_start": 91,
          "cds_end": null,
          "cds_length": 426,
          "cdna_start": 128,
          "cdna_end": null,
          "cdna_length": 507,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000915212.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RPL24",
          "gene_hgnc_id": 10325,
          "hgvs_c": "c.139C>T",
          "hgvs_p": "p.Arg47Trp",
          "transcript": "ENST00000495401.5",
          "protein_id": "ENSP00000419179.1",
          "transcript_support_level": 2,
          "aa_start": 47,
          "aa_end": null,
          "aa_length": 121,
          "cds_start": 139,
          "cds_end": null,
          "cds_length": 366,
          "cdna_start": 168,
          "cdna_end": null,
          "cdna_length": 478,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000495401.5"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RPL24",
          "gene_hgnc_id": 10325,
          "hgvs_c": "c.139C>T",
          "hgvs_p": "p.Arg47Trp",
          "transcript": "ENST00000915210.1",
          "protein_id": "ENSP00000585269.1",
          "transcript_support_level": null,
          "aa_start": 47,
          "aa_end": null,
          "aa_length": 90,
          "cds_start": 139,
          "cds_end": null,
          "cds_length": 273,
          "cdna_start": 181,
          "cdna_end": null,
          "cdna_length": 359,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000915210.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "5_prime_UTR_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LOC124906262",
          "gene_hgnc_id": null,
          "hgvs_c": "c.-1508G>A",
          "hgvs_p": null,
          "transcript": "XM_047449411.1",
          "protein_id": "XP_047305367.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 738,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 2217,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 15260,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047449411.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "5_prime_UTR_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LOC124906262",
          "gene_hgnc_id": null,
          "hgvs_c": "c.-1508G>A",
          "hgvs_p": null,
          "transcript": "XM_047449412.1",
          "protein_id": "XP_047305368.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 738,
          "cds_start": null,
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          "cds_length": 2217,
          "cdna_start": null,
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          "cdna_length": 15139,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047449412.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "5_prime_UTR_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LOC124906262",
          "gene_hgnc_id": null,
          "hgvs_c": "c.-1508G>A",
          "hgvs_p": null,
          "transcript": "XM_047449413.1",
          "protein_id": "XP_047305369.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 738,
          "cds_start": null,
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          "cds_length": 2217,
          "cdna_start": null,
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          "cdna_length": 14882,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047449413.1"
        },
        {
          "aa_ref": null,
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          ],
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          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LOC124906262",
          "gene_hgnc_id": null,
          "hgvs_c": "c.-1508G>A",
          "hgvs_p": null,
          "transcript": "XM_047449414.1",
          "protein_id": "XP_047305370.1",
          "transcript_support_level": null,
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          "cds_start": null,
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          "cdna_start": null,
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          "cdna_length": 14294,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "XM_047449414.1"
        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "5_prime_UTR_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LOC124906262",
          "gene_hgnc_id": null,
          "hgvs_c": "c.-1508G>A",
          "hgvs_p": null,
          "transcript": "XM_047449415.1",
          "protein_id": "XP_047305371.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 708,
          "cds_start": null,
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          "cds_length": 2127,
          "cdna_start": null,
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          "cdna_length": 15170,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "XM_047449415.1"
        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "RPL24",
          "gene_hgnc_id": 10325,
          "hgvs_c": "c.81+611C>T",
          "hgvs_p": null,
          "transcript": "ENST00000915211.1",
          "protein_id": "ENSP00000585270.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 120,
          "cds_start": null,
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          "cds_length": 363,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 449,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000915211.1"
        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RPL24",
          "gene_hgnc_id": 10325,
          "hgvs_c": "n.196C>T",
          "hgvs_p": null,
          "transcript": "ENST00000488288.2",
          "protein_id": null,
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
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          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2060,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000488288.2"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RPL24",
          "gene_hgnc_id": 10325,
          "hgvs_c": "n.139C>T",
          "hgvs_p": null,
          "transcript": "ENST00000704284.1",
          "protein_id": "ENSP00000515814.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
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          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 665,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000704284.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RPL24",
          "gene_hgnc_id": 10325,
          "hgvs_c": "n.162C>T",
          "hgvs_p": null,
          "transcript": "ENST00000704285.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 812,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000704285.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
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        {
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        {
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          "feature": "ENST00000851071.1"
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      ],
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      "gnomad_exomes_af": 6.84139e-7,
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      "computational_score_selected": 0.8727272748947144,
      "computational_prediction_selected": "Pathogenic",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
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      "revel_prediction": "Uncertain_significance",
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      "alphamissense_prediction": null,
      "bayesdelnoaf_score": 0.44,
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      "phylop100way_score": 6.247,
      "phylop100way_prediction": "Uncertain_significance",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
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      "acmg_score": 4,
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PM2,PP3_Moderate",
      "acmg_by_gene": [
        {
          "score": 4,
          "benign_score": 0,
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          "criteria": [
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            "PP3_Moderate"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "NM_000986.4",
          "gene_symbol": "RPL24",
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          "effects": [
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        {
          "score": 4,
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          "criteria": [
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            "PP3_Moderate"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "XM_047449411.1",
          "gene_symbol": "LOC124906262",
          "hgnc_id": null,
          "effects": [
            "5_prime_UTR_variant"
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          "inheritance_mode": "",
          "hgvs_c": "c.-1508G>A",
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        {
          "score": 4,
          "benign_score": 0,
          "pathogenic_score": 4,
          "criteria": [
            "PM2",
            "PP3_Moderate"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "ENST00000851071.1",
          "gene_symbol": "ZBTB11-AS1",
          "hgnc_id": 48573,
          "effects": [
            "downstream_gene_variant"
          ],
          "inheritance_mode": "",
          "hgvs_c": "n.*202G>A",
          "hgvs_p": null
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      ],
      "clinvar_disease": "not specified",
      "clinvar_classification": "Uncertain significance",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "phenotype_combined": "not specified",
      "pathogenicity_classification_combined": "Uncertain significance",
      "custom_annotations": null
    }
  ],
  "message": null
}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.