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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-112347715-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=112347715&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 112347715,
"ref": "G",
"alt": "T",
"effect": "synonymous_variant",
"transcript": "ENST00000315711.12",
"consequences": [
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CD200",
"gene_hgnc_id": 7203,
"hgvs_c": "c.579G>T",
"hgvs_p": "p.Thr193Thr",
"transcript": "NM_005944.7",
"protein_id": "NP_005935.4",
"transcript_support_level": null,
"aa_start": 193,
"aa_end": null,
"aa_length": 269,
"cds_start": 579,
"cds_end": null,
"cds_length": 810,
"cdna_start": 636,
"cdna_end": null,
"cdna_length": 2129,
"mane_select": "ENST00000315711.12",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CD200",
"gene_hgnc_id": 7203,
"hgvs_c": "c.579G>T",
"hgvs_p": "p.Thr193Thr",
"transcript": "ENST00000315711.12",
"protein_id": "ENSP00000312766.8",
"transcript_support_level": 1,
"aa_start": 193,
"aa_end": null,
"aa_length": 269,
"cds_start": 579,
"cds_end": null,
"cds_length": 810,
"cdna_start": 636,
"cdna_end": null,
"cdna_length": 2129,
"mane_select": "NM_005944.7",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CD200",
"gene_hgnc_id": 7203,
"hgvs_c": "n.*121G>T",
"hgvs_p": null,
"transcript": "ENST00000498096.6",
"protein_id": "ENSP00000418576.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2212,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CD200",
"gene_hgnc_id": 7203,
"hgvs_c": "n.*121G>T",
"hgvs_p": null,
"transcript": "ENST00000498096.6",
"protein_id": "ENSP00000418576.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2212,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CD200",
"gene_hgnc_id": 7203,
"hgvs_c": "c.654G>T",
"hgvs_p": "p.Thr218Thr",
"transcript": "NM_001004196.4",
"protein_id": "NP_001004196.2",
"transcript_support_level": null,
"aa_start": 218,
"aa_end": null,
"aa_length": 294,
"cds_start": 654,
"cds_end": null,
"cds_length": 885,
"cdna_start": 711,
"cdna_end": null,
"cdna_length": 2204,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CD200",
"gene_hgnc_id": 7203,
"hgvs_c": "c.654G>T",
"hgvs_p": "p.Thr218Thr",
"transcript": "ENST00000473539.5",
"protein_id": "ENSP00000420298.1",
"transcript_support_level": 2,
"aa_start": 218,
"aa_end": null,
"aa_length": 294,
"cds_start": 654,
"cds_end": null,
"cds_length": 885,
"cdna_start": 711,
"cdna_end": null,
"cdna_length": 1524,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CD200",
"gene_hgnc_id": 7203,
"hgvs_c": "c.579G>T",
"hgvs_p": "p.Thr193Thr",
"transcript": "NM_001365851.2",
"protein_id": "NP_001352780.1",
"transcript_support_level": null,
"aa_start": 193,
"aa_end": null,
"aa_length": 278,
"cds_start": 579,
"cds_end": null,
"cds_length": 837,
"cdna_start": 636,
"cdna_end": null,
"cdna_length": 1075,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CD200",
"gene_hgnc_id": 7203,
"hgvs_c": "c.558G>T",
"hgvs_p": "p.Thr186Thr",
"transcript": "NM_001365852.1",
"protein_id": "NP_001352781.1",
"transcript_support_level": null,
"aa_start": 186,
"aa_end": null,
"aa_length": 262,
"cds_start": 558,
"cds_end": null,
"cds_length": 789,
"cdna_start": 1049,
"cdna_end": null,
"cdna_length": 2542,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CD200",
"gene_hgnc_id": 7203,
"hgvs_c": "c.558G>T",
"hgvs_p": "p.Thr186Thr",
"transcript": "NM_001365853.1",
"protein_id": "NP_001352782.1",
"transcript_support_level": null,
"aa_start": 186,
"aa_end": null,
"aa_length": 262,
"cds_start": 558,
"cds_end": null,
"cds_length": 789,
"cdna_start": 696,
"cdna_end": null,
"cdna_length": 2189,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CD200",
"gene_hgnc_id": 7203,
"hgvs_c": "c.558G>T",
"hgvs_p": "p.Thr186Thr",
"transcript": "NM_001365854.1",
"protein_id": "NP_001352783.1",
"transcript_support_level": null,
"aa_start": 186,
"aa_end": null,
"aa_length": 262,
"cds_start": 558,
"cds_end": null,
"cds_length": 789,
"cdna_start": 771,
"cdna_end": null,
"cdna_length": 2264,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CD200",
"gene_hgnc_id": 7203,
"hgvs_c": "c.558G>T",
"hgvs_p": "p.Thr186Thr",
"transcript": "ENST00000607597.2",
"protein_id": "ENSP00000476114.2",
"transcript_support_level": 4,
"aa_start": 186,
"aa_end": null,
"aa_length": 262,
"cds_start": 558,
"cds_end": null,
"cds_length": 789,
"cdna_start": 922,
"cdna_end": null,
"cdna_length": 2415,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CD200",
