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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-108625856-A-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=108625856&ref=A&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 108625856,
"ref": "A",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_014648.4",
"consequences": [
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DZIP3",
"gene_hgnc_id": 30938,
"hgvs_c": "c.468A>C",
"hgvs_p": "p.Glu156Asp",
"transcript": "NM_014648.4",
"protein_id": "NP_055463.1",
"transcript_support_level": null,
"aa_start": 156,
"aa_end": null,
"aa_length": 1208,
"cds_start": 468,
"cds_end": null,
"cds_length": 3627,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000361582.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_014648.4"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DZIP3",
"gene_hgnc_id": 30938,
"hgvs_c": "c.468A>C",
"hgvs_p": "p.Glu156Asp",
"transcript": "ENST00000361582.8",
"protein_id": "ENSP00000355028.3",
"transcript_support_level": 1,
"aa_start": 156,
"aa_end": null,
"aa_length": 1208,
"cds_start": 468,
"cds_end": null,
"cds_length": 3627,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_014648.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000361582.8"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DZIP3",
"gene_hgnc_id": 30938,
"hgvs_c": "c.468A>C",
"hgvs_p": "p.Glu156Asp",
"transcript": "ENST00000463306.1",
"protein_id": "ENSP00000419981.1",
"transcript_support_level": 1,
"aa_start": 156,
"aa_end": null,
"aa_length": 1208,
"cds_start": 468,
"cds_end": null,
"cds_length": 3627,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000463306.1"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DZIP3",
"gene_hgnc_id": 30938,
"hgvs_c": "c.468A>C",
"hgvs_p": "p.Glu156Asp",
"transcript": "ENST00000927107.1",
"protein_id": "ENSP00000597166.1",
"transcript_support_level": null,
"aa_start": 156,
"aa_end": null,
"aa_length": 1210,
"cds_start": 468,
"cds_end": null,
"cds_length": 3633,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000927107.1"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DZIP3",
"gene_hgnc_id": 30938,
"hgvs_c": "c.468A>C",
"hgvs_p": "p.Glu156Asp",
"transcript": "ENST00000906855.1",
"protein_id": "ENSP00000576914.1",
"transcript_support_level": null,
"aa_start": 156,
"aa_end": null,
"aa_length": 1208,
"cds_start": 468,
"cds_end": null,
"cds_length": 3627,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906855.1"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DZIP3",
"gene_hgnc_id": 30938,
"hgvs_c": "c.468A>C",
"hgvs_p": "p.Glu156Asp",
"transcript": "ENST00000906856.1",
"protein_id": "ENSP00000576915.1",
"transcript_support_level": null,
"aa_start": 156,
"aa_end": null,
"aa_length": 1208,
"cds_start": 468,
"cds_end": null,
"cds_length": 3627,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906856.1"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DZIP3",
"gene_hgnc_id": 30938,
"hgvs_c": "c.468A>C",
"hgvs_p": "p.Glu156Asp",
"transcript": "ENST00000906857.1",
"protein_id": "ENSP00000576916.1",
"transcript_support_level": null,
"aa_start": 156,
"aa_end": null,
"aa_length": 1208,
"cds_start": 468,
"cds_end": null,
"cds_length": 3627,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906857.1"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DZIP3",
"gene_hgnc_id": 30938,
"hgvs_c": "c.468A>C",
"hgvs_p": "p.Glu156Asp",
"transcript": "ENST00000927101.1",
"protein_id": "ENSP00000597160.1",
"transcript_support_level": null,
"aa_start": 156,
"aa_end": null,
"aa_length": 1208,
"cds_start": 468,
"cds_end": null,
"cds_length": 3627,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000927101.1"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DZIP3",
"gene_hgnc_id": 30938,
"hgvs_c": "c.468A>C",
"hgvs_p": "p.Glu156Asp",
"transcript": "ENST00000944671.1",
"protein_id": "ENSP00000614730.1",
"transcript_support_level": null,
"aa_start": 156,
"aa_end": null,
"aa_length": 1208,
"cds_start": 468,
"cds_end": null,
"cds_length": 3627,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000944671.1"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DZIP3",
"gene_hgnc_id": 30938,
"hgvs_c": "c.468A>C",
"hgvs_p": "p.Glu156Asp",
"transcript": "ENST00000944673.1",
"protein_id": "ENSP00000614732.1",
"transcript_support_level": null,
"aa_start": 156,
"aa_end": null,
"aa_length": 1208,
"cds_start": 468,
"cds_end": null,
"cds_length": 3627,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000944673.1"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DZIP3",
"gene_hgnc_id": 30938,
"hgvs_c": "c.468A>C",
"hgvs_p": "p.Glu156Asp",
"transcript": "ENST00000944677.1",
"protein_id": "ENSP00000614736.1",
"transcript_support_level": null,