"gene_hgnc_id": 7203,
"hgvs_c": "c.558G>T",
"hgvs_p": "p.Thr186Thr",
"transcript": "ENST00000714188.1",
"protein_id": "ENSP00000519478.1",
"transcript_support_level": null,
"aa_start": 186,
"aa_end": null,
"aa_length": 262,
"cds_start": 558,
"cds_end": null,
"cds_length": 789,
"cdna_start": 1113,
"cdna_end": null,
"cdna_length": 2975,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CD200",
"gene_hgnc_id": 7203,
"hgvs_c": "c.558G>T",
"hgvs_p": "p.Thr186Thr",
"transcript": "ENST00000714205.1",
"protein_id": "ENSP00000519488.1",
"transcript_support_level": null,
"aa_start": 186,
"aa_end": null,
"aa_length": 262,
"cds_start": 558,
"cds_end": null,
"cds_length": 789,
"cdna_start": 771,
"cdna_end": null,
"cdna_length": 1867,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CD200",
"gene_hgnc_id": 7203,
"hgvs_c": "c.558G>T",
"hgvs_p": "p.Thr186Thr",
"transcript": "ENST00000714208.1",
"protein_id": "ENSP00000519491.1",
"transcript_support_level": null,
"aa_start": 186,
"aa_end": null,
"aa_length": 262,
"cds_start": 558,
"cds_end": null,
"cds_length": 789,
"cdna_start": 746,
"cdna_end": null,
"cdna_length": 2608,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CD200",
"gene_hgnc_id": 7203,
"hgvs_c": "c.492G>T",
"hgvs_p": "p.Thr164Thr",
"transcript": "ENST00000606471.6",
"protein_id": "ENSP00000475860.2",
"transcript_support_level": 3,
"aa_start": 164,
"aa_end": null,
"aa_length": 240,
"cds_start": 492,
"cds_end": null,
"cds_length": 723,
"cdna_start": 687,
"cdna_end": null,
"cdna_length": 2180,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CD200",
"gene_hgnc_id": 7203,
"hgvs_c": "c.357G>T",
"hgvs_p": "p.Thr119Thr",
"transcript": "NM_001318828.2",
"protein_id": "NP_001305757.1",
"transcript_support_level": null,
"aa_start": 119,
"aa_end": null,
"aa_length": 195,
"cds_start": 357,
"cds_end": null,
"cds_length": 588,
"cdna_start": 554,
"cdna_end": null,
"cdna_length": 2047,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CD200",
"gene_hgnc_id": 7203,
"hgvs_c": "c.357G>T",
"hgvs_p": "p.Thr119Thr",
"transcript": "ENST00000383681.7",
"protein_id": "ENSP00000373179.3",
"transcript_support_level": 2,
"aa_start": 119,
"aa_end": null,
"aa_length": 195,
"cds_start": 357,
"cds_end": null,
"cds_length": 588,
"cdna_start": 532,
"cdna_end": null,
"cdna_length": 1997,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CD200",
"gene_hgnc_id": 7203,
"hgvs_c": "c.231G>T",
"hgvs_p": "p.Thr77Thr",
"transcript": "NM_001318826.2",
"protein_id": "NP_001305755.1",
"transcript_support_level": null,
"aa_start": 77,
"aa_end": null,
"aa_length": 153,
"cds_start": 231,
"cds_end": null,
"cds_length": 462,
"cdna_start": 631,
"cdna_end": null,
"cdna_length": 2124,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CD200",
"gene_hgnc_id": 7203,
"hgvs_c": "c.231G>T",
"hgvs_p": "p.Thr77Thr",
"transcript": "NM_001318830.2",
"protein_id": "NP_001305759.1",
"transcript_support_level": null,
"aa_start": 77,
"aa_end": null,
"aa_length": 153,
"cds_start": 231,
"cds_end": null,
"cds_length": 462,
"cdna_start": 549,
"cdna_end": null,
"cdna_length": 2042,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CD200",
"gene_hgnc_id": 7203,
"hgvs_c": "c.231G>T",
"hgvs_p": "p.Thr77Thr",
"transcript": "NM_001365855.1",
"protein_id": "NP_001352784.1",
"transcript_support_level": null,
"aa_start": 77,
"aa_end": null,
"aa_length": 153,
"cds_start": 231,
"cds_end": null,
"cds_length": 462,
"cdna_start": 691,
"cdna_end": null,
"cdna_length": 2184,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CD200",
"gene_hgnc_id": 7203,
"hgvs_c": "c.75G>T",
"hgvs_p": "p.Thr25Thr",
"transcript": "ENST00000714209.1",
"protein_id": "ENSP00000519492.1",
"transcript_support_level": null,
"aa_start": 25,
"aa_end": null,
"aa_length": 101,
"cds_start": 75,
"cds_end": null,
"cds_length": 306,
"cdna_start": 227,
"cdna_end": null,
"cdna_length": 2089,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CD200",
"gene_hgnc_id": 7203,
"hgvs_c": "n.*121G>T",
"hgvs_p": null,
"transcript": "ENST00000478595.1",
"protein_id": "ENSP00000419816.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2017,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CD200",
"gene_hgnc_id": 7203,
"hgvs_c": "n.558G>T",
"hgvs_p": null,
"transcript": "ENST00000607516.2",
"protein_id": "ENSP00000519477.1",
"transcript_support_level": 4,
"aa_start": null,
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}
],
"message": null
}