"aa_start": 156,
"aa_end": null,
"aa_length": 1206,
"cds_start": 468,
"cds_end": null,
"cds_length": 3621,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000944677.1"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DZIP3",
"gene_hgnc_id": 30938,
"hgvs_c": "c.468A>C",
"hgvs_p": "p.Glu156Asp",
"transcript": "ENST00000927085.1",
"protein_id": "ENSP00000597148.1",
"transcript_support_level": null,
"aa_start": 156,
"aa_end": null,
"aa_length": 1197,
"cds_start": 468,
"cds_end": null,
"cds_length": 3594,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000927085.1"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DZIP3",
"gene_hgnc_id": 30938,
"hgvs_c": "c.468A>C",
"hgvs_p": "p.Glu156Asp",
"transcript": "ENST00000944674.1",
"protein_id": "ENSP00000614733.1",
"transcript_support_level": null,
"aa_start": 156,
"aa_end": null,
"aa_length": 1197,
"cds_start": 468,
"cds_end": null,
"cds_length": 3594,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000944674.1"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DZIP3",
"gene_hgnc_id": 30938,
"hgvs_c": "c.468A>C",
"hgvs_p": "p.Glu156Asp",
"transcript": "ENST00000944675.1",
"protein_id": "ENSP00000614734.1",
"transcript_support_level": null,
"aa_start": 156,
"aa_end": null,
"aa_length": 1197,
"cds_start": 468,
"cds_end": null,
"cds_length": 3594,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000944675.1"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DZIP3",
"gene_hgnc_id": 30938,
"hgvs_c": "c.468A>C",
"hgvs_p": "p.Glu156Asp",
"transcript": "ENST00000906858.1",
"protein_id": "ENSP00000576917.1",
"transcript_support_level": null,
"aa_start": 156,
"aa_end": null,
"aa_length": 1188,
"cds_start": 468,
"cds_end": null,
"cds_length": 3567,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906858.1"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DZIP3",
"gene_hgnc_id": 30938,
"hgvs_c": "c.468A>C",
"hgvs_p": "p.Glu156Asp",
"transcript": "ENST00000927083.1",
"protein_id": "ENSP00000597142.1",
"transcript_support_level": null,
"aa_start": 156,
"aa_end": null,
"aa_length": 1188,
"cds_start": 468,
"cds_end": null,
"cds_length": 3567,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000927083.1"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DZIP3",
"gene_hgnc_id": 30938,
"hgvs_c": "c.468A>C",
"hgvs_p": "p.Glu156Asp",
"transcript": "ENST00000944676.1",
"protein_id": "ENSP00000614735.1",
"transcript_support_level": null,
"aa_start": 156,
"aa_end": null,
"aa_length": 1185,
"cds_start": 468,
"cds_end": null,
"cds_length": 3558,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000944676.1"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DZIP3",
"gene_hgnc_id": 30938,
"hgvs_c": "c.393A>C",
"hgvs_p": "p.Glu131Asp",
"transcript": "ENST00000927110.1",
"protein_id": "ENSP00000597168.1",
"transcript_support_level": null,
"aa_start": 131,
"aa_end": null,
"aa_length": 1183,
"cds_start": 393,
"cds_end": null,
"cds_length": 3552,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000927110.1"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DZIP3",
"gene_hgnc_id": 30938,
"hgvs_c": "c.468A>C",
"hgvs_p": "p.Glu156Asp",
"transcript": "ENST00000927105.1",
"protein_id": "ENSP00000597164.1",
"transcript_support_level": null,
"aa_start": 156,
"aa_end": null,
"aa_length": 1175,
"cds_start": 468,
"cds_end": null,
"cds_length": 3528,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000927105.1"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DZIP3",
"gene_hgnc_id": 30938,
"hgvs_c": "c.468A>C",
"hgvs_p": "p.Glu156Asp",
"transcript": "ENST00000927108.1",
"protein_id": "ENSP00000597167.1",
"transcript_support_level": null,
"aa_start": 156,
"aa_end": null,
"aa_length": 1175,
"cds_start": 468,
"cds_end": null,
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"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000927108.1"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DZIP3",
"gene_hgnc_id": 30938,
"hgvs_c": "c.468A>C",
"hgvs_p": "p.Glu156Asp",
"transcript": "ENST00000927103.1",
"protein_id": "ENSP00000597162.1",
"transcript_support_level": null,
"aa_start": 156,
"aa_end": null,
"aa_length": 1172,
"cds_start": 468,
"cds_end": null,
"cds_length": 3519,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000927103.1"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DZIP3",
"gene_hgnc_id": 30938,
"hgvs_c": "c.468A>C",
"hgvs_p": "p.Glu156Asp",
"transcript": "ENST00000927096.1",
"protein_id": "ENSP00000597159.1",
"transcript_support_level": null,
"aa_start": 156,
"aa_end": null,
"aa_length": 1153,
"cds_start": 468,
"cds_end": null,
"cds_length": 3462,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
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